巻号一覧
39 巻, 3 号
選択された号の論文の4件中1～4を表示しています
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山崎 修道, 大西 英子, 榎並 和枝, 名取 克郎, 小長谷 昌功, 阪本 肇, 田中 正敏, 林 紘1986 年 39 巻 3 号 p. 105-118
発行日: 1986年
公開日: 2010/03/19
ジャーナル フリーTwo assay methods for recombinant human tumor necrosis factor (rH-TNF) were developed, one a biological L-cell assay and the other an enzyme-linked immunosorbent assay. The accuracy and reproducibility of each and the correlation between the two were studied. As a result of this investigation, the two assay methods were found appropriate for standardization of rH-TNF. A freeze-dried reference was prepared, and examination of its potency and stability showed it to be suitable for use as a reference standard for rH-TNF assays.抄録全体を表示PDF形式でダウンロード (1116K) -
阿部 賢治, 志方 俊夫, 藤沢 洌, 山内 真義, 松下 寛, 鈴木 宏, 織田 敏次1986 年 39 巻 3 号 p. 119-127
発行日: 1986年
公開日: 2010/03/19
ジャーナル フリーTwo chimpanzees were inoculated intravenously with acutephase sera obtained from two patients with epidemic hepatitis. They developed histopathologically confirmed hepatitis. Electron microscopic examination of the liver showed peculiar cytoplasmic tubular structures in the hepatocytes. These ultrastructural findings were similar to those described for the livers of chimpanzees inoculated with the F strain of non-A, non-B hepatitis agent derived from a posttransfusion hepatitis case. The chimpanzee that had recovered from hepatitis caused by the F strain of non-A, non-B hepatitis agent was re-challenged with the serum from one of the patients. The chimpanzee developed neither clinical signs nor histological changes of hepatitis. These results suggested that non-A, non-B hepatitis agent was involved not only in post-transfusion hepatitis but also in epidemic hepatitis.抄録全体を表示PDF形式でダウンロード (6617K) -
Thuang S. LIM, John C. TWARTZ, Michael G. GROVES1986 年 39 巻 3 号 p. 129-138
発行日: 1986年
公開日: 2010/03/19
ジャーナル フリーLymphocytes from Inbred Balb/cyJ mice infected subcutaneously with 103 MLD50 of Rickettsia tsutsugamushi Karp strain were unresponsive to rickettsial antigens and phytohemagglutinin in the lymphocyte transformation assay between 11 and 28 days post-infection. There was, however, no correlation between this suppressed responsiveness to rickettsial antigens and the immune capacity to resist a normally lethal ip challenge with the Karp strain. Fourteen days after infection, these mice survived a potentially lethal Karp challenge. Naive recipients of day 14 post-infection mouse splenic lymphocytes also were partially protected against ip challenge. Karp strain-specific antirickettsial antibody reached a peak geometric mean titer of 260 during the period of apparent cellular unresponsiveness. However, day 14 post infection mice showed a fourfold decrease of antibody response to a T-dependent antigen, which suggests the presence of T-dependent antibody suppression in these mice.抄録全体を表示PDF形式でダウンロード (912K) -
Suresh R. NAIK, Vinay K. DESHMUKH, Palghat H. RAMAN1986 年 39 巻 3 号 p. 139-149
発行日: 1986年
公開日: 2010/03/19
ジャーナル フリー6MFA, an interferon-inducing substance obtained from fungus, Aspergill us ochraceus, has shown anti-inflammatory activity both in acute and chronic animal models of inflammation. It was found that 6MFA was equally effective in inhibiting both exudative as well as granulative phase of inflammation. The compound suppressed also cellular migration during inflammatory process and potentiated significantly the anti-inflammatory activity of indomethacin. The compound was devoid of analgesic or antipyretic activity.
The probable mechanism of action of this compound is not fully understood. However, the possibility of triggering the induction of endogenous anti-inflammatory substance (s) along with interferon (s), or interaction of induced interferon (s) directly or indirectly with the prostaglandin system has been attributed.抄録全体を表示PDF形式でダウンロード (860K)
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