全文: "Hippocampal gyrus"
17件中 1-17の結果を表示しています
    Neurologia medico-chirurgica
    1960年 2 巻 1-2 号 195a-195
    発行日: 1960年
    公開日: 2007/05/25
    ジャーナル フリー
  • Kenji TANAKA, Michio INUI, Kazufumi ITO, Kiyoshi SATO
    Neurologia medico-chirurgica
    1964年 6 巻 89a-89
    発行日: 1964年
    公開日: 2007/05/25
    ジャーナル フリー
  • Kenji TANAKA, Kiyoshi SATO, Michio INUI
    Neurologia medico-chirurgica
    1965年 7 巻 165-167
    発行日: 1965年
    公開日: 2007/08/17
    ジャーナル フリー
  • 山澤 恵理香, 大野 誠, 里見 介史, 吉田 朗彦, 宮北 康二, 高橋 雅道, 浅野目 卓, 里見 奈都子, 成田 善孝
    2019年 28 巻 1 号 27-32
    発行日: 2019年
    公開日: 2019/01/25
    ジャーナル フリー

     Multinodular and vacuolating neuronal tumor of the cerebrum (MVNT) は比較的新しい疾患概念のため, 長期観察された報告は少ない. 今回われわれは再発なく5年経過した自験例と, これまでに報告された31例を対比しながら, MVNTの画像所見・治療経過をまとめた. これまでのところ年齢中央値は41歳であり, 男女差はない. 病理組織のみでなく画像上も結節を認めるものが約半数存在した. MVNTの症候性てんかんは手術により改善することが多い. これまでのところMVNTの悪性転化は報告されておらず, MVNTの予後は良好である.

  • 岩田 隆信, 中村 芳樹, 村上 秀樹, 村瀬 活郎
    1983年 12 巻 79-82
    発行日: 1983/12/31
    公開日: 2012/10/29
    ジャーナル フリー
    Two cases of aneurysms of the peripheral site of the posterior cerebral artery are reported, and the surgical approaches performed on them are also discussed.
    These patients underwent surgery by the subtemporal approach. Since the distance to the peripheral site of the posterior cerebral artery is long enough even with the subtemperal approach and the posterior site of the temporal lobe is located on the tentorium cerebelli, the temporal bone should be removed sufficiently and an operating microscope should be preliminarily prepared so that the focus can be adequately adjusted toward this side. In our two cases, however, it was necessary to sacrifice the Labbé's vein. (In one case, dysphasia appeared transitionally.) Because the posterior cerebral artery runs inside the hippocampal and the lingual gyri, it is often difficult to reach its peripheral site directly. For safety's sake also, it is more secure to pursue the peripheral site after confirming and securing the proximal part of the posterior cerebral artery with the removal of the cerebrospinal fluid. By this approach, it was necessary to remove a part of the hippocampal gyrus in the second case, but clipping could be accomplished without damaging the cranial nerves, penetrating branches from the posterior cerebral artery or the posterior choroidal arteries.
  • Masaru Uemura
    1970年 22 巻 Supplement 号 S50-S71
    発行日: 1970/03/20
    公開日: 2013/02/19
    ジャーナル フリー
  • The Keio Journal of Medicine
    2000年 49 巻 supplement1 号 A117-A128
    発行日: 2000年
    公開日: 2009/03/27
    ジャーナル フリー
  • Wolf-Dieter Heiss, Karl Herholz, Günter Pawlik, Ina Hebold, Peter Klinkhammer, Brigitte Szelies
    The Keio Journal of Medicine
    1989年 38 巻 2 号 111-135
    発行日: 1989年
    公開日: 2009/03/27
    ジャーナル フリー
    At present, positron emission tomography (PET) is the only technology affording the quantitative three-dimensional imaging of various aspects of brain function. Since glucose is the dominant substrate of the brain's energy metabolism, studies of glucose metabolism by PET of 2 (18F)-fluoro-2-deoxy-D-glucose (FDG) are widely applied for investigating the participation of various brain systems in simple or complex stimulations and tasks. In focal or diffuse disorders of the brain, functional impairment of affected or inactivated brain regions is a reproducible finding. While glucose metabolism is decreased slightly with age in a regionally different degree, in most types of dementia severe changes of glucose metabolism are observed. Degenerative dementia of the Alzheimer type is characterized by a metabolic disturbance most prominent in the parieto-occipito-temporal association cortex and later in the frontal lobe, while primary cortical areas, basal ganglia, thalamus, and cerebellum are not affected. By this typical pattern Alzheimer disease can be differentiated from other dementia syndromes, as e. g. Pick's disease (with the metabolic depression most prominent in the frontal and temporal lobe), multi infarct dementia (with multiple focal metabolic defects), and Huntington's chorea (with metabolic disturbance in the neostriatum). In demented patients PET studies can also be applied to the quantification of treatment effects on disturbed metabolism. Such studies demon-strated an equalization of metabolic heterogeneities in patients responding to muscarinergic cholinagonists and diffuse increase of metabolism during treatment with piracetam. The therapeutic relevance of such metabolic effects, however, must be proved in controlled clinical trials.
  • 北関東医学
    2001年 51 巻 2 号 161-163
    発行日: 2001/03/01
    公開日: 2009/10/21
    ジャーナル フリー
  • 河村 洋二郎, 塚本 周作
    The Japanese Journal of Physiology
    1960年 10 巻 5 号 471-488
    発行日: 1960年
    公開日: 2011/06/07
    ジャーナル フリー
    Brain regions inducing jaw movement and characters of the induced movement were analyzed on the rabbit.
    1. The cortical jaw motor area are strictly circumscribed in the region rostral to area insularis and lateral to area postcentralis. The patterns of the jaw movements from here were single contraction of the jaw at low stimulation frequencies and rhythmic jaw movement of 4.5 to 5.75 c/s at higher frequencies. These jaw movements were predominant in the opening direction. The jaw movements from the. internal capsule and subthalamus were almost similar in characters to those from the cortex.
    The jaw movement from the lateral amygdaloid nucleus was also a single contraction of the jaw at low frequencies below 4 c/s and at high frequencies a rhythmic jaw movement of 3.5 to 4.0 c/s was evoked. In this case the movement was predominant in the jaw closing direction and its rhythm was similar to that of natural chewing. As compared with the cortex, the amygdala had a lower threshold and longer latency.
    2. The cortical and amygdaloid jaw movements could be elicited independently, and the destruction of one of these areas did not affect the jaw movement elicited from the other.
    3. The descending neural pathway from the cortical jaw motor area to the trigeminal motor nucleus is assumed to be via the internal capsule, subthalamus and mesencephalic reticular formation, while the pathway from the amygdaloid nucleus may be via the mesencephalic reticular formation, but not through the internal capsule and subthalamus.
  • Sun-joo Lee, Kwang-Won Lee
    Biological and Pharmaceutical Bulletin
    2007年 30 巻 8 号 1369-1373
    発行日: 2007/08/01
    公開日: 2007/08/01
    ジャーナル フリー
    Advanced glycation endproducts (AGEs) are believed to be secondary factors in the selective neuronal injury associated with several neurodegenerative disorders. In this study, we investigated the protective effects of (−)-epigallocatechin gallate (EGCG), a major monomer of green tea polyphenols, against AGEs-induced damage in neuron cells. The results showed that EGCG treatment protected against glyceraldehyde-derived AGE-induced neurotoxicity, which is associated with an increase in intracellular reactive oxygen species, as well as against decreases in intracellular catalase (CAT) and superoxide dismutase (SOD) activities. EGCG treatment also decreased malondialdehyde and carbonyl levels, and AGEs formation. Treatment with 10 μM EGCG upregulated SOD and CAT levels, whereas glutathione peroxidase activity was reduced. Furthermore, 5 μM EGCG was found to down-regulate the mRNA level of the AGE receptor (RAGE) in neuronal cells up to 2.5 fold, as determined by real time PCR. The results demonstrated that EGCG may exhibit protective effects against AGEs-induced injury in neuronal cells through its antioxidative properties, as well as by interfering with AGEs-RAGE interaction mediated pathways, suggesting a beneficial role for this tea catechin against neurodegenerative diseases.
  • 井上 有史, 三原 忠紘, 松田 一己, 鳥取 孝安, 渡辺 裕貴, 今村 真一, 八木 和一, 清野 昌一
    1994年 12 巻 1 号 1-9
    発行日: 1994/02/28
    公開日: 2011/01/25
    ジャーナル フリー
    側頭葉てんかんの術後に前兆が再発した症例の臨床特性, 術前に施行した前兆時の頭蓋内脳波, および発作の術後経過を検討した。対象は長時間頭蓋内脳波記録を経て側頭葉の切除手術をうけ, 術後2年以上の経過を観察した56例である。前兆と複雑部分発作が共に完全に消失した31例に比べ, 前兆のみが再発した14例は, 幼児期の脳損傷の既往を有し, 罹病期間が長く, 術前に前兆の頻度が多く, 前兆時の頭蓋内脳波では海馬・扁桃核に起始した発作発射が側頭葉内側・底部の後方へ波及しやすい傾向を示した。前兆の再発より遅れて複雑部分発作が再発した6例でも類似の傾向を認めた。残りの5例では複雑部分発作の再発が前兆の再発とほぼ同時期か, または前兆の再発より先行していた。前兆が先行して再発した症例では, 前兆の再発時期は術後半年以内であり, 全例が内側構造にてんかん原性帯域を有し, 切除標本の組織所見では内側側頭葉硬化の症例が多かった。これらの症例の前兆は経年的に減弱ないし消失した。これに反して, 外側皮質にてんかん原性帯域が存在する症例では, 前兆と複雑部分発作が消失するか, あるいは共に再発するかのいずれかであった。
  • 副島 徹, 北村 勝俊
    1975年 4 巻 37-44
    発行日: 1975/10/22
    公開日: 2012/10/29
    ジャーナル フリー
    The authors experienced 81 cases of AVM during the period from 1963 through 1974, in 57 cases of which surgical removal was performed with one case of operative death. The technical problems were discussed, and it was emphasized that serial magnification stereoangiography is very useful in considering the surgical indication and performing surgery. The remaining 24 cases included 17 cases in which no surgical treatment was indicated because of involvement of the deep structures such as the thalamus and basal ganglia or of extensive area above or below the tentorium. The follow-up study of these non-surgical cases showed that in the 24 cases 19 cases survived and 16 cases of them were leading useful life with no or very little handicap. In 2 cases of these, the AVM was removed afterward because of recurrent hemorrhage. Five cases died in 1-10 years after the onset. The total of mortality and morbidity in this non-surgical group counted about 1/3.
    From the study it was concluded that the AVM should be removed totally when the postoperative morbidity could be anticipated to be practically none or only little. The fact that about 2/3 of the lionsurgical cases may survive without considerable disability for a fairly lorg time strongly suggests that the surgical intervention for deep-seated AVM be indicated with greatest care.
  • 杉浦 昌也, 林 輝美, 飯塚 啓, 嶋田 裕之, 片山 宗一
    1971年 8 巻 1 号 33-40
    発行日: 1971/01/30
    公開日: 2009/11/24
    ジャーナル フリー
    脳卒中再発作の比較的早期に失外套症候群を呈し, 剖検の結果, 右内頸動脈サイフォン部のほぼ完全閉塞により, 大脳および脳幹に広汎な軟化巣を認めた老年女子例について, 臨床病理学的検討を加えた. また本症候群の本邦報告例について病因と病変部位に関する若干の検討を行った.
    症例は77才の女性で, 4年前に高血圧を指摘され, 2年前に左不全片麻痺, 高血圧で6ヵ月入院した. 昭和44年4月, 食欲不振, 腰痛を主訴として再入院した. 5日目, 言語不明瞭となり, 左顔面筋麻痺をきたし, 次いで左完全片麻痺: 無言となり, 呼びかけに対して開眼し, 物を追うような眼球運動があった. 痛覚刺激に対する逃避反応, 強制把握, 上下肢の無目的な運動が右側に存在した. 嚥下は不能. 睡眠覚醒の区別は明瞭. 意識水準が次第に低下し, 入院後52日目に死亡した.
    脳波所見は, 本症候群出現前は8~9c/s, 50~70μVのα波が頭頂, 後頭部に優位に出現, 本症候群出現3週後は6~7c/s, 50~70μVのθ波の基礎律動に, 3c/s前後のδ波が少量混在し, 軽度の左右差を認めた. 死亡15日前には1~3c/sの大徐波が連続的に出現し, 右半球に電気的活動の減弱が著明にみられた.
    剖検所見では, 右内頸動脈サイフォン部が器質化した血栓によりほぼ完全に閉塞され, 右中心前回, 前頭葉の帯状回, 脳梁を含む右大脳半球皮質, 白質および海馬回, 視床, 視床下部を中心とした脳幹網様体に新, 旧の融解壊死と脱髄が血管病変に合致してみられた. 本症候群ないし無動性無言の脳の障害部位は 1) 広汎な大脳皮質, 白質. 2) 前頭葉 (帯状回, 脳梁), 3) 視床, 視床下部, 脳幹の三大領域に分類されているが, 本症例は3者にまたがる複雑な病変を示した. 本邦報告例44例において脳腫瘍は単独部位の障害が多く, 各種中毒, 脳血管障害, 頭部外傷では2者ないし3者の領域にまたがる例が11例をしめた.
  • 松尾 奈々, 村上 貴士, 日沖 善治, 貝本 拓也, 窓場 勝之, 兒玉 隆之
    2015年 30 巻 5 号 759-764
    発行日: 2015年
    公開日: 2015/12/06
    ジャーナル フリー
  • 岡 増一郎, 教正院 靖子, 香月 武, 田代 英雄, 藤野 博
    1969年 18 巻 4 号 600-608
    発行日: 1969/10/10
    公開日: 2011/09/07
    ジャーナル フリー
    1970年 11 巻 1 号 15-26
    発行日: 1970年
    公開日: 2009/12/21
    ジャーナル フリー
    During the past several years, there has been an increase of interest in fungal infections of the central nervous system, but with regard to aspergillary infection in the brain, it is relatively uncommon. Consequently, the pathogenesis and morphological characteristics have not been clarified as yet, because of the paucity of the autopsy cases.
    In this paper, the author tended to investigate the intracranial lesions of rabbits produced by intravenous injection of Aspergillus fumigatus. Acute lesions are usually manifested as rapidly spreading suppurative leptomeningitis, chorioditis and intracerebral abscesses which are initially formed around the cortical arterial branches with fungal embolism. Later on the inflammatory process spreads widely through the pia-glial or ependimo-glial membrane and is further extended by the confluence of multiple disseminated lesions. Circulatory disturbance also plays a role in the destruction of the brain tissue with or without remarkable inflammatory reaction. Besides suppurative or necrotic inflammatory lesions, proliferative or productive changes of glial or other mesenchymal elements are also encountered in a few examples, although these are usually localized. The neurons in the lesions are often compressed or destroyed by growing filamentous organisms, and this process is tentatively described as “mycotic neuronophagy”.