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Volume 28, Issue 2
Displaying 1-5 of 5 articles from this issue
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KOITI TAKAHASI, SETSUJI ISHIDA, KENJI NAGASAKA, MASAMI KUROKAWA, SADAO ...1975 Volume 28 Issue 2 Pages 101-116
Published: 1975
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSA table was constructed for use in estimating the mean of distribution of logarithms of titers based on data obtained with a pooled material instead of those with individuals in a sample. A table of standard errors of the estimator was also constructed. Examples showing the utility and applicability of the tables were presented. Several relating problems were discussed.View full abstractDownload PDF (1669K) -
III. NEUROVIRULENCE OF SSPE VIRUS IN FERRETSYASUHIRO YOSHIKAWA, KAZUYA YAMANOUCHI, TAKESHI A. SATO, SHIGETAKA KATO ...1975 Volume 28 Issue 2 Pages 117-126
Published: 1975
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSThe Niigata-1 strain isolated from a patient with subacute sclerosing panencephalitis (SSPE) was inoculated intracerebrally into ferrets. Neurological signs developed in about 1 week in most of the animals. Histopathological examinations of the central nervous tissues revealed degenerative lesions in the parenchyma of the brains and inflammatory reactions predominantly in the meninges and choroid plexus. Virus antigen was demonstrated mainly in the nerve cells by immunofluorescent staining. The results indicated high affinity of the Niigata-1 strain to the nerve cells. In contrast, the Mantooth strain of SSPE virus in cell-free state did not exhibit neurovirulence in ferrets.View full abstractDownload PDF (7184K) -
I. TITRATION OF GUINEA-PIG ANTITOXINS AT VARIOUS PERIODS OF IMMUNIZATIONSHOICHI KAMEYAMA, SATORU KONDO1975 Volume 28 Issue 2 Pages 127-138
Published: 1975
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSAn improved technique for passive hemagglutination (HA) for titration of tetanus antitoxin was described. The use of highly purified tetanus toxoid and of improved diluent increased the specificity and reproducibility of the test. Several hundreds of specimens of guinea-pig serum taken at various stages of immunization were titrated by HA and toxin neutralization (NT) in mice. The ratio of HA to NT titers varied significantly depending on the immunization stage; higher at early stages and lower at later stages. The high HA/NT ratio was not due to the IgM antitoxin, which is very rare in guinea pigs. The variation in discrepancy between HA and NT titers decreased considerably by grouping the serum specimens with respect to the stage of immunization. Thus, it is possible to predict the in vivo titer of a tetanus antitoxin accurately enough for clinical study. The HA test may be useful as an alternative method for titrating tetanus antitoxin in the field trials. Moreover, it can be used for the study of characteristics of antitoxins.View full abstractDownload PDF (986K) -
KOICHIRO FUJITA1975 Volume 28 Issue 2 Pages 139-149
Published: 1975
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSAllergen in crude extract of Dirofilaria immitis was purified and separated from the IgG-inducing antigens by a combination of DEAE-Sephadex A-50 chromatography and Sephadex G-200 gel filtration.
The molecular weight of the purified preparation was estimated to be approximately 20, 000 by gel filtration. The carbohydrate content of the preparation was apparently low, about 2%.
Rats immunized with the allergenic fraction developed only a homocytotropic antibody and no hemagglutination antibody.View full abstractDownload PDF (963K) -
YASUHIRO MIURA1975 Volume 28 Issue 2 Pages 151-155
Published: 1975
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSDownload PDF (3304K)
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