詳細検索結果
以下の条件での結果を表示する:
全文: "LT-35"
188件中 1-20の結果を表示しています
  • Proceedings of the Imperial Academy
    1929年 5 巻 9 号 e1b
    発行日: 1929年
    公開日: 2008/03/19
    ジャーナル フリー
  • Proceedings of the Imperial Academy
    1929年 5 巻 9 号 e1a
    発行日: 1929年
    公開日: 2008/03/19
    ジャーナル フリー
  • Osamu Wakisaka, Morio Shoda, Daigo Yagishita, Bun Yashiro, Koichiro Ejima, Tetsuyuki Manaka, Nobuhisa Hagiwara
    Journal of Arrhythmia
    2011年 27 巻 Supplement 号 PJ3_036
    発行日: 2011年
    公開日: 2012/03/14
    ジャーナル フリー
    Background: Effect of upgrade from permanent right ventricular (RV) apical pacing to biventricular (BiV) pacing has not yet delineated. Aims: The aim of this study is to investigate the role of upgrade from RV pacing to BiV pacing. Methods: Sixty four patients with NYHA>class 2 heart failure and LV ejection fraction (LVEF)<35% were divided into two groups: Group-A (primary BiV pacing in 40 patients with intrinsic QRS>130 msec) and group-B (upgrade to BiV pacing in 24 patients with bradycardia and paced-QRS>150 msec). The LV volume and systolic function were assessed with echocardiography at baseline and 6 months after implantation of a cardiac resynchronization (CRT) device. A reduction in LV end systolic volume (LVESV)>15% was defined as responder. Results: LVESV reduced significantly in group-A (204.7 ml to 181.6 ml, P<0.05) and in group-B (152.6 ml to 124.4 ml, P<0.05). Additionally, the reduction in LVESV showed positive correlation with paced-QRS duration at baseline (r=0.46, P<0.05) in group-B. Responder rate was not different in both groups (50.5% vs. 62.5%, P=0.23). Conclusion: CRT upgrade from chronic RV apical pacing is also effective especially in patients with wider QRS duration.
  • Ping Yang, Pierre Bordachar, Nathan Grenz, Nicole Kirchhof, Douglas Hine
    Journal of Arrhythmia
    2011年 27 巻 Supplement 号 PE2_017
    発行日: 2011年
    公開日: 2012/02/29
    ジャーナル フリー
    Introduction: Animal models which mimic the clinical characteristics of heart failure (HF) with dyssynchrony play a critical role in development of new therapies. Existing HF animal models created by left bundle branch block (LBBB), rapid pacing, or microembolization alone or in combinations only mimic partial HF characteristics and are time-costuming and expensive. The microembolization model creates a stable reduction in left ventricular ejection fraction (LVEF) with minimal change in QRS. Methods: Ten dogs were implanted with two epicardial leads on the left ventricle (LV) and LBBB ablation increased QRS width by 2×. After 4 weeks, HF was induced by microembolization procedures every 1–3 weeks by injecting microspheres into one or both of the coronary arteries (LAD and Left Circumflex) until LVEF decreased to <35% by echocardiography. Results: Two dogs (20%) died during the microembolization procedure. All surviving canines developed severe ischemic cardiomyopathy with dyssynchrony. QRS width significantly increased after LBBB and was stable throughout multiple microembolizations. LVEF significantly decreased after multiple microembolizations but not after LBBB. The pathological examination was performed in the failed hearts at end of the study. Conclusion: This viable and reproducible canine model can mimic heart failure characteristics and serve as a useful tool to evaluate new HF therapies.
  • Katsunori Okajima, Akira Shimane, Koji Fukuzawa, Gaku Kanda, Kiminobu Yokoi, Jin Teranishi, Kosuke Aoki, Takatoshi Hayashi, Mitsuhiro Yokoyama
    Journal of Arrhythmia
    2011年 27 巻 Supplement 号 OP26_3
    発行日: 2011年
    公開日: 2012/02/29
    ジャーナル フリー
    Background: Cardiac resynchronization therapy (CRT) showed complete recovery of cardiac function in some patients with idiopathic dilated cardiomyopathy (DCM).
    Objective: To clarify the incidence, clinical characteristics and prognosis of these patients.
    Methods: Consecutive 44 patients (67±10 years, 29 males) with severe heart failure diagnosed as DCM, left ventricular ejection fraction (LVEF)<35%, NYHA class III or IV and QRS interval>120 ms who underwent CRT excluding previously device implanted cases were studied. We compared clinical characteristics and long term (37±10 months) prognosis among patients with hyperresponders (LVEF>50%), responders (>5% improvement of LVEF but <LVEF 50%) and nonresponders.
    Results: Eight patients (18%) were hyperresponders, 27 patients (61%) were responders and Nine patients (20%) were nonresponders. In all hyperresponder patients, QRS morphology had been typical complete left bundle branch block (LBBB) before CRT and LV leads had been implanted in lateral or posterolateral veins. QRS interval after CRT was significantly shorter in hyperresponders than that in responders and nonresponders (128±15 ms vs. 143±20 ms vs. 160±36 ms). Re-hospitalization caused by heart failure was much less in hyperresponders (0%) and responders (19%) than in nonresponders (78%).
    Conclusion: LBBB induced cardiomyopathy might be included in DCM and hyperresponders after CRT expects the extremely good prognosis.
  • Zulkeflee Muhammad
    Journal of Arrhythmia
    2011年 27 巻 Supplement 号 OP25_3
    発行日: 2011年
    公開日: 2012/02/29
    ジャーナル フリー
    Background: Cardiac resynchronization therapy (CRT) is an established therapy for severe symptomatic heart failure with depressed left ventricle (LV) systolic function and a wide QRS >120 ms. However only 30% heart failure patients will fulfill this criteria. Studies have demonstrated benefits of CRT with narrow QRS <120 ms with mechanical dyssynchrony. Aim: The aim of study was to evaluate the benefit of CRT in heart failure patients with narrow QRS <120 ms with mechanical dyssynchrony. Methods: 72 optimally managed heart failure patients in sinus rhythm, narrow QRS <120 ms, NYHA class III & IV, LV systolic EF <35% with mechanical dyssynchrony demonstrated by Tissue Doppler Imaging (TDI) were implanted with a CRT device. Clinical and echocardiography assessment was performed at baseline, 6 and 12 months. 55 patients completed 12 months follow up. Results: At 12 months 65 patients completed the study. There was significant improvement clinically in NYHA functional class (p<0.001) and 6 min walk (p<0.001). There was significant reduction of LV end systolic diameter (from 56.8±7.4 mm to 53.5±7.8 mm) p<0.001 and LV end diastolic from (66.3±7.6 to 63.8±7.3 mm) p<0.001. LV systolic EF improved significantly from (26.7±5.7% to 32.4±8.0%) p<0.001. Conclusions: CRT in heart failure with narrow QRS and mechanical dyssynchrony result in clinical improvement and LV reverse remodeling. CRT should be offered to heart failure patients with evidence of mechanical dyssynchrony.
  • Kaoru Tanno, Shiro Kawasaki, Yoshimi Onishi, Miwa Kikuchi, Hiroyuki Ito, Fumito Miyoshi, Taro Adachi, Taku Asano, Youichi Kobayashi
    Journal of Arrhythmia
    2011年 27 巻 Supplement 号 OP06_1
    発行日: 2011年
    公開日: 2012/02/02
    ジャーナル フリー
    Electrical storm (ES) is defined more than 3 times ICD therapy per day. Several papers reported that patients who have suffered from ES had poor prognosis and high mortality, therefore clinical characteristics and predicting factors of patients with ES should be identified. Method: The subject is consecutive 93 patients who had ischemic heart disease (IHD), left ventricular ejection fraction (LVEF) <35%, and implantable defibrillators. At the time of ICD implantation, mean age was 67±9.6 years, 77 patients (83%) were male and mean LVEF was 33±13%. NYHA class I, II, or III was 55, 22, or 16 patients, respectively. The outcomes of these patients was investigated retrospectively. Results: During a mean follow-up period of 41 months, 15 patients (15%) suffered from ES. Although there was no significant difference of age, gender, or LVEF between patients with ES and without ES, patients with ES had significantly higher prevalence of NYHA II or III. Cox-regression analysis revealed that the induction of monomorphic VT by non-invasive electrophysiologic study was the predicting factors of ES. Conclusion: In patients with IHD and LV dysfunction, the advanced state of heart failure is related to ES and monomorphic VT induction might predict the occurrence of ES.
  • Kengo Kusano
    Journal of Arrhythmia
    2011年 27 巻 Supplement 号 JAC1_3
    発行日: 2011年
    公開日: 2012/02/02
    ジャーナル フリー
    Atrial fibrillation (AF) is a common rhythm disorder in patients with congestive heart failure (CHF). The prevalence of AF is related to the extent of left ventricular dysfunction and associated with high morbidity and mortality because of an excessive heart rate rise, a loss of atrioventricular synchrony and an irregular ventricular filling. There is also a complex interplay between AF and CHF, with each increasing the morbidity associated with the other. Recent randomized trial (AF-CHF) revealed that no mortality benefit with amiodarone-based rhythm control strategy compared with a rate control strategy. However, in a subgroup study of DIAMOND trial, the maintenance of sinus rhythm at 1 year in patients with low ejection fraction (<35%) was strongly associated with a significant reduction on mortality (RR=0.44). AFFIRM substudy also revealed that if sinus rhythm could be achieved, it was associated with decreased mortality. These data suggested that the treatment approach should be individualized for each patient, with rhythm control strategy being favored when AF is associated with worsening CHF and rate control strategy being reasonable in patients who do not have symptoms related to AF. In this session, we will review current treatment options for AF and heart failure, especially focused on antiarrhythmic drugs.
  • 泉谷 知明, 谷口 佳代, 前田 長正, 深谷 孝夫
    日本産科婦人科内視鏡学会雑誌
    2010年 26 巻 2 号 511-515
    発行日: 2010年
    公開日: 2011/06/02
    ジャーナル フリー
    Objective: To evaluate the efficacy of laparoscopic surgery for endometriosis-associated infertility.
    Design: Retrospective study.
    Setting: Department of Obstetrics and Gynecology, Kochi Medical School.
    Patient(s): Sixty-five women with endometriosis-associated infertility.
    Intervention(s): Laparoscopic evaluation and treatment of endometriosis.
    Main outcome Measure(s): Background of 65 women with endometriosis-associated infertility. Clinical pregnancy rate (PR) of 57 women, who were followed > 6 months after laparoscopic surgery for endometriosis.
    Result: Of 57 women who underwent laparoscopic surgery, 34 conceived (clinical PR, 59.6%), including 28 non-ART pregnancies and 6 ART pregnancies. Eighty percent of non-ART pregnancies conceived within 1 year after laparoscopic surgery. In women with minimal and mild endometriosis, the clinical PR of non-ART after laparoscopic surgery was 61.1%, and in women with moderate and severe endometriosis the clinical PR of non-ART was 43.8%. The clinical PR of non-ART in women < 35 years of age (67.6%) was significantly higher than in older women (27.2%).
    Conclusion: Women with endometriosis-associated infertility can be expected to conceive spontaneously within 1 year after laparoscopic surgery. When patients fail to conceive 1 year after laparoscopic surgery, ART should be considered.
  • 前田 幸子, 千原 呉郎
    GANN Japanese Journal of Cancer Research
    1973年 64 巻 4 号 351-357
    発行日: 1973/08/31
    公開日: 2008/10/23
    ジャーナル フリー
    The rôle of lymphoid cells in the antitumor activity of a polysaccharide, lentinan, has been analyzed.
    1) The antitumor effect of lentinan is produced in the host at an early date, within 2-4 days after tumor transplantation, and X-irradiation after that period does not reduce the antitumor activity of lentinan. (2) During the regression of tumor by administration of lentinan, the peritoneal cells that inhibit the growth of tumor appear already in the peritoneal fluid 4-7 days after transplantation, and after 30 days when the tumor has completely regressed, cytotoxicity of peritoneal cells increases markedly. (3) Lentinan itself has the effect of activating the antitumor effect of peritoneal exudate cells against sarcoma-180, within 7 days after the last administration of lentinan. (4) Passive transfer of the antitumor activity can be achieved with the peritoneal cells, but not with lymph node cells or serum.
  • Mehmet AYDOGDU
    Journal of geomagnetism and geoelectricity
    1987年 39 巻 4 号 177-185
    発行日: 1987年
    公開日: 2010/09/14
    ジャーナル フリー
    Effects of the asymmetrical thermospheric winds on NmF2 at the latitudes 25°N, 35°N, 45°N and their geographically conjugate points have been computed for equinox conditions to study diurnal and longitudinal variations of the north-south differences in NmF2. In our calculations, the asymmetrical wind model of ILL et al. (1975) has been used. Although the effects of the winds on NmF2 are almost equal at latitudes 45°N and S, they give a significant effect on the north-south differences of NmF2 at lower latitude, namely NmF2 at latitudes 25°S and 35°S become about 30 percent greater than those at latitudes 25°N and 35°N between 02 and 08 LT (Local Time). This north-south asymmetry is most pronounced at each longitude around 06 LT. During the daytime, the maximum electron density of the F2-layer in the northern hemisphere becomes comparatively greater than the maximum electron density of the F2-layer in the southern hemisphere by the winds. In the evening, NmF2 at latitudes 25°S, 35°S, and 45°S are greater than NmF2 at their northern conjugate points in the longitude range 0°-120°E, reverse hold true in other longitude ranges. The computed differences in NmF2 between at latitudes 25°N, 35°N, 45°N and at their geographically conjugate points are in agreement with observational differences obtained by the ISS-B satellite, except during the nighttime at the longitude range 180°E-60°W. It is shown that the diurnal and longitudinal variations in the differences between NmF2 at mid-latitude point and those at its geographically conjugate point are well explained by considering the effects of the asymmetrical winds which focus toward the area of 02-05 LT, 35°N-40°N.
  • 白井 俊二, 野村 正敬
    日本物理学会年会講演予稿集
    1955年 1955.4 巻 14G-21
    発行日: 1955/10/09
    公開日: 2018/03/23
    会議録・要旨集 フリー
  • 金 雅子, 高田 友美, 宇垣 弘美, 藤原 和子, 三宅 貴仁, 宮武 崇, 吉野 潔, 藤田 征巳, 榎本 隆之, 木村 正
    産婦人科の進歩
    2007年 59 巻 2 号 102-104
    発行日: 2007年
    公開日: 2007/06/30
    ジャーナル 認証あり
  • 坂田 晴美, 宇治田 麻里, 矢島 さおり, 吉田 隆昭, 中村 光作, 池内 正憲
    産婦人科の進歩
    2006年 58 巻 4 号 375-378
    発行日: 2006年
    公開日: 2006/12/28
    ジャーナル 認証あり
  • 高畠 敏郎, 石川 征靖
    年会講演予稿集
    1987年 42.3 巻 27p-LF-13
    発行日: 1987/03/27
    公開日: 2018/03/27
    会議録・要旨集 フリー
  • 崔 鳳林, 寺田 尚司, 小林 利秋, 佐藤 武郎, 三浦 恒雄, 武居 文彦
    年会講演予稿集
    1987年 42.3 巻 27p-LF-11
    発行日: 1987/03/27
    公開日: 2018/03/27
    会議録・要旨集 フリー
  • 森 覚, 安江 新一, D.B. SWINSON, UNM
    年会予稿集
    1980年 35.1 巻
    発行日: 1980/03/12
    公開日: 2018/03/26
    会議録・要旨集 フリー
  • 上野 裕幸, 山田 良実, 藤井 善次郎, 安野 志津子, 藤本 和彦, 長島 一男
    年会予稿集
    1980年 35.1 巻
    発行日: 1980/03/12
    公開日: 2018/03/26
    会議録・要旨集 フリー
  • Naotake Yanagisawa, Kazunori Shimada, Tetsuro Miyazaki, Atsumi Kume, Yohei Kitamura, Ryoko Ichikawa, Hirotoshi Ohmura, Takashi Kiyanagi, Makoto Hiki, Kosuke Fukao, Katsuhiko Sumiyoshi, Kuniaki Hirose, Rie Matsumori, Hirotaka Takizawa, Kiyotaka Fujii, Hiroshi Mokuno, Nao Inoue, Hiroyuki Daida
    Journal of Atherosclerosis and Thrombosis
    2010年 17 巻 3 号 285-294
    発行日: 2010年
    公開日: 2010/03/31
    [早期公開] 公開日: 2010/03/13
    ジャーナル オープンアクセス
    Aim: We assessed levels of polyunsaturated fatty acid (PUFA) in serum and red blood cells (RBCs) among groups stratified by generation and its clinical significance in Japanese subjects living in an urban area.
    Methods: We enrolled 200 apparently healthy Japanese (126 males, mean age: 50.3±9.2 years) living in an urban area. Levels of PUFA, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), and dihomo-gamma-linolenic acid (DGLA) in serum and RBCs were measured for each generation (G1 <35y, G2 35y-<45y, G3 45y-<55y, G4 55y-<65y, G5≥65y).
    Results: No significant differences in EPA, DHA, AA, or EPA/AA were observed between males and females. After dividing into generations, stepwise increases in EPA and DHA, but not DGLA or AA, were observed in serum (all p<0.0001). EPA/AA ratios were stepwisely increased in serum (mean: G1:0.26, G2:0.29, G3:0.43, G4:0.58, G5:0.68, p<0.0001) and RBCs (mean: G1:0.10, G2:0.09, G3:0.15, G4:0.20, G5:0.23, p<0.0001). Positive correlations of EPA (r=0.83), DHA (r=0.55), DGLA (r=0.54), AA (r=0.29), and EPA/AA (r=0.91) were demonstrated between serum and RBCs. In addition, a significant positive correlation between EPA/AA ratios and insulin sensitivity as well as a negative correlation between those ratios and insulin resistance were observed in subjects with metabolic syndrome.
    Conclusion: Low levels of EPA/AA, which were associated with insulin resistance, were demonstrated in young Japanese adults living in an urban area.
  • 内田 暁子, 堀内 功, 青木 美知, 木下 明美, 福岡 実, 衣田 隆俊, 鍔本 浩志, 小笠原 利忠, 小森 慎二, 香山 浩二
    産婦人科の進歩
    2007年 59 巻 1 号 27-30
    発行日: 2007年
    公開日: 2007/03/31
    ジャーナル 認証あり
feedback
Top