Firstly, the antioxidative activities of the ten kinds of plants extracts were evaluated by three methods. The conker (Aesculus turbinata Blume.), the barilla plant (Salsola Komarovi Iijin.) and the purslane (Potulaca oleracea L.) extract was found to be a strong antioxidant when tested by the TBA method using deoxyribose as the substrate, whereasthe Colorimetric assay using Methyl indole as a reagent and linolenic acid as the substrate indicated that the activity of athers. The seedvessel of a conker, the barilla plant (Salsola Komarovi Iijin) and the purslane (Potulaca oleracea L.) extracts were showed extremaly strong ・OH radical scavenging activity when tested by the ESR method.

Secondly, the effect of Salsola Komarovi Iijin. and Potulaca oleracea L. extracts studied in the overiectmized rat model of osteoporosis.

Twelve week old female SD rats were randomly assigned to following four groups, i.e., sham operated (Sham); over mized (OVX); OVX and fed a diet containing 1. 5% Salsola Komarovi Iijin. extracts (OVX + SK); OVX and fed a diet containing 1. 5% Potulaca oleracea L. extracts (OVX + PO).

In conclusion, the OVX and OVX + SK group were to be sthenia both deossification or osteogenesis.

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Although thrombotic complications during treatment for hemorrhagic diathesis with tranexamic acid (T-AMCHA) were occasionally seen, deep vein thrombosis (DVT) induced by T-AMCHA in idiopathic thrombocytopenic purpura (ITP) has not been reported. We recently experienced an 83-year-old male of ITP associated wist DVT showing the depression in fibrinolytic activity due to administration of T-AMCHA for 16 months. His thrombosis was dissolved by urokinase.

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吐糸速度と繭糸の物理化学的性質との関連を調べるため, 種々の方法で吐糸速度の測定が試みられてきた。しかし, これまでのいずれの方法も三次元的な吐糸口の動きから測定したのではなく, 求められた吐糸速度の精度も明らかではない。そこで本研究では, 吐糸口の位置の三次元測定値から吐糸速度を推定する方法を提案した。また, この方法によって得られる吐糸速度の推定誤差について考察し, その評価を与える式を導いた。次に三種類の蚕を用いて, 吐糸速度の推定を試みた。その結果, これまで長い時間の平均としてしか求まらなかった吐糸速度を1秒単位で精度よく推定できることが明らかとなった。また, 蚕の吐糸速度は短い時間に大きく変化することがわかった。

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During the past fifteen years, we encounterd five of seventy patients with aplastic anemia who developed arterial thrombosis. The thrombotic complication in four of these patients ocurred when the platelet counts began to increase during long-term therapy with steroids or anabolic hormones. Furthermore, a retrospective study on coagulation and fibrinolysis in sixteen patients with aplastic anemia showed shortening of PTT and STT and a reduced level of ATIII. These therapies are known to induce a hypercoagulable state. Our cases suggest that arterial thrombosis develops even in patients with thrombocytopenia (2.7-7.6×10⁴/μl ) during treatment with seroids or anabolic hormones.

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Conventionally, there were many studies about the efficacy of muscular assessment for throwing shoulder injury. On the other hand, there was no report regarding utility of the self-assessment for throwing performance. In this study, we reported whether the evaluations of muscular strength of the shoulder joint contribute to the throwing performance. 126 pitchers affiliated with the Gunma Prefecture High School Baseball Federation in 2007 had medical checkup and evaluated the examination items. Each player was also surveyed on his pitching performance by questionnaire at the examination. All players were male, the average baseball career was 98.5 (10 ∼ 240) months and 68 pitchers (50.8%) had current and past shoulder pain. The average maximum pitching speed was 125.1 (100 ∼ 140) km/h. By logistic regression analysis, the significant item about classification of the performance of the pitcher was throwing side external rotation strength at 0 position. The evaluation of external rotation strength at 0 position may be important when a baseball pitcher cared for the environment of his shoulder joint.

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A 57-year-old woman who suffered from acute myeloblastic leukemia during the course of chronic thyroiditis, is described. The patient was diagnosed as having chronic thyroiditis in 1984 when she was 53 year-old, and was treated with L-T₄·Na. She admitted in July 1988 because of general fatigue, fever, cough and sore throat. On admission, hematological examination in the peripheral blood showed marked anemia and increased leukocytes with 20.5% leukemic cells positive for peroxidase staining. Bone marrow aspiration showed 38.8% leukemic cells. She was diagnosed acute myeloblastic leukemia. She reached complete remission after combination chemotherapy.
The case of acute myeloblastic leukemia associated with chronic thyroiditis is rarely reported. We reviewed the literature and discussed acute myeloblastic leukemia associated with chronic thyroiditis including this case.

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The antioxidative activities of wasabi (Eutrema wasabi MAXIM.) root, stem, and leaf extracts were evaluated by several methods. The wasabi stem extract was found to be a strong antioxidant when tested by the TBA method using deoxyribose as the substrate, whereas the HPTLC assay using linolenic acid as the substrate indicated that the activity of the leaf extract was greater than those of the stem and root extracts. All three extracts showed strong-OH radical scavenging activity when tested by the ESR method. Superoxide scavenging activity was extremely high in the leaf extract, whereas the stem and root extracts did not show any appreciable effect. These results suggest the occurrence of different antioxygenic principles in the leaf and stem of wasabi. As most of the wasabi leaf and stem has not been utilized so far, these findings will contribute to the total utilization of wasabi plants.

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くすぶり型多発性骨髄腫に,肝細胞癌,胃癌を合併した三重複癌の症例を経験した.
症例は, 67歳,男性.くすぶり型多発性骨髄腫で14年間加療中であった.イレウスを併発して入院,その加療中に肝細胞癌,胃癌の合併を発見され,各々に対して一期的に切除術を施行し,術後32日目で内科転科となった.
多発性骨髄腫の予後が化学療法剤の発達により改善が認められるようになるに伴い,重複癌にて外科的治療を余儀なくされる機会の増加が予想される.その際,非常に稀ではあるが,複数臓器に癌が存在する可能性もあることを念頭に置き,診断,治療にあたる必要がある.

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A new welding method, called ultrasonic wave tungsten inert gas (TIG) welding, is developed to decrease porosities in a weld. A1050 aluminum plates are welded at an alternating current (AC) frequency from 10 to 40 kHz. An argon (Ar)-1%hydrogen mixture is used as the shielding gas to generate porosities in the experiments. For comparison, a normal TIG welding is also performed at 60 Hz. After welding, the distribution of the porosities in the welds is observed in order to evaluate the effect of the sonic wave. The number of porosities changes with the frequency. A frequency near 15 kHz is the most suitable to decrease the porosities. Using this new method, the area of porosities is decreased to less than about 1/8 of the normal TIG weld. This method is effective for decreasing the number of porosities.

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症例は54歳男性で1990年6月下旬に右手指の運動障害に気づき, 7月中旬には言語障害が出現し入院となる.右上肢の中等度の脱力, 軽度の感覚性失語, 失書, 失算があり, 頭部CT検査にて左中大脳動脈領域に低吸収域を認め脳梗塞と診断した.入院時検査にて血小板数68,000/μl, 血小板結合IgG (PAIgG) 陽性, 骨髄像正常から特発性血小板減少性紫斑病 (ITP) の合併が認められた.血小板凝集能はADP・アラキドン酸・エピネフリンともに再現性を有し低下していた.梅毒反応生物学的偽陽性を認め, 抗カルジオリピン抗体 (抗CL抗体) が陽性であった.
本例は血小板数が減少しているにもかかわらず脳梗塞を発症しておりITPと脳梗塞の合併の機序として抗CL抗体の関与が考えられた.

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The purpose of this study was to investigate the effect of fatigued external rotator muscles of the shoulder on the shoulder position sense of abduction，internal rotation，and external rotation． Ten healthy male college students participated in this study．All subjects had played baseball in the past．The shoulder position sense of the subjects were tested under 2 conditions：fatigue and control．Measurements in each condition were conducted in 2 days apart．ln the fatigue condition，first，shoulder joint position sense was measured．Subsequently，a fatigue task of the shoulder’s external rotator muscles was perforrned．After the fatigue task，shoulder position sense was measured again．ln the control condition，the fatigue task was not performed． In the fatigue condition，fatigue of the infraspinatus muscle was observed，and shoulder position sense of internal and extemal rotation decreased after the fatigue task was performed．This result suggested that it fatigue caused a reduction in the sensitivity of muscle spindles．However，there was no significant difference in the position sense of abduction before and after the fatigue task was performed. This is partly because the extemal rotator muscles did not act as prime movers in shoulder abduction．These results suggested that fatigue of the external rotator muscles decreased position sense in the direction of motion when the external rotator muscles functioned as prime movers．

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症例は45歳男性。2001年3月に骨髄異形成症候群(RAEB)と診断された。同年5月に左下肢蜂窩織炎を発症し入院となった。末梢血検査で，汎血球減少と，幼弱な顆粒球系細胞の出現を認めた。骨髄検査上，芽球比率の増加(11.2%)と，7番染色体長腕の部分欠失を含む複雑な核型異常を認めた。入院後より，多飲多尿が出現し，中枢性尿崩症と診断した。DDAVPの使用により，尿量は正常化し，同年11月に，TBI+Ara-Cを前処置として，非血縁者間同種骨髄移植を施行した。移植後も症状の再燃は認められず，DDAVPを中止し得た。白血病や骨髄異形成症候群の比較的稀な合併症として，中枢性尿崩症が報告されているが，尿崩症発症の機序は解明されていない。本例では，骨髄移植後にDDAVPを中止し得たことより，下垂体への白血病細胞浸潤が原因であった可能性が推測された。

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症例は29歳女性。平成14年発症のEvans症候群に対して平成16年5月に脾摘術施行された。術後1.5カ月時点で再発した為に，デキサメタゾン大量療法（38mg/日×4日）施行された。投与開始5日目の血小板数8万/mm³に上昇した時点で激しい頭痛出現し，その後昏睡に到った。CT所見にて横静脈洞血栓症と診断され，血腫および傷害脳の部分切除が施行された。その後視野障害や麻痺が残るも，意識状態は徐々に手術前レベルに復した。特発性血小板減少性紫斑病と脳静脈洞血栓症の合併報告は本例で4例目ときわめて稀である。

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Wasabi (Eutrema japonicum (Miq.) Koidz.) was grown in a traditional cultivation field using spring water in Izu peninsula for 12 months. Four different shading nets were applied to the cultivation field to reduce sun light during the whole period. Among 4 nets, white-colored net transmitted photosynthetic active radiation (PAR) most abundantly (64%), whereas black-colored net did least abundantly (22%). Blue-colored and red-colored nets had similar values of PAR transmittance (58%). Transmittance of shortwave radiation including PAR and near infrared (NIR) was almost same among white-colored, blue-colored, and red-colored nets. As a result, temperature of black-painted brass boards placed horizontally was almost same under the three nets, suggesting that white-colored net can effectively reduce NIR and transmit PAR abundantly. Whole plant fresh weight and rhizome weight of wasabi were highest under white-colored nets. Pungent components such as allyl isothiocyanate were not significantly different among the four nets. Our result suggests that white-colored net can enhance wasabi growth compared with the other three nets, probably owing to abundant PAR and suppressed NIR reaching the plant surface.

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各種フレッシュハーブの抗酸化能の評価及びカレープラント中のポリフェノール類の分離同定を行ない,以下の結果を得た.
(1) ロダン鉄法による抗酸化能測定の結果,新たにカレープラント,スイートラベンダーにおいて32mg BHA/ml/g以上に相当する高い抗酸化能が認められた.
(2) DPPH法によるラジカル消去能測定の結果,ナツメグでは約0.6mg BHA/ml/g,フローレンスフェンネル,イタリアンパセリ,ローズマリー,スペアミント,スイートラベンダー,スーパーアロエでは0.4mg BHA/ml/gと同等かそれ以上に相当する高いラジカル消去能が見られた.
(3) カレープラントのラジカル消去能は総活性の約25%がポリフェノール由来と考えられた.
(4) カレープラント中のポリフェノールをHPLCで検出した結果,ヒドロキノン,没食子酸,レゾルシノール,ピロカテコール,クロロゲン酸,(+)-カテキン,ゲンチシン酸,EGCgと思われるピークが検出され,ゲンチシン酸,EGCg,(+)-カテキンが多く含まれていた.またこれらについてラジカル消去能を測定した結果,EGCgが約500mg BHA/ml/gと特に高かった.以上より,カレープラント中ポリフェノールのラジカル消去能はその活性・含量から主にEGCgに由来すると考えられた.

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We studied the antitumor effect of activated vitamin D₃, which is reported to have a proliferation inhibitory action in vitro against several strains of breast cancer cells in vivo using 7, 12-dimethylbenz (a) anthracene (DMBA) -induced rat mammary tumors.
After mammary tumors developed as a result of administration of 20 mg of DMBA to 6-week-old female Sprague-Dawlay (SD) rats, we conducted daily oral administration of 1α-hydroxyvitamin D₃ (1α (OH) D₃) for 4 weeks in a dose of 0.02, 0.1, 0.5 and 1μg/kg. Every week tumor size and body weight were measured, and after 4 weeks the estrogen receptors (ER) of the tumor and serum Ca concentration were determined. Moreover., we compared the rate of change in tumor size when each of the 3 drugs, 5-FU, Medroxyprogesterone acetate (MPA) and Tamoxifen (TAM) was administered alone or in combination with 1α (OH) D₃.
The results showed that 1α (OH) D₃ suppresses the growth of DMBA-induced rat mammary tumors dose-dependently. In combination with 5-FU, potentiation of the antitumor action was suggested, but in combination with MPA and TAM, no potentiation was observed.

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A 71-year-old female was admitted because of fever and malaise. Physically marked pallor was noted. Laboratory investigation revealed severe leukopenia and anemia which required frequent blood transfusions. A bone marrow aspirate showed a markedly hypocellular marrow with 55.6% blast cells. Peroxidase activity and PAS reaction were negative in the blast cells. Surface markers of the blast cells, such as T, B, or myeloid antigens, were all negative except for the Ia like antigen.
A diagnosis of hypoplastic leukemia was made and in September, 1985, treatment with alfacalcidol (2-4 μg, daily) was started. Under this treatment the hemogram showed remarkable improvement and the patient became symptom-and transfusion-free. A bone marrow aspirate in November, 1985, demonstrated regeneration of normal hemopoietic cells with distinct reduction of blast cells (5.4%). From January, 1986, the leukemia became gradually refractory to alfacalcidol. The dosage of the drug was elevated up to 8 μg/day and administrated intermittently with a cycle of 5 days to minimize the side effects. However, this treatment was not helpful and the bone marrow examined in February, 1986, showed a recurrence of the leukemia. In March, 1986, the hemogram returned to pancytopenia and transfusions were needed. At the end of March, 1986, low dose Ara-C (7.5 mg/day) was started in addition to alfacalcidol (3 μg/day) without any benefitial effect.
During the treatment with alfacalcidol there was no hypercalcemia, although urinary calcium levels occasionally exceeded the normal range.
This patient is the first reported case of acute leukemia successfully treated with alfacalcidol alone.
Incubation of the bone marrow cells obtained in March, 1986, with 1α, 25 (OH)₂D₃ for 1 to 5 days, resulted in the dose-dependent reduction of absolute number of cells. While, no evidence of differentiation of leukemic cells was obtained, suggesting cytostatic effect of 1α, 25 (OH)₂D₃ rather than induction of differentiation in this patient.

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