This paper described a case of malignant melanoma of the palate with metastasis of cervical lymphnodes.
A 66-year-old woman visited our department to receive treatment for palate tumors. On the first examination, a dark brown tumor on the palate was found with similar lesions on the maxillary gingiva, buccal mucosa, ventral surface of the tongue and pharyngeal mucosa, which were all clinically suspected of malignant melanoma. On
67Ga-citrate scintigraphic examination, abnormal accumulation of RI was observed both in the maxillary tumor and in the right middle neck lymphnode region.
Immunotherapy with OK-432 was first undertaken and chemotherapy (VBL, PEP, and CDDP) followed. Conservative radical neck dissection, cryosurgery and vaporization using CO
2 laser were carried out successively. After this treatment, chemo-imrnunotherapy (VBL, DTIC, OK-432, and BCG) was initiated.
When nodular swelling of the oral and pharyngeal mucosa were observed, additional palliative laser treatment was given.
After the treatments, neither recurrence nor metastasis were clinically observed, but the patient died of sudden heart failure without any clear relationship to the malignant melanoma.
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