After intraperitoneal injections of neutral red, trypan blue, carmin or bilirubin solutions into rat fetuses on the 17th or 18th day after gestation, the fetuses were killed 48 hours after injection. Serial sections of the fetal brain were made to study how the pigments transport into the brain. As a result, no pigments were observed in the fetal brain in normal states. In the hypoxic state, by clamping the uterine vessels, however, the transportation of pigments into the brain was slightly observed in the solution of 1.0-0.1% of neutral red or O.2% of bilirubin. This may result from the functional decrease of the blood-brain barrier by hypoxia. Based on these facts, it may be presumed that this phenomenon may have the possibilty of being correlated with the mechanism of kernicterus.

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