Yamaguchi Medical Journal
Online ISSN : 1880-4462
Print ISSN : 0513-1731
ISSN-L : 0513-1731
Volume 62, Issue 4
Yamaguchi Medical Journal
Displaying 1-9 of 9 articles from this issue
Review
  • Hiroshi ITOH
    2013 Volume 62 Issue 4 Pages 191-197
    Published: November 01, 2013
    Released on J-STAGE: February 13, 2014
    JOURNAL FREE ACCESS
    MicroRNAs(miRNAs)are non-coding small RNAs that regulate cell proliferation and functions by interfering with the translation of target mRNAs. Altered expression of miRNAs is known to induce various human malignancies. We recently reported that miR-205 might be a specific marker miRNA of both normal and malignant squamous epithelia, while miR-21 might be a putative oncogenic miRNA in human head and neck squamous cell carcinoma(HNSCC),by miRNA microarray analysis. We next confirmed that altered expression of miR-200c and miR-27b directly regulated by hepatocyte growth factor(HGF)might contribute enhanced progressive and invasive characteristics(such as epithelial mesenchymal transition(EMT))of HNSCC by regulating the translation of HGF-induced functional molecules. We also found that the expression of miR-182-5p depended on the cancer grade(Gleason score(GS))even in same Gleason’s pattern(GP)4 prostate cancer, and reported that the expression of miRNA associated with Gleason’s grading system may contribute to more accurate preoperative cancer risk evaluation. These results suggested the significance of miRNAs as diagnositic, prognostic and therapeutic markers. In this paper, we review the relation of cancer with miRNA expression, and discuss the possibility of miRNAs as histopathological diagnostic, prognostic and therapeutic markers.
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Original Paper
  • Masahiko MUTO
    2013 Volume 62 Issue 4 Pages 199-204
    Published: November 01, 2013
    Released on J-STAGE: February 13, 2014
    JOURNAL FREE ACCESS
    Our research project was to collect human biomaterials, as a part of the Research on Measures for Intractable Diseases of the Ministry of Health, Labour and Welfare, Japan, including human blood and skin tissue from the patients who are affected in 7 different intractable skin diseases. The seven diseases consisted of pemphigus, epidermolysis bullosa, congenital ichthyosiform erythroderma, generalized pustular psoriasis, neurofibromatosis(I・II),xeroderma pigmentosum, and tuberous sclerosis(Bourneville-Pringle diseases).We are trying to develop bio bank for a continuous medical research for the intractable skin diseases. In order to carry out the study plan, we have the two major problems;first, who has the property for the corresponding human bio materials? Second, who has an official right based on patent law? To resolve the above problems, between patients including their family members and doctors, there should be fiducial qualities on thinking informed consent, based on freedom of choice from the patient side and fairness. Moreover some practical laws including material transfer agreement should be present in Japan.
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Case Report
  • Daichi KAWAMURA, Takashi NAGASE, Makoto SAMURA, Osamu YAMASHITA, Masa ...
    2013 Volume 62 Issue 4 Pages 205-210
    Published: November 01, 2013
    Released on J-STAGE: February 13, 2014
    JOURNAL FREE ACCESS
    We have experienced 4 cases of endovascular repair for a ruptured abdominal aortic aneurysm. The patients were from 60 to 90 years old. The study population comprised 3 men, and 1 woman. The pre-operative Rutherford classification was level 1 for 1 patient, level 2 for 2 patients, and level 3 for 1 patient. The Fitzgerald classification was type II for 1 patient, and type III for 3 patients. CT angiography was performed for 2 patients, and only plain CT had been performed for the other 2 patients at the previous hospital. The median time interval from arrival at the hospital to the time the operation was performed was 119 ± 48 minutes. For all the patients, the endovascular repair operations were performed using the Gore Excluder device. The median operative time was 212 ± 93 minutes, and the blood loss was 169 ± 197 g. In 3 cases, there was no endoleak;however, re-rupture occurred in the fourth case because of type Ib endoleak and open repair was required. Three of the patients were successfully rehabilitated;1 patient, a 90-year-old woman, died.
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  • Kumiko YOSHIDA, Masahiko ONODA, Takefumi KATSUKI, Akira FURUTANI, Kaz ...
    2013 Volume 62 Issue 4 Pages 211-215
    Published: November 01, 2013
    Released on J-STAGE: February 13, 2014
    JOURNAL FREE ACCESS
    A man in his fifties presenting with jaundice was admitted to our hospital. A detailed examination revealed cancer of the head of the pancreas. While performing a laparotomy, the tumor was found to be unresectable because of metastasis to the para-aortic lymph nodes. Therefore, a choledochojejunostomy and total stomach-preserving duodenojejunostomy were performed. The duodenojejunostomy was performed distal to the jejunojejunostomy so that it was some distance away from the tumor. After surgery, the patient made a good, functional recovery and subsequently survived for 2 years and 5 months with the aid of chemotherapy. Total stomach-preserving duodenojejunostomy may be a useful method of palliative surgery for the treatment of unresectable cancer of the head of the pancreas, because it enables the maintenance of adequate oral intake for a longer period compared with that with a gastrojejunostomy, even in the presence of tumor enlargement or invasion.
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  • Hidefumi KUBO, Chiyo NAKASUGA, Kousuke TADA, Makoto MIYAHARA, Hiroyas ...
    2013 Volume 62 Issue 4 Pages 217-222
    Published: November 01, 2013
    Released on J-STAGE: February 13, 2014
    JOURNAL FREE ACCESS
    We experienced a case in which conservative therapy including administration of octreotide acetate was effective for chylothorax after surgical treatment of esophageal cancer. A 65-year-old male had received neoadjuvant chemotherapy and thereafter underwent subtotal esophagectomy with lymph node excision of three regions(c-T3N1M0, StageⅢ).On third postoperative day, pleural fluid of right pleural cavity was noted and an increase of drainarge fluid was observed and subsequently he was diagnosed as chylothorax. Octreotide acetate and mynomycine were administered daily but observed no dignificant improvement. The persistent conservative treatment, using fat-restricted diet and TPN, and a second infusion of octreotide acetate resulted in gradual decrease of discharge. On the 50th postoperative day, the thoracic drainarge tube was removed and the 59th postoperative day, the patient was discharged. We report this case presented with 24 literatures reported of chyrothorax after esophagectomy for esophageal cancer.
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  • Hidefumi KUBO, Chiyo NAKASUGA, Kousuke TADA, Makoto MIYAHARA, Hiroyasu ...
    2013 Volume 62 Issue 4 Pages 223-228
    Published: November 01, 2013
    Released on J-STAGE: February 13, 2014
    JOURNAL FREE ACCESS
    A 81-year-old man was reffered to our hospital with complaint of hematostool. The colonoscopy revealed a tumor of type 2 in the ascending colon. The patient underwent screening abdominal CT and demonstrated a mass 2 cm in diameter in the right kidney. We simultaneously performed retoroperitoneoscopic radical right nephrectomy and right hemicolectomy. The operation was performed by each different professional team for renal and colon cancer. Total operation time was 252 minutes and estimated blood loss was within 50cc. The surgery was safe and smooth and there were no remarkable complications due to the collaboration.
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  • Yotaro AMASAKI, Takayuki KUGA, Yuya TANAKA, Kazuhito OKA, Yasuhiro FUJ ...
    2013 Volume 62 Issue 4 Pages 229-233
    Published: November 01, 2013
    Released on J-STAGE: February 13, 2014
    JOURNAL FREE ACCESS
    We report a case of a recurred gallbladder carcinoma in the port site after laparoscopic cholecystectomy(LC).A 62 year-old female patient underwent endoscopic sphincteropapillotomy and LC for the treatment of cholecystolithiasis and choledocholithiasis in January 2005. In the pathological examination, she was diagnosed with gallbladder carcinoma. Common bile duct resection and D2 lymph node dissection were performed. She was followed by adjuvant chemotherapy. In June 2008, a port site recurrence was pointed out in the right hypochondrium. The tumor in the muscle layer was resected. The patients who are diagnosed with gallbladder carcinoma after LC are rare. 15.6% among them have had port site recurrence later. Many of the port site recurrences primarily develop in the subperitoneal layer of the abdominal wall and invade the muscle layer, but our case is a rare one in which the recurrence developed only in the muscle layer.
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  • Seiki KOBAYASHI, Masataro HAYASHI, Kazuhiro UEDA, Kimikazu HAMANO
    2013 Volume 62 Issue 4 Pages 235-239
    Published: November 01, 2013
    Released on J-STAGE: February 13, 2014
    JOURNAL FREE ACCESS
    We report a case of non-small cell lung cancer with rhabdoid phenotype that was completely resected by right upper lobectomy and lymphadenectomy. Pathological examination revealed that the tumor was mainly consisted of adenocarcinoma and large cell carcinoma, combined, with scanty of rhabdoid phenotype. Regardless of postoperative chemotherapy, the patient developed duodenal metastasis 7 month postoperatively. According to the pathological examination of resected metastatic lesion, most of the tumor cells represented rhabdoid phenotype. Unfortunately, the patients died of the subsequent liver metastasis 11 month after initial operation. A close follow-up is needed for such non-small cell lung cancer with variety of pathological phenotype.
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  • Norio NOGUCHI, Tadasuke HANAZONO, Kenji MORI, Kousuke OKITA, Isao SAK ...
    2013 Volume 62 Issue 4 Pages 241-246
    Published: November 01, 2013
    Released on J-STAGE: February 13, 2014
    JOURNAL FREE ACCESS
    A 65-year-old woman admitted for lower abdominal pain and hypotension. A ruptured abdominal visceral aneurysm with intraabdominal hemorrhage was shown on abdominal computed tomography(CT). Wide-ranging irregularity in vascular diameter and aneurysm was shown on angiography, suggesting a rupture of an aneurysm of the cecal-colic artery. Hemostasis was achieved by transcatheter arterial embolization(TAE)with microcoils. These findings are attributed to segmental arterial mediolysis(SAM)in this case. The multiple untreated aneurysm and narrowing had almost disappeared on CT 1 year and 10 after the TAE. The natural history of a relatively rare SAM treated by TAE was interesting and valuable in this case.
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