Most hemangiomas in the field of otolaryngology are vascular malformations, with venous malformations being the most common. We report a case of intramuscular venous malformation (IVM) of the masseter muscle which responded well to treatment with a Kampo medicine. The patient was a 22-year-old woman who presented with the complaint of swelling and pain in the left cheek. We diagnosed the patient as having an IVM in the left masseter muscle based on the findings of contrast-enhanced computed tomography, contrast-enhanced magnetic resonance imaging, and fine-needle aspiration biopsy. The patient refused the surgery as she was young and the IVM was not malignant. Therefore, we initiated the patient on a Kampo drug. In Kampo medicine, IVM are regarded as blood stasis, and typically, hemostatic agents are used for treatment. We chose keishibukuryogankayokuinin as the hemostatic agent. The size of the IVM reduced in response to the treatment, and the symptoms disappeared. It is important for patients to be offered the option of oral medication rather than surgery for IVM, where possible.
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