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Volume 47, Issue 7
Displaying 1-8 of 8 articles from this issue
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Yoshio ITO, Shiro TERASHIMA1989 Volume 47 Issue 7 Pages 606-618
Published: July 01, 1989
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSThe 1β-methylcarbapenem antibiotics represented by 3, 4, and 5, have been the focus of current synthetic endeavor due to prominent antibacterial activities and broad spectra as well as enhanced chemical and metabolic stability. Progress of the syntheses of 1β-methylcarbapenem key intermediates represented by 6, are reviewed based on the synthetic methods of the characteristic 1β-methyl substituent involved in the contiguous four chiral centers of 6.View full abstractDownload PDF (1505K) -
Diazotization-Fluorodediazoniation of AminoaromaticsNorihiko YONEDA, Tsuyosi FUKUHARA1989 Volume 47 Issue 7 Pages 619-628
Published: July 01, 1989
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSFluoro-dediazoniation of aromatic diazonium salts, derived from diazotization of amino aromatics, is the most usual means of introducing a fluorine substituent into aromatic rings. But they are not without difficulties. Thus the recent progress and development of entire process is reviewed.View full abstractDownload PDF (1230K) -
Koki NAKAMURA, Keizo KOYA, Kozo SATO1989 Volume 47 Issue 7 Pages 629-635
Published: July 01, 1989
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSRing opening reactions of 2-nitroaryl-4-isoxazolin-3-ones have been studied. N-O bond of 2-nitroary1- 4-isoxazolin-3-ones was cleaved by mild organic reducing agents. The N-O bond cleavage is presumably caused by an electron transfer into 2-nitroaryl group of 4-isoxazolin-3-ones.
2-Nitroaryl-4-isoxazolin-3-ones are very easy to synthesize and widely applicable because an introduction of CH2L (L=leaving group) at 4-position of isoxazoline makes it possible to release a functionalized group.View full abstractDownload PDF (815K) -
Takahiro HOSOKAWA, Shun-ichi MURAHASHI1989 Volume 47 Issue 7 Pages 636-648
Published: July 01, 1989
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSThe functionalization of alkenes with oxygen nucleophiles is attained by a process being referred to as oxypallation which involves nucleophilic attack toward alkenes co-ordinated to Pd (II). In reactions of this type (the Wacker-type reaction), the redox catalysis of palladium and copper (eqs 1 and 2) has been believed to regenerate Pd (II) from Pd (O) formed in situ. This article describes that the catalysis is not generally operative, but that a hydroperoxopalladium (II) species (XPdOOH) coupled with CuXn is most likely the active catalyst which is formed by the oxygenation of XPdH liberated from oxypalladation adduct. This finding has been deduced from the analysis of Pd (II) -catalyzed asymmetric cyclization of 2- (2-butenyl) phenol, which is the first example of the asymmetric Wacker-type oxidation. Furthermore described is the new aspect of the following Wacker-type reactions ; (i) intramolecular oxidative cyclization of alkenes bearing hydroxy group and (ii) acetalization of terminal alkenes with diols. These reactions have synthetic potential for preparing optically active heterocyclic compounds such as (S) - (+) -tremetone and (S) - (-) -frontaline.View full abstractDownload PDF (1319K) -
Jiro TSUJI, Junzo NOKAMI, Tadakatsu MANDAI1989 Volume 47 Issue 7 Pages 649-659
Published: July 01, 1989
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSRecent advances in the oxidation reactions of olefins catalyzed by Pd2+ salts, and the scope and limitations of the reaction are surveyed. Emphasis is placed on the oxidation of terminal olefins with various functional groups to methyl ketones. Useful applications of this reaction to syntheses of various natural products such as steroids, terpenoids are shown. Internal olefins are oxidized to ketones smoothly with high regioselectivity only when there is a good participation of neighbouring oxygen functions.View full abstractDownload PDF (1254K) -
Kazuko MATSUMOTO1989 Volume 47 Issue 7 Pages 660-668
Published: July 01, 1989
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSSince the first report in 1908, a class of platinum compounds called “platinum blues” have attracted interests of chemists because of their unusual dark blue color. However, because of the difficulty in isolating and crystallizing the complexes, their formulas and structures have been left unclarified till a decade ago. About ten years ago when it turned out that the famous anti-tumor complex cis-Pt (NH3) 2CL2 effects its activity by binding to DNA and obstructing the DNA duplication, a study regarding the coordination reaction of cis-Pt (NH3) 2Cl2 with pyrimidine bases started and the platinum pyrimidine blues found in the study again aroused interest of chemists. In the course of intensive studies, the first crystal structure determination of platinum blue was carried out for a compound with α-pyridone as a pyrimidine model and the tetranuclear 5+ mixed-valent chain structure of [Pt4 (NH3) 8 (C5H4NO) 4] was revealed.
In the present article, syntheses, structures and chemical properties of platinum blues and several other related multinuclear platinum complexes containing hetero metal atoms are surveyed with an emphasis on the specific nature of amidate ligands that stabilize unusually high oxidation state of metals.View full abstractDownload PDF (980K) -
Junichi SHIRAOGI1989 Volume 47 Issue 7 Pages 669-670
Published: July 01, 1989
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (169K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1989 Volume 47 Issue 7 Pages 671
Published: July 01, 1989
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (166K)
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