名糖産業 八王子工場のメタノール蒸留塔において，産業用ヒートポンプを用いた廃熱活用システムを構築することで，エネルギー使用量（一次エネルギー換算）を60％削減するという画期的な省エネルギーを実現することができた。本導入事例は，省エネ大賞「経済産業大臣賞」を受賞した。蒸留塔の省エネは大きな課題であるが，本事例は課題解決の一つの切り口になり得ると考える。

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平成12年9月12日未明，東海豪雨により一級河川，新川の堤防が決壊した。まもなく名糖産業（株）名古屋研究所にも濁水が押し寄せ，最高約2メートルの深さに達し，建物，製造プラント，各種試験・分析装置，実験動物試験施設などに加え，研究所の命とも言うべき貴重な実験結果，収集文献，書籍に甚大な被害が出た。それら被害の実態，復旧・修復過程で体験した事柄を紹介するとともに，その体験を踏まえた危機管理の在り方，今後の研究所のあるべき姿等について提案する。

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The concept of “intracellular hyperthermia” is local inductive heating of cancer cells after administration of submicron particles producing magnetic excitation, These particles were taken in the cancer cells intracellularly by phagocytosis, resulting in selective destruction of cancer cells with little effect on normal cells and tissues. We examined effects of intracellular hyperthermia on Meth-A, AH60C and VX-2 tumor cells and a phagocytosis of DM in various tumor cells. Dextran magnetite was used as the submicron particle. DM particles are not simple mixture of dextran and ferrate but submicron complex. The heating unit was a 7 kW generator of 500 kHz with a pancake type coil creating electromagnetic field. DM particles were injected in animals with tumor cells intraperitoneally or intratumorously. These animals were exposed to the external inductive field for 20 min. at a temperature of more than 43°C. The phagocytosis of tumor cells was examined microscopically. DM particles were taken intracellularly in tumor cells at 24 hours after administration. The survival rate of rats and mice and the inhibition for growth of VX-2 tumor were most evident in the each groups of 2 times of hyperthermia. DM particles were very promising in inductive heating of 500 kHz.

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Rice bran foots, a by-product in the purification process of rice bran oil was hydrolyzed without stirring at 30°C by lipase drived from Candida cylindracea. The optimum pH range was 57. The degree of the enzymatic hydrolysis reached to more than 88% at the amount of 20U/g-foots at pH 6.8 for 6h. The hydrolysis was also performed with stirring in the presence of some non-polar organic solvents such as hexane, heptane, and isooctane.

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A new vitamin-free synthetic diet for rats was devised, which consists of sucrose 65,purified frozen-dried bean curd 30,McCollum's salt mixture 4,DL-methionine 0.4 and vitamin mixture 1.0. Commercial frozen-dried bean curd contains 25-30% fat, 45-60% of protein and 0.5% of fibre, and is purified by three times boiling water extraction. In the feeding experiment with the synthetic diet, the rats of thiamine or riboflavin deficiency died within a month, while those of vitamin B_6,B_<12> or pantothenic acid deficiency were alive for a month, though the growth rates were inferior to the control ones.

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Esterification of racemic alcohols with fatty acids and other organic acids by Candida cylindracea lipase was studied. Fatty acids and water insoluble dicarboxylic acids were found to be esterified. Optical selectivities in enzymatic esterification were very low compared with the case of dl-menthol.
The amount of water in the reaction media had serious influence on the ratios of esterification in the case of valeric acid, whereas no effect was observed in the case of lauric acid.

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The riboflavin levels in liver, kidney and small intestine of mice, administered with Ca-salt, such as Ca-gluconate, CaCl_2 or CaCO_3,and calciferol were observed. When the Ca-salts were given the riboflavin contents of kidney and small intestine showed moderate decrease, but there was no change in the liver. When calciferol was given with Ca-gluconate, the decrease of riboflavin contents by Ca-salt could be prevented, especially kiney showed a higher value than that of control organs.

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The concept of “INTRACELLULAR HYPERTHERMIA” is selective heating of cancer cells after administration of magnetic submicron particles. We have reported the characteristics of some kind of particles in previous paper.
In this paper, we examined properties of Dextran Magnetite (DM) in inductive field of 500 kHz. DM was used as the submicron particles in addition to iron metal, stainless steel, Fe₃O₄ and 3C. DM is 5-15 nm in diameter and 3/gFe in susceptibility. DM particles are not simple mixture of dextran and ferrate but submicron complex. The heating unit (type TY-1) was a 7 kW generator of 500 kHz with a pancake type coil of 4 turns creating electro-magnetic field. The temperature of phantom with particles was measured at the inductive field of 500 kHz.
The temperature of DM was raised predominantly rather than that of other particles at the field of 500 kHz but wasn't at the field of 13.56 MHz. The relation of DM and temperature was positive in concentration of DM aqueous sol, susceptibility of DM aqueous sol and diameter of ferrate and nagative in molecular weight of dextran.
We could to create DM for most adequate purpose. This biological approach represents a new technology for effective treatment of cancer by hyperthermia.

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Clical dextranから極端に離れている低分子dextranと高分子dextranの重量平均分子量が, 光散乱法によって測定された。低分子dextranは, Inoueの粘度 < > 数平均分子量の関係式より得られるMnと比較検討された。一方, 高分子dextranでは, 酵素合成法が高重合度のdextranを得る一つの方法であること, およびNative dextranの長時間培養は分子量を逆に小さくすることが確かめられた。

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The concept of “INTRACELLULAR HYPERTHERMIA” is local inductive heating of cancer cells after administration of submicron particles producing magnetic excitation. These particles were taken in the cancer cells intracellularly by phagocytosis, resulting in selective destruction of cancer cells with little effect on normal cells and tissues.
We examined effects of intracellular hyperthermia on Meth-A and AH60C tumor cells and a phagocytosis of AH60C, NTF reticulum cell sarcoma and cultured human esophageal cancer cells (SGF -8a). Dextran magnetite was used as, the submicron particle. DM particles were injected in animals with tumor cells intraperitoneally or intratumorously. These animals were exposed to the external inductive field of 500 kHz for 20 min. at a temperature of more than 43 °C.
The phagocytosis of tumor cells was examined microscopically. DM particles were taken intracellularly in tumor cells at 24 hours after administration. The ILS (Increase in life span) of mice was longer in the group of DM than that of Fe₃O₄ suspension. The inhibition ratio of solid tumor of rats was better in the group of DM than control group. The survival rate of rats and mice were most evident in the each groups of 2 times of hyperthermia. DM particles were very promising in inductive heating of 500 kHz.

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Dextran produced by Leuconostoc mesenteroid from cane sugar is 1, 6-α-_D-glucopyranose polymer. Dextran was attempted to introduce acyl groups as the first step for preparing acyl dextran sulfates.
Dextran, molecular weight of 4800, was acylated with acyl chlorides at 105-110°C in pyridine-toluene solution. The chemical and physicochemical properties of acyl dextrans were examined. Oleyl dextran with 2.3-3.0 acyl groups per one glucose unit and caproyl dextran with 3.0 acyl groups were easily soluble in almost all organic solvents and insoluble in water.
Both acyl dextrans depressed surface tensions of benzene, chloroform and dioxan. By dispersing of both acyl dextrans 5 % per dioxane into water-dioxan solution, stable emulsions were obtained, whereby surface tensions were depressed in the range of 1012 dyne/cm for oeyl dextran and 2027
for caproyl dextran, respectively.
Hemolysis of sheep erythrocyte by both acyl dextrans could not been observed for water-dioxan emulsions containing 1 μg/ml-500 μg/ml of acyl dextrans.

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