We studied on 206 cases of primary atypical pneumonia in broad sense and 283 cases of miscellaneous diseases except acute respiratory infections which attacked the patients from April 1957 to June 1961.
The complementf ixing antibody against adenoviruses of the above cases were examined and the results obtained were as follows:
1) Positive rate of antibody titer 8≤was 39.4% in the group of pneumonia, which was significantly higher than 21.5% in the group of miscellaneous diseases, In the group of miscellaneous diseases positive rates increased with age to 30-39, and had a tendency to decrease in advanced ages. On the other hand significant difference was hardly recognizable in the pneumonia group.
Positive rates in female were significantly higher than in male but with no significant difference. Incidentally we might derive suggestions that adenoviruses were considerably spread among human beings rather than the diseases caused by them were mostly primary atypical pneumonia.
2) In the process of the disease we had an increase or decrease of antibody titer 4≤as the diagnostic critarion of adenoviral infections, and we could detect adenoviral pneumonia in 22 cases (16.1%) out of 140 cases which were given serum tests more than twice.
3) Regarding the occurence of the 22 cases of adenoviral pneumonia, no significant differences were recognized by year. However, a few more cases were found in spring and summer than in the other seasons, but some cases were found in every season.
4) As for distribution by age, the disease was found from age 6-64, that is to say at all ages. Thirteen cases were male and 9 cases female.
5) Clinical picture of the disease was as the following:
The bgeinning symptoms were chill and high temperature which took place all of a sudden and severely. The high temperature came down in 4 or 5 days. One case developed conjunctival hyperemia, 8 cases acute rhinitis, 7 cases acute pharyngitis, 3 cases hoarseness and 3 cases swollen cervical lymphnode. Cough and phlegm always appeared; most phlegm was mucous and disappeared within 20 days. Physical findings in the chest were mild. Rales were ausculated in 11 cases, many of which were crepitant. One case developed diarrhea, and another nausea. Roentgenograms revealed densities mostly at the lower area of lungs, especially in the right lungs, and next on the upper area of right lungs. These densities disappeared in 11-30 days. Red blood cell sedimentation rate increased averaging 59mm and this returned to normal approximately in the 2nd-5th weeks. The white blood cell count was mostly remained normal.
6) Complement fixing antibody titer had a tendency to increase about the end of the 1st week to a maximum in 2nd-3rd week, and then slowly decreased.
7) The chemotherapy generally was ineffective, however, the therapy with antibiotics was found to be effective for cases with secondary infection. There were no deaths.
抄録全体を表示