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  • 大澤 康次, 幡野 恵, 西宮 一尋, 岡崎 彬, 太田 真一, 宇田 文昭, 柳田 由紀, 檜垣 洋子, 吉田 知江里
    薬物動態
    1988年 3 巻 4 号 441-446
    発行日: 1988年
    公開日: 2007/03/29
    ジャーナル フリー
    ラットに
    3H
    -CU-
    83
    (S)を25μg/kgで静脈内あるいは経口投与し,血液中濃度および尿糞中排泄を検討した.
    静脈内投与後の血液中濃度推移は投与後
    5
    分より上昇し,投与後45分に25.74ng eq./mlのCmaxを示し,それ以後t1/2
    3
    .05時間とt1/2 33.09時間の二相で減少した.投与後72時間までのAUCは135.42ng eq.·hr/mlであった.
    経口投与では,投与後
    3
    時間でCmax 4.10ng eq./mlに達し,以後t1/2α 4.46時間とt1/2β 26.
    83
    時間の二相で減少した.投与後72時間までのAUCは48.62ng eq.·hr/mlであった.
    静脈内投与と経口投与のいずれの場合も,尿および糞中への放射能の排泄は,投与後48時間でほぼ終了した.静脈内投与では,投与後72時間までに投与量の30.52%が尿中に,60.42%が糞中に排泄された.経口投与では,同じく72時間までに40.34%が尿中に,69.24%が糞中に排泄された.
  • Yosizo YAMAMOTO
    Nippon Sugaku-Buturigakkwai Kizi Dai
    3
    Ki

    1940年 22 巻 12 号 1048-1052
    発行日: 1940年
    公開日: 2009/06/09
    ジャーナル フリー
    The numerical values of the intervals betrween optieal levels are competed for the configurations
    1s22s22p83s23p83
    *94s,
    5
    s, 6s and
    7
    s of Cu+, according to the general expression of energy-levels derived in the previous paper The self-consistent field radial functions computed by Hartree adn Hartree are used for1s, 2s, 2p,
    3
    s,
    3
    p and
    3
    d
    . Those of 4s,
    5
    s,
    e
    .s and are ealenlated from Hartree Hartree's core-functions by the numerical integrations. The calculated results are shown in Table I.The agreement with experiment is satisfactory
  • E. camaldulensis, E. globulus における容積重, および材形質含量の樹幹内変異と標準値を示す位置について
    小名 俊博, 園田 哲也, 伊藤 一弥, 柴田 勝
    紙パ技協誌
    1995年 49 巻 8 号 1227-1234
    発行日: 1995/08/01
    公開日: 2009/11/16
    ジャーナル フリー
    Within-tree variations, whole-tree values and the representative heights for the whole tree value of basic density, and contents of wood components per volume were analysed for two trees of Eucalyptus camaldulensis and
    E
    . globulus
    respectively, grown at the seed orchard in Western Australia to do quality breeding.
    Within-tree variation of
    E
    . camaldulensis
    was rather uniform as 500±40, 532 ±34 kg/
    m3
    , but that of
    E
    . globulus
    was large as 595 ± 69, 616 ± 79 kg/
    m3
    and the basic density was higher in bark side and upper part in the trunk, to be expected to have higher pulp productivity.
    The whole-tree values of
    E
    . camaldulensis
    were 501, 520 kg/
    m3
    and those of
    E
    . globulus
    were 594, 640 kg/
    m3
    and the difference of the species was observed.
    Representative heights for the whole-tree contents ±
    5
    % were 0.32.
    8
    m on
    E
    . camaldulensis
    , and 0.
    8
    and 2.
    8
    m on
    E
    . globulus
    regardless the differences in the whole-tree height and the within-tree variation when they were chosen below
    3
    .
    3
    m height for sampling an increment core.
    Representative heights were also determined for contents of wood components per volume as follows ; for
    E
    . camaldulensis
    , holocellulose : 1.
    3
    , 2.
    8
    m, cellulose : 2.
    83
    .
    3
    m, hemicellulose : 0.82.
    8
    m, lignin : 0.81.
    3
    , 2.
    8
    m, extractives : 2.
    3
    m, alkali-extractives : 1.
    3
    m, and total-extractives : 2.32.
    8
    m, for
    E
    . globulus
    , 2.
    8
    m, 2.32.
    8
    m, 2.
    8
    m, 0.30.
    8
    m, 2.
    83
    .
    3
    m, 2.
    83
    .
    3
    m and 2.
    8
    m in the same manner.
    It is expected that whole-tree pulp properties including pulp productivity are predicted by the increment core taken from these representative heights.
  • 高木 徹, 林 賢治, 板橋 豊
    日本水産学会誌
    1984年 50 巻 8 号 1413-1418
    発行日: 1984/08/25
    公開日: 2008/02/29
    ジャーナル フリー
    The acetone extracts from three samples of the hepatopancreas of the poisonous scallops obtained on the Okhotsk Coast of Hokkaido Island were fractionated into two parts, hexane soluble fraction (fraction H) and 85% aqueous ethanol soluble fraction (fraction
    E
    ) by partition to two layers. The majortoxic components in the mouse assay of “diarrheic shellfish toxin” by intra-peritoneal injection were found to be free unsaturated fatty acids showed the following toxicity in MU per g, 18:1 n-9 35, 18:2 n-6
    83
    , 18:
    3
    n-
    3
    167, 18:4 n-
    3
    83
    , 20:
    5
    n-
    3
    167, and
    22
    :6 n-
    3
    83
    , respectively. Toxicity of the fraction Hin MUper g was much lower than that of the fraction
    E
    . However, the toxicity of the fraction H per 1 g of the hepatopancreas was about twice that of the fraction
    E
    , since the fraction Hwas much more abundant than the fraction
    E
    in the hepatopancreas. The method for the assay of the diarrhetic shellfish toxin must be reexamined by considering the toxic effect of the free unsaturated fatty acids.
  • Keishi Hata, Fuyuki Sugawara, Naganori Ohisa, Saori Takahashi, Kazuyuki Hori
    Biological and Pharmaceutical Bulletin
    2002年 25 巻 8 号 1040-1044
    発行日: 2002年
    公開日: 2002/08/01
    ジャーナル フリー
    We screened the differentiation-inducing activities of 39 mushroom extracts from Akita prefecture, Japan, on the mouse osteoblastic cell line, MC
    3
    T
    3
    -
    E
    1. Sixteen phosphate buffered saline (PBS),
    8
    boiled PBS, 14 ethanol and 12 methanol extracts induced alkaline phosphatase (ALP) activities, an indicator of MC
    3
    T
    3
    -
    E
    1 cell differentiation. The enzyme activities were markedly induced by extracts of Tricholoma auratum, and we isolated the active compound from methanol extracts of this mushroom. Physical data for the isolated active compound were identical to those for (
    22E
    ,24R)-ergosta-
    7
    ,
    22
    -diene-
    ,
    ,6β-triol (1). 1 induced ALP activities of MC
    3
    T
    3
    -
    E
    1 cells and promoted cell proliferation. To investigate the relationships between the chemical structure and differentiation-inducing activity of the compound, ALP-inducing activities of MC
    3
    T
    3
    -
    E
    1 cells by 1, ergosterol (2), ergocalciferol (
    3
    ), cholesta-
    ,
    ,6β-triol (4),
    7
    -dehydrocholesterol (
    5
    ) and cholecalciferol (6) were tested. The enzyme activities of MC
    3
    T
    3
    -
    E
    1 cells were increased
    3
    .0-fold by 10 μM 1 and 2.4-fold by 10 μM 4. However, 2,
    3
    ,
    5
    and 6 did not induce MC
    3
    T
    3
    -
    E
    1 cell ALP activity at 0.1—10 μM. These results suggested that the OH groups at C-
    5
    and/or C-6 of 1 and 4 played an important role in their differentiation-inducing activities on MC
    3
    T
    3
    -
    E
    1 cells. Furthermore, 1 suppressed induction of MC
    3
    T
    3
    -
    E
    1 cell apoptosis by serum starvation.
  • EMIL BUCHTA, Dieter Kiessling
    International Symposium on the Chemistry of Natural Products
    1964年 1964 巻 E-8-3
    発行日: 1964/04/12
    公開日: 2017/08/18
    会議録・要旨集 フリー
  • Kenji FUKUZAWA, Aya OUCHI, Shin-ichi NAGAOKA, Akira SHIBATA, Kazuo MUKAI
    Journal of Nutritional Science and Vitaminology
    2014年 60 巻 6 号 443-446
    発行日: 2014年
    公開日: 2015/04/06
    ジャーナル フリー
    Vitamin
    E
    is localized in membranes and functions as an efficient inhibitor of lipid peroxidation in biological systems. In this study, we measured the second-order rate constants (ks) for the reaction of tocotrienol homologues (α-, β-, γ-, and δ-Toc-
    3
    Hs) with the aroxyl radical (ArO•) used as a model for lipid peroxyl radicals (LOO•) in the membranes of egg yolk phosphatidylcholine (EYPC) vesicles by stopped-flow spectrophotometry, and compared them to those of tocopherol homologues (α-, β-, γ-, and δ-TocHs). The relative rate constants of Toc-
    3
    H homologues to α-Toc-
    3
    H in membranes (α/β/γ/δ=100/
    83
    .
    7
    /63.2/20.2) were not much different to those of TocH homologues to α-TocH (α/β/γ/δ=100/
    88
    .4/
    83
    .
    8
    /17.
    3
    ). Each ks value of Toc-
    3
    H homologues in membranes was 60-80% of that of the corresponding TocH homologues except for the almost identical ks values of δ-homologues, but there was no difference in EtOH solution between each ks value of the corresponding homologues of Toc-
    3
    H and TocH. These results indicate that the difference of the alkyl-side chain structure of vitamin
    E
    causes a change in the mobility of vitamin
    E
    molecules and/or the location of their antioxidant OH-groups in membranes, resulting in lowered radical-trapping rates of Toc-
    3
    Hs. By use of the ratio of the kinh value of α-TocH with LOO• (
    3
    .20×106 M1s1) to the ks value of α-TocH with ArO• (
    8
    .05×104 M1s1) in chlorobenzene (that is, 39.
    8
    ), the kinh value for the reaction of α-TocH with LOO• in membrane was estimated to be 1.03×105 M1s1.
  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • 百目鬼 郁男, 中原 達夫, 山内 亮
    家畜繁殖研究會誌
    1974年 20 巻 2 号 76-80
    発行日: 1974/08/30
    公開日: 2008/05/15
    ジャーナル フリー
    性周期における牛の末梢血中遊離estrogen測定にITTRICH螢光法を応用して次の成績を得た。
    Ittrich colorの最大波長をspectrofluorometer Hitachi MPF-2AおよびType203で測定した結果,励起光538nm,螢光552.
    5
    nmであった。この螢光特性は
    E1
    ,
    E2
    および
    E3
    にそれぞれ共通であった。実際の測定では最大波長が接近しているので感度は若干低下するが510~520nmで励起し•螢光側552•
    5
    ±
    22
    5nm
    を読み,ALLENの補正を行なった。この条件において
    E1
    ,
    E2
    および
    E3
    -methyletherの最少検出量は1ngであった。回収率補正の目的で加えた6,
    7
    -
    3H
    -
    E2
    -17βの全過程における回収率は平均60.
    3
    ±11.
    7
    %であった。正常性周期を示す黒毛和種2頭の頸静脈血についてestrogenを分画測定した。その結果,両牛共
    E1
    ,
    E2
    の各消長型は性周期の全期間を通じてほぼ同じ傾向を示したが,
    E2
    E1
    にくらべ全般に高値であった。また
    E3
    は検出されなかった。これらの牛のtotalestrogenは発情前期に増加し,排卵前に鋭いピーク(35.
    3
    および
    99.8ng
    /l;
    E15.9
    および16.0ng/l,
    E229.4
    および
    83.8ng
    /l)を形成し,排卵後は急激に減少して最低値(
    3
    .
    8
    ~
    5.3ng
    /l;
    E11.6
    および1.9ng/l,
    E22.2
    および
    3.4ng
    /l)を示した。黄体期の最高値(10.1および27.0ng/l;
    E12.4
    および
    3.4ng
    /l,
    E27.7
    および23.6ng/l)は排卵後6~
    8
    日に認めた。すなわちestrogenの血中濃度は性周期の間に2つのピークを形成することを認めた。
  • 石畝 史, 東方 美保, 山崎 貢, 松雪 星子, 森屋 一雄, 田中 大祐, 磯部 順子, 京田 芳人, 村岡 道夫
    感染症学雑誌
    2006年 80 巻 5 号 507-512
    発行日: 2006/09/20
    公開日: 2011/02/07
    ジャーナル フリー
    1991年~2005年の福井県など4県における散発下痢症患者由来の大腸菌0153107株について, 市販の薬剤感受性ディスクを用いたKB (Kirby-Bauer) 法で12剤の薬剤感受性を調べた. 薬剤別耐性菌出現率はampicillinが72.9%, streptomycinが48.6%, tetracyclinおよびsulfisoxazoleが46.
    7
    %, nalidixic acid (NA) が29.9%およびciprofloxacin (CPFX) が24.
    3
    %などであった.
    7
    ~10剤に耐性を示す18株中16株など計26株が, NAおよびCPFXに耐性を示した. NAおよびCPFXに耐性を示した24株とNAに耐性を示した1株について, gyrAおよびparC遺伝子の解析を行った結果, 次の4typesに分けられた. type1 (1株) GyrA (S
    83
    L) ・ParC (S80I), type2 (12株) GyrA (S
    83
    L &
    D
    87N) ・ParC (S80I), type
    3
    (
    8
    株) GyrA (S
    83
    L &
    D
    87N) ・ParC (S80I &
    E
    84G) または (S80R &
    E
    84V), type4 (4株) GyrA (S
    83
    L &
    D
    87N) ・ParC (S80I & A108T). アミノ酸変異とfluoroquinolone (FQ) 系薬剤の最小発育阻止濃度 (MIC) との関連をみると, CPFX, ofioxacinおよびnorfloxacinのMICはtype1では, それぞれ1μg/mL, 2μg/mLおよび
    8
    μg/mL, type2では
    8
    ~32μg/mL,
    8
    ~32μg/mLおよび16~256μg/mL, type
    3
    , 4では32~256μg/mL, 32~128μg/mLおよび128~>512μg/mLであった. 患者由来のFQ系剤耐性大腸菌O153が多剤耐性傾向を示すとともに, gyrAおよびparCで各々1~2カ所の変異がみられた.
  • Suk-Kyung LIM, Keum-Gi LIM, Hee-Soo LEE, Suk-Chan JUNG, Mun-Il KANG, Hyang-Mi NAM
    Journal of Veterinary Medical Science
    2010年 72 巻 5 号 611-614
    発行日: 2010年
    公開日: 2010/06/04
    [早期公開] 公開日: 2009/12/15
    ジャーナル フリー
    A total of 176
    E
    . coli
    isolates were retrieved from 203 diarrheic fecal samples collected from Korean cattle on 117 different farms. The most frequently observed resistance in
    E
    . coli
    isolates was to tetracycline (
    88
    .6%), followed by streptomycin (80.
    7
    %) and ampicillin (64.
    8
    %). Resistance to cefazolin, cefoperazone, cefepime and amikacin was very low. Of the 176
    E
    . coli
    strains, forty (
    22
    .
    7
    %) isolates from 30 farms showed resistance to fluoroquinolones (FQ). All the FQ-resistant strains possessed double mutations at codons
    83
    and 87 in the gyrA gene, and a single mutation mostly at codon 80 in the parC gene, except in one isolate. The pulsed-field gel electrophoresis profiles of the FQ-resistant
    E
    . coli
    isolates were heterogeneous, but two or three isolates that showed an identical pattern originated from the same or different farms. This study demonstrates that FQ resistance is frequently observed in
    E
    . coli
    from diarrheic cattle and that mutations in the quinolone resistance-determining region are the same as those seen in
    E
    . coli
    originating from other animal species and humans. The FQ resistance in diarrheic cattle might have been mostly acquired independently, although the possibility of transmission of FQ-resistant
    E
    . coli
    within a farm or between farms is plausible.
  • 梶谷 剛, 川瀬 智博, 山田 和芳, 平林 真
    日本金属学会誌
    1986年 50 巻 9 号 769-777
    発行日: 1986年
    公開日: 2008/04/04
    ジャーナル フリー
    A structure analysis of
    Ti5Si3D0.9
    has been carried out to determine the deuterium trap sites by neutron powder diffraction with the Rietveld profile analysis. It is revealed that the deuterium atoms are located at octahedral (
    2b
    ) sites surrounded by six Ti atoms in the crystal structure of
    Ti5Si3D0.9
    , space group P63/mcm. Local vibration spectra of hydrogen in
    Ti5Si3H0.83
    measured by neutron inelastic scattering support this result; the energy eigenvalue of the primary vibration mode is found at
    7
    .53 kJ/mol (78 meV). The hole radius and the spring constant of the Ti-H(
    D
    ) bond are discussed.
  • C. M. Hall, T. Aso
    Earth, Planets and Space
    2000年 52 巻 9 号 639-643
    発行日: 2000年
    公開日: 2010/03/09
    ジャーナル フリー
    The EISCAT Svalbard Radar (ESR) has been used to obtain ion velocities in the lower thermosphere. By using beam swinging and assuming homogeneity and stationarity of the plasma, first approximations to the electric field have been deduced, and thus the thermospheric neutral wind has been estimated. From these derived parameters, we have estimated the gradient Richardson Number. Although many assumptions must be made, there is an indication that electrodynamics is able to contribute to enhancement or even production of neutral-air turbulence in the lower thermosphere. Finally, we outline a proposal for an analogy to the Reynolds Number, but reflecting the relative importance's of the contribution of ion-drag to the neutral dynamics and the kinematic viscosity.
  • Suguru TAKATSUTO, Kiyomi KOBAYASHI, Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE
    Agricultural and Biological Chemistry
    1988年 52 巻 12 号 3217-3218
    発行日: 1988年
    公開日: 2006/04/05
    ジャーナル フリー
  • 橘 健太郎, 木田 博太, 上野山 充, 中村 年宏, 山田 貴久, 林 晃正
    日本透析医学会雑誌
    2019年 52 巻 4 号 227-232
    発行日: 2019年
    公開日: 2019/05/18
    ジャーナル フリー

    本検討は, 経皮的冠動脈形成術 (PCI) 後の翌日血液透析 (HD) 時における透析中低血圧 (IDH) の発生因子について検討した. 対象は待機的PCI後, 翌日HDを施行した慢性HD患者連続

    83
    名 (年齢70±
    7
    歳, 男性64名). IDHの定義は, 収縮期血圧20mmHg以上の低下で, 症状を伴いかつHD中断を要したものとした. また, HD記録よりIDHを後方視的に調査し, Logistic回帰分析にてIDHの予測因子を検討した. IDH群 (12名) は非IDH群 (71名) に比して, 有意に低体重 (52.0±
    3
    .
    8
    vs. 62.9±1.
    5
    kg; p=0.007), 造影剤量/体重が多く (2.
    5
    ±0.
    3
    vs. 1.
    8
    ±0.1mL/kg; p=0.018), 低左室駆出率で (45.
    8
    ±4.2 vs. 56.0±1.
    8
    % ; p=0.030),
    E
    /
    e
    ’ が高値 (
    22
    .9±
    3
    .
    8
    vs. 17.2±0.9cm/sec; p=0.038) であった. また, 冠動脈病変や侵襲的な治療について有意差は認めなかった. Logistic回帰分析では, 造影剤量/体重 (OR, 6.87; 95%CI, 1.
    83
    -25.
    8
    ; p=0.004) がIDHの有意な予測因子であった. 造影剤使用量が多い症例は, IDHを生じる危険性が高いことが示唆された.

  • 佐藤 敬之輔
    デザイン学研究
    1970年 1970 巻 11 号 45-55
    発行日: 1970/03/30
    公開日: 2017/07/25
    ジャーナル フリー
    [1] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with
    7
    kinds of factors, as follows ; A^^〜=
    B
    +C+
    D
    +K+aE+
    bF
    +cG. A^^〜=estimated values of the readership score. 1)
    B
    , C,
    D
    , K : these four factors are given as category values (so we call them); each factor is classified into several categories.
    B
    =week day, classified into
    7
    categories. C=pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into
    22
    categories.
    D
    =kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys. 2)
    E
    ,
    F
    , G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into 6 kinds of area (2.
    5
    ,
    3
    .
    5
    ,
    5
    ,
    7
    , 10, 15) and 15 column means a whole page, about 2,000cm^2.
    E
    ,
    F
    are the marks obtained in the design of advertizements.
    E
    =sum of the marks obtained in each design element on the advertizement.
    F
    =the marks obtained on the whole effect of the design.
    3
    ) a,
    b
    , c : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score: aE+
    bF
    =A-(
    B
    +C+
    D
    +K+cG). In this research, I used 1,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was
    3
    ,541, 2,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is 0.951. The table 2^* shows the contribution indexes of each factor by
    3
    kinds of expression-(1) Range : the absolute difference between the maximum and the minimum category values, (2) Standard deviations of the category values, (
    3
    ) Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table 2 in the thesis in Japanese. [2] The important point was in the determination of the values of
    E
    ,
    F
    .
    E
    is the sum of the marks obtained in each design element, classified into four kinds :
    E
    =
    E
    _1+
    E
    _2+
    E
    _
    3
    +
    E
    _4. design elements [table]
    E
    _1,
    E
    _2,
    E
    _
    3
    ,
    E
    _4, these values have the
    5
    grades, as 0, 1, 2,
    3
    , 4 and 0 is given to the design that has no attractive effect or no applicable element. And
    E
    obtain the marks of 0 to 9 grades as the sum of them. The values of
    F
    have also
    5
    grades, 0 to 4. The principles to determine the values of
    E
    ,
    F
    are as follows : a) The marks obtained of
    E
    ,
    F
    must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained.
    b
    ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula. c) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of
    E
    ,
    F
    values, as the table
    5
    -4, and
    5
    -
    5
    in the thesis in Japanese.
  • 琴尾 幸徳, 石川 成実, 田辺 順子, 御園 生尭久
    日本化学会誌(化学と工業化学)
    1980年 1980 巻 9 号 1391-1396
    発行日: 1980/09/10
    公開日: 2011/05/30
    ジャーナル フリー
    Nアルキル
    3
    ,4:9,10-ペリレンテトラカルボン酸モノアンヒドリド=モノイミド[4a~
    e
    ]と芳香族アミン(アニリン,p-トルイジン,p-アニシジン,
    3
    ,
    5
    -キシリジン,4-アミノナゾベンゼン,およびo-フェニレンジアミン)を縮合して非対称型
    3
    ,4:9,10-ペリレンビス(ジカルボキシミド)誘導体-N-アルキル-N'-アリール-
    3
    ,4:9,10-ペリレンビス(ジカルボキシミド)(〔
    5
    a~
    e
    〕,〔6a~
    e
    〕,〔
    7
    a~
    e
    〕,〔
    8
    a~
    e
    〕,〔9a~
    e
    〕,および〔10a~
    b
    〕)を合成した. これらの各誘導体はすべて赤色系の色相を示し, 顔料試験の結果N-ブチル-N'-アリール-
    3
    ,4:9,10-ペリレンビス(ジカルボキシミド)(たとえば〔
    5
    e
    〕や〔6
    e
    〕)がとくにすぐれた耐光性を示した.
  • 横山 晶, 木滑 孝一, 栗田 雄三
    気管支学
    1986年 8 巻 Special 号 104-
    発行日: 1986/07/15
    公開日: 2016/09/15
    ジャーナル フリー
  • Yao Sun, Jianzhong Ye, Yuanbo Hou, Huale Chen, Jianming Cao, Tieli Zhou
    Japanese Journal of Infectious Diseases
    2017年 70 巻 5 号 485-489
    発行日: 2017年
    公開日: 2017/09/25
    [早期公開] 公開日: 2017/03/28
    ジャーナル フリー

    The aim of the present study was to evaluate the predation efficacy of Bdellovibrio bacteriovorus on multidrug-resistant (MDR) or extensive drug resistant (XDR) gram-negative pathogens and their corresponding biofilms. In this study, we examined the ability of

    B
    . bacteriovorus to prey on MDR and XDR gram-negative clinical bacteria, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Results showed that
    B
    . bacteriovorus
    was able to prey on all planktonic cultures, among which the most efficient predation was observed for drug-resistant
    E
    . coli
    , with a
    3
    .11 log10 reduction in viability. Furthermore,
    B
    . bacteriovorus
    demonstrated promising efficacy in preventing biofilm formation and dispersing the established biofilm. Reductions in biofilm formation of
    E
    . coli, K. pneumoniae, P. aeruginosa
    , and A. baumannii co-cultured with
    B
    . bacteriovorus
    were 65.2%, 37.1%, 44.
    7
    %, and 36.
    8
    %, respectively. Meanwhile, the established biofilms of
    E
    . coli, K. pneumoniae, P. aeruginosa
    , and A. baumannii were significantly reduced by
    83
    .4%, 81.
    8
    %,
    83
    .1%, and 79.9%, respectively. A visual analysis supported by scanning electron microscopy demonstrated the role of
    B
    . bacteriovorus
    in removing the established biofilms. This study highlights the potential use of
    B
    . bacteriovorus
    as a biological control agent with the capability to prey on MDR/XDR gram-negative pathogens and eradicate biofilms.

  • Jerry P. JASINSKI, Ray J. BUTCHER, T. V. SREEVIDYA, H. S. YATHIRAJAN,
    B
    . NARAYANA
    Analytical Sciences: X-ray Structure Analysis Online
    2008年 24 巻 x245-x246
    発行日: 2008年
    公開日: 2008/11/29
    ジャーナル フリー
    The compound, (
    2E
    )-1-(1,
    3
    -benzodioxol-
    5
    -yl)-
    3
    -(4-chlorophenyl)prop-2-en-1-one (I),
    C16H11ClO3
    , crystallizes in the monoclinic crystal system with space group P21/c and cell constants: a =
    22
    .7231(15),
    b
    = 4.9239(4), c = 11.9995(
    7
    )Å, β = 99.953(6)°, V = 1322.37(16)
    Å3
    , Z = 4. (
    2E
    )-1-(1,
    3
    -Benzodioxol-
    5
    -yl)-
    3
    -(
    3
    ,4-dimethoxyphenyl)prop-2-en-1-one (II),
    C18H16O5
    , crystallizes in the triclinic crystal system, space group P1 with a =
    8
    .2961(2),
    b
    = 13.8829(6), c = 14.6713(
    7
    )Å, α = 64.185(4), β =
    83
    .560(
    3
    ). γ = 84.966(
    3
    )°, V = 1510.10(10)
    Å3
    , Z = 4. Hydrogen bonding and crystal packing effects influence the twist angle between the mean planes of the 1,
    3
    -benzodioxol-
    5
    -yl and benzene groups in both I and II, while π-π stacking interactions help to stabilize the crystal packing.
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