Studies on sulfur-containing amino acids performed in our department were reviewed. The subjects discussed were: (1) cysteine metabolism via 3-mercaptopyruvate pathway, (2) the chemical modification of a protein with glutathione or cysteine, (3) developments of analytical methods for sulfur compounds and sialic acid, and (4) the sulfur balance in the animal body. In section 1, 3-mercaptolactate-cysteine mixed disulfide (HCETC), mercaptoacetate-cysteine mixed disulfide, β-mercaptolactate cysteine disulfiduria, 3-mercaptopyruvate pathway, biosynthesis of HCETC, sulfate formation in mitochondria and β-[(carboxymethyl) thio]-1H-imidazole-4-propanoic acid were discussed. Preparation and properties of ribonuclease A-glutathione mixed disulfide and ribonuclease A-cysteine mixed disulfide were discussed in section 2.

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