巻号一覧
24 巻, 5 号
選択された号の論文の6件中1～6を表示しています
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清水 孜, 広鰭 律子, 野村 泰子, 栗飯原 景昭, 宮木 高明1971 年 24 巻 5 号 p. 271-279
発行日: 1971年
公開日: 2010/03/19
ジャーナル フリーIn order to prove sodium toxicity of MSG, baby chicks known to be the most susceptible one to sodium chloride were chosen as the experimental animal. Almost isotonic solution of MSG, NaCl or monopotassium glutamate was given ad libitum as the sole source of drinking water. Two-day old chickens given MSG died of gout within a few days and showed higher mortality and lesions severer than those given physiological saline, while none died nor was weakened among those receiving monopotassium glutamate. Very rapid development of kidney lesions and a large amount of urate deposits were the two main features resulting from MSG ingestion, and primary histological changes were tubular degeneration and tophi obstruction in collecting ducts. Even at half concentration, MSG ingestion caused lobar atrophy in the kidney and some died of gout. Besides sodium toxicity, glutamate counterpart is suspected of contributing to uric acid synthesis.抄録全体を表示PDF形式でダウンロード (8540K) -
近藤 了, 貞弘 省二, 山内 清澄, 近藤 久, 村田 良介1971 年 24 巻 5 号 p. 281-294
発行日: 1971年
公開日: 2010/03/19
ジャーナル フリーHabu venom and the purified toxic principles (HR1 and HR2) were converted to toxoid with formalin. Immunogenicity was preserved well consistently if formalin was added in several steps to a final concentration of about 0.8%. An adsorbed mixed toxoid composed of purified HR1 and HR2 toxoids was proved to contain all the important antigens necessary for the protection against the envenomation by the Habu bite. Potency of the toxoid preparations can be determined by titrating the circulating antitoxins (anti-HR1 and antiHR2) of the immunized guinea pigs. A practical method for potency test was proposed, in which the potency is expressed in the relative value to a reference toxoid.抄録全体を表示PDF形式でダウンロード (1322K) -
曽田 研二1971 年 24 巻 5 号 p. 295-311
発行日: 1971年
公開日: 2010/03/19
ジャーナル フリーConditions for the production of plaques by cytopathogenic strains of coxsackie A 7 (CA 7) virus were examined, and plaque characteristics and biological properties of the virus strains were studied. Out of 14 strains of CA 7 virus, AB-IV-KH and two lines of the prototype strains showed remarkable heterogeneity in size of plaques in monkey kidney cells, while the other strains produced uniform, small plaques only. An appropriate concentration of DEAE-dextran or protamine sulfate in the agar overlay enhanced significantly the formation of plaques by these strains, especially of small plaques, and the concentration of sodium bicarbonate in the agar overlay was also proved to be one of the important factors affecting the plaque formation of the virus. A large plaqueforming (LP) and a small plaqueforming (SP) viruses were obtained from AB-IV-KH strain by serial plaque purifications or terminal dilution passages. LP virus was genetically less stable than SP virus, and plaque production of SP virus was significantly enhanced by DEAE-dextran or protamine sulfate and reversely inhibited by agar extract or sulfated polysaccharides. No differences in growth rate in monkey kidney cell cultures, serological property or pathogenicity in suckling mice were observed between LP and SP viruses.抄録全体を表示PDF形式でダウンロード (3695K) -
金井 興美, 近藤 瑩子1971 年 24 巻 5 号 p. 313-321
発行日: 1971年
公開日: 2010/03/19
ジャーナル フリーViable forms of tubercle bacillus, even when they are essentially drug-sensitive, can persist in mouse tissue under the treatment with antituberculous drugs. This peculiar phenomenon characteristics of the chronic stage of infection is called “microbial persistence”. To explain the underlying mechanism, some model experiments were conducted. Infection with resting bacilli was attained in mice with a streptomycin-dependent strain having completed residual growth on the medium lacking the antibiotic. Isoniazid administration failed to eliminate such resting bacilli from the mouse tissue. An additional experiment showed that the challenge inoculum whose multiplication was inhibited by vaccine-induced immunity did not respond satisfactorily to the mycobactericidal action of isoniazid. These observations and others led us to a view that microbial persistence results from the insensitiveness to chemotherapeutics of the bacilli in a resting condition under the pressure of infection immunity.抄録全体を表示PDF形式でダウンロード (900K) -
近藤 久, 近藤 了, 貞弘 省二, 山内 清澄, 村田 良介1971 年 24 巻 5 号 p. 323-327
発行日: 1971年
公開日: 2010/03/19
ジャーナル フリーPDF形式でダウンロード (505K) -
FRANK T. PERKINS1971 年 24 巻 5 号 p. 329-344
発行日: 1971年
公開日: 2010/03/19
ジャーナル フリーPDF形式でダウンロード (1653K)
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