巻号一覧
18 巻, 2 号
選択された号の論文の5件中1～5を表示しています
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宍戸 亮, 本庄 重男, 菅沼 優, 大滝 サチ, 疋田 美智子, 藤原 徹, 高坂 精夫1965 年 18 巻 2 号 p. 73-83
発行日: 1965年
公開日: 2010/03/19
ジャーナル フリーRickettsia sennetsu was inoculated experimentally into cynomolgus monkeys, Macaca irus, for study on infectious mononucleosis. The monkeys manifested a certain disease by intraperitoneal and subcutaneous injection with the agent, but did not by oral administration with it. The disease induced in these monkeys can be called clinically as an infectious mononucleosis, and the infection was confirmed through etiological investigations. Monkey to monkey passage with the agent was also successful. The comparison between Rickettsia sennetsu and the agent of infectious mononucleosis described in old publications of Japan is discussed.抄録全体を表示PDF形式でダウンロード (3216K) -
大滝 サチ, 宍戸 亮1965 年 18 巻 2 号 p. 85-100
発行日: 1965年
公開日: 2010/03/19
ジャーナル フリーIn a preceding paper (Shishido et al., 1965), it was disclosed that a typical infectious mononucleosis was established in monkeys by experimental infection with Rickettsia sennetsu. In this paper, the pathological investigations were carried out on those monkeys which were infected with Rickettsia sennetsu.
Monkeys infected with Rickettsia sennetsu by the intraperitoneal or subcutaneous route showed clinically mild fever and swelling of lymph nodes. Characteristic changes observed in the lymph nodes were diffuse proliferation of large basophilic lymphatic cells, disappearance of follicles, and obscure boundary of the medullary cord and sinus. These findings may be well consistent with those of infectious mononucleosis in the human being. In this meaning, it can be safely said that the disease induced in monkeys by experimental infection with Rickettsia sennetsu was confirmed as infectious mononucleosis by pathologic investigation.抄録全体を表示PDF形式でダウンロード (16848K) -
STANDARDIZATION OF ANTIVENINE I. A METHOD FOR DETERMINATION OF ANTILETHAL POTENCY OF HABU ANTIVENINE近藤 久, 近藤 了, 貞弘 省二, 山内 清澄, 逢坂 昭, 村田 良介1965 年 18 巻 2 号 p. 101-110
発行日: 1965年
公開日: 2010/03/19
ジャーナル フリーAttempts were made to establish an authentic method for assay of the antilethal potency of Habu antivenine. In spite of its wide use the expression of the antivenine potency in “animal animal unit” is not reasonable. The expression of the antivenine potency as the relative potency is not valid either so far as a crude venom is used as test toxin, since the neutralization curves of various antivenines with the crude venom are not always parallel with each other. By using the main lethal fraction of the venom as test toxin, however, the antivenine potency can be successfully determined as the relative potency to the standard antivenine using the parallel line assay method.抄録全体を表示PDF形式でダウンロード (858K) -
武田 久雄, 山田 正篤, 青山 友三1965 年 18 巻 2 号 p. 111-120
発行日: 1965年
公開日: 2010/03/19
ジャーナル フリーPS (Y-15) cells, a porcine kidney stable cell line, were infected with Japanese encephalitis virus (JEV), a member of RNA-containing viruses. Immediately after virus adsorption, the cells were treated with chromomycin A3 in a concentration sufficient to suppress cellular RNA synthesis. The synthesis of viral particles and the production of viral antigen in chromomycin-treated cells were similar to those in non-treated controls in respect to the rate as well as the time course. The results suggest that chromomycin A3 dose not inhibit RNA synthesis by JEV infection. Eventually, RNA synthesis by JEV infection under the condition in which cellular RNA synthesis was completely suppressed by chromomycin A3 was demonstrated autoradiographically to occur in the nucleus several hours prior to the production of viral particles.抄録全体を表示PDF形式でダウンロード (1014K) -
西村 千昭1965 年 18 巻 2 号 p. 121-126
発行日: 1965年
公開日: 2010/03/19
ジャーナル フリーPDF形式でダウンロード (502K)
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