Fundamental and clinical experiments for gynecologic use of doxycycline were performed and theresult summarized as follows
1) The
in vitro antibacterial activity of doxycycline was almost the same with that of tetracyclineand DMCT against
E. coli and
Staphylococcus isolated from clinical materials.
2) Concentrations of doxycycline in the blood, amniotic fluid, umbi lical blood and milk after theoral doses of 100 mg∼200 mg doxycycline were examined. The results show that doxycycline has aprolonged action.
3) Clinic al application were performed to 13 cases.
4) Doxycycline may be an excellent drug so far as the infections due to
Staphylococcus are concerned.
5) Severe side effects were not noticed except nausea that some of patients experienced.
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