Dextran produced by
Leuconostoc mesenteroid from cane sugar is 1, 6-α-
D-glucopyranose polymer. Dextran was attempted to introduce acyl groups as the first step for preparing acyl dextran sulfates.
Dextran, molecular weight of 4800, was acylated with acyl chlorides at 105-110°C in pyridine-toluene solution. The chemical and physicochemical properties of acyl dextrans were examined. Oleyl dextran with 2.3-3.0 acyl groups per one glucose unit and caproyl dextran with 3.0 acyl groups were easily soluble in almost all organic solvents and insoluble in water.
Both acyl dextrans depressed surface tensions of benzene, chloroform and dioxan. By dispersing of both acyl dextrans 5 % per dioxane into water-dioxan solution, stable emulsions were obtained, whereby surface tensions were depressed in the range of 1012 dyne/cm for oeyl dextran and 2027
for caproyl dextran, respectively.
Hemolysis of sheep erythrocyte by both acyl dextrans could not been observed for water-dioxan emulsions containing 1 μg/m
l-500 μg/m
l of acyl dextrans.
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