Japanese Journal of Medical Science and Biology
Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISSN-L : 0021-5112
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Volume 25, Issue 3
Displaying 1-4 of 4 articles from this issue
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  • SUBCELLULAR AND INTERCELLULAR ASPECTS OF TUBERCULOUS INFECTION IN REFERENCE TO PROTECTION AND SENSITIZATION
    KOOMI KANAI, EIKO KONDO
    1972 Volume 25 Issue 3 Pages 133-167
    Published: 1972
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.25.133
    JOURNAL FREE ACCESS
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  • GENETIC STABILITY OF SABIN STRAIN OF TYPE 3 POLIOVIRUS IN THE SENSITIVITY TO INHIBITORY BOVINE SERUM I. SELECTION OF INHIBITORY BOVINE SERUM AGAINST TYPE 3 SABIN STRAIN AND SENSITIVITY TO THE SERUM OF VACCINE PROGENIES
    TOMOKO URASAWA, SHOZO URASAWA, MASATSUGU KANAMITSU
    1972 Volume 25 Issue 3 Pages 169-177
    Published: 1972
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.25.169
    JOURNAL FREE ACCESS
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    Investigations were carried out on the identification and genetic stability of type 3 Sabin vaccine (Leon 12 a1b) strain using a bovine inhibitor marker.
    Sera with strong inhibitory activity to the virus were rarely found in calves, while with high frequencies in heifers, and found to be reduced slightly in number at advanced ages.
    Of 495 sera tested, two (BS-19 and BE-19) specifically neutralized 3 laboratory strains of type 3 poliovirus including Leon 12 a1b, and left wild virus strains of the same type entirely unaffected. The strain-specific reactivity of the inhibitory sera was clearly demonstrated in the kinetic neutralization test.
    In vitro or human passage progenies of the vaccine virus were investigated for their sensitivity to the two bovine sera. While both the vaccine virus and its progenies were equally sensitive to BS-19, the progenies were less sensitive than the original vaccine virus to the inhibition by BE-19.
    On the basis of these results, the practical utility of bovine inhibitor marker for the identification of vaccine-derived viruses was discussed.
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  • IN VITRO PRODUCTION OF ENTEROTOXIN AND HEMORRHAGIC PRINCIPLE BY VIBRIO CHOLERAE, NAG
    MAKOTO OHASHI, TOSHIO SHIMADA, HIDEO FUKUMI
    1972 Volume 25 Issue 3 Pages 179-194
    Published: 1972
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.25.179
    JOURNAL FREE ACCESS
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    In vitro production of enterotoxin by Vibrio cholerae, NAG isolated from human diarrheal cases in India, the Philippines and Sudan was tested. Of a total of 41 strains tested, 8 proved to produce the toxin characterized by permeability-increasing activity in the guinea pig skin.
    Characterization of the toxin produced by a representative strain was also made in comparison with cholera enterotoxin produced by V. cholerae, serotype 1, 569B strain.
    This toxin was heat labile, nondialyzable and immunogenic. It evoked positive ileal-loop reaction in rabbit and also fatal diarrhea in suckling mice after oral administration. However, the maximum volume-length ratio in the ileal-loop test produced by the toxin did not reach the level given by cholera enterotoxin. Toxicity of the toxin for suckling mice was unexpectedly higher than that of cholera enterotoxin when they were compared on the basis of their permeability increasing activity.
    It was only partially neutralized by anti-choleragenoid serum, whereas antiserum against the crude NAG toxin was able to neutralize completely the activity of the purified or crude cholera enterotoxin.
    From these findings, we conclude that the crude NAG toxin contains an exotoxinn closely related to the enterotoxin produced by strain 569B. In addition to this, other substance (s) participating in the permeability increase or toxicity for suckling mice or both mayy also exist in this crude material.
    The present studies also demonstrated that some strains of V. cholerae, serotype 1 and NAG elaborate a “hemorrhagic principle” in vitro. A brief description of this principle has also been made.
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  • SYMPOSIUM ON TOXINS
    1972 Volume 25 Issue 3 Pages 195-247
    Published: 1972
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.25.195
    JOURNAL FREE ACCESS
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