巻号一覧
74 巻, 6 号
選択された号の論文の11件中1～11を表示しています
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巻頭言
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澤村 正也2016 年 74 巻 6 号 p. 581
発行日: 2016/06/01
公開日: 2016/07/14
ジャーナル オープンアクセスPDF形式でダウンロード (620K)
総説および総合論文
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松尾 淳一2016 年 74 巻 6 号 p. 582-587
発行日: 2016/06/01
公開日: 2016/07/14
ジャーナル 認証ありCyclobutanones having an electron donating substituents at their 3-position were activated by a Lewis acid to form a zwitterionic intermediate, which reacted with molecules having C=O, C=N, or C=C unsaturated bonds to form the corresponding six-membered cycloadduct.抄録全体を表示PDF形式でダウンロード (1398K) -
岡田 洋平, 千葉 一裕2016 年 74 巻 6 号 p. 588-598
発行日: 2016/06/01
公開日: 2016/07/14
ジャーナル 認証ありPeptides have been recognized as promising pharmaceutical candidates that potentially can have both advantages of small molecules and antibodies. Although solid-phase methods have dominated current peptide synthesis, soluble-polymer-assisted liquid-phase methods have also been studied. In this context, we have been developing a soluble-support-assisted liquid-phase method using not polymers but hydrophobic benzyl alcohols and amines. A supported-reactant is soluble in less-polar solvent and both couplings and deprotections can be carried out in solution. After reaction completion, polar solvent is added into the solution to precipitate a supported-product. By using our method, several bioactive peptides, including linear and cyclic, have been prepared. Only precipitation and washing are needed at each coupling or deprotection, enabling an effective multistep synthesis.抄録全体を表示PDF形式でダウンロード (2116K) -
佐藤 隆章, 千田 憲孝2016 年 74 巻 6 号 p. 599-610
発行日: 2016/06/01
公開日: 2016/07/14
ジャーナル 認証ありNucleophilic addition to amide carbonyl groups is the simplest way to access multi-substituted amines found in biologically active natural alkaloids and pharmaceuticals. However, this promising transformation has received less attention due to their high stability. In this article, we describe our recent progress with N-alkoxyamides. Incorporation of an alkoxy group as a reactivity control element into the nitrogen atom of an amide successfully overcomes issues inherent to the nucleophilic addition. Especially, chemoselective version with the Schwartz reagent was useful, and enabled the concise total synthesis of (±)-gephyrotoxin.抄録全体を表示PDF形式でダウンロード (1630K) -
品田 哲郎2016 年 74 巻 6 号 p. 611-620
発行日: 2016/06/01
公開日: 2016/07/14
ジャーナル 認証ありThe first structure determination of the new juvenile hormone (JH) isolated from a heteropteran insect, Plautia stali is described. To identify the target JH, a new isolation approach starting from a JH molecular library was attempted. We proposed the structure of the target JH based on the in vitro radiochemical TLC and mass analyses of the corpus allatum product of P. stali. The molecular library including 32 molecules was prepared from geranylacetone. The mixture was screened by the bioassay-guided separation using P. stali. The highly potent JH molecules found in the library were subjected to GCMS analysis to identify the naturally occurring heteropteran JH obtained from P. stali. One of the candidates was identical with the natural product by a chiral GCMS analysis. The novel JH was named as juvenile hormone III skipped bisepoxide(JHSB3). To identify the key functional groups of JHSB3, we conducted the structure-activity relationship study of JHSB3. These results as well as our efforts for the stereoselective synthesis of JH0 and JHI are also described.抄録全体を表示PDF形式でダウンロード (2016K) -
大迫 隆男, 山田 陽一, 魚住 泰広2016 年 74 巻 6 号 p. 621-630
発行日: 2016/06/01
公開日: 2016/07/14
ジャーナル 認証ありOrganic transformations using continuous-flow reactors containing polymer-supported catalysts have recently attracted much attention in synthetic organic chemistry. The continuous-flow reaction systems provide safe, green-sustainable, efficient, reliable, and practical methods to prepare valuable organic compounds. Herein we report our recent development of the continuous-flow reaction systems using packed catalyst cartridges of platinum and iron nanoparticles dispersed in an amphiphilic polystyrene-poly(ethylene glycol) polymer (ARP-Pt or ARP-Fe), and a macroporous polymeric acid catalyst. The continuous-flow system containing ARP-Pt catalyst showed dual functions to catalyze the oxidation of alcohols with O2 as well as the reduction of olefins and nitrobenzenes with H2 to give the corresponding products in high yield. Iron nanoparticles dispersed in an amphiphilic polymer (ARP-Fe) were also applied to the catalytic hydrogenation of olefins, aromatic imines, and aldehydes under flow conditions. Moreover, the direct esterification of carboxylic acids was achieved by using the column-packed macroporous polymeric acid catalyst under mild conditions in a flow manner without removal of water, which was successfully applied to the biofuel preparation.抄録全体を表示PDF形式でダウンロード (3290K)
Review de Debut
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保野 陽子2016 年 74 巻 6 号 p. 631-632
発行日: 2016/06/01
公開日: 2016/07/14
ジャーナル オープンアクセスNigricanoside A, isolated from the green alga Avrainvillea nigricans, is a structurally unique natural product in which two fatty acids, galactose, and glycerol are connected with ether linkages. Its dimethyl ester showed potent antitumor activities to cancer cell lines. The structure determination of nigricanoside A has not been solved due to the limited availability of this natural product. In this review, the structure elucidation of nigricanoside A by total synthesis is described.抄録全体を表示PDF形式でダウンロード (974K)
ケミカルズ覚え書き
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杉山 幸宏, 浅輪 智丈2016 年 74 巻 6 号 p. 633-637
発行日: 2016/06/01
公開日: 2016/07/14
ジャーナル 認証ありPDF形式でダウンロード (1591K)
ラウンジ
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鷹谷 絢2016 年 74 巻 6 号 p. 638-644
発行日: 2016/06/01
公開日: 2016/07/14
ジャーナル 認証ありPDF形式でダウンロード (2296K)
十字路
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松尾 淳一, 佐藤 隆章, 品田 哲郎, 大迫 隆男2016 年 74 巻 6 号 p. 645
発行日: 2016/06/01
公開日: 2016/07/14
ジャーナル オープンアクセスPDF形式でダウンロード (566K)
Let's Challenge!
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2016 年 74 巻 6 号 p. 647-648
発行日: 2016/06/01
公開日: 2016/07/14
ジャーナル 認証あり
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