Eight kinds of papaveraceous plants growing wild in Japan were examined with dilute ethanolic extract for total crude alkaloid content, for papaverine-like antispasmodic action, using mouse intestine and guinea pig trachea, and median lethal dose in mice. Further, antispasmodic action of the crude total alkaloid extracted from the ethanolic extract was also examined. The content of total crude alkaloid was the highest in
Pteridophyllum racemosum and lowest in
Chelidonium japonicum var.
typicum. Antispasmodic action of the extract was generally stronger in the trachea than in the intestine, being the strongest in
P. racemosum and weakest in
Ch. majus.
Ch. japonicum var.
typicum alone showed contracting action. The antispasmodic action of the alkaloidal fraction was 15-30% of papaverine hydrochloride in all of the eight plants. Toxicity was the strongest in
C. decumben and weakest in
Ch. majus.
抄録全体を表示