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Volume 20, Issue 3
Displaying 1-6 of 6 articles from this issue
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RIICHI SAKAZAKI1967 Volume 20 Issue 3 Pages 205-212
Published: 1967
Released on J-STAGE: December 08, 2010
JOURNAL FREE ACCESSA group of the Enterobacteriaceae has been studied using 256 cultures which were isolated mainly from snakes. Although the term“Asakusa”group was first used as the designation for the organisms by Sakazaki and Murata (1962), a scientific name Edwardsiella tarda was recently proposed by Ewing and his co-workers.
The members of the group are closely related to the Salmonella group in hydrogen sulfide production and lysine decarboxylation, but differ in their indol production, and mannitol-, arabinose-, xylose-, and trehalose-non-fermentable characteristics.
Within the 256 cultures of the group, seventeen O groups and eleven H antigens were established, and an antigenic schema was set up for 18 serotypes of the group.
It was considered that the organisms are normal intestinal inhabitants of reptiles. Several cultures were isolated from human pathological materials, but no conclusive results on pathogenicity have been obtained in this study.View full abstractDownload PDF (755K) -
AKIKO NAKAMURA1967 Volume 20 Issue 3 Pages 213-223
Published: 1967
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSTo explore the mechanism of development of healthy carrier state of dysentery bacilli, the virulence has been compared among Shigella strains freshly isolated from dysentery patients and healthy carriers and the old laboratory strains. The virulence was principally determined using infection models for shigellosis, that is, the abilities to produce keratoconjunctivitis in guinea pigs (KC-reaction) and to multiply intracellularly in HeLa-S3 cell cultures, along with the tests for cytopathic effect on cultured cells, for mouse virulence as determined by intraperitoneal injection with mucin and for acid agglutinability.
Freshly isolated strains of Shigella both from dysentery patients and from carriers were equally capable to produce KC-reaction and to multiply intracellularly, whereas these capacities were found to be lost in the majority of the laboratory strains. Cytopathic effect on HeLa cells, mouse virulence and acid agglutinability of the strains presently examined proved not to show any significant parallelism with the capacities to produce KC-reaction or to multiply intracellularly. On the basis of our present findings, it seems very likely that the Shigella strains isolated from healthy carriers are as pathogenic as those from dysentery patients.
The usefulness of various tests for the study on the pathogenesis of dysentery has also been discussed.View full abstractDownload PDF (1211K) -
HIROSHI YOSHIKURA, YASUKO HIROKAWA, MASA-ATSU YAMADA, HARUO SUGANO1967 Volume 20 Issue 3 Pages 225-236
Published: 1967
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSThree cell lines persistently infected with Friend leukemia virus were obtained by treating MLg cells with a homogenate of Friend leukemia virusinfected mouse spleens. Two of them were highly leukemogenic and the other was low leukemogenic. The virus titer of the culture fluid of the highly leukemogenic cell lines was about 103 ID50/0.2 ml or more and the undiluted culture fluid induced leukemia in young adult mice within one or two weeks. Virus particles in the low leukemogenic cell line revealed by electronmicroscopy were morphologically indistinguishable from and not fewer than those found in one of the former two cell lines. The persistently infected cell lines could be stored at -70 C without impairing the virus production from the cells.View full abstractDownload PDF (6293K) -
HIROSHI YOSHIKURA1967 Volume 20 Issue 3 Pages 237-242
Published: 1967
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSMLg cells originated from lung tissues of newborn ddY mice were successfully infected with tissue culture-grown Friend leukemia virus and a growth curve of the virus in vitro was obtained. The leukemogenicity of the culture fluid was detectable as early as 18 hr post-infection and the maximum virus titer was 104 ID50/ml on the 5th day post-infection. Cytosine arabinoside, a specific inhibitor of DNA synthesis, as well as actinomycin D, when added during adsorption or immediately after adsorption, inhibited the growth of Friend leukemia virus in vitro, suggesting that a transitory DNA synthesis is required for the growth of Friend leukemia virus in the early stages of the infection.View full abstractDownload PDF (489K) -
ICHIRO MIYAZAKI, SUVAJRA VAJRASTHIRA1967 Volume 20 Issue 3 Pages 243-249
Published: 1967
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSParagonimus bangkokensis sp. nov. was found in Sarika village, Nakorn-nayok province, Central Thailand, known as an endemic area of human paragonimiasis and situated about 90 km from Bangkok. The metacercariae were abundant in the liver and muscle of a crab, Potamon smithianus Rathbun, and matured experimentally in a cat and a bandicoot, Bandicota indica (Bechstein) . In addition, adults of the new species were found in the lungs of two out of five small Indian mongooses, Herpestes javanicus Geoff roy captured in the same locality. As the crab host is frequently eaten uncooked by inhabitants of the area, there is a possibili y of human infection by the new fluke.View full abstractDownload PDF (3314K) -
1967 Volume 20 Issue 3 Pages 251-261
Published: 1967
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSDownload PDF (1062K)
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