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Volume 60, Issue 5
Displaying 1-29 of 29 articles from this issue
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Takashi Takahashi, Takayuki Doi2002 Volume 60 Issue 5 Pages 426-433
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSCombinatorial chemistry is among the most recent topics in synthetic organic chemistry. A key feature is diversification in the development of organic reactions and in the synthesis of organic compounds. A crucial chemistry is solid-phase synthesis, which is a powerful method in order to optimize reaction conditions, to investigate scope and limitations of new reactions, and to synthesize a variety of compound libraries. Solid-supports, linkers, and strategies for the combinatorial chemistry are described. Synthetic methods (parallel synthesis and mix-and-split synthesis), analysis, and purification in the solid-phase synthesis are also described.View full abstractDownload PDF (1332K) -
Yasuhiro Uozumi2002 Volume 60 Issue 5 Pages 434-441
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSCombinatorial chemistry has been rapidly recognized as a powerful tool in the domain of synthetic organic chemistry, particularly for the pharmaceutical purpose. This methodology is now being extended to the research field of materials, catalysts, reagents and so on. This review article surveys recent progress of discovery and optimization of organic synthetic methods (development of catalysts, conditions etc.) with diversity-based high-throughput preparation, screening, systems.View full abstractDownload PDF (1451K) -
Koichi Fukase2002 Volume 60 Issue 5 Pages 442-453
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSThe present review surveys basic methodologies for solution-phase combinatorial synthesis by using polymer-supported reagents, scavengers, and phase tagging strategies. Several applications of combinatorial libraries prepared by split & mix synthesis are also described.View full abstractDownload PDF (1878K) -
Toshiro Suenaga2002 Volume 60 Issue 5 Pages 454-464
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSAnalytical methods for solid phase synthesis are discussed. The advent of combinatorial organic synthesis has accelerated the development of reliable, rapid and sensitive analytical methods for solid phase organic synthesis. Classical colorimetric assays and spectrophotometric-based quantification methods for peptide synthesis are extended to solid phase organic synthesis. The analytical methods familiar to solution-phase synthesis, such as IR spectroscopy, mass spectroscopy, NMR spectroscopy are rapidly adapted for the analysis of solid phase synthesis.View full abstractDownload PDF (1878K) -
Tohru Sugawara2002 Volume 60 Issue 5 Pages 465-475
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSHistorically chemical automation was started in the field of analytical chemistry and until around 1992 only a few instrument makers and laboratories had studied the automation of organic synthesis chemistry (1st stage). Along side the growth of combinatorial chemistry, considerable attention has since been paid to developing automated synthesis apparatus and the accompanying peripheral apparatus, especially for the efficient development of new drugs in pharmaceutical companies (2nd stage). Recently many kinds of special-purpose automated modules and units have been developed for solid and solution phase synthesis, especially for high throughput parallel synthesis, isolations and purifications.
In this report, I will briefly look at the history of laboratory automation, offer some advice on how to carry it out and then describe some future prospects.View full abstractDownload PDF (2547K) -
Yukishige Ito, Shino Manabe2002 Volume 60 Issue 5 Pages 476-477
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (354K) -
Yoshihiro Ito2002 Volume 60 Issue 5 Pages 478-479
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (370K) -
Hideaki Hioki2002 Volume 60 Issue 5 Pages 480-481
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (315K) -
Jun-ich Yoshida, Seiji Suga2002 Volume 60 Issue 5 Pages 482-483
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (373K) -
Takeaki Naito, Hideto Miyabe2002 Volume 60 Issue 5 Pages 484-485
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (323K) -
Yoshinori Kondo2002 Volume 60 Issue 5 Pages 486-487
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (336K) -
Ken Suzuki, Seiichi Takami, Momoji Kubo, Akira Miyamoto2002 Volume 60 Issue 5 Pages 488-489
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (375K) -
Takashi Takahashi, Hiroshi Tanaka2002 Volume 60 Issue 5 Pages 490-491
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (351K) -
Mitsuo Komatsu2002 Volume 60 Issue 5 Pages 492-493
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (323K) -
Koichi Fukase2002 Volume 60 Issue 5 Pages 494-495
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (323K) -
Shu Kobayashi, Ryo Akiyama2002 Volume 60 Issue 5 Pages 496-497
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (384K) -
Shigeki Sasaki2002 Volume 60 Issue 5 Pages 498-499
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (294K) -
Kenichi Akaji2002 Volume 60 Issue 5 Pages 500-501
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (325K) -
Michinori Suginome, Yoshihiko Ito2002 Volume 60 Issue 5 Pages 502-503
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (361K) -
Yujiro Hoshino, Hisashi Yamamoto2002 Volume 60 Issue 5 Pages 504-505
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (333K) -
Hikaru Takaya, Shun-Ichi Murahashi2002 Volume 60 Issue 5 Pages 506-507
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (366K) -
Nicholas Hird, Katsumi Itoh2002 Volume 60 Issue 5 Pages 508-509
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (493K) -
Kazuya Takenouchi, Minoru Imai2002 Volume 60 Issue 5 Pages 510-511
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (340K) -
Masaki Yamada, Hiroshi Ohmizu2002 Volume 60 Issue 5 Pages 512-513
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (418K) -
Hirohisa Shindo, Masahiro Sakagami2002 Volume 60 Issue 5 Pages 514-515
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (389K) -
Takuya Shintani, Makoto Shimazaki2002 Volume 60 Issue 5 Pages 516-517
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (450K) -
Tamiki Nishimura2002 Volume 60 Issue 5 Pages 518-519
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (333K) -
Toshikazu Takase, Hisayuki Tsuno, Shinya Fujiwara, Kenichiro Kotake, H ...2002 Volume 60 Issue 5 Pages 520-521
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (578K) -
Michiko Kanai, Shunya Sasaki2002 Volume 60 Issue 5 Pages 522-523
Published: May 01, 2002
Released on J-STAGE: November 13, 2009
JOURNAL FREE ACCESSDownload PDF (400K)
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