A rare case of autoimmune hemolytic anemia which complicated with refractory cryptococcal meningitis during treatment with corticosteroid had been presented. A 48 years-old male who had been suffering from autoimmune hemolytic anemia treated with corticosteroid for 7 years developed cryptococcal meningitis 4 months ago complaining of headache, hearing difficulty, nausea and vomiting. Meanwhile, he developed hearing difficulty and blindness. He was transferred to our department for the aggravation of anemia resulting in the shock state. Anemia improved after pulse therapy with methyl-prednisolone (m-PSL) . Visual loss slowly occurred after 4 months. The symptoms of the cryptococcal meningitis improved after administration of amphotericin B (dAMPH-B) and liposomal AMPH-B (L-AMP) , 5-fluorocytosine (5-FC) , and azoles (fluconazole FLCZ, and voriconazole VRCZ) . After administration of these agents for a year and half, the titer for cryptococcal antigen and the number of cryptococcus in the cerebrospinal fluid markedly diminished, however, those are not completely negative and are refractory treatment. Visual loss and hearing difficulty still remained.

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