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全文: "小児歯科学"
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  • 小児歯科学雑誌
    1982年 20 巻 Special 号 3
    発行日: 1982/05/21
    公開日: 2013/01/18
    ジャーナル フリー
  • 菊池 進
    日本歯内療法協会雑誌
    1986年 7 巻 1 号 119-120
    発行日: 1986年
    公開日: 2020/02/22
    ジャーナル フリー
  • 小児歯科学雑誌
    2001年 39 巻 4 号 915-
    発行日: 2001年
    公開日: 2013/01/18
    ジャーナル フリー
  • Wesley O. Ydung
    小児歯科学雑誌
    1963年 1 巻 1 号 ix
    発行日: 1963/12/01
    公開日: 2013/01/18
    ジャーナル フリー
  • 小島 幸美
    九州歯科学会雑誌
    2002年 56 巻 1 号 14-26
    発行日: 2002/02/25
    公開日: 2017/12/20
    ジャーナル フリー
    D-aspartate oxidase (D-AspO : EC 1.4.3.1.) is a flavoprotein that catalyzes the oxidative deamination of dicarboxylic D-amino acids with the production of H_2O_2, NH_3, and corresponding α-keto acid. D-AspO has been found in many mammalian tissues, showing that D-AspO differs from D-amino-acid oxidase (DAO : EC 1.4.3.3) and is located in the peroxisomes of mammalian liver and kidney. However, there is no report on the properties of D-AspO in mammalian brain. Therefore, we examined the properties of DAO and D-AspO in bovine brain, and highly purified D-AspO from fetal bovine brain stem of 10-month-old. 1) The D-AspO activity was detected in all tissues of bovine tested. Strikingly, a very high activity of D-AspO was detected in brain stem, and the activity increased with growth of fetal bovine. 2) D-AspO was located in the peroxisomes of brain tissues in fetal and post natal bovine. 3) Peroxisomes in bovine brain tissues were microperoxisomes and differed from peroxisomes of liver and kidney in density. 4) Very low DAO activities were detected in all tissues of bovine brain tested. 5) The D-AspO activity increased following growth of fetal bovine. 6) D-AspO purified from brain stem of 10-month-old fetal bovine consists of four identical subunits with a molecular weight of 29, 000Da. 7) The enzyme was highly specific towards NMDA and D-aspartate as substrate. On the basis of the above results, D-AspO may be used as a peroxisomal marker enzyme in the brain.
  • 森本 彰子
    九州歯科学会雑誌
    2000年 54 巻 1 号 1-19
    発行日: 2000/02/25
    公開日: 2017/12/20
    ジャーナル フリー
    Male Wistar rats, six-week-old corresponding to the human school age were used, and the effect of high calcium diet intake on bone formation in the mandibular condyle at the growing stage was investigated. The results were as follows : 1. Body weght The rats, 6-week old, were divided into their respective groups and maintained to 11-week old. As a result, no significant differences (p<0.01) were found among the groups. 2. Hematologic findings No changes were found in electrolyte in blood serum and in biochemical examinations among the groups. 3. Histopathological findings Calcium deficient food group, as compared with the controls, showed decrease in calcified matrix enclosing hypertrophic layer and in chondroclasts resorbing calcified matrix. Calcium-low diet group, especially Unical^[○!R] diet group, showed increase in chondroclasts and in invasion of calcified matrix around, which continued with densely arranged bone trabeculae where bone formation was identified active by increased osteoblasts and osteoclasts. The group showed marked findings of recovery of bone architecture and approximated the control group. 4. Scanning electron microscopic findings Calcium deficient food group, as compared with the controls, showed decrease in calcified matrix in cartilage lacuna. Calcium-low diet group showed increased calcified matrix in cartilage lacuna. Particularly Unical^[○!R] diet group showed active bone formation while bone formation and resorption areas mixed. From the above results, calcium facilitated bone formation in rat's condylar cartilage. Dietary treatment itself could not help with recovery of bone tissue from calcium deficiency in weaning age ; while the restoration and promotion of bone matrix formation were revealed in school childhood, where bone loss from calcium insufficiency was followed by continuing balanced dietary therapy. The action was thought to be related to the activity of hormones regulating bone metabolism
  • 太田 和子, 牧 憲司, 西岡 孝浩
    九州歯科学会雑誌
    1999年 53 巻 1 号 149-164
    発行日: 1999/02/25
    公開日: 2017/12/20
    ジャーナル フリー
    成長発育期の特に思春期のカルシウム不足により虚弱骨を惹起した場合, 直ちにバランスのとれた食餌療法を長期間継続することにより, 骨基質形成が回復するかを明らかにすることを目的に検討した.生後8週齢(ヒトの思春期に相当)のWistar系雄ラット30匹を使用した.対照群(標準食群)は, ラット標準A配合飼料と水道水で3週間飼育した.カルシウム欠乏食群は, A食変型カルシウム欠乏飼料と蒸留水で3週間飼育した.低カルシウム食群は, A食変型30%低カルシウム飼料と水道水で3週飼育した.脛骨骨幹皮質骨における骨基質形成について検索し, 以下の結果を得た.小児期の中でも生体組織が最も大きく変化する時期は思春期, いわゆる第二次性徴期であることはいうまでもない.この時期では小児にとって低年齢児で日常の食生活を学習し, 高年齢児で一つの習慣として規則正しい食生活へと自己の管理をする時期でもある.このような流れの中で成長期の若年期には骨の内部構造はある程度の骨塩量を保っていることになる.従って, 低年齢児と異なり, バランスのとれた食生活を長期間にわたって行うことにより, 骨の変換は活発になり回復することが考えられる.このことは当教室の一連の研究から骨構築状態は低年齢児と大きく異なった所見である.ヒトの思春期に相当する時期での低カルシウム食群は乳児期, 幼児期, 学童期に至る食生活のカルシウムを十分摂取しておくことにより予防は十分可能であることが示唆された.
  • 石 四箴
    九州歯科学会雑誌
    1998年 52 巻 5 号 613-623
    発行日: 1998/10/25
    公開日: 2017/12/20
    ジャーナル フリー
    齲蝕罹患率の減少や予防のために様々な研究が行われている.齲蝕活動性試験はその中の一つであり, 現在は数種類の齲蝕活動性試験法が使われている.永久歯よりも乳歯の時点から着手することが最も有効な手段であるが, いずれの方法も高価なものであるから, 広範囲(特に中国の場合)に普及することが困難だと思われる.そのため, 上海鉄道大学式齲蝕活動性試験(以下SCATと略)という新しい齲蝕活動性試験方法を開発した.本研究は, この試験法の乳歯齲蝕状況を予測する手段としての有用性を調べたものである.SCATは歯垢からの酸生成能による試薬の変色を利用し, 標準色溶液との比較から齲蝕活動を4段階に分類している.就学前の小児398名についてSCATによる試験を行い, その結果を口腔内診査から得られた齲蝕状況と対比し, 検討を加えた.また, 従来からあるDentocult LB試験およびDentobuff strip試験も同時に行い, これらの結果と齲蝕状況との関連についても比較検討した.4段階のSCAT齲蝕活動度の間で, 齲蝕罹患率, dftおよびCSI(齲蝕重度指数)に高度な有意差がみられ, 齲蝕活動度と各々の間には正の相関が認められた.本研究の結果では, Dentocult LB試験では口腔内診査と一部に相関がみられたが, Dentobuff strip試験では相関は認められず, SCAT齲蝕活動度が齲蝕状況と最も密接な関連性を示した.以上の結果は, SCATが乳歯の齲蝕罹患を予測できるすぐれた手段であることを示しており, 操作が容易であること, 経済的であることなどの利点とともに有用な試験方法であることを示唆している.
  • 西田 郁子
    九州歯科学会雑誌
    1998年 52 巻 5 号 585-602
    発行日: 1998/10/25
    公開日: 2017/12/20
    ジャーナル フリー
    Five-week-old male Wistar rats, corresponding to childhood in human beings, were used to investigate the effect of zinc and activated vitamin D_3 (VD_3) administration on bone formation induced by endochondral ossification. The animals were divided into such 4 groups as control, standard diet and VD_3, low zinc diet and VD_3, and high zinc diet and VD_3 groups. 1. Densitometric measurement Differences were statistically significant between control and high zinc diet and VD_3 and between control and standard diet and VD_3 groups (p<0.01). 2. X-ray microanalysis of Ca and P As compared with control group, relative ratio of Ca was higher in standard diet and VD_3 and high zinc diet and VD_3 groups, while lower in low zinc diet and VD_3. In contrast, relative ratio P was lower in standard diet and VD_3 and high zinc diet and VD_3 groups, while higher in low zinc diet and VD_3 group. 3. Histopathologic findings As compared with control group, standard diet and VD_3 group showed expanded calcified matrix enclosing hypertrophic layer, and increased number of chondroclasts resorbing calcified matrix. Increasad osteoblasts and osteoclasts with active bone formation were revealed next to subcartilaginous bone formative layer. While low zinc diet and VD_3 group showed less calcified matrix, decreased number of chondroclasts, and reduced subcartilaginous bone formation. Thin trabeculae were arranged almost perpendicularly. As compared to standard diet and VD_3 group, high zinc diet and VD_3 group showed enlarged chondrocytes evenly distributed in hypertrophic layer, with calcified matrix around. Number of chondroclasts and invasion of calcified matrix around were revealed increased, which was continued with densely arranged bone trabeculae where bone formation was identified active by increased osteoblasts and osteoclasts. 4. SEM findings As compared with control group, standard diet and VD_3 group showed expansive areas of bone resorption and formation in matrix with active new bone formation. While low zinc diet and VD_3 group showed indistinct cartilage lacunae where irregularly scattered calcified vesicles and cord-like distributed collagen fibrils were seen ; bone trabeculae were thinned and irregularly arranged. As Compared with standard and VD_3 group, high zinc diet and VD_3 group showed that lacunae were clearly demarcated by matrix formed by fused calcified vesicles, with more collagen fibrils calcified on bottom of the lacunae. Active bone formation was seen while bone formation and resorption areas mixed. From the above results, VD_3 administration facilitated in bone formation in rat's condylar cartilge, but it was shown that adequate zinc intake would promote the action of VD_3, because the present study had revealed that bone structure was damaged by insufficiency of zinc intake.
  • 堤 隆夫
    九州歯科学会雑誌
    1997年 51 巻 6 号 821-841
    発行日: 1997/12/25
    公開日: 2017/12/20
    ジャーナル フリー
    Endochondral ossification in tibial metaphysis was investigated with electronic microscopy using male Wistar rats of four weeks of age, subjected to three kinds of physical exercise, for cellular level study of their effect on longitudinal growth of growing long bones. 1. SEM findings In control group, it is distinctable among the chondral layers such as growing layer, rest layer, hypertrophic layer, erosive layer, and subchondral bone formative layer ; bone formation was mixed with resorption within the trabeculae. Calcified vesicles within the chondral lacunae increased in ascending order of control group, 10 m/min group, 30 m/min group, 40 m/min group ; with vesicles undistinctable. Bone matrix formation was promoted, in trabeculae continuing with subchondral bone formative layer, in ascending order of control group, 30 m/min, 40 m/min group ; the trabeculae were shown thickly and regularly distributed. 2. TEM findings In control group, active osteoblast distributed in single layer or mosaic pattern. The ratio of nucleus and plasma increased, while the organelle decreased in rest osteoblast. A little amount of osteoid was shown between the osteoblast and bone matrix. The young osteocyte in the vicinity of osteoblasts, abundant in organelle, resembling the shape of osteocytes, were shown to be embeded in the organic matrix that was secreted by themselves. The mature osteocytes deep in location, becoming small and lacking in organelle, were surrounded by the lamina limitans with the ratio of nucleus and plasm increased. Cellular network was built up by intercellular connection with plasm processes. Osteoclasts were revealed to absorb bone matrix with ruffled border. The active osteoblasts, osteoblastoid cells and undifferentiated cells and osteocytes in forming stage were shown increased in ascending order of control group, 10 m/min group, 30 m/min group and 40 m/min group. The organellae were shown developed, and mature osteocytes increased in deep location in 40 m/min group. Osteolclasts were shown to get activated in ascending order of control group, 10 m/min group, 30 m/min group, and 40 m/min group. On the basis of the findings mentioned above, the physical exercise facilitated in bone formation of endochandral ossification in metaphysis of tibia.
  • 大里 泰照
    九州歯科学会雑誌
    1997年 51 巻 5 号 601-622
    発行日: 1997/10/25
    公開日: 2017/12/20
    ジャーナル フリー
    Calcium deficient food and low calcium-deficiency food were given for three weeks to Wistar rats of 6-week old corresponding to human school age period and to those 9-week old corresponding to adulthood, and bone debility was induced in them. Then a singular therapy with standard food containing calcium was used, and formation of bone matrix affecting the growth of cartilage of mandibular condyle was investigated. The results were as follows : I. Body weight The rats, 6-week old and 9-week old, were divided into their respective groups and maintained to 12-week old and 15-week old. As a result, no significant differences (p<0.01) were found in any group. The body weight was 6-week old<9-week old. II. Radiological findings 6-week old In the calcium deficient food group as compared with the controls, the trabeculae were found increased in the central and posterior portions but running irregularly. The low calcium-deficiency food group showed the same regularity of trabeculae as the controls. 9-week old In the calcium deficient food group as compared with the controls, the osseous layer was uneven in thickness and the trabeculae were running irregularly. The low calcium-deficiency food group showed about the same findings as the controls. III. Findings on Ca and P analysis on the X-ray Microanalyzer Relative Ca ratio and P ratio were determined by quantitative analysis by point analysis. 6-week old The controls and low calcium-deficiency food group showed about the same relative Ca ratios, but the calcium deficient food group showed low values. Relative P ratios were in the order of the low calcium-deficiency food group>controls>calcium deficient food group. 9-week old Relative Ca ratios were in the order of controls>calcium deficient food group=low calcium-deficiency food group. Relative P ratios were in the order of controls>low calcium-deficiency food group>calcium deficient food group. IV. Histopathological findings 6-week old In the calcium deficient food group as compared with the low calcium-deficiency food group, chondroclasts were restricted in the hypertrophic chondrocyte layer, and intrachondral ossification directly below the invasion zone was decreased. 9-week old In the calcium food group as compared with the controls, intrachondral ossification was restricted. In the low calcium-deficiency food group as in the controls, calcification of the matrix in growing chondrocyte layer was progressed and growth of the mandibular condyle by the mechanism of intrachondral ossification was seen. V. Hematologic findings 6-week old and 9-week old No changes were found in electrolyte in blood serum and in biochemical examinations in any group. Comparison between 6-week old and 9-week old K was high in value (p<0.01) for 6-week old in the low calcium-deficiency food group. Cl was high in value (p<0.01) for 6-week old in the controls and calcium deficent food group. CPK was high in value (p<0.01) for 9-week old in all groups. ALP was high in value (p<0.01) for 6-week old in all groups. On the basis of the foregoing findings, growth of the cartilage of mandibular condyle is affected by insufficient intake of calcium in the growing stage. In the low calcium-deficiency food group especially, findings of recovery of formation of bone matrix related to growth of the cartilage of mandibular condyle were evident.
  • 尾崎 章寿
    九州歯科学会雑誌
    1997年 51 巻 4 号 441-461
    発行日: 1997/08/25
    公開日: 2017/12/20
    ジャーナル フリー
    The bone formation proceeds with balance in maxillofacial, skull and long bones during development in childhood. The absorption rate of calcium within intestine has a tendancy to get higher during early childhood in rat, corresponding to the adolescence, or secondary sex characteristics stage, in human. However, the related studies have not been reported. Here the author presented the report on changes in bone structure after the standard diet feeding in place of calcium-deficient and calcium low-deficient diet, with which bone debility was induced experimentally in male Wistar rats of 8 weeks old. The results were as follows. 1. Body weight There was not significant difference among the control group, calcium-deficient → standard diet group and calcium low-deficient → standard diet group. 2. X-ray findings Compared with control group, calcium-deficient → standard diet group showed diaphyseal cortex formed more thinly. Calcium low-deficient → standard diet group, however, maintained the radiopaque appearence of diaphyseal cortex almost unchanged, and so did the control group. 3. X-ray findings on bone density The significant differences of diaphyseal cortical density were demonstrated between the calcium-deficient → standard diet group and control group (p<0.01), as well as between calcium low-deficient → standard diet group and control group (p<0.05). 4. Hematologic findings No significant differences were shown among the three groups in such parameters as serum Ca, P, Ca/P, Na, K, Cl, and GOT, GPT, LDH, CPK, ALP (p<0.05). 5. Histopathologic findings Compared with the control group, the diaphyseal cortex showed decrease of Harversian system, incomplete Harversian canal, bone resorption, and decrease of bone lacunac in calcium-deficient → standard diet group. While the whold layer of diaphyseal cortex in calcium low-deficient → standard diet group recovered to almost the same appearanco as in control group. 6. Scanning electron microscope findings There were not any morphological changes shown in the two experimental groups. compared with the control group. In calcium-dificient → standard diet group, the resorptive layer was shown more extensively than the rest layer. However, the calcium low-deficient → standard diet group was shown more extensive rest layers, abundant collagen fibrils with certain direction in the osteogenetic layer, interlocked and tallied collagen fibrils, and bone formation. On the basis of foregoing findings, for bone debility in growth stage derived from calcium-deficiency, the bone formation would be recovered sufficiently with balanced calcium diet therapy, even though not combined with supplemental active Vitamin D_3, PTH or calcitonin.
  • 上田 秀朗
    九州歯科学会雑誌
    1997年 51 巻 3 号 383-405
    発行日: 1997/06/25
    公開日: 2017/12/20
    ジャーナル フリー
    For this study, male Wistar rats at the growth stage were given physical exercise and food of different calcium contents and intramembranous ossification of the cortex of diaphysis tibia was investigated. The results were as follows : I. Findings on bone density Standard diet with exercise group showed higher values (p<0.01) for intraosseous cortex and medial cortex than standard diet with no exercise groups. No significant differences were found among calcium-deficient groups. Comparison between any pair of standard diet with no exercise group and calcium-deficient group showed significant differences and standard diet with no exercise groups showed higher values (p<0.01). Significant differences were shown between intraosseous cortex and medial cortex intraosseous cortex showed higher values in all of the following groups : standard diet with no exercise group (p<0.01), calcium deficient diet with no exercise group (p<0.01), calcium deficient diet with one-exercise group (p<0.01), and calcium deficient diet with two-exercise group (p<0.05). II. Histopathologic findings As compared with standard diet with no exercise group, standard diet with 2-exercise group especially showed significantly bone remodeling layers, increase in bone quantity, cement lines, degree and thickness of calcification of inner and outer circumferential lamellae, and findings of displacement of bone lacuna with bone, and these expedited formation of bone matrix. Calcium deficient diet groups showed enlargment of marrow, bone resorption, decrease in Haversian system, undermineralized layers, decrease in Haversian lamellae, decrease in inner and outer circumferential lamellae, decrease in bone lacunae, and showed about the same findings as the exercise groups. III. Compression strength of bone Among the standard diet groups, the group with 2-exercise showed the highest compression strength (p<0.01). Among the calcium deficient diet groups, no differences were shown between any two groups. Between the standard diet group and calcium deficient group, significant differences were found in all and the standard diet group showed greater strength (p<0.01). On the basis of the foregoing findings, physical exercise given to rats at the growing stage expedites increase in bone quantity although it differes with the degress of mechanical load placed on the cortex of diaphysis of tibia, and has an effect of promoting formation of bone matrix. Importance of the correlation with calcium deficiency was suggested.
  • 小児歯科学雑誌
    2017年 55 巻 4 号 501-505
    発行日: 2017/11/25
    公開日: 2018/11/25
    ジャーナル フリー
  • 小児歯科学雑誌
    2001年 39 巻 3 号 796-797
    発行日: 2001/06/25
    公開日: 2013/01/18
    ジャーナル フリー
  • 小児歯科学雑誌
    2006年 44 巻 5 号 748b-
    発行日: 2006年
    公開日: 2013/01/18
    ジャーナル フリー
  • 小児歯科学雑誌
    2006年 44 巻 5 号 748a-
    発行日: 2006年
    公開日: 2013/01/18
    ジャーナル フリー
  • 香西 克之, 鈴木 淳司, 内川 喜盛, 木本 茂成, 田村 康夫, 中島 一郎, 小野 俊朗, 有田 憲司, 新谷 誠康, 福本 敏, 海原 康孝, 林 文子, 土屋 友幸
    小児歯科学雑誌
    2008年 46 巻 5 号 517-523
    発行日: 2008/12/25
    公開日: 2013/01/18
    ジャーナル フリー
    本邦における小児歯科学教育の現状を調査するために,全国29歯科大学・大学歯学部の小児歯科学担当講座(分野)に対してアンケート調査を行った.アンケートは小児歯科学授業(講義),基礎実習,臨床実習の3項目について行った.アンケートの結果から以下の実態が確認された.授業では,ほとんどの大学で小児歯科,あるいは成長,発達などの小児歯科学と関連のあるシラバスの科目名称を有していたが,小児歯科学単独のシラバスを持たない大学もあった.授業時問は平均55時間程度であったが,最も少ない大学と多い大学では6倍の差があった.基礎実習は平均35時間行われていたが,国公立大学の平均に比べ私立大学は有意に多かった.臨床実習実施期間は平均11.9か月で大学間の差は少なかったが,実施時期は国公立大学に比べ私立大学が約6か月程度早期に行われていた.また,臨床実習での学生の参加形態や評価方法などは大学問で大きな差があった.
    以上のことから,小児歯科学の教育は各歯科大学・大学歯学部で大きな差があることが確認された.特に授業時間や実習時間は私立大学が多い傾向にあった.また臨床実習の実習期問は大学問で大きな差はないが,開始時期は私立大学が国公立大学に比べ有意に早いことが示された.
  • 三箇 正賢
    九州歯科学会雑誌
    2000年 54 巻 1 号 70-85
    発行日: 2000/02/25
    公開日: 2017/12/20
    ジャーナル フリー
    Bone mineral content increases with age in developing children and it has been reported that peak bone mass is obtained around 17-20 years of age. Therefore, the accumulation of adequate bone mass in this period is a key determinant in prevention of osteoporosis. Rats aged 5 weeks, corresponding to schoolchildren in human, were used in the present study. The effects of dietary therapy rich in calcium content on mandibular osteoporosis produced by calcium deficiency were investigated, using computed X-ray densitometry and cephalometry. The results were as follows. 1. Weight Calcium deficient animals exhibited significantly lower weight than control animals 4 weeks post-experimentally (p<0.05). The difference disappeared, however, after the animals were fed standard diet for 8 weeks. 2. Densitometry No significant differences were identified between the control and experimental groups in bone density of mandibular angle, condylar and coronoid processes. 3. Cephalometry A. Coordinate analysis The experimental groups exhibited significantly lower values than control group in mandibular angle, condylar and coronoid processes (p<0.05). However, no significant differences were found between the experimental and control groups in mandibular body and alveolar process. B. Distance measurement The experimental groups showed significantly shorter mandibular border, ramus, and coronoid process than the control animals (p<0.05). C. Area measurement The experimental groups showed significantly less area of mandibular angle and condylar process than the control animals (p<0.05). From the foregoing results, dietary therapy rich in calcium content showed a nagetive result for recovery of mandibular osteoporosis in school childhood with cephalometric investigation, but gave a positive result measured by computed X-ray densitometry.
  • 永山 雅大
    九州歯科学会雑誌
    2000年 54 巻 1 号 37-55
    発行日: 2000/02/25
    公開日: 2017/12/20
    ジャーナル フリー
    The influence of diet therapy on bone matrix formation was examined in the tibial metaphysis by endochondral ossification. Eight-week-old male Wistar rats corresponding to humans during adolescence were fed a calcium-deficient diet (0.01mg/100mg) or a low-calcium diet (144mg/100g) for 6 weeks, or the same diet for 3 weeks to induce a fragile state, followed by a standard diet for 3 weeks as a diet regimen. The following results were obtained. 1. Histopathologic findings showed a wider chondrocyte layer, decreased calcified matrix, and reduced erosion of the calcified matrix in the thickened zone chondrocytes and columnar gaps, particularly in the group fed a calcium-deficient diet compared with those in the control group. In the group fed low-calcium and standard diets, the width of the chondrocyte layer was reduced, and the calcified matrix and erosion of the calcified matrix in the columnar gaps were increased, which were findings similar to those in the control group, indicating facilitation of bone matrix formation by endochondral ossification. 2. In enzymohistochemical findings, ALP-positive cells indicating osteoblasts on the surface of the osseous beam continuing from the new osseous beam toward the lower part in the group fed low-calcium and standard diets were similar to those in the control group. TRAP-positive cells indicating osteoclast-like cells in the group fed low-calcium and standard diets were similar to those in the control group. 3. Histomorphometric findings demonstrated that the number of osteoclasts per unit area of the secondary cancellous bone was significantly increased in the order of the group fed a low-calcium diet<the group fed calcium-deficient and standard diets<the group fed a calcium-deficient diet, compared with that in the control group. However, there was no significant difference between the group fed low-calcium and standard diets and the control group. This study performed histopathologic examination, enzymohistochemical examination, and measured the number of osteoclast-like cells concerning bone resorption of bone metastasis as histomorphometry for quantification, to concretely examine the effects of diet therapy by administering calcium for bone in a fragile state on bone matrix formation. Consequently, bone that had been in a fragile state during adolescence, particularly in the group fed low-calcium and standard diets, showed almost the same findings as those in the control group after balanced diet therapy with calcium, demonstrating recovery of bone matrix formation by endochondral ossification.
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