Japanese Journal of Medical Science and Biology
Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISSN-L : 0021-5112
Volume 50, Issue 2
Displaying 1-6 of 6 articles from this issue
  • Cahide GÖKKUSU, Evin ADEMOGLU, Hikmet ÖZ, Ümit Mutlu T& ...
    1997 Volume 50 Issue 2 Pages 45-53
    Published: 1997
    Released on J-STAGE: March 19, 2010
    JOURNAL FREE ACCESS
    Thymosin alpha-1 is an active polypeptide isolated from thymus. This polypeptide is widely used in the diagnosis and treatment of many diseases, especially immune diseases. In this present study, we examined the effects of thymosin alpha-1 on plasma and erythrocyte lipid levels and the changes in erythrocyte membrane (Na+, K+) ATPase activity in hypercholesterolemic rabbits. The erythrocyte lipid levels decreased, whereas the erythrocyte membrane (Na+, K+) ATPase activity increased significantly in these rabbits after thymosin alpha-1 injection. These findings suggest that thymosin alpha-1 is effective on both the lipid level and erythrocyte membrane (Na+, K+) ATPase activity.
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  • Muhammad Golam MORSHED, Fatema JINNAH, Md. Shafiqul ISLAM, M. Azharul ...
    1997 Volume 50 Issue 2 Pages 55-62
    Published: 1997
    Released on J-STAGE: March 19, 2010
    JOURNAL FREE ACCESS
    Helicobacter pylori, a gram-negative, microaerophilic bacterium, has been established to have a causal association with chronic gastritis, peptic ulcer, gastric adenocarcinoma, and low-grade lymphoma. The present study was undertaken to evaluate the efficacy of culture, histological examination, the rapid urease test, and serology for the diagnosis ofH. pyloriinfection. A total of 45 consecutive subjects with various upper gastrointestinal symptoms were included in this study. The rates of diagnosis ofH. pyloriinfection were 51.1%, 55.6%, 82.2%, and 93.3%, by culture, rapid urease test (RUT), histological examination, and serology, respectively. The sensitivity, specificity, and positive and negative predictive values were 95.5%, 82.6%, 84.0%, and 95.0%, respectively for RUT; 95.5%, 30.4%, 56.8%, and 87.5% for histological examination; 100%, 13.6%, 54.8% and 100% for serology.
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  • Akinobu SAITO, Takuo SAWADA, Yoshikazu TOKUMARU, Ryo HONDO
    1997 Volume 50 Issue 2 Pages 63-71
    Published: 1997
    Released on J-STAGE: March 19, 2010
    JOURNAL FREE ACCESS
    Epidemiologically related cheese and environmental strains and epidemiologically unrelated strains ofListeria monocytogenesserotype 4b were examined by restriction enzyme analysis of chromosomal DNA with a total of 10 restriction enzymes. The DNA fingerprint patterns generated from each restriction enzyme digest of total DNA of all strains were classified. The restriction enzyme patterns of seven strains recovered from cheese and environmental samples in the same plant were identical to each other, but differed from those of seven epidemiologically unrelated strains. Two, originating from sporadic human patients, of eight epidemiologically unrelated strains exhibited the identical restriction enzyme patterns. Excepting these two strains, restriciton enzyme analysis of the chromosomal DNA ofL. monocytogenesserotype 4b can discriminate serologically indistinguishable strains.
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  • Kenny L. SAMUI, Shingo INOUE, Aaron S. MWEENE, Andrew M. NAMBOTA, Jame ...
    1997 Volume 50 Issue 2 Pages 73-77
    Published: 1997
    Released on J-STAGE: March 19, 2010
    JOURNAL FREE ACCESS
    In the present study, 1, 421 cattle in 32 herds within nine districts, which are important cattle-producing centers in the nine provinces of Zambia, were tested for Rift Valley fever by the indirect immunofluorescence assay. One hundred and forty-seven cattle (10.5%) in 28 herds (88.9%) in the nine districts tested were positive for Rift Valley fever implying a country-wide distribution. In districts associated with flood plains and/or“dambos” (low lying areas of perpetual flooding), high herd and individual positive rates (100% and >10%, respectively) were found, suggesting a significance of these features in the distribution of the disease.
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  • Eiji WATARI, Kozo YOKOMURO
    1997 Volume 50 Issue 2 Pages 79-85
    Published: 1997
    Released on J-STAGE: March 19, 2010
    JOURNAL FREE ACCESS
    The effects of cyclosporin A (CsA) on the polykaryocyte formation induced by measles virus (MV) in a monkey kidney cell line (BSC-1) were studied. CsA inhibited virus-induced polykaryocyte formation as well as the production of infectious MV. The development of polykaryocyte formation in the presence of the CsA varied with virus strains, while pretreatment of the cells with 5 μM CsA for 24 hr before the virus infection enhanced polykaryocyte formation. These data demonstrated that CsA not only inhibits but also enhances virus-induced polykaryocyte formation depending on the conditions of its use.
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  • Motohide TAKAHASHI, Takako KOMIYA, Takashi FUKUDA, Yoshiaki NAGAOKA, R ...
    1997 Volume 50 Issue 2 Pages 87-95
    Published: 1997
    Released on J-STAGE: March 19, 2010
    JOURNAL FREE ACCESS
    The antitoxin levels for diphtheria and tetanus were measured with samples of a young group immunized with diphtheria-tetanus-acellular pertussis combined vaccine and those of an aged group, members of which had not received vaccination in their youth. In the young group members of which had already received basic immunization with diphtheria-tetanus-acellular pertussis combined vaccine, the levels of both antitoxins rose well after injection at 11 to 12 years old with diphtheria-tetanus combined toxoids and remained high until 20 years of age. In the aged group, more than 80% showed antitoxin levels above 0.01 u/ml for diphtheria, while all had levels below that for tetanus, except three persons with confirmed tetanus immunization history. Maintenance of the protective antitoxin levels in the population by vaccination is necessary to prevent outbreaks of infection among unvaccinated or only partially immunized persons.
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