Japanese Journal of Medical Science and Biology
Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISSN-L : 0021-5112
Volume 44, Issue 1
Displaying 1-4 of 4 articles from this issue
  • Paula VIRGINIA, Kouichi NAGAKURA, Oliveira FERREIRA, Seiki TATENO
    1991 Volume 44 Issue 1 Pages 1-6
    Published: 1991
    Released on J-STAGE: March 19, 2010
    JOURNAL FREE ACCESS
    Sera from 54 Brazilian children with a history of tropical eosinophilia syndrome were screened for toxocariasis. The enzyme-linked immunosorbent assay detected 21 positive sera (40%) . Many of these cases (15 of 21) were positive for Dilofilaria immitis as well. Of the six Toxocara-positive children with hypereosinophilia, two were asthmatic. Their sera were further examined by the Toxocara species-specific Ouchterlony's diffusion-in-gel test and one Toxocara canis and one T. cati infections were identified. This is the first report of serologically diagnosed toxocariasis in Brazil.
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  • Arun KUMAR, Jayant Neelkanth DHULEY, Suresh Ramnath NAIK
    1991 Volume 44 Issue 1 Pages 7-16
    Published: 1991
    Released on J-STAGE: March 19, 2010
    JOURNAL FREE ACCESS
    Trypanosomiasis is a parasitic disease, prevailing in both humans and animals, caused by a single-cell parasite, Trypanosoma spp. Three microbial metabolites, namely antiamoebin, F-857 and 6-MFA, were evaluated for trypanocidal activity by using a mouse model of trypanosomiasis, which is caused by T. evansi. The significance of the biological and biochemical parameters with respect to physio-pathology of trypanosomiasis and their implications in the evaluation of new trypanocidal compounds were discussed.
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  • Keiji TERAO, Yoko FUKASE
    1991 Volume 44 Issue 1 Pages 17-28
    Published: 1991
    Released on J-STAGE: March 19, 2010
    JOURNAL FREE ACCESS
    The effect of hyperlipaemic serum on mitogen-induced T lymphocyte proliferation was investigated with cynomolgus monkeys. The mitogen-induced blastogenesis was remarkably inhibited when either hyperlipaemic or normal monkey lymphocytes were incubated with hyperlipaemic sera. Hyperlipaemic serum also inhibited ConA-induced interleukin 2 (IL-2) production as well as IL-2 receptor (IL-2R) expression of normal monkey lymphocytes. On the other hand, it showed slight inhibition of T-cell proliferation induced by adding recombinant human IL-2 to IL-2R-positive normal monkey lymphocytes. These results indicate that hyperlipaemic serum inhibited an early stage of T-cell autocrine activation pathway including IL-2 production and IL-2R expression.
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  • A report of the national epidemiological surveillance of infectious agents in Japan
    Shizuko YAMADERA, Kazuyo YAMASHITA, Nobuko KATO, Masae AKATSUKA, Kikuk ...
    1991 Volume 44 Issue 1 Pages 29-39
    Published: 1991
    Released on J-STAGE: March 19, 2010
    JOURNAL FREE ACCESS
    In Japan, herpangina cases increase every summer with an incidence peak in July. During the past eight years from January, 1982 to December, 1989, a total of 3, 974 viruses from herpangina cases were reported from 47 participating laboratories, and coxsackie A (CA) viruses accounted for most of them, 3, 055 (76.9%) . The major types associated with herpangina were, in order of frequency, CA4, 10, 5, 6, 2 and 3, representing 87.2%-80.8% of total isolations reported for each respective type in this period. Eighty-four point four percent of the total virus isolations were from children at four years of age or younger. More than 80% of total CA virus isolations were from nasopharyngeal specimens and nearly 90% of the viruses were isolated in mice.
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