Japanese Journal of Medical Science and Biology
Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISSN-L : 0021-5112
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Volume 24, Issue 1
Displaying 1-3 of 3 articles from this issue
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  • CELLULAR IMMUNITY INDUCED BY ROUS SARCOMA VIRUS IN JAPANESE QUAIL
    II. EFFECT OF THYMECTOMY AND BURSECTOMY ON ONCOGENESIS OF ROUS SARCOMA VIRUS
    KAZUYA YAMANOUCHI, MASANORI HAYAMI, SATOSHI MIYAKURA, AKIKO FUKUDA, FU ...
    1971 Volume 24 Issue 1 Pages 1-8
    Published: 1971
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.24.1
    JOURNAL FREE ACCESS
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    Suppression of the cellular and humoral immune capacities of Japanese quails was attempted by surgical thymectomy on the 7th day of hatch and surgical bursectomy on the day of hatch. Degree of immunosuppression on cellular immune response was evaluated by graft-versus-host reaction and skin graft rejection, and that on humoral immune response was evaluated by antibody production to sheep red blood cells and virus antigen. In thymectomized quails significant suppressionn of cellular immunity was demonstrated, whereas humoral immune capacity remained almost normal. In bursectomized quails, significant suppression of humoral antibody response was observed without any detectable suppression of cellular immune response. When the quails immunosuppressed either by thymectomy or bursectomy were inoculated with the Schmidt-Ruppin strain of Rous sarcoma virus, regression of primary tumors and induction of resistance to challenge with the same virus were significantly inhibited in thymectomized quails, but not in bursectomized ones. From the results, cell-mediated immune response was suggested to play a major role in the course of autochthonous virus-induced tumors in quails.
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  • PURIFICATION AND SOME PROPERTIES OF KAPPA TOXIN OF CLOSTRIDIUM PERFRINGENS
    SHOICHI KAMEYAMA, KIYOTO AKAMA
    1971 Volume 24 Issue 1 Pages 9-23
    Published: 1971
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.24.9
    JOURNAL FREE ACCESS
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    κ-Toxin of Clostridium perfringens type A was purified by gel filtration through Sephadex G-100 followed by column chromatography on DEAE-cellulose. The purified preparation showed no activities of other toxins produced by the organism and of such enzymes as neuraminidase, deoxyribonuclease, hyaluronidase or proteinase (caseinolytic) . The purified toxin behaved as a single component by immunoelectrophoresis and by centrifugation in sucrose density gradient. An approximate molecular weight of 80, 000 was estimated. A definite hemorrhage was produced with 0.7μg of the toxin in the depilated rabbit skin. Mice were killed with 30μg; on autopsy severe hemorrhage in the lungs was the only visible pathological change. An extensive destruction of connective tissue resulted from the subcutaneous injection of the toxin into the guinea pig. Intact muscle was also destroyed severely by the intramuscular injection of the toxin.
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  • SYMPOSIUM ON TOXINS
    1971 Volume 24 Issue 1 Pages 25-81
    Published: 1971
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.24.25
    JOURNAL FREE ACCESS
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