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Volume 20, Issue 6
Displaying 1-6 of 6 articles from this issue
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I. DISTRIBUTION OF PHAGE-TYPES OF SALMONELLA TYPHI AND SALMONELLA PARATYPHI B IN JAPAN, 1956-1965HIDEO FUKUMI, MAKOTO OHASHI, NORIKO ZAITU, TOMIE NOJIMA, HIROKO SATO, ...1967 Volume 20 Issue 6 Pages 447-460
Published: 1967
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSIn order to elucidate the typhoid and paratyphoid B phage type distributions in Japan, during the period of 1956-1965, a total of 1, 808 typhoid cases from 1, 002 foci and 114 paratyphoid B cases from 87 foci were submitted for phage typing of their infected organisms, and the following results were obtained.
1. The typhoid strains tested fell into at least 30 Vi-phage types. The sequence of frequency as counted by foci was as follows : types D2 (20%), M1 (13%), E1 (12%), A (7.8%), N+D1 (7.4%), D1 (2.9%), D6 (2.8%), B2 (2.7%), 39 (1.5%), H (1.1%), J1 and 46 (0.80%) ; C5, L1 and 41 (0.50%) ; B1, B3, C4, D4, D10, E2, E4, E9, L2, T, 28, 29, 36, 38 and 47 (less than 0.50%) . Distri-bution of typhoid Vi-phage types in Japan was characteristic of preponderance of types D2 and M1.
2. Of the foci studied, 5.3% could not be assigned that their causative organisms belonged to any hitherto recognized Vi-phage type.
3. The prevalent typhoid Vi-phage types, D2, M1, E1, A and N+D1 were evenly encountered throughout the last ten years and distributed among almost throughout the country.
4. Some of the rearly recognized typhoid Vi-phage types were indigenous to the relatively limited areas.
5. Three new Vi-phage types, 39, 41 and 47 were identified.
6. Paratyphoid B phage types encountered were as follows: Types 3a (49%), 1 (33%), 3b (5.7%), Dundee (2.3%), 3aI (1.1%) and Beccles (1.1%) . The remainders could not he assigned to any known type.View full abstractDownload PDF (1589K) -
TAKESHI YOSHIDA1967 Volume 20 Issue 6 Pages 461-470
Published: 1967
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSThe capacity of newborn guinea pigs to develop the delayed type hypersensitivity was investigated by active sensitization with 10 mg of heat-killed BCG, and also by the local or systemic passive transfer with granulomatous spleen cells from adult guinea pigs sensitized to tuberculin. Local passive transfer of the sensitivity using the sensitive cell-PPD mixture was successful in one-third of the recipients. In contrast, almost all newborn recipients in the systemic (intravenous) passive transfer with sensitive cells responded to intracutaneous injection of 40μg of PPD with a substantially intensive skin reaction. In response to the active sensitization at birth, all the guinea pigs turned tuberculin positive to 40 g PPD within 7 days of age, and produced circulating antibody measurable by means of Middlebrook-Dubos's method. These observations indicate the immunological maturity of the guinea pig at birth.View full abstractDownload PDF (3351K) -
I. DISTRIBUTIONS AND PROPERTIES OF POLIOVIRUS INHIBITORS IN BOVINE AND EQUINE SERAMASATSUGU KANAMITSU, NOBUO HASHIMOTO, SHOZO URASAWA, SHUNZO CHIBA1967 Volume 20 Issue 6 Pages 471-482
Published: 1967
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSA study was made on the distribution and properties of poliovirus inhibitors in equine and bovine sera. The inhibitors were readily detectable at a high frequency in bovine serum, independently of the method of examination. In contrast to this, the detection of inhibitors in equine serum was affected greatly by the method employed. Inhibitors active to particular couples of the same type viruses were found in equine as well as in bovine sera. The activity of inhibitors against poliovirus differed with its antigenic types, suggesting that the inhibitors may differ qualitatively. A bovine serum similar to a certain equine serum in the activity to the same group of type 1 viruses was found. Differentiation of poliovirus strains by comparing their sensitivities to inhibitors was possible with some limitations. The inhibitors developed in sera of both species of animals, at the ages of between 6 and 12 months, increased with the age up to 2 years, but its annual increase at higher age levels was irregular.View full abstractDownload PDF (1229K) -
FUMITOSHI CHINO, TAKASHI TSURUHARA, YASUYUKI EGASHIRA1967 Volume 20 Issue 6 Pages 483-500
Published: 1967
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSThe sequence of tumor development induced in hamsters by adenovirus type 12 was studied in the subcutaneous tissue by means of light- and electron microscopy and fluorescent antibody technique.
The results showed that: (i) the inoculated virus penetrated into mesenchymal cells within 2 hr after inoculation, (ii) the similar cells produced tumor (T) antigen within 24 hr, and (iii) a few of these cells seemed to change into malignant cells about 3 weeks later.
The histology of well developed tumors revealed a sarcomatous pattern in most areas and an epithelioid in part. Argyrophile and collagen fibers were abundant in early tumors, while in well developed tumors they were not so prominent. Electron-microscopically fibrogenetic and phagocytic findings were observed in the tumor cells. Neither desmosome nor basement membrane was recognized in the tumor cells, though an increase of density was rarely found in the intercellular space where the cytoplasmic fingers were in contact with the membrane of other cells.
The tumors found in subserosa by intraperitoneal and intrapleural injections and those developed from parenchyma of the liver and lymph nodes by intravenous inoculation, were histologically identical to the subcutaneous ones. The tumors were also found in the lumbar spinal cord after intracranial inoculation, which was histologically similar to the subcutaneous ones with no evidence of neuroglial fibers.
Under these circumstances, it seems justifiable to conclude that adenovirus 12 tumors are originated from “primitive, multipotential mesenchymal cells”.View full abstractDownload PDF (20972K) -
NOBUICHI MOROOKA, NAOKO NAKANO, NOBUYUKI UCHIDA, AKIRA TAKASE1967 Volume 20 Issue 6 Pages 501-504
Published: 1967
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSDownload PDF (308K) -
TOORU FUJIWARA, IKUYOSHI UCHINO, SHIGEO HONJO, KIYOSHI IMAIZUMI, TOMON ...1967 Volume 20 Issue 6 Pages 505-507
Published: 1967
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSDownload PDF (255K)
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