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  • 大澤 康次, 幡野 恵, 西宮 一尋, 岡崎 彬, 太田 真一, 宇田 文昭, 柳田 由紀, 檜垣 洋子, 吉田 知江里
    薬物動態
    1988年 3 巻 4 号 441-446
    発行日: 1988年
    公開日: 2007/03/29
    ジャーナル フリー
    ラットに
    3H
    -CU-
    83
    (S)を25μg/kgで静脈内あるいは経口投与し,血液中濃度および尿糞中排泄を検討した.
    静脈内投与後の血液中濃度推移は投与後5分より上昇し,投与後45分に25.74ng eq./mlのCmaxを示し,それ以後t1/2
    3
    .05時間とt1/2 33.09時間の二相で減少した.投与後72時間までのAUCは135.42ng eq.·hr/mlであった.
    経口投与では,投与後
    3
    時間でCmax 4.10ng eq./mlに達し,以後t1/2α 4.46時間とt1/2β 26.
    83
    時間の二相で減少した.投与後72時間までのAUCは48.62ng eq.·hr/mlであった.
    静脈内投与と経口投与のいずれの場合も,尿および糞中への放射能の排泄は,投与後48時間でほぼ終了した.静脈内投与では,投与後72時間までに投与量の30.52%が尿中に,60.42%が糞中に排泄された.経口投与では,同じく72時間までに40.34%が尿中に,69.24%が糞中に排泄された.
  • 西日本皮膚科
    2021年 83 巻 3 号 Index3_1-Index3_2
    発行日: 2021/06/01
    公開日: 2021/07/22
    ジャーナル 認証あり
  • C. M. Hall, T. Aso
    Earth, Planets and Space
    2000年 52 巻 9 号 639-643
    発行日: 2000年
    公開日: 2010/03/09
    ジャーナル フリー
    The EISCAT Svalbard Radar (ESR) has been used to obtain ion velocities in the lower thermosphere. By using beam swinging and assuming homogeneity and stationarity of the plasma, first approximations to the electric field have been deduced, and thus the thermospheric neutral wind has been estimated. From these derived parameters, we have estimated the gradient Richardson Number. Although many assumptions must be made, there is an indication that electrodynamics is able to contribute to enhancement or even production of neutral-air turbulence in the lower thermosphere. Finally, we outline a proposal for an analogy to the Reynolds Number, but reflecting the relative importance's of the contribution of ion-drag to the neutral dynamics and the kinematic viscosity.
  • 梶谷 剛, 川瀬 智博, 山田 和芳, 平林 真
    日本金属学会誌
    1986年 50 巻 9 号 769-777
    発行日: 1986年
    公開日: 2008/04/04
    ジャーナル フリー
    A structure analysis of
    Ti5Si3D0.9
    has been carried out to determine the deuterium trap sites by neutron powder diffraction with the Rietveld profile analysis. It is revealed that the deuterium atoms are located at octahedral (
    2b
    ) sites surrounded by six Ti atoms in the crystal structure of
    Ti5Si3D0.9
    , space group P63/mcm. Local vibration spectra of hydrogen in
    Ti5Si3H0.83
    measured by neutron inelastic scattering support this result; the energy eigenvalue of the primary vibration mode is found at 7.53 kJ/mol (78 meV). The hole radius and the spring constant of the Ti-H(D) bond are discussed.
  • 山口 昭彦
    日本中東学会年報
    1994年 9 巻 37-65
    発行日: 1994/03/31
    公開日: 2018/03/30
    ジャーナル フリー
    L'entree en Iran des armees britannique et sovietique s'est produite en aout 1941. Elle ebranla du coup le regime de la dynastie pahlavi qui etait au pouvoir depuis 16 ans, et mena le pays vers l'instabilite politique et le chaos social. La defaite de l'arme gouvernementale, qui etait le pivot du regime de Reza Shah, reduisit considerablement le controle du gouvernement central dans le pays. Cette situation politico-sociale confuse permit le developpement de differents mouvements politiques en Iran. C'est ainsi que le 16 aout 1942 le parti clandestin Komeley Jiyanewey Kurdistan (J-K) est ne a Mehabad, une ville au nord-ouest de l' Iran. Des sa formation, ce parti a su etendre sa sphere d'activite et, en une courte periode de temps, a fini par mettre sous son influence la ville et ses alentours. A la fin de la Seconde Guerre mondiale, en ete 1945, le J-K etait devenu une organisation representant le mouvement nationaliste kurde en Iran. C'est a ce moment-la qu'un autre parti politique, le Hizbi Dimokratiki Kurdistan (HDK), fonde par Qazi Mihemed a Mehabad aussi, devait remplacer le J-K. Des le
    22
    janvier 1946, le HDK proclama l'instauration de la≪Republique de Kurdistan≫. Cependant, les troupes sovietiques qui avaient pris sous leur protection la Republique evacuerent les terres iraniennes, en mai 1946. Six mois plus tard, sous la pression militaire du gouvernement central iranien, la republique s'ecroula. Deux theories tentent d'expliquer le passage du J-K au HDK. William Eagleton Jr., par exemple, affirme dans The Kurdish Republic of 1946 que le HDK a ete cree sur le conseil des autorites sovietiques. L'ex-secretaire general du Parti Democratique du Kurdistan d'Iran, 'Ebd el-Rehman Qasimlu maintient par contre que Qazi Mihemed a etabli le nouveau parti de sa propre initiative, eu regard a la situation politique de cette epoque-la. Il considere que la passage du J-K au HDK comme etant l'evolution d'un parti nationaliste clandestin en un parti democratique. En analysant ces deux theories et en se basant sur les autobiographies des personages qui se sont engages dans cet evenement, cette etude tentera d'examiner le principe directeur et les activites du J-K et de mieux comprendre les raisons pour lesquelles le J-K devait etre remplace par le HDK. La conclusion generale portera sur les differents objectifs politiques du J-K et du HDK. Le J-K visait l'elevation du niveau culturel du peuple tout en luttant contre le tribalisme, qui etait, selon lui, le probleme majeur de≪la nation kurde≫, et cela en ecartant toute idee de revolte militaire. Le J-K a aussi exclu de son cadre les elites sociales telles que les leaders des tribus et dirigeants religieux de peur qu'ils n'excercent une influence sur les membres du parti. L'automne de 1944 fut le debut d'une nouvelle ere pour le mouvement kurde. Alors que l'espoir de l'autodetermination augmentait parmi le peuple a mesure que s'approchait la fin de la guerre, la necessite de la force militaire a commence a se faire sentir dans le J-K. C'est pour cela que s'est produite au sein du parti une tendance a compter sur l'aide militaire des sovietiques et a recourir au leadership de Qazi Mihemed, qui avait une certaine influence meme sur les leaders tribaux. Mais cette tendance etait essentiellement incompatible avec la ligne fondamentale du J-K et, graduellement, a prive ce parti de sa raison d'etre. Ainsi, le HDK se substitua au J-K en tant que≪parti democratique≫visant a rallier d'abord les elites sociales sous sa banniere, en s'appuyant sur l'autorite personnelle de Qazi Mihemed.
  • 日本水産学会誌
    2017年 83 巻 4 号 727-729
    発行日: 2017年
    公開日: 2017/08/07
    ジャーナル フリー
  • 石畝 史, 東方 美保, 山崎 貢, 松雪 星子, 森屋 一雄, 田中 大祐, 磯部 順子, 京田 芳人, 村岡 道夫
    感染症学雑誌
    2006年 80 巻 5 号 507-512
    発行日: 2006/09/20
    公開日: 2011/02/07
    ジャーナル フリー
    1991年~2005年の福井県など4県における散発下痢症患者由来の大腸菌0153107株について, 市販の薬剤感受性ディスクを用いたKB (Kirby-Bauer) 法で12剤の薬剤感受性を調べた. 薬剤別耐性菌出現率はampicillinが72.9%, streptomycinが48.6%, tetracyclinおよびsulfisoxazoleが46.7%, nalidixic acid (NA) が29.9%およびciprofloxacin (CPFX) が24.
    3
    %などであった. 7~10剤に耐性を示す18株中16株など計26株が, NAおよびCPFXに耐性を示した. NAおよびCPFXに耐性を示した24株とNAに耐性を示した1株について, gyrAおよびparC遺伝子の解析を行った結果, 次の4typesに分けられた. type1 (1株) GyrA (S
    83
    L) ・ParC (S80I), type2 (12株) GyrA (S
    83
    L & D
    87
    N) ・ParC (S80I), type
    3
    (
    8
    株) GyrA (S
    83
    L & D
    87
    N) ・ParC (S80I &
    E
    84
    G) または (S80R &
    E
    84
    V), type4 (4株) GyrA (S
    83
    L & D
    87
    N) ・ParC (S80I & A108T). アミノ酸変異とfluoroquinolone (FQ) 系薬剤の最小発育阻止濃度 (MIC) との関連をみると, CPFX, ofioxacinおよびnorfloxacinのMICはtype1では, それぞれ1μg/mL, 2μg/mLおよび
    8
    μg/mL, type2では
    8
    ~32μg/mL,
    8
    ~32μg/mLおよび16~256μg/mL, type
    3
    , 4では32~256μg/mL, 32~128μg/mLおよび128~>512μg/mLであった. 患者由来のFQ系剤耐性大腸菌O153が多剤耐性傾向を示すとともに, gyrAおよびparCで各々1~2カ所の変異がみられた.
  • 高木 徹, 林 賢治, 板橋 豊
    日本水産学会誌
    1984年 50 巻 8 号 1413-1418
    発行日: 1984/08/25
    公開日: 2008/02/29
    ジャーナル フリー
    The acetone extracts from three samples of the hepatopancreas of the poisonous scallops obtained on the Okhotsk Coast of Hokkaido Island were fractionated into two parts, hexane soluble fraction (fraction H) and 85% aqueous ethanol soluble fraction (fraction
    E
    ) by partition to two layers. The majortoxic components in the mouse assay of “diarrheic shellfish toxin” by intra-peritoneal injection were found to be free unsaturated fatty acids showed the following toxicity in MU per g, 18:1 n-9 35, 18:2 n-6
    83
    , 18:
    3
    n-
    3
    167, 18:4 n-
    3
    83
    , 20:5 n-
    3
    167, and
    22
    :6 n-
    3
    83
    , respectively. Toxicity of the fraction Hin MUper g was much lower than that of the fraction
    E
    . However, the toxicity of the fraction H per 1 g of the hepatopancreas was about twice that of the fraction
    E
    , since the fraction Hwas much more abundant than the fraction
    E
    in the hepatopancreas. The method for the assay of the diarrhetic shellfish toxin must be reexamined by considering the toxic effect of the free unsaturated fatty acids.
  • E. camaldulensis, E. globulus における容積重, および材形質含量の樹幹内変異と標準値を示す位置について
    小名 俊博, 園田 哲也, 伊藤 一弥, 柴田 勝
    紙パ技協誌
    1995年 49 巻 8 号 1227-1234
    発行日: 1995/08/01
    公開日: 2009/11/16
    ジャーナル フリー
    Within-tree variations, whole-tree values and the representative heights for the whole tree value of basic density, and contents of wood components per volume were analysed for two trees of Eucalyptus camaldulensis and
    E
    . globulus
    respectively, grown at the seed orchard in Western Australia to do quality breeding.
    Within-tree variation of
    E
    . camaldulensis
    was rather uniform as 500±40, 532 ±34 kg/
    m3
    , but that of
    E
    . globulus
    was large as 595 ± 69, 616 ± 79 kg/
    m3
    and the basic density was higher in bark side and upper part in the trunk, to be expected to have higher pulp productivity.
    The whole-tree values of
    E
    . camaldulensis
    were 501, 520 kg/
    m3
    and those of
    E
    . globulus
    were 594, 640 kg/
    m3
    and the difference of the species was observed.
    Representative heights for the whole-tree contents ±5 % were
    0
    .32.
    8
    m on
    E
    . camaldulensis
    , and
    0
    .
    8
    and 2.
    8
    m on
    E
    . globulus
    regardless the differences in the whole-tree height and the within-tree variation when they were chosen below
    3
    .
    3
    m height for sampling an increment core.
    Representative heights were also determined for contents of wood components per volume as follows ; for
    E
    . camaldulensis
    , holocellulose : 1.
    3
    , 2.
    8
    m, cellulose : 2.
    83
    .
    3
    m, hemicellulose :
    0
    .82.
    8
    m, lignin :
    0
    .81.
    3
    , 2.
    8
    m, extractives : 2.
    3
    m, alkali-extractives : 1.
    3
    m, and total-extractives : 2.32.
    8
    m, for
    E
    . globulus
    , 2.
    8
    m, 2.32.
    8
    m, 2.
    8
    m,
    0
    .30.
    8
    m, 2.
    83
    .
    3
    m, 2.
    83
    .
    3
    m and 2.
    8
    m in the same manner.
    It is expected that whole-tree pulp properties including pulp productivity are predicted by the increment core taken from these representative heights.
  • 川又 紀彦, 渡部 良平
    臨床血液
    2019年 60 巻 7 号 767-772
    発行日: 2019年
    公開日: 2019/08/06
    ジャーナル 認証あり

    BCR-ABL1 International Scale(IS)測定はチロシンキナーゼ阻害剤で治療されている慢性骨髄性白血病(CML)患者の治療効果をモニターする上で重要な検査法である。稀ではあるが,BCR-ABL1 IS測定ができないCMLが存在することが知られている。本研究において,我々は,そのようなBCR-ABL1 IS測定のできないCML患者を経験し,分子生物学的な方法で,その原因を解明した。本例ではABL1遺伝子における切断点がa2エクソン内にあることが分かり,そのことがABL1のa2エクソンを欠いた

    e
    14a
    3
    b
    3
    a
    3
    )キメラ遺伝子のmRNAのみの発現を誘導していた。a2エクソンは本邦における検査部でのIS測定において重要な要素であり,これが欠損することが測定不能の原因であった。このようなIS測定ができない稀なCML症例をさらに集積して,その分子構造を解明することが待たれる。

  • Yosizo YAMAMOTO
    Nippon Sugaku-Buturigakkwai Kizi Dai
    3
    Ki

    1940年 22 巻 12 号 1048-1052
    発行日: 1940年
    公開日: 2009/06/09
    ジャーナル フリー
    The numerical values of the intervals betrween optieal levels are competed for the configurations
    1s22s22p83s23p83
    *94s, 5s, 6s and 7s of Cu+, according to the general expression of energy-levels derived in the previous paper The self-consistent field radial functions computed by Hartree adn Hartree are used for1s, 2s, 2p,
    3
    s,
    3
    p and
    3
    d. Those of 4s, 5s,
    e
    .s and are ealenlated from Hartree Hartree's core-functions by the numerical integrations. The calculated results are shown in Table I.The agreement with experiment is satisfactory
  • 植物研究雑誌
    2008年 83 巻 3 号 論文ID: 83_3_10043
    発行日: 2008/06/20
    公開日: 2022/10/20
    ジャーナル フリー
  • Akimi Oono, Takafumi Miyanaga, Takeshi Kubota
    e
    -Journal of Surface Science and Nanotechnology

    2012年 10 巻 651-654
    発行日: 2012/12/15
    公開日: 2012/12/15
    ジャーナル フリー
    We investigated the local structure changes of
    Fe83.3Si4B8P4Cu0.7
    nanocrystalline alloy prepared by arc melting with various annealing conditions by XAFS. It was found that individual structural changes occur around each element (Fe, Si, P, Cu) by several annealing steps. The as-spun sample shows amorphous like structure. The Fe and Si phase crystallize by annealing at first transition temperature (693 K). On the other hand the local structure around Cu and P atoms changed by two steps at 693 K and 823 K. In order to examine the structure more detail, the XANES comparison and the curve fitting method for EXAFS were performed. The Cu atoms were embedded in bcc Fe phase between the first and second transition temperatures and changes to fcc Cu phase over 823 K. It was suggested that α-Fe phase including the isolated Cu atoms can be easily crystallized and shows the high magnetic performance. [DOI: 10.1380/ejssnt.2012.651]
  • H. K. Mahanty
    CYTOLOGIA
    1970年 35 巻 1 号 13-49
    発行日: 1970/03/25
    公開日: 2009/03/19
    ジャーナル フリー
    1. The chromosome numbers of 64 species have been studied on which 56 are investigated for the first time.
    2. Morphological, anatomical and cytological findings on the Musaceae in the broad sense are considered from a phylogenetical standpoint and three distinct groups:
    a) Musa-Ensete,
    b
    ) Ravenala-Strelitzia-Phenakospermum and c) Holiconia are recognised as suggested by some authors. For these groups sub-familial status is proposed.
    3
    . Lowiaceae have been studied for the first time cytologically and their chromosome morphology, distinct from that of any other group of Zingiberales, confirms their claim to familial status.
    4. Consideration of the conflicting theories proposed to account for the higher chromosome number in genera like Globba, Alpinia, and Phaemeria, etc. leads to rejection of Chakravorti's hypothesis of wholesale fragmentation of chromosomes and the acceptance of the opposed view of Raghavan and Venkatasubban and others.
    5. Holttum's transference of the genus Zingiber to the tribe Hedychieae has been given cytological support on the following points:
    a) the basic number in the genus Zingiber correlates with that of Kaempferia.
    b
    ) the new tribe Alpinieae (which is infact Zingibereae without Zingiber) have consistently 48 chromosomes in their somatic complements.
    6. It is suggested that the African representatives of Kaempferia should be given the status of genus; Cienkowskya on the following points:
    a) the difference in floral morphology
    b
    ) geographical separateness and
    c) the difference in the number and morphology of the chromosomes. By comparing the present and past findings, various lines of evolution of the chromosome complements within each group are discussed.
    7. The basic number 11 is considered to be probably the original one for the Zingiberales as a whole, being present in Ravenala which is the most primitive member in the order. From this secondary basic numbers have arisen through evolution.
  • Daria Kurguzova, Svetlana Serebrova, Alexey Prokofiev, Ludmila Krasnykh, Galina Vasilenko, Marina Zhuravleva, Elena Smolyarchuk, Anton Barkov
    日本薬理学会年会要旨集
    2018年 WCP2018 巻 WCP2018_PO3-5-27
    発行日: 2018年
    公開日: 2020/09/10
    会議録・要旨集 オープンアクセス

    Background

    The differences in conditions of enteric-coated acid-labile drug release and absorption between healthy subjects in bioequivalence studies and gastrointestinal patients in clinical practice can lead to significant differences in gastric stability of original PPIs and generics. Thus, pathologic duodenogastric reflux (PDGR) and the pH increasing within PPIs administration still remain unaccounted for.

    Methods

    Two-stage modified comparative dissolution testing of original omeprazole (OO) and four generics (G1;2;

    3
    ;4) was performed. At first, we moved drugs from solution with pH 1.2 (1.2±
    0
    .05) to pH 7.
    0
    (7.
    0
    ±
    0
    .05) and measure concentration of omeprazole in solution by high-performance liquid chromatography. According to our self-developed formula, pH 7 exposure time of resistance to PDGR for omeprazole is 4 minutes, i.
    e
    . the active substance should not be released within 4 minutes at pH 7. The exposure at the second stage was conducted with pH 4 (4.
    0
    ±
    0
    .05), that imitated gastric pH after PPI administration. And then we also moved drugs to pH 7 with the subsequent measurement of omeprazole concentration.

    Results

    Omeprazole concentrations after 4, 10, 15, 20, 30, 45, 60 minutes in pH 7 solution at the first stage were different for OO and generics. For OO, these values were 4,7±

    0
    ,7%; 41,4±
    3
    ,
    0
    %; 62,
    8
    ±4,
    0
    %; 79,5±2,9%;
    83
    ,5±2,9%; 81,6±2,9%; 80,6±4,4%; for Generic1 -
    0
    ; 49,
    3
    ±9,9%; 88,
    8
    ±2,
    8
    %; 90,4±
    3
    ,7%; 88, 2±2,2%;
    87
    ,
    3
    ±2,
    0
    %; 85,9±1,1%; for Generic2 -
    0
    ; 30,6±6,
    3
    %; 66,7±
    8
    ,2%; 76,4±7,4%; 82,
    8
    ±5,
    3
    %; 86,
    0
    ±
    3
    ,7%;
    84
    ,6±
    3
    ,
    3
    %: for Generic
    3
    - 80,
    8
    ±
    3
    ,6%;
    83
    ,5±1,9%;
    83
    ,
    8
    ±
    3
    ,2%;
    83
    ,
    3
    ±2,7%; 81,9±2,1%; 82,1±2,
    0
    %; 82,
    0
    ±2,4%; for Generic4 - 82,5±1,7%;
    84
    ,4±
    0
    ,
    8
    %;
    84
    ,2±1,2%; 82, 9±
    0
    ,9%; 82,9±
    0
    ,9%; 82,9±
    0
    ,9%; 82,
    8
    ±1,1%, respectively.

    An analysis of the omeprazole concentration in pH 7 solution at the second stage revealed the following parameters after the same time: for OO - 4,4±

    0
    ,6%; 40, 5±
    3
    ,
    0
    %; 62,
    8
    ±2,
    0
    %; 80,
    0
    ±
    3
    ,1%; 85,4±2,9%; 82,
    8
    ±
    3
    ,4%; 80,9±
    3
    ,5%; for Generic1 -
    0
    ; 67,
    0
    ±7,
    8
    %; 89,7±2,
    3
    %;
    91
    , 9±4,
    3
    %; 89,1±1,6%; 88,
    3
    ±1,4%;
    87
    ,
    8
    ±1,2%; for Generic2 -
    0
    ; 42,2±5,6%; 75,1±7,
    3
    %; 81,
    0
    ±6,
    0
    %; 88,4±
    3
    ,2%; 88, 6±1,
    3
    %;
    87
    ,9±1,
    0
    %; for Generic4 - 85,5±
    0
    ,5%; 85,6±
    0
    ,5%;
    84
    ,7±
    0
    ,9%; 82,7±
    3
    ,
    0
    %;
    84
    ,4±
    0
    ,
    3
    %;
    84
    ,4±
    0
    ,
    3
    %;
    84
    ,
    3
    ±
    0
    ,4%, respectively. Generic
    3
    release and degradation were completely realized at pH 4.

    Conclusion

    Decreased gastric stability of Generic

    3
    and Generic4 makes PDGR and inhibited gastric acid secretion due to PPIs administration the potential causes of decreased enteric-coated acid-labile drugs stability.

  • 横山 晶, 木滑 孝一, 栗田 雄三
    気管支学
    1986年 8 巻 Special 号 104-
    発行日: 1986/07/15
    公開日: 2016/09/15
    ジャーナル フリー
  • Martin Ohlson, Muni S. Srivastava
    JOURNAL OF THE JAPAN STATISTICAL SOCIETY
    2010年 40 巻 1 号 001-021
    発行日: 2010/11/12
    公開日: 2011/05/12
    ジャーナル フリー
    In this paper, we consider profile analysis of several groups where the groups have partly equal means. This leads to a profile analysis for a growth curve model. The likelihood ratio statistics are given for the three hypotheses known in literature as parallelism, level hypothesis and flatness. Furthermore, exact and asymptotic distributions are given in the relevant cases.
  • Philippe Biane
    Publications of the Research Institute for Mathematical Sciences
    1995年 31 巻 1 号 63-79
    発行日: 1995年
    公開日: 2009/04/24
    ジャーナル フリー
  • Tsuyoshi Kajitani, Tomohiro Kawase, Kazuyoshi Yamada, Makoto Hirabayashi
    Transactions of the Japan Institute of Metals
    1986年 27 巻 9 号 639-647
    発行日: 1986年
    公開日: 2007/06/01
    ジャーナル フリー
    A structure analysis of
    Ti5Si3D0.9
    has been carried out to determine the deuterium trap sites by neutron powder diffraction with the Rietveld profile analysis. It is revealed that the deuterium atoms are located at octahedral (2
    b
    ) sites surrounded by six Ti atoms in the crystal structure of
    Ti5Si3D0.9
    , space group P63/mcm. Local vibration spectrum of hydrogen in
    Ti5Si3H0.83
    measured by neutron inelastic scattering supports this result; the energy eigenvalue of the primary vibration mode is found at 7.53 kJ/mol (78 meV). The hole radius and the spring constant of the Ti–H(D) bond are discussed.
  • 日本水産学会誌
    2017年 83 巻 3 号 436-437
    発行日: 2017年
    公開日: 2017/05/22
    ジャーナル フリー
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