Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for 2 weeks. Cholesterol amounts in VLDL, LDL, HDL, HDL
2 and
HDL3
were estimated on the
0
th, 7th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II,
B
,
C
-II,
E
levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL, HDL
2 and
HDL3
were 15.
9
±7.
5
mg/dl (mean±SD), 150.
9
±58.1mg/dl 43.8±
9
.
6
mg/dl, 16.
4
±
5
.8mg/dl and 24.
9
±
6
.
3
mg/dl respectively. Plasma apoprotein A-I, A-II,
B
,
C
-II and
E
levels were 81.7±
22
.
0
mg/dl, 15.1±
5
.
4
mg/dl, 93.7±36.
0
mg/dl,
3
.
83
±1.00mg/dl and
4
.29±1.36mg/dl respectively. After 2 weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL-
C
(r=
0
.348), HDL
2-
C
(r=
0
.612) and
HDL3
(r=
0
.569). Apoprotein
B
correlated with total cholesterol (TC) (r=
0
.610), VLDL-
C
(r=
0
.341), LDL-
C
(r=
0
.726), HDL-
C
(r=
0
.432) and HDL
2-
C
(r=
0
.465). Apoprotein
C
-II correlated with TC (r=
0
.765), TG (r=
0
.679), VLDL-
C
(r=
0
.651), LDL-
C
(r=
0
.461) and HDL
2-
C
(r=
0
.326). Apoprotein
E
correlated with TC (r=
0
.580), TG (r=
0
.575) and VLDL-
C
(r=
0
.666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=
0
.468). Apoprotein
B
correlated with apoprotein
C
-II (r=
0
.393). Apoprotein
C
-II correlated with apoprotein
B
(r=
0
.393) and
E
(r=
0
.549). Apoprotein
E
only correlated with apoprotein
C
-II (r=
0
.549).
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