Japanese Journal of Medical Science and Biology
Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISSN-L : 0021-5112
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Volume 46, Issue 5-6
Displaying 1-4 of 4 articles from this issue
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  • RELATIONSHIPS BETWEEN THE ANTHELMINTIC ACTIVITY OF EIGHT DERIVATIVES OF BENZIMIDAZOLE CARBAMATES AGAINST TRICHINELLA SPIRALIS AND THEIR CHEMICAL STRUCTURES
    Latif Abdol LATIF, Johari SURIN
    1993 Volume 46 Issue 5-6 Pages 203-214
    Published: March 10, 1994
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.46.203
    JOURNAL FREE ACCESS
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    Efficacy of eight recently developed and used anthelmintics of the benzimidazole carbamates; mebendazole, flubendazole, oxfendazole, albendazole, oxibendazole, 790163 proflubendazole, 780118 “cyanide” benzimidazole and 780120 “selenium” benzimidazole was tested orally against the enteral immature larval and adult stages of Trichinella spiralis in mice. Six of these derivatives of methyl benzimidazole-2-carbamates have an aryl and two have an alkyl substituent at the 5'-position of the parent benzimidazole ring. The nature of these substituents was found to be related to the antitrichinellous activity of the compounds. Compounds with the 5'-substituent linked to the parent benzimidazole ring by either a carbon, sulfur or an oxygen atom are more potent than those bridged by selenium or by the carbon with an attached -CN group. The result clearly indicates that the benzimidazoles are invariably more potent against immature enteral phase than the adult worms. This finding would be of importance in a targeted synthesis of new, effective derivatives of benzimidazole, e.g., in the screening for more important tissue-dwelling nematodes like filarial worms.
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  • INABILITY OF A STRAIN OF SEOUL VIRUS TO TRANSMIT ITSELF VERTICALLY IN RATS
    Chiharu MORITA, Hiroshi UENO, Shigeru MORIKAWA, Kazuyoshi SUGIYAMA, To ...
    1993 Volume 46 Issue 5-6 Pages 215-219
    Published: March 10, 1994
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.46.215
    JOURNAL FREE ACCESS
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    SR-11 strain of Seoul virus was inoculated into new-born female rats. These rats at the age of 13 weeks were mated with uninfected male rats. The virus was transmitted to the male rats, but the offsprings were not infected from their mather rat owing to the maternal antibody. No intrauterine transmission of the virus was observed. We assumed that SR-11 type strain of Seoul virus could not be disseminated among rats in nature.
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  • SEROTYPING OF HUMAN ROTAVIRUS BY ENZYME IMMUNO-ASSAY WITH MONOCLONAL ANTIBODIES
    Ayako HASEGAWA, Atsushi MUKOYAMA, Kaoru AKATANI, Nobuko IKEGAMI, Shozo ...
    1993 Volume 46 Issue 5-6 Pages 221-226
    Published: March 10, 1994
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.46.221
    JOURNAL FREE ACCESS
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    Two series of enzyme immunoassays with monoclonal antibodies produced in two laboratories (A and B) were compared in use for serotyping of human rotavirus in stool samples collected in Japan between 1988 and 1991 from patients with gastroenteritis. Of 358 samples, 222 were determined to be the same serotype, while 61 samples could not be serotyped by either assay. A hundred and one and 92 samples were not serotyped by the A and B antibodies, respectively. We believe that the A and B monoclonal antibodies are useful clinically for serotyping rotaviruses at the present time.
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  • SYMPOSIUM ON TOXINS
    1993 Volume 46 Issue 5-6 Pages 227-258
    Published: March 10, 1994
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.46.227
    JOURNAL FREE ACCESS
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