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Successor
Volume 22 (1969)
- Issue 6 Pages 341-
- Issue 5 Pages 279-
- Issue 4 Pages 191-
- Issue 3 Pages 133-
- Issue 2 Pages 75-
- Issue 1 Pages 1-
Predecessor
Volume 22, Issue 6
Displaying 1-6 of 6 articles from this issue
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TAKAYUKI TOMIZAWA, SHIGEO KASAMATSU, SHUN-ICHI YAMAYA1969 Volume 22 Issue 6 Pages 341-350
Published: 1969
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSThe passive hemagglutination test for serodiagnosis of syphilis with an antigen derived from pathogenic Treponema pallidum was investigated. The use of an improved reaction medium and the pretreatment of test serum with an antigen derived from a strain of non-pathogenic treponemes eliminated most of non-specific reactions. The method is highly specific and sensitive and is very simple to perform. The lyophilized antigen can be stored for a year without any appreciable change in the antigenicity. Thus, the method will be very useful for routine serodiagnosis of syphilis.View full abstractDownload PDF (1035K) -
HIDEMASA OGAWA, AKIKO NAKAMURA1969 Volume 22 Issue 6 Pages 351-362
Published: 1969
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSRelation between the development of inflammatory response and invasion of Shigella into the mucosa (epithelial lining) was studied with the ligated intestine of rabbits immunized actively or passively through different routes.
When the intestinal segments of rabbits pretreated with heat-killed Via or Avia organisms or perfused intravenously with antiserum, were challenged with a virulent strain, they responded with hypersensitivity reactions, characterized by an enhanced circulatory disturbance and necrosis of the mucosa especially in epithelial lining. The invasion of Shigella into the mucosa was not prevented by those immune-treatment.
The hypersensitivity reaction was more remarkable in the large intestinal segments than in the small intestinal ones. This fact seemed relevant to the fact that the large intestine was preferentially affected in natural bacillary dysentery.
On the contrary, neither dilatation nor inflammatory response of the segments in immune-treated animals were observed either in the case of challenge with an avirulent strain, which was lacking in ability to penetrate into the mucosa, or in the challenge with a heat-killed virulent strain.
When injected with antiserum into the intestinal segments at the same time of challenge, the penetration of a virulent strain into the mucosa as well as the dilatation of the segments due to inflammatory response were effectively inhibited.View full abstractDownload PDF (9049K) -
I. MANIFESTATION AND PATHOLOGICAL OBSERVATIONTAKESHI MUTO, MASARO NAKAGAWA, YOSHIO ISOBE, MANABU SAITO, TAKESHI NAK ...1969 Volume 22 Issue 6 Pages 363-374
Published: 1969
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSA diarrheal disease hitherto unknown explosively occurred in a mouse colony of DDY strain, causing death in a great number of sucklings. Two to three-week-old sucklings were most frequently and severely affected, but mice after weaning acquired gradual resistance to the disease as they grew older and no fatal cases were usually observed in these animals. Lactating mothers were sometimes severely affected when they had sick babies. The disease rarely appeared in sucklings younger than 2 weeks of age. In pathological examinations, thickened walls of various degrees were found in either or both of the jejunum and colon. The lesions of the small intestine were characterized by an increased number of the villi, a replacement of the villus cells due to the hyperplasia of the crypt type cells over the epithelium, a formation of the thickened mucosal folds and a paucity or lack of the inflammatory reactions in any layers of the intestinal wall. Characteristic figures of the large intestine were almost the same as those of the small intestine, except that a marked decrease was observed in the number of the goblet cells. A provisional name “megaenteron of mice” was given to the disease.View full abstractDownload PDF (9089K) -
II. DETECTION OF COLIFORM ORGANISMS OF AN UNUSUAL BIOTYPE AS THE PRIMARY CAUSEMASARO NAKAGAWA, TAKESHI MUTO, MANABU SAITO, TOSHIKATSU HAGIWARA, KIYO ...1969 Volume 22 Issue 6 Pages 375-382
Published: 1969
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSA large number of coliform organisms of an unusual biotype was isolated frequently from the intestinal tract and sometimes from the liver and spleen of mice affected with megaenteron (Muto et al., 1969) . In contrast, only a few healthy mice harbored the organisms in their guts. When healthy mice were inoculated orally with the organisms, a fatal diarrheal disease, indistinguishable clinically and pathologically from the natural cases, developed consistently in 1-week-aged mice after an 8- to 10-day incubation period. Weanlings aged 4 weeks were also affected but not so severely as sucklings. Bacteria-free filtrate of the intestines of diseased mice failed to affect sucklings by oral administration. Thus, the organisms of the biotype were regarded as the causative agent of megaenteron of mice.View full abstractDownload PDF (820K) -
HIDEMASA OGAWA, AKIKO NAKAMURA1969 Volume 22 Issue 6 Pages 383-387
Published: 1969
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSDownload PDF (3218K) -
MASAO TAKASAKA, SHIGEO HONJO, KIYOSHI IMAIZUMI, HIDEMASA OGAWA, RINTAR ...1969 Volume 22 Issue 6 Pages 389-393
Published: 1969
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSDownload PDF (601K)
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