Clinical symptoms were observed on large animals, mostly horses, administered with a single dose of chlorpromazine.
1. In horses, a dose of 1.0mg/kg injected by the intravenous (i. v.) route had a very specific, comparatively good tranquillizing effect. A longer time was needed until such effect was exhibited and less remarkable symptoms were manifested in the case of intramuscular injection than in the case of i. v. injection.
2. In horses, a dose of 1. 5-2.0mg/kg injected by the i. v. route caused severe ataxy, sleeping on the ground for a short time, and a very unusual attitude. The horses bent and spread out their fore limbs so widely that the anterior parts of the body almost touched the ground. They exhibited this appearance repeatedly, but seldom lay down on the ground in that condition.
3. Tachycardia due to administration of chlorpromazine was remarkable, especially in the case of large dosage. The respiration rate remained normal or decreased slightly, while no abatement of temperature was recognized beyond a limit of 0.5-1.0°C.
4. Other important clinical signs which had been observed in this experiment were specific sedative conditions and relaxation and dropping of the penis from the sheath.
5. In this experiment, the severity of symptoms did not always coincide with the dose administered.
It was supposed that this phenomenon was mainly due to individual variation. Therefore, carefull attention should be paid when the drug is used in practice.
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