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Volume 51, Issue 4
Displaying 1-7 of 7 articles from this issue
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Shoji IKEDA, Kim D. Janda1993 Volume 51 Issue 4 Pages 284-297
Published: April 01, 1993
Released on J-STAGE: January 28, 2010
JOURNAL FREE ACCESSMonoclonal Antibodies raised against transition state analogs have been shown to catalyze a number of reactions and so far more than fifty examples catalyzed by antibodies have been reported.
The Research on Catalytic Antibody promises the advance in understanding reaction mechanisms and molecular recognition and their applications in biotechnology and medicine.
This review will descrive the recent advances in the field of catalytic antibodies and discuss their potential applications to organic chemistry and medicine.View full abstractDownload PDF (1721K) -
Yoshifumi MAKI, Magoichi SAKO1993 Volume 51 Issue 4 Pages 298-307
Published: April 01, 1993
Released on J-STAGE: January 28, 2010
JOURNAL FREE ACCESSThe chemistry of taxane diterpenoids has a long history since about 1850. Recent advances in this field brought about the discovery of taxol and its derivatives (e.g., taxotére) which are under the development as a new antitumor agent. This review describes the novel chemistry of the taxane diterpenoids including the historical matters in the initial period of researches. The present status in the chemical and biological studies of taxol is mentioned as one of highlights.View full abstractDownload PDF (1297K) -
Organic Synthesis on Solid SurfaceTakeshi NISHIGUCHI1993 Volume 51 Issue 4 Pages 308-316
Published: April 01, 1993
Released on J-STAGE: January 28, 2010
JOURNAL FREE ACCESSMetallic sulfates supported on silica gel efficiently catalyze dehydration and transesterification of alcohols. Symmetrical primary and secondary diols from C2 to C16 have been monoprotected in high selectivity by acylation and THP-ether formation by these catalysts in ester/alkane and DHP/alkane mixtures, respectively. The selectivity of these reactions depends upon the composition and the volume of the solvent systems. The selectivity can be explained by (1) preferential adsorption of diols to monoesters or monoethers and (2) the formation of thin liquid films of diols on the surface of the catalysts caused by the limited dissolution of the diols in the solvents. Metallic nitrates supported on silica gel efficiently oxidized secondary and primary benzyl and allyl alcohols and ethers to the corresponding ketones and aldehydes under mild conditions. Silica gel is essential for the efficient oxidation and Cu (NO3)2 and Zn (NO3)2 are suitable for practical use. Mechanistic study suggests that NO2 is an active species. Alcohols and ethers are readily oxidized by NO2 to give the corresponding aldehydes or ketones in the presence of silica gel.View full abstractDownload PDF (1232K) -
Kazuyuki KASUGA, Takuji HIROSE, Kazuhisa HIRATANI1993 Volume 51 Issue 4 Pages 317-326
Published: April 01, 1993
Released on J-STAGE: January 28, 2010
JOURNAL FREE ACCESSSeveral kinds of N-substituted amide compounds, derived from malonic acid, glutaric acid, amino acids etc. have been prepared and their properties have been investigated. It has been found that N, N'-di (8-quinolyl) malonamide derivatives are highly selective extractants for Cu (II) ion among heavy metals from the nearly neutral pH range of aqueous solution. Their extractability largely depends on the structure of substituents. When 1-naphthyl group was substituted for 8-quinolyl group, these malonamide derivatives could exhibit the clathrate-type inclusion phenomenon with organic molecules like benzene, cyclohexane, etc. Glutaramide derivatives having two 8-quinolyl groups were found to be available as highly Cu (II)-selective carrier for the transport through liquid membranes, although their extractability was very low compared with that of malonamide derivatives. Furthermore, selective ionophores for heavy metal ions based on malonamide and oligoamide derivatives of amino acids, 2, 6-dicarbamoyl-pyridine and 2, 9-dicarbamoyl-1, 10-phenanthroline have been synthesized, and their functions have been investigated.View full abstractDownload PDF (1327K) -
Shigeharu INOUYE, Masaji SEZAKI1993 Volume 51 Issue 4 Pages 327-349
Published: April 01, 1993
Released on J-STAGE: November 16, 2009
JOURNAL FREE ACCESSRecently, opportunistic fungal infections are becoming more important in the compromised patients.
The review summarizes current attempts to find new and useful antifungal antibiotics mainly active against opportunistic fungal pathogens. Based on the chemical structures, antifungal antibiotics reported since 1987 are conveniently classified into 12 types : 1) polyene macrolide and related antibiotics, 2) lipopeptide antibiotics, 3) glycolipid antibiotics, 4) glycolipid/lipopeptide related antibiotics, 5) alkylphenol antibiotics, 6) terpenoid antibiotics, 7) cyclodepsipeptide antibiotics, 8) peptidonucleoside antibiotics, 9) amino acid antibiotics, 10) condensed polycyclic aromatic antibiotics, 11) halogenopyrrole antibiotics and 12) miscellaneous antibiotics. Finally, the principles and strategy for screening of antifungal antibiotics are discussed.View full abstractDownload PDF (2826K) -
Katsuya MITSUI1993 Volume 51 Issue 4 Pages 350-351
Published: April 01, 1993
Released on J-STAGE: November 16, 2009
JOURNAL FREE ACCESS -
[in Japanese], [in Japanese], [in Japanese]1993 Volume 51 Issue 4 Pages 352
Published: April 01, 1993
Released on J-STAGE: November 16, 2009
JOURNAL FREE ACCESSDownload PDF (179K)
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