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全文: "Frontal pole"
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  • Shigenobu TAKAYAMA, Tetsuhiko KIMURA, Takezo ARAGAKI
    Neurologia medico-chirurgica
    1966年 8 巻 277
    発行日: 1966年
    公開日: 2007/08/17
    ジャーナル フリー
  • Teru KAWAMATA, Kiyoshi MATSUMOTO, Noboru GOTO, Minoru KOHDA
    The Showa University Journal of Medical Sciences
    1996年 8 巻 1 号 103-111
    発行日: 1996年
    公開日: 2010/09/09
    ジャーナル フリー
    The morphometric anatomy of the superficial cerebral veins in relation to cerebral gyri was studied in 244 cadaveric cerebral hemispheres. Our morphometry revealed that the position of the central sulcus and that of the parieto-occipital sulcus near the superior sagittal sinus were at 55% and 83.6% respectively of the half-perimeter running from the frontal pole to the occipital pole (FO) . The drainage position of the central sulcal vein (of Rolando) into the superior sagittal sinus was about 65% of the FO half-perimeter on each side. The three main drainage veins among the superficial cerebral veins are classified into four types: (1) left predominant, (2) right predominant, (3) no laterality, and (4) absent. No laterality predominance was observed regarding the superficial middle cerebral vein (of Sylvius) . The inferior anastomotic vein (of Labbe), however, was predominant on the left hemisphere. The superior anastomotic vein (of Trolard) was observed with similar frequency in each type. In conclusion, the superficial cerebral veins can be classified into eight different types according to venous drainages.
  • Kimiyoshi HIRAKAWA, Keizo HASHIZUME, Norio NAKAMURA, Keiji SANO
    Neurologia medico-chirurgica
    1971年 11 巻 34-45
    発行日: 1971年
    公開日: 2007/01/12
    ジャーナル フリー
    Optic nerve injury or blindness after head trauma has well been known since the days of Hippocrates, and has still remained one of the serious posttaumatic sequelae. Statistically about 2% of head-injured persons suffer from the visual loss and are impelled to have limited social activites3). As the victims of traffic accidents are increasing every year, the studies about this problem are urgent.
    Clinical manifestations of the injury of the optic nerve have been well known. The reports of many institutions have shown almost the same results. The summaries are as follows3): There is a constant mode of trauma to make an injury. It occurs frequently in motorcycle accidents. Sometimes it occurs even in trivial accidents, where impact force is not always so large. The blow is usually given to the front of the head. Symptomatologically visual loss occurs immediately after the trauma and is limited usually to the eye on the ipsilateral side to the impact and spares the eye on the contralateral side. Diagnosis is guided from the loss of direct light reflex of the affected side. The fracture of the optic canal is often visualized in X-ray studies. Surgical intervention is not fully effective.
    From the pathological view point, there are so many therories as to the causative factors of the injury of the optic nerve. The fracture of the optic canal, the bleeding of the sheath of the optic nerve, and the tearing of nerve fibers are prominent among them. Fracture theory seems most attractive because the fracture of the optic canal is found in 60-90% cases in X-ray studies.
    So far, these clinical and pathological data have strongly suggested that mechanical factors play an important role to cause the lesion. However, there has never been a fundamental engineering study. Therefore in this paper, mechnical studies were performed to investigate the mechanism and to clarify the threshold of the impact force of the fracture of the optic canal, which is thought to be closely relevent to the ipsilateral optic nerve injury. The studies were made up of series of experiments.
  • Jerome V. Murphy
    Journal of Nutritional Science and Vitaminology
    1976年 22 巻 Supplement 号 69-73
    発行日: 1976年
    公開日: 2009/06/16
    ジャーナル フリー
    A series of children with Leigh's disease had normal hepatic pyruvate carboxylase activity, increased cerebral thiamine diphosphate, and decreased cerebral thiamine triphosphate. These thiamine esters were normal in liver. The author suggests that the histologic changes of Leigh's disease, as well as the similar changes of Wernicke's disease, could be due to a deficiency of cerebral thiamine triphosphate.
  • Kouhei KAMIYA, Shiori AMEMIYA, Yuichi SUZUKI, Naoto KUNII, Kensuke KAWAI, Harushi MORI, Akira KUNIMATSU, Nobuhito SAITO, Shigeki AOKI, Kuni OHTOMO
    Magnetic Resonance in Medical Sciences
    2016年 15 巻 1 号 121-129
    発行日: 2016/01/01
    公開日: 2016/01/12
    [早期公開] 公開日: 2015/09/04
    ジャーナル オープンアクセス
    Background and Purpose: We analyzed the ability of a machine learning approach that uses diffusion tensor imaging (DTI) structural connectomes to determine lateralization of epileptogenicity in temporal lobe epilepsy (TLE).
    Materials and Methods: We analyzed diffusion tensor and 3-dimensional (3D) T1-weighted images of 44 patients with TLE (right, 15, left, 29; mean age, 33.0 ± 11.6 years) and 14 age-matched controls. We constructed a whole brain structural connectome for each subject, calculated graph theoretical network measures, and used a support vector machine (SVM) for classification among 3 groups (right TLE versus controls, left TLE versus controls, and right TLE versus left TLE) following a feature reduction process with sparse linear regression.
    Results: In left TLE, we found a significant decrease in local efficiency and the clustering coefficient in several brain regions, including the left posterior cingulate gyrus, left cuneus, and both hippocampi. In right TLE, the right hippocampus showed reduced nodal degree, clustering coefficient, and local efficiency. With use of the leave-one-out cross-validation strategy, the SVM classifier achieved accuracy of 75.9 to 89.7% for right TLE versus controls, 74.4 to 86.0% for left TLE versus controls, and 72.7 to 86.4% for left TLE versus right TLE.
    Conclusion: Machine learning of graph theoretical measures from the DTI structural connectome may give support to lateralization of the TLE focus. The present good discrimination between left and right TLE suggests that, with further refinement, the classifier should improve presurgical diagnostic confidence.
  • 中尾 善明, 高田橋 篤史, 鎗田 勝, 藤元 登四郎, 田村 俊世
    生体医工学
    2011年 49 巻 6 号 805-814
    発行日: 2011/12/10
    公開日: 2012/04/10
    ジャーナル フリー
    Remarkable progress in cognitive neuroscience has revealed the involvement of the prefrontal cortex and the orbitofrontal cortex in human working memory, but the orbitofrontal cortex is still one of the least understood regions in the human brain. To elucidate the contribution of the orbitofrontal cortex to human working memory, we studied EEG P300 activity in n-back task. We elicited early P3 around 300 ms and late P3 around 360 ms of P300 components in n-back ERP. The amplitudes of the respective peaks changed depending on the working memory load (0-back, 1-back, 2-back, 3-back). We used source analysis to evaluate the orbitofrontal cortex in P3 components. A source model was constructed with the sources seeded from fMRI meta-analysis of n-back task and additional sources in the orbitofrontal cortex and the visual cortex estimated with P100 and late P3 components in the n-back ERP. This source model had more than 99% of GOF (goodness of fit) in n-back ERP. It gave us an insight of brain activity at the positions where sources existed. Early P3 was mainly produced by the dorsolateral prefrontal cortex, the ventrolateral prefrontal cortex, the inferior parietal lobule, the medial posterior parietal and the visual cortex. Late P3 was mainly produced by the medial premotor, the lateral premotor, the frontal pole and the orbitofrontal cortex. The contribution of the frontal pole and the orbitofrontal cortex had peaks around 390 ms which were later than late P3 component. In this study, the method to evaluate the orbitofrontal cortex activity in n-back ERP was provided. Our results elicited the involvement of the orbitofrontal cortex in late P3 component of n-back ERP.
  • Katsuhiko Kimoto, Yumie Ono, Atsumichi Tachibana, Yoshiyuki Hirano, Takero Otsuka, Akinori Ohno, Katsuhiko Yamaya, Takayuki Obata, Minoru Onozuka
    Journal of Prosthodontic Research
    2011年 55 巻 2 号 89-97
    発行日: 2011年
    公開日: 2011/03/30
    ジャーナル 認証あり
    Purpose: We used functional magnetic resonance imaging (fMRI) to investigate the change in brain regional activity during gum chewing when edentulous subjects switched from mandibular complete dentures to implant-supported removable overdentures.
    Methods: Four edentulous patients (3 males and 1 female, aged 64 to 79 years) participated in the study. All subjects received a set of new maxillary and mandibular complete dentures (CD), followed by a maxillary complete denture and a new mandibular implant-supported removable overdentures (IOD). A 3-T fMRI scanner produced images of the regional brain activity for each subject that showed changes in the blood-oxygenation-level-dependent (BOLD) contrast in the axial orientation during gum-chewing with CD and IOD.
    Results: Region-of-interest analysis showed that IOD treatment significantly suppressed chewing-induced brain activity in the prefrontal cortex. The chewing-induced brain activities in the primary sensorimotor cortex and cerebellum tended to decrease with IOD treatment, however they did not reach to significance level. There was no change in brain activity in the supplementary motor area, thalamus and insula between gum chewing with CD and IOD. Group comparison using statistical parametrical mapping further showed that, within the prefrontal cortex, the neural activity of the frontal pole significantly decreased during gum-chewing with IOD when compared to that with CD (P < 0.05).
    Conclusion: Despite the limitation of a small sample size, these results suggest that the gum-chewing task in elderly edentulous patients resulted in differential neural activity in the frontal pole within the prefrontal cortex between the 2 prosthodontic therapies—mandibular CD and IOD.
  • Kyu Sun Lee, Sung Eun Lee, Jun Young Choi, Yu-Rha Gho, Minjung Kathy Chae, Eun Jung Park, Mun Hee Choi, Ji Man Hong
    Circulation Journal
    2017年 81 巻 11 号 1628-1635
    発行日: 2017/10/25
    公開日: 2017/10/25
    [早期公開] 公開日: 2017/06/06
    ジャーナル フリー HTML

    Background:The Alberta Stroke Program Early CT Score (ASPECTS) is used to assess early ischemic stroke damage. This study compared bilateral ASPECTS (ASPECTS-b) with the gray:white matter ratio (GWR) and quantitative regional abnormality (QRA) to evaluate the prognostic utility of early computed tomography (CT) findings in post-cardiac arrest patients.

    Methods and Results:Out-of-hospital cardiac arrest patients with return of spontaneous circulation (ROSC) who underwent brain CT (<6 h after onset) and therapeutic hypothermia were recruited from a university hospital over a 2-year period. General demographics, ROSC characteristics, ASPECTS-b (total score=20 points), GWR, and QRA were assessed. Multivariate logistic regression analysis was used to predict neurologic outcome using cerebral performance category (CPC) at 1 month. The study population was divided into good (n=20; CPC 1–2) and poor (n=47; CPC 3–5) outcome groups. The good (vs. poor) outcome group was younger (mean [±SD] age 46.7±11.8 vs. 60.3±17.2 years; P=0.002) and had more initial shockable rhythms (40.0% vs. 8.5%; P=0.002). In addition, the good outcome group had a higher mean ASPECTS-b score (15.3±2.7 vs. 9.0±4.9; P<0.001), despite no differences in QRA and mean GWR. Age and ASPECTS-b were independent predictors of outcome after adjusting for potential confounders.

    Conclusions:These findings suggest that an initial CT score (ASPECTS-b) could help estimate early neurologic outcomes in post-cardiac arrest patients treated with therapeutic hypothermia.

  • Taiko KITAMURA, Hiroko SUZUKI, Hidenori YOKOTA, Eiju WATANABE, Jinzo YAMADA
    Okajimas Folia Anatomica Japonica
    2017年 94 巻 1 号 7-15
    発行日: 2017年
    公開日: 2017/12/06
    ジャーナル フリー

    We measured the lengths of some parts of the right and left hemispheres (HEs) in 70 formalin-fixed brains and on 15 computed tomography/magnetic resonance imaging (CT/MRI) images (7 left-handed and 8 right-handed cases) to clarify the morphological changes indicating which HE developed earlier and handedness. In many cases of the fixed brains, 1) the distance from the frontal pole to the occipital pole was longer in the left HE than in the right HE, 2) the distance from the middle plane to the lateral-most portion of the HE was wider in the right HE than in the left HE, 3) the left occipital pole elongated more posteriorly and covered the right occipital pole, and 4) the volume of each HE was nearly the same. The results indicate that the left HE develops and grows slightly earlier in the larger semi-cranium (half of the cranium) than the right HE which develops later in the smaller semi-cranium. The whole brain was more spherical in the female cases than in the male cases. The morphological changes in both HEs for handedness were not evident on the CT/MRI images.

  • 太田 雅博
    The Japanese Journal of Physiology
    1968年 18 巻 1 号 100-124
    発行日: 1968年
    公開日: 2011/06/07
    ジャーナル フリー
    1. Adult rats (Wistar King A) were used, thirty-seven animals for recording antidromic cortical responses, five for observation of the motor effect of cortical stimulation and three for histological sections of the cerebral cortex.
    2. Electrical stimuli were applied to the medullary pyramidal tract in slightly anesthetized rats and the potential changes were recorded at the cortical surface and from various depths of the cortex.
    3. The resultant responses of the cortex consisted of an initial sharp positive wave (P I) followed by a secondary small positive wave (P II) and a slow negative wave (N). The P I had the lowest threshold to medullary pyramid stimulation and most faithfully followed the increase in frequency of stimulation up to a frequency of 300/sec.
    4. The distribution of the potential changes at various points of the cortical surface evoked with submaximal stimulation to the medullary pyramidal tract was measured. The maximal potential was recorded at a point 6.0 mm anterior from the line connecting the both ears and 3.0 mm lateral from the midline. The amplitude of the waves gradually decreased in the frontal direction from the maximal responsive point, and in the occipital direction it rapidly decreased to an immeasurably small level. The potential at the frontal pole was about one sixth of the maximum. In a lateral direction, the amplitude at a point 2.0 mm lateral from the midline was slightly small than at 3.0 mm and the amplitude both at 1.0 and 4.0 mm was about a half of that at 3.0 mm.
    5. The distribution of the antidromic cortical response coincided fairly well with the histological distribution of the pyramidal cell in the cerebral cortex of the rat.
    6. Recording from the depths of the cortex, the P I changed its polarity into a negative deflection at about 2.0 mm below the pial surface and the P II changed into a negative potential at a depth of about 1.5 mm. The N decreased to zero and sometimes seemed to reverse into a very small positive wave at about 1.5 mm below the surface.
    7. The above results suggest that the P I corresponds to antidromic impulses which invaded the large pyramidal cells in the deeper cortical layers with axons of faster conduction velocity and that the P II is composed of the antidromic impulses of the pyramidal neurons in the more superficial layers with axons of slower conduction velocity. It is considered that the N might represent the potentials of the apical dendrites of pyramidal cells conducting toward. the pial surface.
    8. The studies of cortical hemisphere stimulation reveal that the functional motor area occupies a part a little anterior to a location of the antidromic cortical response and the pyramidal cells.
    9. The functional significance of the pyramidal tract in the rat was discussed.
  • 藤澤 隆史, 細川 豊治, 長田 典子, 片寄 晴弘
    感情心理学研究
    2010年 18 巻 1 号 73-82
    発行日: 2010/07/31
    公開日: 2011/09/01
    ジャーナル フリー
    In this study, we investigated brain activity under social pressure using Solomon Asch's experimental paradigm. We replicated the group situation using the MORI technique and recorded the brain activity using functional near-infrared spectroscopy (fNIRS). Eight Japanese healthy males in groups of four participated in this study. The Asch experiment can be replicated without using confederates using MORI technique. The subject assessed with fNIRS was seated in a fixed position and assigned to answer third. A multichannel fNIRS system was used to measure the changes in the concentrations of oxy-hemoglobin (oxy-Hb) and deoxy-hemoglobin (deoxy-Hb). Nine optodes consisting of 12 channels were placed over the prefrontal cortex (PFC) of each hemisphere. In the behavioral data, the error rate (%) for the judgment tasks increased to 39.7% under the group pressure conditions, while it was 3.2% under the control conditions. Comparing the group pressure and control conditions in the fNIRS data, a difference in the increasing rate of oxy-Hb in the frontal pole (ch02, 05, 13 & 15) was observed. Therefore, we found that the frontal pole was activated when the subject felt social pressure under group situations.
  • Shota Hori, Akitoshi Seiyama
    The Journal of Physical Fitness and Sports Medicine
    2014年 3 巻 1 号 91-100
    発行日: 2014/03/25
    公開日: 2014/03/20
    ジャーナル フリー
    This review summarizes the regulation of cerebral blood flow (CBF) during stimulus-induced brain activation, mainly in functional near infrared spectroscopy (fNIRS) studies. fNIRS is less restrictive than other techniques for measuring brain activation, as it requires only a light burden to participants during measurements. Hence, fNIRS is used in multiple fields. On the other hand, fNIRS results are questionable due to the influence of various artifacts. Thus, we report the influence and countermeasures for important artifacts. Furthermore, we discuss about CBF regulation based on mechanisms at the cellular level, hemodynamic models suggested by functional magnetic resonance imaging (fMRI), and previous studies using simultaneous measurement with fNIRS and fMRI.
  • TAKASHI HAYASHI, AKIRA ISHIBASHI, MASAHIKO KATAYAMA, TAKEO HASHIMOTO, JIRO NISHIMURA, EIICHIRO HONDA, SHINKEN KURAMOTO
    The Kurume Medical Journal
    1981年 28 巻 2 号 153-157
    発行日: 1981/12/25
    公開日: 2009/08/11
    ジャーナル フリー
    A male child, born by normal spontaneous vaginal delivery, was noted to have a soft tumor, in the shape of an “elephant's nose, with a diameter of 2.5 cm×2.5 cm and 5.5 cm long in the inter-orbital region. With the diagnosis of naso-frontal type of fronto-ethmoidal encephalomeningocele with congenital hydrocephalus, corrective surgery was performed in two stages. At the first operation, a ventriculoperitoneal shunt and bilateral frontal craniectomy were performed, and closed with frozen human dura mater intracranially. Twenty days after the first operation, the encephalomeningocele was excised. The patient tolerated the surgery well.
  • 野村 郁也, 鮫島 和行, 植田 一博, 鷲田 祐一, 岡田 浩之, 大森 隆司
    日本認知心理学会発表論文集
    2012年 2012 巻 P2-4
    発行日: 2012年
    公開日: 2012/07/20
    会議録・要旨集 フリー
    新商品が次々と発売される消費社会において,既知の商品と未知の商品との間の選択は日常的に行われており,いずれを選択するかは消費者行動の重要な一面となっているが,このような選択に関する実験的研究はまだ少ない.本研究では,ミネラルウォーターを用いて,実験参加者にとって既知の商品と未知の商品との間の選択を繰り返し行い,その選択に関わる個人特性について検討した.さらに,商品選択を行っているときの脳活動をfMRI計測によって調べた.その結果,情報探索的な実験参加者ほど未知の商品を選択する割合が高くなる傾向が見られ,また,未知の商品の選択時には右前頭極に活動が見られた.これらの結果はともに未知の商品を選択することが情報を得るための行動であることを示唆するとともに,損得勘定に基づく判断であるとする従来のマーケティング現場の通念を変えうるものである.
  • Aya Murakami, Yusuke Watanabe, Kenshi Takechi, Akinori Fujiwara, Chiaki Kamei
    Journal of Pharmacological Sciences
    2008年 106 巻 1 号 78-83
    発行日: 2008年
    公開日: 2008/01/22
    [早期公開] 公開日: 2008/01/11
    ジャーナル フリー
    The changes of electroencephalogram induced by maximal electroshock were studied in comparison with behavioral seizures in mice. After electroshock, mice showed tonic flexor (TF) seizure, tonic extensor (TE) seizure, and clonic (CL) seizure, in this order of occurrence. At the same time, high frequency spike or spike and wave complex in the cortex was observed, and thereafter, the frequency of the spike or spike and wave complex gradually fell. The antiepileptics used in the present study, except for ethosuximide, caused a dose-dependent shortening of the TE seizure duration. In addition, phenobarbital and carbamazepine at relatively high doses also showed a significant shortening of the duration of CL seizure. Although the duration of total electroencephalographic (EEG) seizures was not influenced by all the antiepileptics used in the present study, the duration of high frequency spike or spike and wave complex observed for 7 – 8 s after electroshock was dose-dependently shortened by all the antiepileptics used. From these findings, it may be concluded that high frequency spike or spike and wave complex induced by maximal electroshock is a useful index to assess antiepileptics that are effective in not only tonic-clonic seizures but also absence seizures in humans.
  • Yuelin ZHANG, Shigeru AOMURA, Hiromichi NAKADATE, Satoshi FUJIWARA
    Journal of Biomechanical Science and Engineering
    2011年 6 巻 3 号 191-202
    発行日: 2011年
    公開日: 2011/06/30
    ジャーナル フリー
    In this study, the mechanism of cerebral contusion was investigated using finite element analysis. A finite element human head model was constructed and used to simulate of 9 real-world fatal cerebral contusion accident cases. In these simulations, the impact velocities of the impact objects were estimated on the basis of the available information such as the regions of skull fracture and cerebral contusion. The pressure fluctuations inside the skull and the input force durations in each case were obtained using these simulations. These results show that in case of coup contusion, a negative pressure occurs on the impact side and is directly correlated with short force durations. In contrast, in case of contrecoup contusion, negative pressure occurs on the opposite side of impact and is directly correlated with long force durations. As the result, coup contusions are caused when the input force durations are short, contrecoup contusions are caused when the input force durations are long.
  • Nursyairah Azman, Kota SUZUKI, Tatsuya SUZUKI, Yumie ONO, Yuki EDANAKA, Fukuo KUNIEDA, Masahiro NAKATA, Kazuko WATANABE
    生体医工学
    2017年 55Annual 巻 Proc 号 526-529
    発行日: 2017/05/03
    公開日: 2017/09/13
    ジャーナル フリー

    We used dance video game (DVG) training as a mean of improving elderly's cognitive function and investigated whether the elderly with MCI could overcome the once affected cognitive function via continuous DVG training. Nine elderly participated in 6-weeks of DVG training for almost 3 months on 2015 and 2016 with 6 months break. Their cognitive ability (MoCA-J scores) and the prefrontal activity during DVG play were evaluated throughout the intervention. The cognitive ability and the performance of the DVG showed improvement especially in the elderly with MCI. The prefrontal activity showed increase through initial training of DVG and decrease at the end of the intervention, suggesting the cognitive load required for DVG play. Our results suggest that DVG is a promising intervention for elderly people with MCI to maintain their cognitive ability, and that we can utilize the prefrontal activity during DVG play to determine an appropriate difficulty of the DVG training.

  • Yusuke Watanabe, Kenshi Takechi, Akinori Fujiwara, Chiaki Kamei
    Journal of Pharmacological Sciences
    2010年 112 巻 3 号 282-289
    発行日: 2010年
    公開日: 2010/03/19
    [早期公開] 公開日: 2010/02/18
    ジャーナル フリー
    The present study was undertaken to investigate changes of the electroencephalogram (EEG) induced by pentetrazol (PTZ) in comparison with behavioral seizures in mice. Under pentobarbital anesthesia, mice were fixed to a stereotaxic apparatus, and electrodes were implanted into the frontal and occipital cortex. Behavioral and EEG changes were observed for 30 min following PTZ administration. After PTZ administration, mice showed myoclonic seizure (MCL) and clonic seizure (CL) in order. At the same time, spiking activity and spike-wave discharge in the cortex were observed. Phenobarbital, sodium valproate, diazepam, ethosuximide, and gabapentin caused a dose-dependent shortening of the duration of MCL and CL. In addition, they shortened the duration of spiking activity and spike-wave discharge dose-dependently. Moreover, phenytoin significantly inhibited the duration of spiking activity. It can be concluded that PTZ-induced spiking activity and spike-wave discharge serve as useful indices to assess the potential of antiepileptic activity in absence and MCLs in humans. Moreover, it is supposed that employing an index of EEG activity in addition to that of behavioral activity is desirable for objectivity.
  • Tetsuya Yoshikawa, Yuki Akiyoshi, Teruo Susumu, Hiroshi Tokado, Koichiro Fukuzaki, Ryoichi Nagata, Keiichi Samukawa, Hiroshi Iwao, Go Kito
    Journal of Pharmacological Sciences
    2008年 107 巻 1 号 32-40
    発行日: 2008年
    公開日: 2008/05/20
    [早期公開] 公開日: 2008/04/29
    ジャーナル フリー
    Ginsenoside Rb1 (GRb1), a major component of the traditional herb ginseng, has been reported to show a neuroprotective effect in a rodent ischemic model. The purpose of this study was to investigate effects of GRb1 on early and delayed brain injuries in a non-human primate thromboembolic stroke model. Thromboembolic stroke was induced by occlusion of the middle cerebral artery by injection of an autologous blood clot into the left internal carotid artery. GRb1 (300 μg/kg per day, i.v.) and vehicle were administered from 7 days before embolization to the day following embolization (total: 8 times). Neurological deficits were observed at 1, 6, and 24 h and at 2, 4, and 7 days after embolization. At 7 days after embolization, neuron damage in the peri-infarct area and core region were assessed by NeuN, TUNEL, and GFAP staining. GRb1 improved the skeletal muscle coordination score of the neurologic deficits (median: GRb1 vs vehicle = 10 vs 12, P<0.05). In the GRb1 group, positive neurons expressed by NeuN staining were noted in the ischemic peri-infarct area, and TUNEL- and GFAP-positive cells significantly decreased, when compared with vehicle. These results demonstrated that GRb1 ameliorated both early and delayed injuries in the thromboembolic stroke model in non-human primates.
  • Keiji SANO, Norio NAKAMURA, Kimiyoshi HIRAKAWA, Hideaki MASUZAWA, Keizo HASHIZUME, Tsuyoshi HAYASHI, Sumiji FUJII
    Neurologia medico-chirurgica
    1967年 9 巻 21-33
    発行日: 1967年
    公開日: 2007/08/17
    ジャーナル フリー
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