Um den äusseren Einfluss auf den Sexualzyklus der Maus festzustellen, stellte ich diesbeziigliche experimentelle Untersuch-ungen an. Es sei folgende Zusammenfassung gegeben :
I. Die Wiederholung des Sexualzyklus bei Mäusen.
1) Bei Mäusen ist die Wiederholung des Sexualzyklus nicht immer regelmässig, sondern sie kommt nicht selten auch unregelmässig vor.
2) Das Verhältnis zwischen dem regelmässigen und dem unregelrnässigen Sexualzyklus ist je nach der Jahreszeit verschieden. Der Prozentsatz des letzteren beträgt im Frühling 82.4 %, im Sommer 56.7 %, im Herbst 81.3 % und im Winter 60.7 %.
II. Die Fortdauer des Sexualzyklus bei Mäusen.
1) Die Dauer des Sexualzyklus ist je nach der Jahreszeit verschieden und beträgt im Frühling 6.8, im Sommer 9.5, im Herbst 7.7 und im Winter 9.3 Tage.
III. Der äussere Einfluss auf den Sexualzyklus.
1) Hohe oder niedrige Temperatur kann den Dioestrus verlängern.
2) Ein starker Schall kann als Reiz den Dioestrus verlängern.
3) Die ultravioletten Strahlen können den Dioestrus verkiirzen und die Ovariaifunktion verstärken.
4) Ausschaltung der Sonnenstrahlen kann den Dioestrus verlängern.
IV. Bei der Untersuchung des Scheideninhaltes muss man daher Licht und Ventilation möglichst berücksichtigen, die Temperatur auf einem bestimmten Grade halten und jeden starken Schall, der sls Reiz wirken könnte, vermeiden.

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妊娠中の糖代謝異常と診断基準の統一化について HAPO Study（N Engl J Med. 2008）をもとに，International Association of Diabetes and Pregnancy Study Groups（IADPSG）では，世界統一の妊娠糖尿病（GDM）診断基準を作成し提唱しました（Diabetes Care. 2010；33：676-682）．わが国でも，これと並行して日本糖尿病・妊娠学会でそれに準拠した新診断基準作成を行い，日本糖尿病学会，日本産科会に提言してきました．そして，2010年7月から妊娠中の糖代謝異常に関する新診断基準が使用されていますが，最後のすり合わせが不十分であったため，日本糖尿病学会の診断基準と日本産科会，日本糖尿病・妊娠学会の診断基準に一部不一致点がありました．このため，日本糖尿病学会と日本糖尿病・妊娠学会との間で合同委員会を立ち上げ，診断基準の統一化を検討し，両学会，および日本産科会の三学会の合意を得て統一案を作成しました．各学会においては，2015年8月より，改訂新診断基準を使用下さいますようお願いいたします．2015年8月1日

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本論文の一部は昭和27年10月第20回日本医科大学医学会に於て, 又その要旨は昭和28年5月第3回日本産科会に於て報告した

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From January, 1961 to December, 1965, we treated 28 malignant ovarian tumors, 9.6% of all operated ovarian tumors in our Nagoya National Hospital. The classification of malignant ovarian tumor was as follows; dysgerminoma 4; malignant teratoma 2; primary ovarian carcinoma 16 ; metastatic ovarian carcinoma 6.
1. Dysgerminoma and malignant teratoma.
In all cases, the tumor was confined to the ovary. Therefore, unilateral salpingooophorectomy and chemotherapy offered favorable prognosis.
2. Primary ovarian carcinoma.
In all cases, diagnosis was confirmed at laparotomy. The scheme proposed by Jikei University was employed for clinical classification. The distribution of cases in this series was stage I, 3 cases; stage II, 6 cases; stage III, 7 cases. The standard therapy of these tumors was surgical removal combined with postoperative irradiation and chemotherapy. The nature of surgery was determined by the extent of the disease. Each number of initial surgery was as follows; 1 hysterectomy and bilateral salpingo-oophorectomy, 6 supracervical hysterectomy and bilateral salpingo-oophorectomy, 7 bilateral salpingo-oophorectomy, 2 exploratory laparotomy. The 16 cases were treated with abdominal surgery and postoperative chemotherapy. 15 cases of them were treated with Tespamin. The drug, in dosis of 10mg, was given intraperitoneally at laparotomy and then 5 mg daily intramusculary for 18 days, that means total amount reached to 100mg. Mitomycin and Endoxan were used in a few cases. Postoperative irradiation of ⁶⁰Co was performed in 12 of 16 cases. In the majority of these cases, dose of 5, 000r or more was given within 6 or 8 weeks. 8 patients, 50% of them were dead within one year. Only 2 patients survived for 5 years. In addition, 3 patients are still alive now after 3 or 4 years. (October, 1967)
3. Metastatic ovarian carcinoma.
In 5 of 6 patients, metastatic carcinoma developed during the course of gastrointestinal carcinoma. All of these cases were dead within one year. One patient of metastatic carcinoma, originated from cervical carcinoma, was treated with operation, postoperative irradiation and chemotherapy. In spite of incomplete surgical removal of pelvic carcinoma, the patient survived, and now well after 4 years and 6 months.
Conclusion:
As generally accepted idea, prognosis of malignant ovarian tumor was related rather to the extent of abdominal involvement and the degree of histologic maturation than to the ways of treatment.

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As the material of experiments the author has chosen Salmo irideus G_IBBONS and Oncorhynchus masou (B_REVOORT). The first method adopted was to select a parent fish and keep it for several hours or several days in a weak solution of lactic acid (0•0025-0•015%) or of soda (0•15-0•3%). Subsequently, taking the female or male generative matter out of it, the normal male or female generative matter was matched, as follows:- ?? (acid)× ?? (normal); ?? (acid)× ?? (acid); ?? (normal)× ?? (acid); ?? (soda)× ?? (normal); ?? (soda)× ?? (soda); ?? (normal× ?? sodia); ?? (acid)× ?? (soda); ?? (soda)× ?? (acid). The second method was that, at the time of fertilization, the female or male generative matter was soaked in a solution of acid (lactic acid 0•005-0•1%) or of alkali (soda 1-2%) for 17-50 seconds, and then the normal male or female generative matter was matched with it in the 8 different combinations as above referred to.
In the above experiments the author has, for convenience' sake, termed the cases of ?? (acid)× ?? (normal), ?? (normal)× ?? (acid), and ?? (acid)× ?? (acid) the acid participation; ?? (soda)× ?? (normal), ?? (normal)× ?? (soda), and ?? (soda)× ?? (soda) the alkaline participation, and ?? (soda)× ?? (acid) and ??(acid)× ?? (soda) the inter-acid and alkaline participation.
The result of the above experiments is summarized hereunder:-
(1) In 19 cases of regular fertilization experiments, excess of male over female always occurred, the sex ratio of 4, 348 fry being on the average ?? 48•4% to ?? 51•6%.
(2) In various kinds of fertilization experiments, in which the acid solution participated, the influence brought to bear upon the newly-hatched fry was generally in favour of the female fry. Out of 48 cases, those scoring over 50% of female fry were 35, and the average sex ratio of 13, 268 fry was ?? 50•9% to ?? 49•1%.
(3) In various kinds of fertilization experiments, in which the alkaline solution participated, the influence upon the fry was generally in favour of male ones. In 47 cases of experiments, those scoring below 50% of female fry were 43, and the sex ratio of the 10, 779 fry was ?? 46•4% to ?? 53•6%, showing a remarkable excess of male over the other sex.
(4) In 16 cases of fertilization experiments, in which the inter-acid and alkaline solution participated, the influence was in favour of the male sex, as will be instanced by the fact that out of the 16 cases there were only 6 cases which scored over 50% for the female fry. It was further shown that in the 3, 416 fry the average sex ratio was ?? 47•5% to ?? 52•5%, male fry being far in excess of the female ones.

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