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Volume 43, Issue 10
Displaying 1-9 of 9 articles from this issue
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Functional Analogs of BleomycinYuichi HASHIMOTO, Koichi SHUDO1985 Volume 43 Issue 10 Pages 908-920
Published: 1985
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSBis-intercalators and hemin-intercalators (Hemin-Glu-P-1's) which recognize and/or cleave DNA were designed and synthesized. 2-Aminodipyrido [1, 2-a : 3', 2' -d] imidazoles (Glu-P's) which are potent muta-carcinogens isolated from a pyrolysate of L-glutamic acid were used as intercalator moieties. Bis-intercalators possess extremely high affinity toward double stranded DNA and stabilize the double helix structure of DNA from heat denaturation effectively. Hemin-Glu-P-1's cleaved DNA at G-C and G-T sequences preferentially. Glu-P-1 moiety which recognizes DNA by intercalation and a functional group which can be an intramolecular fifth ligand of the ferrous ion in the hemin moiety are required for strong DNA-cleaving ability. The mode of DNA-cleaving reaction of Hemin-Glu-P-1's is quite similar to that of bleomycin (BLM). In other words, Hemin-Glu-P-1's are functional analogs of BLM. The mechanism of DNA cleavage by Hemin-Glu-P-1's and by BLM is not single. One of the mechanisms involves two bases elimination from the DNA.View full abstractDownload PDF (2157K) -
Akio TOSHIMITSU1985 Volume 43 Issue 10 Pages 921-931
Published: 1985
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSThe results of the search for new organoselenium reagents and their utilization in organic synthesis are described herein. They include 1) phenylselenenyl chloride in acetonitrile/water (hydroxyselenation of olefins), 2) phenylselenenyl chloride/trifluoromethanesulphonic acid/water in acetonitrile (amidoselenation of olefins), 3) phenylselenenyl chloride/mercury (II) thiocyanate [selective synthesis of β- (phenylseleno) alkyl isothiocyanates], 4) phenylselenenyl bromide (intramolecular amidoselenation of N-alkenyl amides), 5) phenylselenenyl iodide (carbon-carbon bond formation in diolefins), 6) 2-pyridylselenenyl bromide (2-pyridylseleno group is a better leaving group than phenylseleno group in selenoxide elimination), 7) phenyl selenocyanate/copper or nickel halide/alcohol (oxyselenation of olefins), and 8) potassium selenocyanate/copper (II) halide (selenium-containing heterocycles from diolefins) and related reactions.View full abstractDownload PDF (1473K) -
Yoshio IMAI1985 Volume 43 Issue 10 Pages 932-940
Published: 1985
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSSyntheses of various types of condensation polymers by Michael-type polyaddition reaction are reviewed. After a brief introduction of the chemistry of Michael-type addition, the polyaddition reactions of Michael donors like diamines and dithiols to various Michael acceptors such as bisacrylamides, bismaleimides, divinyl sulfones, and other reactive divinyl compounds are described.View full abstractDownload PDF (862K) -
Masanobu HIDAI1985 Volume 43 Issue 10 Pages 941-950
Published: 1985
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSIn homogeneous reactions catalyzed by transition metal complexes, the active species are in general mononuclear transition metal complexes and their catalytic activities are controlled by an appropriate choice of metals and ligands, especially phosphine ligands. Recently, homogeneous multimetallic catalysis has been receiving much attention because of the potential for the different metals cooperating during chemical transformations. It is expected that this cooperativity aids in the design of new, more active and selective catalysts and new types of reactions which are inaccessible through monometallic systems. Reviewed here are activation of substrates on metal clusters and various types of reactions catalyzed by metal clusters and mixed metal complexes.View full abstractDownload PDF (1230K) -
Hiroshi YAMANAKA, Takao SAKAMOTO1985 Volume 43 Issue 10 Pages 951-961
Published: 1985
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSIn the first half of the present paper, the methods with experimental simplicity for the preparation of various alkyl (aryl) pyrimidines are reviewed. In the second half, the reactions of alkylpyrimididines are described in view of synthetic chemistry. Some of these are utilizable for the construction of carbon functional groups on pyrimidine rings.View full abstractDownload PDF (1338K) -
Akihiko MAEKAWA, Yoshihito OHMORI1985 Volume 43 Issue 10 Pages 962-966
Published: 1985
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSNow, there are many chemicals in our environment. In addition, new chemicals over one thousand are coming in the world yearly. Therefore, impact of toxic chemicals coming from environment on human health is now the most important international problem. In this paper, we give the outline of guideline, which had been proposed recently in the Subcommitee on Chemical Substances, The Central Pharmaceutical Affairs Council, Japan, for testing of chemicals, and also describe the current state and problems on safety evaluation of chemicals.View full abstractDownload PDF (922K) -
Noboru YAKEISHI1985 Volume 43 Issue 10 Pages 967-968
Published: 1985
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (210K) -
Toshiaki MIYATA1985 Volume 43 Issue 10 Pages 969-970
Published: 1985
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESS -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]1985 Volume 43 Issue 10 Pages 971
Published: 1985
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (162K)
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