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Volume 21 (1968)
- Issue 6 Pages 369-
- Issue 5 Pages 301-
- Issue 4 Pages 239-
- Issue 3 Pages 173-
- Issue 2 Pages 95-
- Issue 1 Pages 1-
Predecessor
Volume 21, Issue 4
Displaying 1-7 of 7 articles from this issue
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SEIYA KOHNO, MASAYOSHI KOHASE, MASARU SUGANUMA1968 Volume 21 Issue 4 Pages 239-248
Published: 1968
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSAn antimalarial drug chloroquine produced a potent and specific inhibition on the interferon synthesis by primary chick embryonic cells (PCE) inoculated with UV-irradiated Newcastle disease virus (NDV) . This inhibition was not mediated by the induction of a substance antagonistic to interferon both in vitro and in vivo. Within the concentration range where chloroquine blocked interferon synthesis almost completely (20 to 30μg/ml), the growth of live NDV was not suppressed. Moreover, no alteration in the cellular incorporation capacities of leucine or uridine into acid insoluble fraction were observed. PCE cells once inoculated with UV-irradiated NDV and treated with a sufficient concentration of chloroquine to stop interferon synthesis, acquired a tolerant state to subsequent induction of interferon. This interferon producing system was most sensitive to chloroquine for about four hr from the addition of the inducer.View full abstractDownload PDF (963K) -
FUMITOSHI CHINO, TAKASHI TSURUHARA1968 Volume 21 Issue 4 Pages 249-257
Published: 1968
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSThree cases of von Recklinghausen's disease were examined electron-microscopically to obtain characteristics of cellular arrangement and of component cells in the tumors. The tumors consisted of the axons, Schwann cells and fibroblasts, associated with abundant collagenous fibers. Three types of Schwann cell proliferation were found; 1) almost normal structure of the peripheral nerve with axon, 2) Schwann cell wrapping itself in its cytoplasmic process without axon, 3) discrete Schwann cell with neither axon nor wrapping cytoplasmic process. Each Schwann cell element was invariably provided with basement membrane and the axons were all unmyelinated. Dense areas like desmosomes were scarcely present between the wrapping cytoplasmic processes. The fibroblasts were closely connected with the Schwann cells, being present in the gap of wrapping Schwann cell or in contact with the outside of wrapping one. The Schwann cell was capable of producing collagenous fibers, although the majority of fibers in the tumors would be derived from the fibroblasts. Also, the Schwann cell was observed to produce the fibers showing the peculiar banded structure at the end of wrapping cytoplasmic process, which was the same area as the collagenous fibers were formed.View full abstractDownload PDF (10812K) -
HIDEMASA OGAWA, AKIKO NAKAMURA, RINTARO NAKAYA1968 Volume 21 Issue 4 Pages 259-273
Published: 1968
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSHeLa S3 and Henle's intestinal epithelial cells infected with virulent and avirulent strains of Shigella flexneri bacilli were studied by phase contrast, time-lapse cinemicrography. Virulent Shigella bacilli were found to attach to the surface of the cells evoking vigorous ruffling movement of the cell membrane. This was followed by the formation of pinocytotic vesicles and incorporation of bacilli into cells. In contrast, avirulent bacilli never became attached to cultured cells.
Intracellular Shigella bacilli moved conspicuously independent of the movement of cellular organella and were seen within microfibrillar protrusions from the surface of the host cell. The bacilli exhibited polarity while moving and this movement was inhibited or halted by tetracycline. The nature of the movement of intracellular Shigella bacilli is discussed.View full abstractDownload PDF (16496K) -
VI. THE INOCULATION WITH VARIOUS DOSES OF SHIGELLA FLEXNERI 2a INTO CECAL LUMENMASAO TAKASAKA, SHIGEO HONJO, TOORU FUJIWARA, KIYOSHI IMAIZUMI, HIDEMA ...1968 Volume 21 Issue 4 Pages 275-281
Published: 1968
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSVarious doses of a virulent strain of S. flexneri 2a were injected into the cecal lumen of 20 cynomolgus monkeys.
Seven of 8 monkeys inoculated with 109 of the bacilli developed pronounced dysentery, 3 of 6 monkeys with 107 organisms and 1 of 6 monkeys with 105 developed dysentery, respectively. Clinical and pathological findings in these dysenteric cases were essentially the same as those in the oral administration with 109 of the bacilli. Thus, the method of direct injection of S. flexneri 2a into the cecal lumen proved useful to produce experimental dysentery even with relatively small doses such as 107 or 105 bacilli with which the authors could not produce dysentery by the oral route.
The possible mechanisms of the establishment of S. flexneri 2a infection in the alimentary tract of the monkeys are discussed from the viewpoint of the inoculum size and the inoculation route.View full abstractDownload PDF (646K) -
SHIGEO HONJO, MASAO TAKASAKA, KIYOSHI IMAIZUMI, HIDEMAS OGAWA, RINTARO ...1968 Volume 21 Issue 4 Pages 283-287
Published: 1968
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSDownload PDF (1882K) -
SEIYA KOHNO, MASAYOSHI KOHASE, MASARU SUGANUMA1968 Volume 21 Issue 4 Pages 289-293
Published: 1968
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSDownload PDF (414K) -
1968 Volume 21 Issue 4 Pages 295-300
Published: 1968
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSDownload PDF (435K)
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