Japanese Journal of Medical Science and Biology
Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISSN-L : 0021-5112
Search
Advanced search
OR
Browse
Search
Volume 29, Issue 4
Displaying 1-6 of 6 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
  • GROWTH OF MEASLES VIRUS IN NERVOUS TISSUES
    IV. NEUROVIRULENCE OF WILD MEASLES AND SSPE VIRUSES IN MONKEYS
    Kazuya YAMANOUCHI, Nobuyuki UCHIDA, Shigetaka KATOW, Takeshi A. SATO, ...
    1976 Volume 29 Issue 4 Pages 177-186
    Published: 1976
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.29.177
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Neurovirulence of in vivo-passed wild measles virus and that of the cell-associated SSPE virus were compared by intracerebral inoculation into monkeys. The wild measles virus was found to lack neurovirulence without producing neurological signs or significant histological changes in the brains, whereas the virus was confirmed to preserve the properties characteristic of the wild virus. In contrast, inoculation of the SSPE virus induced rapid onset of neurological signs with mild but definite histological changes including degeneration of nerve cells. The fact that SSPE virus exhibited neurovirulence in monkeys indicated importance of the current assay system for neurovirulence of measles vaccine by intracerebral inoculation into monkeys.
    View full abstract
    Download PDF (5564K)
  • FAILURE TO PROVE ARENAVIRUS INFECTION AMONG THE SMALL MAMMALS FROM AN ENDEMIC AREA OF KOREAN HEMORRHAGIC NEPHROSONEPHRITIS
    Takeshi OKUNO, Jordi CASALS, Kyong-Ho KIM, Dan W. WALTON, Hak-kin SHIN ...
    1976 Volume 29 Issue 4 Pages 187-197
    Published: 1976
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.29.187
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    In the light of recent knowledge on a complex of diseases caused by a new group of viruses, arenaviruses, virological studies largely directed toward small field mammals were undertaken during 1973-1974 aiming at etiological clarification of Korean hemorrhagic nephrosonephritis (KHNN) . Specimens were collected in an endemic area of KHNN located north to northeast of Seoul. Virus isolation tests with 299 urine specimens and 131 mite pools recovered from small mammals and 14 acute stage sera from typical cases yielded negative results. Com-plement-fixation (CF) tests failed to detect antibodies against the antigens of Congo, lymphocytic choriomeningitis (LCM), Tacaribe, and Pichinde viruses among 366 small mammal sera. In addition, CF tests of 59 of the above sera against Apoi and Lassa virus antigens were negative. The results do not support the likelihood of an arenavirus being transmitted among Korean small field mammals, the overwhelming majority of which wereApodemus agrarius. A hypothesis that KHNN is caused by a virus of small field mammal origin was not proved within the technical limit of relatively unsophisticated methods employed herein.
    View full abstract
    Download PDF (944K)
  • A SUGGESTED ROLE OF A HOST-PARASITE LIPID COMPLEX IN MYCOBACTERIAL INFECTION
    Eiko KONDO, Koomi KANAI
    1976 Volume 29 Issue 4 Pages 199-210
    Published: 1976
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.29.199
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    On the basis of our previous observations and related literatures, we assumed that cholesterol esters of host origin and phthiocerol dimycocerosate of bacterial origin are located as a lipid mixture around the periphery of pathogenic mycobacteria growing in vivo, probably within the phagocytic vacuole of macrophages.
    To examine the role of such a postulated lipid complex in mycobacterial infection, a model experiment was made in which tubercle bacilli grown in vitro were “coated” with both lipids and then suspended homogenously in water to serve as an inoculum to infect mice intravenously. Their fate in mouse tissue was compared with that of untreated control bacilli.
    The results indicated that the lipid-“coating” had an infection-promoting effect as revealed by the longer persistence of the treated avirulent bacilli at higher levels of viable counts.
    When virulent tubercle bacilli were “coated” with the lipid mixture, they became less sensitive to the protective mechanism of BCG-immunized mice.
    View full abstract
    Download PDF (999K)
  • LATEX AGGLUTINATION-INHIBITION TEST FOR SCREENING BLOOD-CLOTTING FACTOR XIII IN HUMAN PLASMA
    KAZUSHIGE MASUDA, HIROSHI ISHIYAMA, JUNICHI YASUDA
    1976 Volume 29 Issue 4 Pages 211-214
    Published: 1976
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.29.211
    JOURNAL FREE ACCESS
    Download PDF (372K)
  • EFFECT OF CYCLOHEXIMIDE ON THE REPLICATION OF WESTERN EQUINE ENCEPHALITIS VIRUS
    KATSUYUKI HASHIMOTO, BUNSITI SIMIZU
    1976 Volume 29 Issue 4 Pages 215-219
    Published: 1976
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.29.215
    JOURNAL FREE ACCESS
    Download PDF (395K)
  • A-TYPE INCLUSION MARKERS OF WILD WHITE AND OTHER VARIOLA-RELATED POXVIRUSES
    YASUO ICHIHASHI, TAKASHI KITAMURA
    1976 Volume 29 Issue 4 Pages 221-225
    Published: 1976
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.29.221
    JOURNAL FREE ACCESS
    Download PDF (2252K)
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top