In the previous paper, it was reported that methyl
a-hyodesoxy-cholate was partially oxidized only at C
3-hydroxyl group with NBS. By the same oxidation procedure pregnane-3(
a)-6(
a)-diol-20-one, derived from u-hyodesoxycholate, afforded pregnan-6(
a)-hydroxy-3, 20-dione, which was dehydrated to progresterone. By using excess
N-bromosuccinimide, it afforded some allo-pregnane-3, 6, 20-trione as a by-product.
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