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全文: "Temporal pole"
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  • Lauren Wallaert, Akifumi Hagiwara, Christina Andica, Masaaki Hori, Kazuo Yamashiro, Saori Koshino, Tomoko Maekawa, Koji Kamagata, Shigeki Aoki
    Magnetic Resonance in Medical Sciences
    2018年 17 巻 4 号 275-276
    発行日: 2018年
    公開日: 2018/10/10
    [早期公開] 公開日: 2017/12/12
    ジャーナル オープンアクセス
  • Junichiro Ohira, Nobuyuki Mori, Shunsuke Kajikawa, Takeshi Nakamura, Tetsuya Arisato, Makio Takahashi
    Internal Medicine
    2016年 55 巻 23 号 3529-3533
    発行日: 2016/12/01
    公開日: 2016/12/01
    ジャーナル オープンアクセス

    Posterior reversible encephalopathy syndrome (PRES) typically affects the posterior subcortical white matter. We report the case of a 55-year-old man with atypical PRES, who had malignant hypertension and renal dysfunction. Magnetic resonance imaging of the brain revealed extensive vasogenic edema in the deep white matter including the temporal pole, as well as in the brainstem and cerebellum. Antihypertensive therapy and hemodialysis contributed to both clinical and radiological improvement. Involvement of the deep white matter including the temporal pole, which is rarely affected in an ischemic stroke, should be recognized as a potential sign of PRES.

  • Takashi Ando, Yoji Goto, Kazuo Mano, Akihiko Ueda, Yukio Ando, Ikuko Mizuta, Toshiki Mizuno
    Internal Medicine
    2016年 55 巻 19 号 2873-2876
    発行日: 2016/10/01
    公開日: 2016/10/01
    ジャーナル オープンアクセス

    A 37-year-old man was hospitalized for an evaluation of acute bilateral multiple subcortical infarcts. There were no specific signal abnormalities in the temporal pole or external capsule. An abdominal skin biopsy showed granular, electron-dense, osmiophilic material (GOM) in the smooth muscle cells on electron microscopy. A direct sequencing analysis of NOTCH3 revealed a heterozygous c.986G>A substitution in exon 6, resulting in a Cys329Tyr amino acid replacement. According to these findings, the patient was diagnosed with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencehalopathy (CADASIL). Thus, early phases of CADASIL can present as acute bilateral multiple subcortical infarcts without a characteristic temporal pole or any external capsule lesions.

  • Toshiki Mizuno, Manabu Muranishi, Torusunjian Torugun, Hiromi Tango, Yoshinari Nagakane, Tukasa Kudeken, Yuji Kawase, Kiyokazu Kawabe, Fumiko Oshima, Takeshi Yaoi, Kyoko Itoh, Shinji Fushiki, Masanori Nakagawa
    Internal Medicine
    2008年 47 巻 23 号 2067-2072
    発行日: 2008年
    公開日: 2008/12/01
    ジャーナル オープンアクセス
    Most previously reported mutations in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) result in an odd number of cysteine residues within the epidermal growth factor (EGF)-like repeats in Notch3. We report here R75P mutation in two Japanese CADASIL families not directly involving cysteine residues located within the first EGF-like repeats. Probands in both families had repeated episodes of stroke, depression, dementia as well as T2 high-intensity lesions in the basal ganglia and periventricular white matter, but fewer white matter lesions in the temporal pole on MRI. These families provide new insights into the diagnosis and pathomechanisms of CADASIL.
  • 今野 卓哉, 梅田 麻衣子, 梅田 能生, 野崎 洋明, 小宅 睦郎, 藤田 信也
    臨床神経学
    2011年 51 巻 10 号 770-773
    発行日: 2011年
    公開日: 2011/10/24
    ジャーナル フリー
    症例は40歳男性である.脳血管障害の危険因子がないものの,1年間に5回の脳虚血発作をきたし,頭部MRIで小血管病を示唆する多発性の病変をみとめた.家族歴からCADASILをうたがったが,特徴的とされる側頭極の白質病変に乏しかった.皮膚生検で電子顕微鏡下に血管平滑筋の基底膜にGOMの沈着をみとめ,CADASILと診断した.皮膚生検は遺伝子診断に比して簡便に施行可能であり,画像上の非定型例を診断する上でとくに有用である.
  • Yuri Masaoka, Youhei Onaka, Yuuki Shimizu, Shyunsuke Sakurai, Ikuo Homma
    The Journal of Physiological Sciences
    2007年 57 巻 2 号 121-126
    発行日: 2007年
    公開日: 2007/04/26
    [早期公開] 公開日: 2007/03/29
    ジャーナル フリー
    In this study, we focused on two types of perspiration, one triggered by anticipatory anxiety and the other by voluntary deep inspiration. We have previously found that the anticipation of anxiety causes increases of respiratory frequency, and that these increases are related to an activation of the temporal pole and amygdala in humans. Our interest is in the difference between the two natures of perspiration, both of which are closely related to respiratory responses. The level of sweating responses did not differ between deep and active inspiration or between three trials. This means that there was no habituation with repetitive trials for voluntary breathing. On the other hand, sweating responses during anticipation of anxiety showed habituation with repetitive trials. Habituation and nonhabituation differences with respect to these two characteristics of perspiration could be the result of differences in the related central networks. The former might be involved cortical structures associated with conscious changes of respiration. The latter was induced unconsciously, and this unconscious response is similar to the respiratory response during anticipatory anxiety, which may be related to the activation of the limbic system. Further, there was a positive correlation found between the amount of perspiration response and the state anxiety scores in deep inspiration, and also in trial 1 of the anticipatory anxiety experiment. Both types of responses were related to the individual state anxiety scores, and this may contribute to the defense mechanism with regard to adjustments to changes in the outer environment and situations.
  • Michihiko Koeda, Amane Tateno, Kosuke Ishizaka, Tomoyuki Saijo, Yoshiro Okubo
    Journal of Nippon Medical School
    2010年 77 巻 4 号 188-189
    発行日: 2010年
    公開日: 2010/08/31
    ジャーナル フリー
  • Chiho Ishida, Ken-ichi Sakajiri, Mitsuhiro Yoshita, Anne Joutel, Florence Cave-Riant, Masahito Yamada
    Internal Medicine
    2006年 45 巻 16 号 981-985
    発行日: 2006年
    公開日: 2006/09/15
    ジャーナル オープンアクセス
    We report a 38-year-old Japanese woman who had cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with a novel mutation (TGT to TAT) at nucleotide position 1241 (C388Y) in exon 7 of the Notch3 gene (NOTCH3). Immunostaining of a skin biopsy with a Notch3 monoclonal antibody is a beneficial method for the screening of CADASIL, particularly in the case of rare mutations outside the mutation hotspots in NOTCH3 as shown in this patient.
  • YOSHIHIKO TAKAHASHI, TAKASHI YAMAMOTO, TOSHI ABE, TAKASHI TOKUTOMI, FUMIHIDE YOSHIMURA, TATSUO YUGE, JUN MIYAGI, MINORU SHIGEMORI
    The Kurume Medical Journal
    1996年 43 巻 3 号 223-229
    発行日: 1996/09/14
    公開日: 2009/08/11
    ジャーナル フリー
    Dural arteriovenous fistula (AVF) of the anterior cranial fossa is associated usually with cerebral hemorrhage or subarachnoid hemorrhage, while an association with transient global amnesia has not been reported previously. A case presenting the latter unusual symptom is described and the surgical treatment of AVF is discussed. A 64-year-old woman was hospitalized complaining of transient memory impairment. Magnetic resonance (MR) imaging demonstrated a flow void in the left frontal lobe and temporal pole. Cerebral angiography revealed an AVF in the anterior cranial fossa, which was fed bilaterally by the ethmoidal arteries and by branches of the external carotid arteries. The AVF drained into the superior sagittal sinus and the superficial sylvian vein via large varices. Following transfemoral embolization, surgical treatment was carried out . Postoperative angiography revealed complete obliteration of the anomaly. There were no further episodes of amnesia. In our presented case, there is an association between the presenting symptoms and the AVF. The combination of ischemia and congestion in the frontal and temporal lobes may have caused transient memory impairment. From our surgical experience, the excision of the vascular connection between the dura and the frontal lobe following the coagulation of the dura mater of the anterior part of the base of the skull without extensive excision seems to be recommended.
  • Yasuteru Sano, Fumitaka Shimizu, Motoharu Kawai, Masatoshi Omoto, Kiyoshi Negoro, Tetsu Kurokawa, Hirosuke Fujisawa, Michiyasu Suzuki, Naoko Okayama, Yutaka Suehiro, Yuji Hinoda, Takashi Kanda
    Internal Medicine
    2011年 50 巻 22 号 2833-2838
    発行日: 2011年
    公開日: 2011/11/15
    ジャーナル オープンアクセス
    Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy is a cerebrovasuclar disease caused by NOTCH3 mutations, usually localized to exons 3 and 4. This report describes the clinical and neuroradiological findings of 2 subjects of two unrelated Japanese families who shared a common p.Arg332Cys mutation. The subject from family A presented syncope attacks as the sole clinical presentation at the beginning of his disease course. The subject from family B showed recurrent ischemic attacks, followed by a large intracranial hemorrhage. This is the first report to describe the detailed phenotypes of patients with a rare p.Arg332Cys mutation in Japan.
  • KIYOAKI KATAHIRA, EIICHI IWAI
    The Tohoku Journal of Experimental Medicine
    1975年 115 巻 2 号 137-143
    発行日: 1975年
    公開日: 2008/11/28
    ジャーナル フリー
    The experiment was designed to elucidate the question whether the unilateral ablation of the amygdala significantly affects sexual behavior or not. For this purpose, the effect of the unilateral amygdalecto-my upon Matatabi-response was investigated in the cat (R-cat), particularly in cats which showed unmanifested Matatabi-response in the innate status (NR-cat). Following the unilateral damage to the amygdala, NR-cats showed a significant manifestation in their Matatabi-response behavior, while R-cats indicated no change in it, their performance level being the same as preoperatively. It is concluded from the present results that even the unilateral ablation of the amygdala affects sexual behavior significantly, this being in contrast to many previous reprots. The present finding implies that individual differences in sexual behavior appear to depend on the neural basis of the amygdala, supporting an assumption that the amygdala is a controlling center of sexual and emotional behaviors.
  • 数又 研, 上山 博康, 石川 達哉, 滝澤 克己, 前田 高宏, 磯部 正則, 牧野 憲一, 後藤 聡
    脳卒中の外科
    2003年 31 巻 6 号 431-435
    発行日: 2003年
    公開日: 2008/03/18
    ジャーナル フリー
    Because ventrally directing IC aneurysm is sometimes difficult to treat by the standard pterional approach, we attempted to modify our distal transsylvian approach. We describe this modified distal transsylvian approach (anterior temporal approach) in this paper.
    The surgical method comprises the following steps; 1. Superficial sylvian veins are displaced to the frontal side of the fissure without sacrificing those veins. An anastomotic trunk of the deep middle cerebral vein is dissected from the medial temporal lobe. 2. A posterior division of M2 segment, M1 segment and anterior temporal artery are dissected from the medial temporal lobe. 3. Arachnoid trabecula between the uncus and the anterior choroidal artery is incised. This allows posterolateral retraction of the temporal pole without significant retraction.
    Although the anterior temporal approach is employed for the surgical treatment of distal BA aneurysm, it is also available for the IC ventral aneurysm.
  • Keiji SANO
    Neurologia medico-chirurgica
    1960年 2 巻 1-2 号 138-146
    発行日: 1960年
    公開日: 2007/05/25
    ジャーナル フリー
  • Yasunori MUROMACHI
    Asian Transport Studies
    2019年 5 巻 3 号 470-479
    発行日: 2019/03/01
    公開日: 2019/03/01
    ジャーナル フリー

    I conducted functional magnetic resonance imaging (fMRI) experiments to examine the relationship between moral consciousness and travel behavior by monitoring the activation of the participant's brain areas in a situation where questions in relation to moral consciousness were indicated. I successfully extracted the brain areas in relation to “sympathy” or “memory,” which were more activated during a social dilemma than a general situation, such as baseline questions when legal bicycle parkers with higher moral consciousness answered them. According to the individual analysis, I found that the dorsolateral prefrontal cortex activation was more common for legal than illegal parkers. I also conducted an analysis on the response time difference between legal and illegal parkers. The response time for a legal parker is longer than that for an illegal parker with 5% statistical significance, which is assumed to reflect the activation of more brain areas before answering questions.

  • 青木 寧子, 望月 葉子, 磯崎 英治, 板東 充秋, 小栁 清光, 水谷 俊雄
    臨床神経学
    2014年 54 巻 4 号 325-329
    発行日: 2014/04/01
    公開日: 2014/05/03
    ジャーナル フリー
    症例は死亡時73歳女性である.68歳より記銘力障害を生じ,71歳時に小手筋萎縮が出現した.病識が低下し,多弁,多幸的で,アルツハイマー病(Alzheimer disease; AD)に認知症をともなう筋萎縮性側索硬化症(amyotrophic lateral sclerosis with dementia; ALS-D)を合併したと診断した.病理学的には孤発性ALSの所見と吻側側頭葉内側と海馬支脚に高度の神経細胞脱落,歯状回顆粒細胞に多数のTAR DNA binding protein-43陽性封入体があり,ALS-Dに合致した.大脳皮質の神経細胞脱落部位には多数のリン酸化タウ陽性構造と老人斑がみられたが,ADとしては神経原線維変化と定形斑が少数だった.今後,このような合併症例が増えると考えられ,その診断への参考として報告する.
  • 内野 誠
    臨床神経学
    2011年 51 巻 11 号 945-948
    発行日: 2011年
    公開日: 2012/01/24
    ジャーナル フリー
    CADASIL has been reported notably in Europe, has recently been found to occur in Japan and, with the increase in the number of reported cases, has been attracting attention. Currently, the diagnosis of CADASIL is established clinically if the patient: (1) develops the condition at a relatively young age (40-50 years), (2) is not at risk for stroke, (3) has repeated attacks of lacunar infarction with gradual progression to pseudobulbar paralysis and dementia, and (4) has other family members with similar symptoms. The diagnosis is also established by imaging and laboratory studies if: (1) MRI reveals leukoaraiosis and multiple small infarcts in the deep white matter, basal ganglia, thalamus, and pons, with hyperintensities of the temporal pole and external capsule bilaterally; (2) electron microscopy demonstrates granular osmiophilic material (GOM) around vascular smooth muscles in the brain, skeletal muscle, and skin; and (3) DNA analysis shows notch3 mutations.
    The mechanism of development of CADASIL due to notch3 mutations is still unknown. However, a recent study revealed that Notch3 ectodomain is a major component of GOM. On binding to the ligand, Notch3 normally undergoes proteolytic cleavage, with the resulting clearance of the extracellular domain. However, in CADASIL, it accumulates as GOM and potentially inhibits normal metabolism in smooth muscle cells. It is necessary to suppress the production of GOM for fundamental therapy of CADASIL.
  • Toshiyuki SAITO, Sei-etsu FUJIWARA, Yumetaro SASAKI, Koichi NIWA, Tetsu NEMOTO, Etsuko KASUYA, Ryosuke SAKUMOTO, Takashi YAMAGUCHI
    Japan Agricultural Research Quarterly: JARQ
    2009年 43 巻 3 号 247-254
    発行日: 2009年
    公開日: 2012/02/16
    ジャーナル フリー
    We modified a wireless system to measure hippocampal neural activity in pigs, and tested a handmade microdrive for adjusting the tip of the electrode. Under general anesthesia with halothane inhalation we stereotaxically placed tungsten electrodes (5 MΩ) fitted with handmade microdrives in the temporal hippocampus of male Landrace piglets, and fixed a high-input-resistance transmitter (10 MΩ; 1000-fold amplification) to the skull. Oscillation and saturation were evident in the recording system for several days after surgery. When these phenomena ceased, we successfully recorded the hippocampal electrical activity in four of eight piglets. At 5 or 6 days following surgery, hippocampal electrical activity ‹0.15 mV in amplitude was observed in resting piglets during the daytime. In this recording, delta (1.0-3.9 Hz) and theta (4.0-7.9 Hz) waves with large amplitude were frequently predominant. However, these activities often alternated with high-frequency and low-amplitude activity, even while piglets were lying down. Manipulation of the microdrive enabled us to reposition the electrodes in the hippocampus 1 week after surgery. This technical development maintains the electrode within the hippocampus to enable neuronal activity with behavioral correlates to be determined in unrestrained piglets.
  • Masanori KURIMOTO, Akiko TAKAIWA, Shoichi NAGAI, Nakamasa HAYASHI, Shunro ENDO
    Neurologia medico-chirurgica
    2010年 50 巻 1 号 36-40
    発行日: 2010年
    公開日: 2010/01/25
    ジャーナル オープンアクセス
    A 47-year-old man was admitted to our hospital with an intrinsic brain tumor in the left anterior temporal lobe. Preoperative sodium thiopental test demonstrated left hemispheric dominance. Awake craniotomy was performed for dominant-hemispheric tumor resection using language mapping to identify the stimulation-induced positive language area. The tasks of object naming and repetition were used, along with specific tests for famous people's names. The language area was detected on the superior temporal gyrus and preserved. Following surgery, this patient was unable to retrieve the names of famous individuals (i.e. anomia for people's name) despite preservation of semantic knowledge for those individuals. This anomia for people's names showed no improvement at all for a period of 15 months. This case report and other sporadic cases with this type of deficit reveal the left anterior temporal lobe is an important brain area for retrieving people's names.
  • 牧 徳彦, 池田 学, 鉾石 和彦, 小森 憲治郎, 田辺 敬貴
    失語症研究
    1999年 19 巻 1 号 9-16
    発行日: 1999年
    公開日: 2006/04/25
    ジャーナル フリー
    前交通動脈瘤破裂の手術後に著明な健忘症状と性格変化を呈した1例を報告した。即時記憶や知的能力は保たれていたが,見当識障害,重篤な前向健忘,作話傾向,多弁多幸を認めた。本例では,自伝的にも社会的にも逆向健忘を認めなかったが,過去の有名人の名前を想起することが困難であった。人名の語想起障害の責任病巣として左側頭極が示唆されており,同部位と前脳基底部領域あるいは前頭葉底面は鉤状束で結ばれていることから,本例の特異性もこの線維連絡の障害と関連するものと考えられた。
  • Takuya Kobayashi, Masafumi Kubota, Toshiyuki Takahashi, Ayaka Nakasato, Taro Nomura, Junichi Furuya, Hisatomo Kondo
    Journal of Prosthodontic Research
    2018年 62 巻 3 号 337-341
    発行日: 2018年
    公開日: 2018/08/27
    ジャーナル 認証あり

    Purpose: One of the most prominent issues in a super-aging society is the rapid increase in dementia patients. Cross-sectional studies in dentistry have indicated that patients with dementia have worse oral health compared to healthy people. The purpose of this study was to clarify the influence of tooth loss on brain structure by comparing the volumes of gray matter (GM) and white matter (WM) between edentulous and dentulous subjects.

    Methods: Subjects were recruited from the Denture Clinic at Iwate Medical University Hospital Dental Center. Experiments were performed on edentulous (5 males, 8 females, 81.8±1.24 years) and dentulous subjects (4 males, 7 females, 77.1±4.25 years). Patients with dementia were excluded from this study. Brain volumes of GM and WM in edentulous and dentulous subjects were compared using intracranial volume, age, gender and history of hypertension as covariates. Analyzed brain areas were identified by transforming the Montreal Neurological Institute coordinate into the anatomical coordinate in edentulous subjects.

    Results: The analysis of WM structural images found no morphological differences between dentulous and edentulous subjects. However, significant atrophy of GM was observed in the hippocampus, caudate nucleus and temporal pole of the right hemisphere in edentulous subjects.

    Conclusions: The results of this study suggest that tooth loss was a causal factor for volume reduction in brain areas related to memory, learning and cognition.

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