近年、管理放棄された竹林での、造林木の枯死による土砂災害の誘発が懸念されている。従来では、タケノコの生産活動によって、竹林が整備されていたが、タケノコ生産量の減少に伴い、管理放棄される放置竹林が増加した。石川県内のタケノコ生産量は、中国からの輸入増加の影響を受け、大きな減少傾向にある。放置竹林は毎年、周辺の造林地に2m程度拡大進行しており、造林地への竹の侵入により、県内各地で造林木の枯死が発生している。竹林の駆除を効率的に行うために、放置竹林における竹駆除後の新竹再生状況調査を毎年行った。その結果、新竹の発生本数は、竹林の伐採率によって異なり、伐採率が高いほど翌年の新竹の発生本数は増加していた。竹の無伐採区では、成立竹本数の0.2‐2.1%の新竹が毎年継続的に発生していたが、皆伐区においては、伐採後3年目に新竹の発生本数が大きく減少した。新竹の直径は、間伐区に比べ、皆伐区では小さくなる傾向にあった。本研究により、竹の駆除後1～2年目に、その再生力が最も盛んになるが、光合成によるエネルギー供給が無い場合は、駆除後3年目には、再生力が大きく減少することが明らかになった。

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The effects of four dihydropyridine calcium channel blockers (nifedipine, nisoldipine, nitrendipine and manidipine) on the plasma digoxin level were studied in patients and the effects of nitrendipine and nisoldipine were compared in beagle dogs . In the clinical study, the mean plasma concentration of digoxin was significantly higher during combined administration with nitrendipine than with the other calcium channel blockers. In addition, the digoxin level was decreased by about 50% at one month after changing the calcium channel blocker from nitrendipine to nisoldipine. In dogs, combined administration with nitrendipine resulted in a significantly higher plasma digoxin level after 2 and 4 hrs and a significantly larger mean area under the plasma concentration time curvecompared with administration without nitrendipine (p<0.05). These findings demonstrate that the plasma concentration of digoxin is influenced by dihydropyridine calcium channel blockers, with nitrendipine increasing the digoxin level more than the other agents tested. Since digoxin has a narrow therapeutic range, careful monitoring of the plasma digoxin level during combined therapy with nitrendipine is suggested to minimize the risk of toxicity.

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症例は41歳,女性.下腹部腫瘤を主訴として当院婦人科受診.画像診断および血清CA19-9が2,200U/mlと高値を示した事より,膵体尾部の腫瘍が疑われ当科転科,膵体尾部切除を施行した.腫瘍は18×17×8cm, 1,570gr,多房性嚢胞で異型性なく病理組織学的検索にて膵粘液嚢胞腺腫の診断が得られた.また,血清と同様に嚢胞液中のCA19-9は3,800,000U/mlと異常高値を示し,酵素抗体法によりCA19-9染色を行うと嚢胞内膜細胞に陽性所見が証明された.膵嚢胞腺腫は比較的まれな腫瘍とされてきたがCTやMRIなどの画像診断の進歩により最近その報告は増加してきている.しかしCA19-9が高値を示した症例の報告は極めて少なく,本症例はわれわれが調べえた文献では本邦3例目の報告である.

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A 22 month old girl of sacrococcygeal yolk carcinoma is reported. She was admitted with a painful mass in the buttock region. She died of the tumor 11 months after the admission, in spite of 2-staged operation and post-operative irradiation (10,000 rads), chemotherapy (VCR, MMC, CPA) and immunotherapy (OK-432 etc.). At autopsy, there were wide infiltration and multiple distant metastases of yolk sac carcinoma in and around the retroperitoneal space extending to the back and the pleular cavities. Such macroscopic apperances, as well as histological findings, suggested no effectiveness of radio-chemo-immunotherapy in this case. We could successfully culture the yolk sac carcinoma obtaine from the operatively resected specimen. Using the sub-cultured cells following trypsinization, we performed anti-tumor drug sensitivity test, radio-sensitivity test and cytotoxicity test by mixed lymphocyte-tumor cell cultured method. Following results were obtained. 1) Only high doses of MMC and VCR showed moderately sensitive responses. 2) After 72 hours of tissue culture following one shot irradiation of 50 to 1,400rads of 60^Co., almost all tumor cells were visible and growth rate was virtually unchanged. 3) No remarkable cytotoxicity response was noted by mixed patient's lymphocyte-tumorcell culture method. The results obtained from the studies related to tissue culture showed a significant coincidence with clinical course and autopsy findings. These clinical and laboratory results suggested that an ealier diagnosis and an ealier operation are most important for the treatment of sacrococcygeal yolk sac carcinoma. Otherwise post-operative radio-chemo-immuno-therapy might be in-effective to reduce the residual tumor or to prevent recurrence.

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