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  • 計画制度小委員会専門委員を務めて
    木下 敬之助
    日本不動産学会誌
    2000年 14 巻 3 号 31-37
    発行日: 2000/09/29
    公開日: 2011/06/15
    ジャーナル フリー
  • PTH抑制の評価と予測因子としてのwhole PTH
    椎崎 和弘, 根木 茂雄, 半羽 慶行, 児玉 直也, 児玉 敏宏, 宇治田 卓司, 嶋 渡, 木下 敬之助, 秋澤 忠男
    日本透析医学会雑誌
    2004年 37 巻 5 号 1311-1316
    発行日: 2004/05/28
    公開日: 2010/03/16
    ジャーナル フリー
    進行した二次性副甲状腺機能亢進症 (SHPT) に対する安全かつ有効な治療として, 活性型ビタミンDアナログであるmaxacalcitol (OCT) を副甲状腺内に直接注入するpercutaneous maxacalcitol injection therapy (PMIT) が開発された. PMITのPTH抑制効果を, intact PTH, 高感度 (HS) PTH, さらに最近開発されたwhole PTHを用いて検討した.
    OCT静注などの内科的治療に抵抗性のSHPTを有する維持透析患者8症例に対しPMITを6日間連日施行し, 終了後OCT静注を中心とする後療法を行った. PMIT前・直後・4週後・12週後に血清intact PTH, HS PTH, whole PTH, カルシウム (Ca), リン (P) を測定した.
    血清intact PTH, HS PTH, whole PTHはほぼ平行して有意に低下し, この間血清CaおよびPに有意な変動はみられなかった. また, whole PTHおよびintact PTHとwhole PTHの差により算出したPTHのC端フラグメント (CPTH) との比もPMIT直後で有意に低下した. 6か月以内にPTHの低下が不十分または高Ca血症によりOCT静注の継続が不能なため副甲状腺内エタノール直接注入 (PEIT) を必要とした効果不十分群 (3症例) とそれ以外の有効群 (5症例) について比較したところ, PMIT直後のHS PTHおよびwhole PTHの低下率は有効群で有意に大きかった. またPMIT後の経過についてはwhole PTHのみに両群間で有意差を認めた.
    PMITによりintact PTH, HS PTH, whole PTHは一様に低下したが, PTH抑制効果はwhole PTHが最も鋭敏に反映すると考えられ, PMIT前後に測定することによりPMITの有効性予測指標となる可能性が示唆された.
  • 1964年2月29日 大阪科学技術センター
    The Journal of Antibiotics, Series B
    1964年 17 巻 4 号 202-212
    発行日: 1964/08/25
    公開日: 2013/05/17
    ジャーナル フリー
  • 日本臨床外科医学会雑誌
    1968年 29 巻 4-5 号 371-376
    発行日: 1968/09/01
    公開日: 2009/02/10
    ジャーナル フリー
  • 前田 益孝, 神田 英一郎, 桑名 仁, 棚瀬 健仁, 小林 隆彦, 椎貝 達夫
    日本透析医学会雑誌
    2005年 38 巻 1 号 41-50
    発行日: 2005/01/28
    公開日: 2010/03/16
    ジャーナル フリー
    近年開発されたマキサカルシトール (OCT) はカルシトリオールに比し, 高Ca血症をきたしにくいビタミンD製剤であり, 静注投与が一般的であるが, 副甲状腺への局注療法も有効とされている. しかし, 静注投与では血清Ca値の上昇をきたすために投与量が制限され, 充分な副甲状腺ホルモンの抑制が得られない例があり, また局注療法は集中的に連日ないしは隔日投与が必要とされ, 通院患者への適用は困難である. われわれはOCTの静注にもかかわらず, 副甲状腺ホルモンの充分な改善が得られず, 高Ca血症などのためにOCTの増量が困難であり, エコー上, 副甲状腺の腫大を認めた維持透析患者12名 (男5人, 女7人) に対し, OCTの静注療法は継続したまま, 副甲状腺内にOCTを間欠的に局注し, その併用効果を検討した. 12人の平均年齢は59.8±1.8歳, 平均透析歴は159.4±24.5か月, 血液透析11名, 血液・腹膜併用透析1名, 血清intact PTH値は555±78pg/mL, 平均腫大腺数は1.6腺で容積は1.3±0.4cm3であった. これらの症例に対し, エコーガイド下, 腫大副甲状腺内にOCT 10μgを局注した. 半年間のPIT回数は平均2.3 (1-6)回/症例であった. 全例で経過中, 12mg/dLを超える高度な血清Ca上昇はなく, 反回神経麻痺等の重篤な副作用もみられなかった. 12人中, 11人では一時的または永続的な副甲状腺ホルモンの低下がみられ, 初回局注より半年の時点で40%以上のintact PTH値の低下が得られたのは5例であったが, 他の症例に比し, 有意な臨床的相違はみられなかった. 1例は局注にても副甲状腺ホルモンの低下がみられず, 副甲状腺摘出術に至った. 以上からOCTの静注に副甲状腺内局注を併用する治療は透析患者の二次性副甲状腺機能亢進症に対し, 治療選択肢のひとつになりえると考えられた.
  • The Journal of Antibiotics, Series B
    1964年 17 巻 4 号 213-225
    発行日: 1964/08/25
    公開日: 2013/05/17
    ジャーナル フリー
  • 日本臨床外科医学会雑誌
    1967年 28 巻 6 号 293-305
    発行日: 1967/10/01
    公開日: 2009/02/10
    ジャーナル フリー
  • CHEMOTHERAPY
    1963年 11 巻 4 号 214-224
    発行日: 1963/07/25
    公開日: 2010/09/24
    ジャーナル フリー
  • ―国会議員と地方首長の選挙政治―
    砂原 庸介
    年報政治学
    2011年 62 巻 2 号 2_98-2_121
    発行日: 2011年
    公開日: 2016/02/24
    ジャーナル フリー
      As for the relationship between Diet members and local assembly members in Japan, previous empirical researches mainly focus on their clientelistic relations among them and upward political career move from local assembly to the Diet. In this article, the author presents a different perspective from these previous researches, and elaborates the tendency that Diet members try to change their career to local politicians, especially governors and mayors of local governments. Two political reforms in the 1990s affected the ambition of Diet members; the electoral reform changed patterns of political competition in electoral districts, and the decentralization reform enhanced the attractiveness of the position of mayors.
      In this article, the author investigates the cases that Diet members / former Diet members, who stood as a candidate in the five elections before and after the electoral reform, challenge governor / mayor / local assembly elections. The results show that more Liberal Democratic Party members challenge to local elections after the electoral reform, and the more leading opposition members, who were affiliated with Japan Socialist Party or New Frontier Party or Democratic Party, challenge to local elections than LDP members. Besides, this article reveals that by measuring the effective numbers of candidate the patterns of political competitions in governor / mayor elections are different before and after the electoral reform.
  • 第1編 骨髄培養による骨髄障害の研究
    島谷 信人
    岡山医学会雑誌
    1966年 78 巻 4-5 号 521-548
    発行日: 1966/05/30
    公開日: 2009/02/13
    ジャーナル フリー
    Since there is a considerable individual difference in bone-marrow disturbances induced by the administration of anticancer agents, the author conducted a series of study on human bone marrow by the clinical tissue culture method devised by Hiraki et al. for the purpose to know the susceptibility of bone-marrow in the individuals bearing cancer, prior to the administration of anticancer agent. The anticancer agents used were Mitomycin C, Cyclophosphamide and Chromomycin A3, and these were added to the tissue culture at varying concentrations. Observations were carried out as to their effects on the growth of bone-marrow in order to find out the tolerance to anticancer agents of human bone-marrow in in vitro. The results of these observations were compared with those clinical examinations such as the extent of bone-marrow disturbances brought about by the clinical application of each of these anticancer agents, histological pictures of the bone-marrow prior to the administration of the agent, the number of peripheral leucocytes, the serum protein contents, and ratio A/G before the administration of the agent. The findings of the present study are briefly presented in the following.
    1. By conducting tissue culture of the bone-marrow obtained from noncancer bearing and cancer bearing patients with the addition of various anticancer agents in varying concentrations, the in vitro tolerance of the bone-marrow to these agents was studied.
    i) In the case of bone-marrow tissue culture with the addition of Mitomycin C, both the bone-marrow of the patients with stomach-cancer and that of non-cancer bearing patients showed a marked individual difference in the tolerance to the anticancer agents, and the maximum tolerance proved to be about six time that of the minimum.
    ii) In the tissue culture with the addition of Cyclophosphamide, likewise the bone-marrow of both non-cancer bearing and stomach-cancer bearing patients showed the difference of as much as three-fold between its maximum tolerance and the minimum. This proves that the range of individual differences in the tolerance is narrower than that observed in the case with the addition of Mitomycin C.
    iii) In the tissue culture with the addition of Chromomycin A3 the range of individual differences in the tolerance to it was about two-fold between its maximum and the minimum with the bone-marrow of stomach-cancer bearing patients while it was about three-fold in the case with non-cancer bearing patient. This denotes as in the case with the addition of Cyclophosphamide that the range of the individual differences in the tolerance is narrower than that with Mitomycin C.
    2. The range between the maximum tolerance and the minimum observed in the bone-marrow in tissue culture is widest in the addition of Mitomycin C, followed by the range in the case with Cyclophosphamide and Chromomycin A3. However, the decreasing rate of the peripheral leucocytes in the patients after the administration of the agent in clinic proved to be highest with Mitomycin C, followed by that with Chromomycin A3 and Cyclophosphamide. This fact reveals an interesting mutual relationship between the tolerance range observed in the bone-marrow tissue culture just described and the decreasing rate of peripheral leucocytes after clinical administration of these agents.
    3. There was recognized a close mutual relationship between the degree of tolerance to the anticancer agents in the bone-marrow tissue culture added with these agents and the decreasing rate of peripheral leucocytes in the patients administered with these same agents. This finding indicates that the bone-marrow tissue culture conducted with anticancer agent prior to its use can predict the tolerance of the bone-marrow to the agent.
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