Japanese Journal of Medical Science and Biology
Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISSN-L : 0021-5112
Volume 31, Issue 4
Displaying 1-6 of 6 articles from this issue
  • OSAMU MAEDA, KUNIHACHI TAKENOKUMA, YOSHIAKI KAROJI, AKIO KURODA, OSAMU ...
    1978 Volume 31 Issue 4 Pages 317-324
    Published: 1978
    Released on J-STAGE: March 19, 2010
    JOURNAL FREE ACCESS
    Natural infection with Japanese encephalitis virus in three sentinel pigs held in separate experimental huts was examined daily by virus recovery from blood samples of the pigs and from mosquitoes after incubation for about 7 days from their blood feeding and by HI antibody titration of the blood samples. After a period of low infection rates, below 6%, for about two weeks in engorged Culex tritaeniorhynchus summorosus, high mosquito infections of over 30% from each viremic pig occurred for two to three days. The pigs may be probably have been bitten by many infected but not infective mosquitoes in a period of about 10 days before infection.
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  • YASUO MORITSUGU, TOMOYUKI TANAKA, TOSHIO SHIKATA
    1978 Volume 31 Issue 4 Pages 325-338
    Published: 1978
    Released on J-STAGE: March 19, 2010
    JOURNAL FREE ACCESS
    Ninety-eight acute non-B hepatitis cases recently observed in Japan and household contacts with these cases were subjected to serologic examinations for hepatitis A; 400 serum specimens obtained in 1971 from healthy individuals living in areas near Tokyo and 16 preparations of human immunoglobulin produced in Japan in 1975 and 1976 were examined for antibody to hepatitis A antigen. Hepatitis A virus infection was confirmed in all 25 patients and in 8 of 26 household contacts found in association with non-B hepatitis outbreaks, and also in 11 of 60 sporadic non-B hepatitis patients, but in none of 13 non-B hepatitis patients found in association with blood transfusion. There was no difference between males and females in the prevalence of antibody to hepatitis A antigen among healthy individuals, however, there was a strong relationship to age. Rates of antibody positives were only 2.5% in the groups younger than 20 years of age, but the rates were markedly higher in the groups older than 30 years of age. An ample amount of antibody to hepatitis A antigen was detected in the preparations of human immunoglobulin. Hepatitis A virus was thus found to be endemic in Japan, but considered not popular during at least these 20 years. Infection with non-A non-B hepatitis virus (es) seems to be common in Japan especially in such cases as sporadic non-B hepatitis or post-transfusion non-B hepatitis.
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  • AKIRA SHISHIDO, CHIEKO SUGISHITA, CHIYO TAKAHASHI, HIROKO SAKATA, MUNE ...
    1978 Volume 31 Issue 4 Pages 339-356
    Published: 1978
    Released on J-STAGE: March 19, 2010
    JOURNAL FREE ACCESS
    A long-term surveillance system using a computer system was established for the follow-up study on the protective effect of measles vaccination. More than 3, 000 children, 3 to 6 years of age, who were immunized with measles vaccines by various methods have been registered in the system since 1971, and their outcomes with regard to measles have been followed up every year. The subjects were divided into three groups by the vaccination method: live vaccine alone (L), further attenuated live vaccine alone (FL), and the combined use of live and killed vaccines (KL) . From comparative studies with these groups, the following results were obtained: (1) Annual measles incidence rates were found to be the lowest in L group followed by FL and KL. (2) Accumulated incidence rates of measles for 10 years in L, FL and KL groups calculated were 1.90, 2.49 and 17.84%, respectively. A linear regression was observed only from 0 to 3 years after vaccination in L and FL groups, and from 0 to 9 years in KL group. KL group showed a significantly larger regression coefficient than did the former two groups. (3) Protection rates against close contact with measles in families calculated were 97% in L and FL and 80% in KL group, respectively. (4) Low but detectable levels of antibody titers were observed in the sera for at least 4-6 years after vaccination.
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  • TOKUMITSU TANAKA, MITSUKO TSUNODA, SUSUMU MITSUHASHI
    1978 Volume 31 Issue 4 Pages 357-359
    Published: 1978
    Released on J-STAGE: March 19, 2010
    JOURNAL FREE ACCESS
    We collected Escherichia coli strains from 59 Nepalese porters in 1971 and surveyed for their drug resistance. Drug-resistant E. coli strains were isolated from four porters. (TC. CM. SM. SA. APC.) -resistant strains were isolated from two porters and SA- or APC-resistant strains were isolated from each of the others. The R factors were demonstrated from the multiple-resistant E. coli strains.
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  • JOE CHIBA, YASUYUKI EGASHIRA
    1978 Volume 31 Issue 4 Pages 361-364
    Published: 1978
    Released on J-STAGE: March 19, 2010
    JOURNAL FREE ACCESS
    The authors investigated the adjuvant effect of a cationic surface active lipid, dimethyl dioctadecyl ammonium bromide (DDA), on the induction of delayed-type hypersensitivity (DTH) to sheep red blood cells (SRBC) in mice. Markedly enhanced DTH to SRBC was induced by subcutaneous injection of 2×108SRBC suspended in saline containing DDA as compared to DTH responses in control animals sensitized with the same doses of SRBC without DDA. The enhancement of DTH responses seemed to be closely related to the delayed appearance of circulating antibody to SRBC and not to depend on the strain or the age of mice.
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  • TOORU FUJIWARA, YURIKO SUZAKI, SHIGEO HONJO
    1978 Volume 31 Issue 4 Pages 365-369
    Published: 1978
    Released on J-STAGE: March 19, 2010
    JOURNAL FREE ACCESS
    A gross anatomical survey of the placental development was carried out in 24 cynomolgus monkeys (Macaca fascicularis) of 4, 5, 6, 7, 8, 9, 10, 15 and 20 weeks of gestational age. Eight of the 24 placentas examined were found to be single discoidal and the remaining 16 bidiscoidal. The weight and size of placentas of each animal were measured. The average weight of the 20th week placentas was about 94 times heavier than that of the 4th week ones; the average diameter of the former was about 5 times larger than that of the latter.
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