Cross protective antigenicities of
Leptospira were studied with 16 antisera to 13 serovars of
Leptospira interrogans and a virulent strain “Shibaura (v) ”, which is now considered to belong to serovar
copenhageni, for challenge. The antisera of the rabbits highly immunized with various serovar live antigens were examined for leptospiricidal activity; cross immunity was recognized only in the same serogroup, Icterohaemorrhagiae.
Serovar
icterohaemorrhagiae lacks a part of the antigenic components of
copenhageni, but the antiserum to the former showed potent leptospiricidal activity to Shibaura (v) . Anti-
copenhageni immune serum absorbed with the
icterohaemorrhagiae antigen did not show any protective activity to Shibaura (v) .
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