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Volume 36, Issue 1
Displaying 1-10 of 10 articles from this issue
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KEIJI TERAO, KOJI FUJIMOTO, FUMIAKI CHO, SHIGEO HONJO1983 Volume 36 Issue 1 Pages 1-10
Published: 1983
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSAnti-A and anti-B blood group antibodies in the cynomolgus monkey sera were serologically characterized. 2-Mercaptoethanol (2-ME) inactivated these antibodies of both group-A and group-B sera. Furthermore, soluble human ABH substances neutralized these antibody activities. However, these activities were not inhibited by anti-human IgG or IgA serum but by anti-human IgM serum. By gel filtration on Sephacryl S-300, the anti-A and anti-B antibodies reacting readily in saline media were detected in the fractions corresponding to the IgM antibodies. Thus, anti-A and anti-B antibodies in group-B and group-A sera were judged to be mainly of IgM.
In contrast to group-A and group-B sera, group-O serum contained IgG antibodies of high titers besides IgM antibodies. Neither 2-ME nor anti-human IgM serum affected these antibody activities. On the basis of the results of the inhibition test using anti-human immunoglobulin sera as well as of gel filtration, group-O sera were divided into the following two categories, the one having only IgG reacting well in the Coombs method and the one having both IgM and IgG.View full abstractDownload PDF (824K) -
TADASHI HORIMI, DAVID CHIA, PAUL I. TERASAKI, TAKAO MATSUMOTO, YUICHI ...1983 Volume 36 Issue 1 Pages 11-16
Published: 1983
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSInhibiting factors against mixed lymphocyte culture (MLC) are contained in normal human sera. Of 298 random normal human sera, 66 (22.1%) were found to be MLC-inhibiting sera. B cold cytotoxins and anti-F (ab') 2 antibodies in these sera were significantly associated with MLC inhibition.View full abstractDownload PDF (565K) -
TAKASHI KITAMURA, TOSHIHIKO KOMATSU, KAZUYOSHI SUGIYAMA, CHIHARU MORIT ...1983 Volume 36 Issue 1 Pages 17-25
Published: 1983
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSTwenty-three rat lung specimens collected in outbreaks of hemorrhagic fever with renal syndrome (HFRS) in three medical institutions were inoculated onto the VERO-E6 cell monolayers. After several blind passages, an agent growing serially in the cell cultures and reacting specifically with known HFRS-positive sera was isolated from two of these specimens. The two isolates were antigenically identical each other. The agent, named strain SR-11, was identified as the causative virus of HFRS by its antigenic identity with E6 cell-adapted HFRS virus, Hantaan 76-118 strain, and the specific reactions with sera from various HFRS cases.View full abstractDownload PDF (1551K) -
MASAO TAKASAKA, AYAKO KONO, MISAO KONO, IPPEI SAKAKIBARA, SHIGEO HONJO ...1983 Volume 36 Issue 1 Pages 27-37
Published: 1983
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSThe provisional serovar 1621-54 of “Shigella” was isolated from 36 (13.2%) of 273 cynomolgus monkeys newly imported into Tsukuba Primate Center for Medical Science (TPC) from Indonesia during the period from 1980 through 1981. The biochemical properties of the isolates were in good agreement with those of previously described provisional “Shigella” serovar 1621-54.
Clinically, 13 (36.1%) of 36 monkeys being positive for the organisms excreted diarrheal stools on arrival at TPC. In addition, the organisms were isolated also from three other monkeys contracting dysentery during the quarantine period at TPC. One of them died 2 days after the onset of dysentery. Histopathological findings of this case were essentially the same as those of Shigella-infected monkeys.
Pathogenicity of the isolates was examined in three experimental infection models; (1) the infection model using cultured HeLa-S3 cells, (2) the keratoconjunctival infection model of the guinea pig, and (3) the intestinal infection model of the cynomolgus monkey. All the strains tested showed positive results in these experimental models, causing intracellular penetration and multiplication in HeLa-S3 cell cultures, keratoconjunctivitis in guinea pigs, and dysentery in cynomolgus monkeys.
These results indicate that provisional “Shigella” serovar 1621-54 is a causative agent of dysentery in man as well as in monkeys.View full abstractDownload PDF (3324K) -
KAZUSHIGE MASUDA1983 Volume 36 Issue 1 Pages 39-41
Published: 1983
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSEach of the three major components isolated from a commercial plasmin-treated human immunoglobulin preparation, namely, the plasmin-resistant 7S IgG fraction (PRG), Fab fragment and Fc fragment, was tested before and after heat treatment for binding Clq and fixing C3bi. In unheated state, only PRG was found to bind Clq, whereas none bound C3bi. The binding of Clq by PRG was enhanced by heat treatment which also conferred the activity of binding C3bi to PRG and to Fc fractions. From these results, anticomplementary activity of unheated PRG fraction seems to be due mainly to the complement activation via the classical pathway, whereas the activation by the heat-treated Fc fragment might be via an alternative pathway.View full abstractDownload PDF (294K) -
ASHIM K. CHAKRAVARTY, TAPAS K. CHAUDHURI1983 Volume 36 Issue 1 Pages 43-46
Published: 1983
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSBlastogenesis and DNA synthesis of murine T cells were studied after in vivo stimulation with Concanavalin A; blastogenic response does not dosewise correlate with the rate of DNA synthesis although these two responses are often considered synonymous.View full abstractDownload PDF (316K) -
KAZUMICHI TAMURA, SHIGEHIKO KURAMOCHI, RIICHI SAKAZAKI, HARUO YOSHIMUR ...1983 Volume 36 Issue 1 Pages 47-48
Published: 1983
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSA new Salmonella serovar, here named Salmonella ibaragi, was isolated from domestic feed. The isolate belonged to the subgenus I of Salmonella, and the antigenic formula was determined to be 21: y: 1, 2.View full abstractDownload PDF (139K) -
MITSUGU MUROFUSHI, MICHIO SHIOMI, KAGEAKI AIBARA1983 Volume 36 Issue 1 Pages 49-53
Published: 1983
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSThe effect of oral administration of a polysaccharide (KGF-C), isolated from the kefir grain, on delayed-type hypersensitivity (DTH) induced by picryl chloride and on the growth of solid tumor was examined in mice. KGF-C caused an increase in DTH response in intact mice and also tumor-bearing mice. The growth of tumor inoculated after the DTH test was markedly inhibited in the groups with high DTH response. A significant correlation between the DTH response and the antitumor activity was observed in intact mice.View full abstractDownload PDF (1516K) -
CHIHARU MORITA, YOSHIHARU MATSUURA, KAZUYOSHI SUGIYAMA, TAKASHI KITAMU ...1983 Volume 36 Issue 1 Pages 55-57
Published: 1983
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSDownload PDF (259K) -
KIYOSHI NAGASAWA, YOSHIYUKI MORISHITA1983 Volume 36 Issue 1 Pages 59-66
Published: 1983
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSDownload PDF (715K)
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