詳細検索結果
以下の条件での結果を表示する: 検索条件を変更
クエリ検索: %22%E3%82%A8%E3%82%AF%E3%82%B9%E3%83%8A%E3%83%AC%E3%83%83%E3%82%B8%22 %E5%87%BA%E7%89%88%E7%A4%BE
5,080,150件中 1-20の結果を表示しています
  • Daria Kurguzova, Svetlana Serebrova, Alexey Prokofiev, Ludmila Krasnykh, Galina Vasilenko, Marina Zhuravleva, Elena Smolyarchuk, Anton Barkov
    日本薬理学会年会要旨集
    2018年 WCP2018 巻 WCP2018_PO3-5-27
    発行日: 2018年
    公開日: 2020/09/10
    会議録・要旨集 オープンアクセス

    Background

    The differences in conditions of enteric-coated acid-labile drug release and absorption between healthy subjects in bioequivalence studies and gastrointestinal patients in clinical practice can lead to significant differences in gastric stability of original PPIs and generics. Thus, pathologic duodenogastric reflux (PDGR) and the pH increasing within PPIs administration still remain unaccounted for.

    Methods

    Two-stage modified comparative dissolution testing of original omeprazole (OO) and four generics (G1;2;

    3
    ;
    4
    ) was performed. At first, we moved drugs from solution with pH 1.2 (1.2±0.05) to pH
    7
    .0 (
    7
    .0±0.05) and measure concentration of omeprazole in solution by high-performance liquid chromatography. According to our self-developed formula, pH
    7
    exposure time of resistance to PDGR for omeprazole is
    4
    minutes, i.
    e
    . the active substance should not be released within
    4
    minutes at pH
    7
    . The exposure at the second stage was conducted with pH
    4
    (
    4
    .0±0.05), that imitated gastric pH after PPI administration. And then we also moved drugs to pH
    7
    with the subsequent measurement of omeprazole concentration.

    Results

    Omeprazole concentrations after

    4
    , 10, 15, 20, 30, 45, 60 minutes in pH
    7
    solution at the first stage were different for OO and generics. For OO, these values were
    4
    ,
    7
    ±0,
    7
    %; 41,
    4
    ±
    3
    ,0%; 62,
    8
    ±
    4
    ,0%; 79,
    5
    ±2,
    9
    %;
    83
    ,
    5
    ±2,
    9
    %; 81,6±2,
    9
    %; 80,6±
    4
    ,
    4
    %; for Generic1 - 0; 49,
    3
    ±
    9
    ,
    9
    %;
    88
    ,
    8
    ±2,
    8
    %; 90,
    4
    ±
    3
    ,
    7
    %;
    88
    , 2±2,2%;
    87
    ,
    3
    ±2,0%; 85,
    9
    ±1,1%; for Generic2 - 0; 30,6±6,
    3
    %; 66,
    7
    ±
    8
    ,2%; 76,
    4
    ±
    7
    ,
    4
    %;
    82
    ,
    8
    ±
    5
    ,
    3
    %; 86,0±
    3
    ,
    7
    %; 84,6±
    3
    ,
    3
    %: for Generic
    3
    - 80,
    8
    ±
    3
    ,6%;
    83
    ,
    5
    ±1,
    9
    %;
    83
    ,
    8
    ±
    3
    ,2%;
    83
    ,
    3
    ±2,
    7
    %; 81,
    9
    ±2,1%;
    82
    ,1±2,0%;
    82
    ,0±2,
    4
    %; for Generic
    4
    -
    82
    ,
    5
    ±1,
    7
    %; 84,
    4
    ±0,
    8
    %; 84,2±1,2%;
    82
    ,
    9
    ±0,
    9
    %;
    82
    ,
    9
    ±0,
    9
    %;
    82
    ,
    9
    ±0,
    9
    %;
    82
    ,
    8
    ±1,1%, respectively.

    An analysis of the omeprazole concentration in pH

    7
    solution at the second stage revealed the following parameters after the same time: for OO -
    4
    ,
    4
    ±0,6%; 40,
    5
    ±
    3
    ,0%; 62,
    8
    ±2,0%; 80,0±
    3
    ,1%; 85,
    4
    ±2,
    9
    %;
    82
    ,
    8
    ±
    3
    ,
    4
    %; 80,
    9
    ±
    3
    ,
    5
    %; for Generic1 - 0; 67,0±
    7
    ,
    8
    %;
    89
    ,
    7
    ±2,
    3
    %; 91,
    9
    ±
    4
    ,
    3
    %;
    89
    ,1±1,6%;
    88
    ,
    3
    ±1,
    4
    %;
    87
    ,
    8
    ±1,2%; for Generic2 - 0; 42,2±
    5
    ,6%; 75,1±
    7
    ,
    3
    %; 81,0±6,0%;
    88
    ,
    4
    ±
    3
    ,2%;
    88
    , 6±1,
    3
    %;
    87
    ,
    9
    ±1,0%; for Generic
    4
    - 85,
    5
    ±0,
    5
    %; 85,6±0,
    5
    %; 84,
    7
    ±0,
    9
    %;
    82
    ,
    7
    ±
    3
    ,0%; 84,
    4
    ±0,
    3
    %; 84,
    4
    ±0,
    3
    %; 84,
    3
    ±0,
    4
    %, respectively. Generic
    3
    release and degradation were completely realized at pH
    4
    .

    Conclusion

    Decreased gastric stability of Generic

    3
    and Generic
    4
    makes PDGR and inhibited gastric acid secretion due to PPIs administration the potential causes of decreased enteric-coated acid-labile drugs stability.

  • E. camaldulensis, E. globulus における容積重, および材形質含量の樹幹内変異と標準値を示す位置について
    小名 俊博, 園田 哲也, 伊藤 一弥, 柴田 勝
    紙パ技協誌
    1995年 49 巻 8 号 1227-1234
    発行日: 1995/08/01
    公開日: 2009/11/16
    ジャーナル フリー
    Within-tree variations, whole-tree values and the representative heights for the whole tree value of basic density, and contents of wood components per volume were analysed for two trees of Eucalyptus camaldulensis and
    E
    . globulus
    respectively, grown at the seed orchard in Western Australia to do quality breeding.
    Within-tree variation of
    E
    . camaldulensis
    was rather uniform as 500±40, 532 ±34 kg/
    m3
    , but that of
    E
    . globulus
    was large as 595 ± 69, 616 ± 79 kg/
    m3
    and the basic density was higher in bark side and upper part in the trunk, to be expected to have higher pulp productivity.
    The whole-tree values of
    E
    . camaldulensis
    were 501, 520 kg/
    m3
    and those of
    E
    . globulus
    were 594, 640 kg/
    m3
    and the difference of the species was observed.
    Representative heights for the whole-tree contents ±
    5
    % were 0.32.
    8
    m on
    E
    . camaldulensis
    , and 0.
    8
    and 2.
    8
    m on
    E
    . globulus
    regardless the differences in the whole-tree height and the within-tree variation when they were chosen below
    3
    .
    3
    m height for sampling an increment core.
    Representative heights were also determined for contents of wood components per volume as follows ; for
    E
    . camaldulensis
    , holocellulose : 1.
    3
    , 2.
    8
    m, cellulose : 2.
    83
    .
    3
    m, hemicellulose : 0.
    82
    .
    8
    m, lignin : 0.81.
    3
    , 2.
    8
    m, extractives : 2.
    3
    m, alkali-extractives : 1.
    3
    m, and total-extractives : 2.32.
    8
    m, for
    E
    . globulus
    , 2.
    8
    m, 2.32.
    8
    m, 2.
    8
    m, 0.30.
    8
    m, 2.
    83
    .
    3
    m, 2.
    83
    .
    3
    m and 2.
    8
    m in the same manner.
    It is expected that whole-tree pulp properties including pulp productivity are predicted by the increment core taken from these representative heights.
  • 浅岡 顕, 小高 猛司
    土質工学会論文報告集
    1992年 32 巻 3 号 117-129
    発行日: 1992/09/15
    公開日: 2008/02/29
    ジャーナル フリー
    Failure problems of saturated soils are classified in the present study into the following four types : Type I : The failure of loose and/or normally consolidated soils under fully drained loading conditions. Type II : The same soils but under perfectly undrained conditions. Type III : The failure of dense and/or overconsolidated soils under fully drained conditions. Type IV : The same soils but under perfectly undrained conditions. The soil-water coupling limiting equilibrium analysis on the basis of the critical state concept is shown possible to draw a distinction between type I, II and IV problems, and the limitations of the analysis procedure happen in solving the type problem in the above. This is demonstrated experimentally, in which seepage failure experiments in laboratory with the use of a saturated silty sand are employed to make distinctions clearly between the four types of failure problems. The definite distinctions both in failure load and failure mode appeared in the four types of experiments are summarized as follows : (1) the smallest failure load in loose sand in the undrained condition, (2) the largest failure load with the largest failure region in dense sand under undrained loading, (
    3
    ) the observation of no global deformation before failure within the soil under the fully drained condition that suggests the development of very localized shear deformation in the sand. Three out of four experiments are described well by the limit analysis computation mentioned above as far as the failure load and the shape and the size of the failure region after boiling failure are concerned, and thus the type III problem is identified to be the problem that should be solved by any other means in near future.
  • 膵臓
    2007年 22 巻 1 号 e399-e401
    発行日: 2007年
    公開日: 2007/03/27
    ジャーナル フリー
  • 山口 昭彦
    日本中東学会年報
    1994年 9 巻 37-65
    発行日: 1994/03/31
    公開日: 2018/03/30
    ジャーナル フリー
    L'entree en Iran des armees britannique et sovietique s'est produite en aout 1941. Elle ebranla du coup le regime de la dynastie pahlavi qui etait au pouvoir depuis 16 ans, et mena le pays vers l'instabilite politique et le chaos social. La defaite de l'arme gouvernementale, qui etait le pivot du regime de Reza Shah, reduisit considerablement le controle du gouvernement central dans le pays. Cette situation politico-sociale confuse permit le developpement de differents mouvements politiques en Iran. C'est ainsi que le 16 aout 1942 le parti clandestin Komeley Jiyanewey Kurdistan (J-K) est ne a Mehabad, une ville au nord-ouest de l' Iran. Des sa formation, ce parti a su etendre sa sphere d'activite et, en une courte periode de temps, a fini par mettre sous son influence la ville et ses alentours. A la fin de la Seconde Guerre mondiale, en ete 1945, le J-K etait devenu une organisation representant le mouvement nationaliste kurde en Iran. C'est a ce moment-la qu'un autre parti politique, le Hizbi Dimokratiki Kurdistan (HDK), fonde par Qazi Mihemed a Mehabad aussi, devait remplacer le J-K. Des le
    22
    janvier 1946, le HDK proclama l'instauration de la≪Republique de Kurdistan≫. Cependant, les troupes sovietiques qui avaient pris sous leur protection la Republique evacuerent les terres iraniennes, en mai 1946. Six mois plus tard, sous la pression militaire du gouvernement central iranien, la republique s'ecroula. Deux theories tentent d'expliquer le passage du J-K au HDK. William Eagleton Jr., par exemple, affirme dans The Kurdish Republic of 1946 que le HDK a ete cree sur le conseil des autorites sovietiques. L'ex-secretaire general du Parti Democratique du Kurdistan d'Iran, 'Ebd el-Rehman Qasimlu maintient par contre que Qazi Mihemed a etabli le nouveau parti de sa propre initiative, eu regard a la situation politique de cette epoque-la. Il considere que la passage du J-K au HDK comme etant l'evolution d'un parti nationaliste clandestin en un parti democratique. En analysant ces deux theories et en se basant sur les autobiographies des personages qui se sont engages dans cet evenement, cette etude tentera d'examiner le principe directeur et les activites du J-K et de mieux comprendre les raisons pour lesquelles le J-K devait etre remplace par le HDK. La conclusion generale portera sur les differents objectifs politiques du J-K et du HDK. Le J-K visait l'elevation du niveau culturel du peuple tout en luttant contre le tribalisme, qui etait, selon lui, le probleme majeur de≪la nation kurde≫, et cela en ecartant toute idee de revolte militaire. Le J-K a aussi exclu de son cadre les elites sociales telles que les leaders des tribus et dirigeants religieux de peur qu'ils n'excercent une influence sur les membres du parti. L'automne de 1944 fut le debut d'une nouvelle ere pour le mouvement kurde. Alors que l'espoir de l'autodetermination augmentait parmi le peuple a mesure que s'approchait la fin de la guerre, la necessite de la force militaire a commence a se faire sentir dans le J-K. C'est pour cela que s'est produite au sein du parti une tendance a compter sur l'aide militaire des sovietiques et a recourir au leadership de Qazi Mihemed, qui avait une certaine influence meme sur les leaders tribaux. Mais cette tendance etait essentiellement incompatible avec la ligne fondamentale du J-K et, graduellement, a prive ce parti de sa raison d'etre. Ainsi, le HDK se substitua au J-K en tant que≪parti democratique≫visant a rallier d'abord les elites sociales sous sa banniere, en s'appuyant sur l'autorite personnelle de Qazi Mihemed.
  • 馬場 輝郎
    照明学会雑誌
    1968年 52 巻 3 号 107-111
    発行日: 1968/03/25
    公開日: 2011/07/19
    ジャーナル フリー
  • Cbesseredes HORTS
    Journal of Human Ergology
    1982年 11 巻 Supplement 号 429-440
    発行日: 1982/12/15
    公開日: 2011/02/23
    ジャーナル フリー
  • 布施川 雄一, 多田 博己, 小熊 利明, 椎名 豊, 玉地 寛光, 半田 俊之介
    動脈硬化
    1996年 23 巻 9 号 545-551
    発行日: 1996/04/10
    公開日: 2011/09/21
    ジャーナル フリー
    The association between apolipoprotein
    E
    (Apo-
    E
    ) polymorphism and the response of plasma cholesterol to dietary therapy (cholesterol intake of less than 300mg/day) was investigated for about
    8
    weeks in 208 nonfamilial hypercholesterolemia patients (
    E
    3
    /
    3
    161,
    E
    4
    /
    3
    47). The baseline lipoprotein concentration and the intake of energy and lipids were not significantly different between subjects with
    E
    3
    /
    3
    and those with
    E
    4
    /
    3
    phenotypes. After the dietary therapy plasma total cholesterol and low density lipoprotein cholesterol were significantly decreased in both phenotype groups (p<0.05). The patients with
    E
    4
    /
    3
    had significantly smaller reductions of LDL-C than the patients with
    E
    3
    /
    3
    . The changes of LDL-C showed a significant difference between the patients with
    E
    3
    /
    3
    and
    E
    4
    /
    3
    by the Kruskal Wallis test (p=0.041). The presence of
    E
    4
    /
    3
    predicted the degree of cholesterol reduction following dietary therapy.
  • ASHRAF GHALY, ADEL HANNA, MIKHAIL HANNA
    土質工学会論文報告集
    1991年 31 巻 2 号 77-92
    発行日: 1991/06/15
    公開日: 2008/02/29
    ジャーナル フリー
    The performance of single pitch and multi pitch screw anchors during the application of installation torque is presented. An experimental testing program was conducted using five models of screw anchors with different geometry. The effect of the shape of the screw element, sand properties, and installation depth on the required installation torque value was examined. A theoretical model was developed from which the required installation torque value can be calculated in terms of the influencing factors. The required installation torque can be determined in terms of the ultimate uplift resistance calculated from any of the available theories. Based on the actual installation torque value measured in the field, the anticipated pullout capacity can be back calculated from the present theory. A comparison between theoretical and experimental results showed good agreement. Also, good agreement was observed when the present theoretical results were compared with the available field results reported in the literature.
  • ―St. Jude Medical valveの抗血栓性について―
    藤田 康雄, 林 純一, 山崎 芳彦, 江口 昭治, 大谷 信一
    人工臓器
    1988年 17 巻 3 号 1133-1136
    発行日: 1988/06/15
    公開日: 2011/10/07
    ジャーナル フリー
    SJM弁の抗血栓性についてS-
    E
    ボール弁との比較検討を行った。S-
    E
    ボール弁で単弁置換をうけた132例と、SJM弁で単弁置換をうけた135例を対象とした。僧帽弁置換群の血栓塞栓症の発生頻度は、S-
    E
    非被覆弁2.14%/患者・年、S-
    E
    被覆弁1.
    82
    %/患者・年、SJM弁1.69%/患者・年であった。術後
    7
    年のThrombo-embolism Free RateはS-
    E
    非被覆弁で60.
    5
    ±
    7
    .
    5
    %、S-
    E
    被覆弁で
    83
    .
    9
    ±
    5
    .2%、SJM弁で92.
    4
    ±
    3
    .1%であった。大動脈弁置換群の血栓塞栓症の発生頻度は、S-
    E
    非被覆弁1.36%/患者・年、S-
    E
    被覆弁、SJM弁では0であった。術後
    7
    年のThromboembolism Free RateはS-
    E
    非被覆弁75.6±10.6%、S-
    E
    被覆弁80.0±10.
    3
    %、SJM弁96.
    7
    ±
    3
    .
    3
    %であった。SJM弁の抗血栓性はS-
    E
    非被覆弁に比し良好であったが、S-
    E
    被覆弁に比べ著しく向上したとはいえず、近年における血栓塞栓症の減少には厳重な抗凝固療法の施行も寄与していると考えられる。
  • 木村 裕恵, 松下 次用, 吉田 正樹, 野坂 博行, 山瀬 裕彦, 川島 司郎, 平石 孝
    日本農村医学会学術総会抄録集
    2010年 59 巻 P1-B4-8
    発行日: 2010年
    公開日: 2010/12/01
    会議録・要旨集 フリー
    (はじめに)血清クレアチニン(Cre)は性・年齢による影響をうけるため正確に 腎機能を反映しないとされる。このため日本腎臓病学会から腎機能の評価に
    e
    ―GFRを用いることが提唱されている。そこで、今回、本院のドック・健診受診者の腎機能を
    e
    -GFRで評価し、その有用性について検討したので報告する。 (対象・方法)対象は平成21年
    月~
    月までの受診者、男219名、女350名(計569名)である。改訂MDRD簡易式により血清Creから
    e
    -GFRを算出し、性・年代別に集計し、有用性を評価した。 (結果)男性のCre平均値は0.
    82
    ±0.11、女性は0.58±0.08(基準値:男0.
    5
    ~1.0・女0.2~0.
    8
    )であった。男性の年代別の
    e
    -GFR平均値は、20代97.1±15.
    9
    、30代94.
    8
    ±10.0、40代
    82
    .
    8
    ±
    9
    .1、50代
    82
    .1±12.
    8
    、60代76.
    9
    ±13.2、70代↑75.
    5
    ±12.
    8
    。女性の20代104.
    8
    ±18.0、30代96.
    3
    ±15.6、40代
    87
    .1±13.
    9
    、50代
    83
    .0±11.
    8
    、60代80.
    9
    ±15.1、70代↑74.
    8
    ±17.
    9
    であった。日本腎臓病学会のCKDステージ分類ではステージ_II_(
    e
    -GFR60~
    89
    )をGFR軽度低下としている。
    e
    -GFRの結果からするとステージ_II_は、男性131名(59.
    8
    %)、女性164名(46.
    8
    %)。ステージ_III_は男性16名(
    7
    .
    3
    %)、女性14名(
    4
    .0%)であった。 (まとめ)腎機能の指標として
    e
    -GFRは血清クレアチニンよりは鋭敏とみなされるが女性高齢者では体表面積で補正した
    e
    -GFRで評価すべきと考えられた。  
  • Tohsuke Urabe
    Publications of the Research Institute for Mathematical Sciences
    1984年 20 巻 6 号 1185-1245
    発行日: 1984年
    公開日: 2009/04/24
    ジャーナル フリー
  • H. K. Mahanty
    CYTOLOGIA
    1970年 35 巻 1 号 13-49
    発行日: 1970/03/25
    公開日: 2009/03/19
    ジャーナル フリー
    1. The chromosome numbers of 64 species have been studied on which 56 are investigated for the first time.
    2. Morphological, anatomical and cytological findings on the Musaceae in the broad sense are considered from a phylogenetical standpoint and three distinct groups:
    a) Musa-Ensete,
    b
    ) Ravenala-Strelitzia-Phenakospermum and c) Holiconia are recognised as suggested by some authors. For these groups sub-familial status is proposed.
    3
    . Lowiaceae have been studied for the first time cytologically and their chromosome morphology, distinct from that of any other group of Zingiberales, confirms their claim to familial status.
    4
    . Consideration of the conflicting theories proposed to account for the higher chromosome number in genera like Globba, Alpinia, and Phaemeria, etc. leads to rejection of Chakravorti's hypothesis of wholesale fragmentation of chromosomes and the acceptance of the opposed view of Raghavan and Venkatasubban and others.
    5
    . Holttum's transference of the genus Zingiber to the tribe Hedychieae has been given cytological support on the following points:
    a) the basic number in the genus Zingiber correlates with that of Kaempferia.
    b
    ) the new tribe Alpinieae (which is infact Zingibereae without Zingiber) have consistently 48 chromosomes in their somatic complements.
    6. It is suggested that the African representatives of Kaempferia should be given the status of genus; Cienkowskya on the following points:
    a) the difference in floral morphology
    b
    ) geographical separateness and
    c) the difference in the number and morphology of the chromosomes. By comparing the present and past findings, various lines of evolution of the chromosome complements within each group are discussed.
    7
    . The basic number 11 is considered to be probably the original one for the Zingiberales as a whole, being present in Ravenala which is the most primitive member in the order. From this secondary basic numbers have arisen through evolution.
  • Philippe Biane
    Publications of the Research Institute for Mathematical Sciences
    1995年 31 巻 1 号 63-79
    発行日: 1995年
    公開日: 2009/04/24
    ジャーナル フリー
  • Shingo Nakamura, Tadahiro Hasegawa, Tsubasa Hiraoka, Yoshinori Ochiai, Shin’ichi Yuta
    Journal of Robotics and Mechatronics
    2018年 30 巻 4 号 540-551
    発行日: 2018/08/20
    公開日: 2018/08/20
    ジャーナル オープンアクセス

    The Tsukuba Challenge is a competition, in which autonomous mobile robots run on a route set on a public road under a real environment. Their task includes not only simple running but also finding multiple specific persons at the same time. This study proposes a method that would realize person searching. While many person-searching algorithms use a laser sensor and a camera in combination, our method only uses an omnidirectional camera. The search target is detected using a convolutional neural network (CNN) that performs a classification of the search target. Training a CNN requires a great amount of data for which pseudo images created by composition are used. Our method is implemented in an autonomous mobile robot, and its performance has been verified in the Tsukuba Challenge 2017.

  • 越野 広雪, 吉原 照彦, 研谷 啓, 寺田 俊一, 塚田 聡子, 奥野 美智, 野口 顕, 坂村 貞雄, 市原 耿民, 島貫 忠幸, 但見 明俊, 佐藤 徹
    天然有機化合物討論会講演要旨集
    1989年 31 巻 33
    発行日: 1989/09/17
    公開日: 2017/08/18
    会議録・要旨集 フリー
    Choke disease fungus Epichloe typhina is associated with resistance to leaf spot disease in timothy plants (Phleum pratense). We have proposed the hypothesis that this resistance is caused by antifungal compounds existing in infected plants. We investigated the fungitoxic constituents of the stromata of
    E
    . typhina. Seventy-eight compounds were isolated, including twenty novel sesquiterpenoids chokols (1,2,
    7
    -17,19-21,23-26), five novel oxygenated fatty acids(27-31), gamahonolide A(34) and
    B
    (37), gamahorin(38) and non-fungitoxic chokorin(71) and an anthrasteroid(80). Their structures were determined by spectroscopic methods. The absolute configuration of chokol
    E
    (2) was elucidated by its CD spectrum with Eu(fod)_
    3
    and a chemical correlation with epicyclonerodiol oxide(
    5
    ). Phytol(81), phytyl acetate(
    82
    ) and phytyl palmitate(
    83
    ) were identified as an inducer of aerial hyphae formation of Cladosporium herbarum. Pinoresinol(60) and diosmetin(73) were metabolized in cultures of
    E
    . typhina. Pinoresinol(60) was transformed into C6 norlignan(59) and α-ribofuranoside(
    87
    ). Diosmetin(73) was transformed into
    7
    -O-α-ribofuranoside(
    88
    ). Antifungal activities of the isolated compounds were investigated.
  • Yasuhiro SUGIMOTO, Kazuma SAKATOH
    IEICE Transactions on Electronics
    2013年 E96.C 巻 6 号 867-874
    発行日: 2013/06/01
    公開日: 2013/06/01
    ジャーナル 認証あり
    Circuit techniques to enhance the linearity of input-voltage-to-current (V/I) conversion and to increase the output impedance of a current source by compensating for the low intrinsic gain of a transistor were introduced to realize a high-frequency operational transconductance amplifier (OTA) for a low supply voltage using sub-100-nm CMOS processes. Applying these techniques, a MOS
    7
    th-order Gm-C linear-phase low-pass filter (LPF) was realized using a 65nm CMOS process. A simplified biquad LPF that can serve as a component of a
    7
    th-order LPF was newly developed by replacing OTAs with resistors. As a result, the -
    3
    dB frequency bandwidth, group delay ripple,
    3
    rd-order distortion, and
    3
    rd-order input intercept point (IIP
    3
    ) were 200MHz, 2.2%, ≤ -55dB with a 100MHz input, and +10.
    3
    dBm, respectively, all with a ±0.1Vp-p input signal at each input terminal in the pseudodifferential configuration. The LPF including an output buffer dissipated 60mW in the case of a 1.2V supply. Wide spurious-free dynamic range (SFDR) characteristics were confirmed up to high frequencies.
  • 膵臓
    2007年 22 巻 1 号 e350-e352
    発行日: 2007年
    公開日: 2007/03/27
    ジャーナル フリー
  • M. L. GHOSH
    Journal of Physics of the Earth
    1972年 20 巻 2 号 165-186
    発行日: 1972年
    公開日: 2009/04/30
    ジャーナル フリー
    The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.
  • 川又 紀彦, 渡部 良平
    臨床血液
    2019年 60 巻 7 号 767-772
    発行日: 2019年
    公開日: 2019/08/06
    ジャーナル 認証あり

    BCR-ABL1 International Scale(IS)測定はチロシンキナーゼ阻害剤で治療されている慢性骨髄性白血病(CML)患者の治療効果をモニターする上で重要な検査法である。稀ではあるが,BCR-ABL1 IS測定ができないCMLが存在することが知られている。本研究において,我々は,そのようなBCR-ABL1 IS測定のできないCML患者を経験し,分子生物学的な方法で,その原因を解明した。本例ではABL1遺伝子における切断点がa2エクソン内にあることが分かり,そのことがABL1のa2エクソンを欠いた

    e
    14a
    3
    b
    3
    a
    3
    )キメラ遺伝子のmRNAのみの発現を誘導していた。a2エクソンは本邦における検査部でのIS測定において重要な要素であり,これが欠損することが測定不能の原因であった。このようなIS測定ができない稀なCML症例をさらに集積して,その分子構造を解明することが待たれる。

feedback
Top