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  • M. L. GHOSH
    Journal of Physics of the Earth
    1972年 20 巻 2 号 165-186
    発行日: 1972年
    公開日: 2009/04/30
    ジャーナル フリー
    The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.
  • 増大する資源
    E
    . F. Boswell
    紙パ技協誌
    1998年 52 巻 7 号 885-889
    発行日: 1998/07/01
    公開日: 2009/11/19
    ジャーナル フリー
    The world is in the midst of a huge fundamental shift in fibre supply, demand balances, and policy changes. Governments around the world are introducing policy changes which influence the supply demand balance as the politicians' thoughts are uttered. Government agencies and their bureaucrats are imposing changes on industry even before the legislation is passed by the government in question.
    This ad hoc change process will continue for a time to come until the countries in question show a tough-mindedness with regard to their land use policies. Policies affecting forest areas such as protection areas, Native land claims, the protection of biodiversity and a true goal of sustainable development ; which addresses the combined issues of cultural, environmental, social and economic matters.
    Eventually all of these difficult issues will reach essential closure. Then there will be great new opportunities for investment to meet the growing demand for forest products ; leading to a strengthening competitive position in the more traditional producing areas such as Canada.
  • 川又 紀彦, 渡部 良平
    臨床血液
    2019年 60 巻 7 号 767-772
    発行日: 2019年
    公開日: 2019/08/06
    ジャーナル 認証あり

    BCR-ABL1 International Scale(IS)測定はチロシンキナーゼ阻害剤で治療されている慢性骨髄性白血病(CML)患者の治療効果をモニターする上で重要な検査法である。稀ではあるが,BCR-ABL1 IS測定ができないCMLが存在することが知られている。本研究において,我々は,そのようなBCR-ABL1 IS測定のできないCML患者を経験し,分子生物学的な方法で,その原因を解明した。本例ではABL1遺伝子における切断点がa2エクソン内にあることが分かり,そのことがABL1のa2エクソンを欠いた

    e
    14a
    3
    b
    3
    a
    3
    )キメラ遺伝子のmRNAのみの発現を誘導していた。a2エクソンは本邦における検査部でのIS測定において重要な要素であり,これが欠損することが測定不能の原因であった。このようなIS測定ができない稀なCML症例をさらに集積して,その分子構造を解明することが待たれる。

  • ―特にアポ蛋白Eの変化について―
    本間 康彦, 三神 美和, 佐藤 美智子, 石原 仁一, 吉川 広, 木下 栄治, 田川 隆介, 星合 充基, 古屋 秀夫, 井出 満, 田辺 晃久, 玉地 寛光, 兼本 成斌, 友田 春夫, 中谷 矩章, 五島 雄一郎
    動脈硬化
    1984年 12 巻 3 号 599-603
    発行日: 1984/08/01
    公開日: 2011/09/21
    ジャーナル フリー
    Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for 2 weeks. Cholesterol amounts in VLDL, LDL, HDL, HDL2 and
    HDL3
    were estimated on the 0th, 7th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II,
    B
    , C-II,
    E
    levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL, HDL2 and
    HDL3
    were 15.
    9
    ±7.5mg/dl (mean±SD), 150.
    9
    ±58.1mg/dl 43.
    8
    ±
    9
    .6mg/dl, 16.4±5.
    8
    mg/dl and 24.
    9
    ±6.
    3
    mg/dl respectively. Plasma apoprotein A-I, A-II,
    B
    , C-II and
    E
    levels were 81.7±
    22
    .0 mg/dl, 15.1±5.4mg/dl, 93.7±36.0mg/dl,
    3
    .
    83
    ±1.00mg/dl and 4.29±1.36mg/dl respectively. After 2 weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL-C (r=0.348), HDL2-C (r=0.612) and
    HDL3
    (r=0.569). Apoprotein
    B
    correlated with total cholesterol (TC) (r=0.610), VLDL-C (r=0.341), LDL-C (r=0.726), HDL-C (r=0.432) and HDL2-C (r=0.465). Apoprotein C-II correlated with TC (r=0.765), TG (r=0.679), VLDL-C (r=0.651), LDL-C (r=0.461) and HDL2-C (r=0.326). Apoprotein
    E
    correlated with TC (r=0.580), TG (r=0.575) and VLDL-C (r=0.666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=0.468). Apoprotein
    B
    correlated with apoprotein C-II (r=0.393). Apoprotein C-II correlated with apoprotein
    B
    (r=0.393) and
    E
    (r=0.549). Apoprotein
    E
    only correlated with apoprotein C-II (r=0.549).
  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • S. Datta, J. Sil, M. K. Banerjee
    ISIJ International
    1999年 39 巻 10 号 986-990
    発行日: 1999/10/15
    公開日: 2007/05/31
    ジャーナル フリー
    The effect of composition and controlled thermomechanical process parameters on the mechanical properties of HSLA steels is modelled using the Widrow-Hoff's concept of training a neural net with feed-forward topology by applying Rumelhart's back propagation type algorithm for supervised learning, using a Petri like net structure. The data used are from laboratory experiments as well as from the published literature. The results from the neural network are found to be consistent and in good agreement with the experimented results.
  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • 香山 滉一郎, 森下 政夫, 張 国鋒
    粉体および粉末冶金
    2006年 53 巻 5 号 419-429
    発行日: 2006年
    公開日: 2006/12/19
    ジャーナル オープンアクセス
    The phase diagrams of the Ni-Mo-
    B
    and Ni-W-
    B
    ternary systems in the region of less than 50mol%
    B
    were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
    E1
    :L (1365K, 71.5mol%Ni-6.0mol%Mo-
    22
    .5mol%
    B
    )=(Ni)+
    Ni3B
    +
    NiMo2B2

    E2
    :L (1355K, 62.5mol%Ni-2.5mol%Mo-30.5mol%
    B
    )=
    Ni3B
    +
    Ni2B
    +
    NiMo2B2

    E3
    :L (1445K, 42.0mol%Ni-30.6mol%Mo-10.
    3
    mol%
    B
    )=(Ni)+NiMo+
    NiMo2B2

    P1:L (1812K, 34.
    9
    mol%Ni-42.
    3
    mol%Mo-
    22
    .
    8
    mol%
    B
    )+MoB=
    Mo2B
    +
    NiMo2B2

    P2:L (1633K, 42.
    3
    mol%Ni-40.4mol%Mo-17.
    3
    mol%
    B
    )+Mo=
    Mo2B
    +
    NiMo2B2

    P3
    :L (1812K, 53.5mol%Ni-33.7mol%Mo-12.
    8
    mol%
    B
    )+Mo=NiMo+
    NiMo2B2

    E1
    :L (1622K, 51.0mol%Ni-31.6mol%W-17.4mol%
    B
    )=(Ni)+W+
    NiW2B2

    E2
    :L (1260K, 71.0mol%Ni-7.0mol%W-
    22
    .0mol%
    B
    )=(Ni)+
    Ni3B
    +
    NiW2B2

    E3
    :L (1291K, 65.4mol%Ni-4.
    8
    mol%W-29.
    8
    mol%
    B
    )=
    Ni2B
    +
    Ni3B
    +
    NiW2B2

    P1:L (2115K, 23.
    8
    mol%Ni-43.1mol%W-33.1mol%
    B
    )+WB=
    W2B
    +
    NiW2B2

    P2:L (1657K, 48.
    9
    mol%Ni-33.1mol%W-18.0mol%
    B
    )+
    W2B
    =W+
    NiW2B2

    The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.
  • Keishi Hata, Fuyuki Sugawara, Naganori Ohisa, Saori Takahashi, Kazuyuki Hori
    Biological and Pharmaceutical Bulletin
    2002年 25 巻 8 号 1040-1044
    発行日: 2002年
    公開日: 2002/08/01
    ジャーナル フリー
    We screened the differentiation-inducing activities of 39 mushroom extracts from Akita prefecture, Japan, on the mouse osteoblastic cell line, MC
    3
    T
    3
    -
    E
    1. Sixteen phosphate buffered saline (PBS),
    8
    boiled PBS, 14 ethanol and 12 methanol extracts induced alkaline phosphatase (ALP) activities, an indicator of MC
    3
    T
    3
    -
    E
    1 cell differentiation. The enzyme activities were markedly induced by extracts of Tricholoma auratum, and we isolated the active compound from methanol extracts of this mushroom. Physical data for the isolated active compound were identical to those for (
    22E
    ,24R)-ergosta-7,
    22
    -diene-
    ,5α,6β-triol (1). 1 induced ALP activities of MC
    3
    T
    3
    -
    E
    1 cells and promoted cell proliferation. To investigate the relationships between the chemical structure and differentiation-inducing activity of the compound, ALP-inducing activities of MC
    3
    T
    3
    -
    E
    1 cells by 1, ergosterol (2), ergocalciferol (
    3
    ), cholesta-
    ,5α,6β-triol (4), 7-dehydrocholesterol (5) and cholecalciferol (6) were tested. The enzyme activities of MC
    3
    T
    3
    -
    E
    1 cells were increased
    3
    .0-fold by 10 μM 1 and 2.4-fold by 10 μM 4. However, 2,
    3
    , 5 and 6 did not induce MC
    3
    T
    3
    -
    E
    1 cell ALP activity at 0.1—10 μM. These results suggested that the OH groups at C-5 and/or C-6 of 1 and 4 played an important role in their differentiation-inducing activities on MC
    3
    T
    3
    -
    E
    1 cells. Furthermore, 1 suppressed induction of MC
    3
    T
    3
    -
    E
    1 cell apoptosis by serum starvation.
  • B
    .C. CHATTOPADHYAY, P.J. PISE
    土質工学会論文報告集
    1986年 26 巻 4 号 16-22
    発行日: 1986/12/15
    公開日: 2008/02/29
    ジャーナル フリー
    Horizontal plate anchors are widely used in civil engineering constructions to resist vertical pulling loads. The available theoretical model suggested by Vesic to estimate the breakout resistance of plate anchors is in significant error, particularly for dense sandy soils. A theoretical model assuming a curved surface of failure through the surrounding soil, to evaluate the ultimate breakout resistance of horizontal plate anchors, has been proposed. It successfully brings out the concept of characteristics relative depth beyond which the breakout factor reaches a constant final value. It is capable of predicting breakout factors for wide range of values of angle of shearing resistance of sand.
  • 高木 徹, 林 賢治, 板橋 豊
    日本水産学会誌
    1984年 50 巻 8 号 1413-1418
    発行日: 1984/08/25
    公開日: 2008/02/29
    ジャーナル フリー
    The acetone extracts from three samples of the hepatopancreas of the poisonous scallops obtained on the Okhotsk Coast of Hokkaido Island were fractionated into two parts, hexane soluble fraction (fraction H) and 85% aqueous ethanol soluble fraction (fraction
    E
    ) by partition to two layers. The majortoxic components in the mouse assay of “diarrheic shellfish toxin” by intra-peritoneal injection were found to be free unsaturated fatty acids showed the following toxicity in MU per g, 18:1 n-
    9
    35, 18:2 n-6
    83
    , 18:
    3
    n-
    3
    167, 18:4 n-
    3
    83
    , 20:5 n-
    3
    167, and
    22
    :6 n-
    3
    83
    , respectively. Toxicity of the fraction Hin MUper g was much lower than that of the fraction
    E
    . However, the toxicity of the fraction H per 1 g of the hepatopancreas was about twice that of the fraction
    E
    , since the fraction Hwas much more abundant than the fraction
    E
    in the hepatopancreas. The method for the assay of the diarrhetic shellfish toxin must be reexamined by considering the toxic effect of the free unsaturated fatty acids.
  • S. DATTA, M. K. BANERJEE
    ISIJ International
    2005年 45 巻 1 号 121-126
    発行日: 2005年
    公開日: 2006/01/27
    ジャーナル フリー
    An unsupervised learning technique and an associative memory have been used for encoding weights by a special type of Petri network named Petri neural net for modelling the influence of alloying elements on the final property of the high strength low alloy steel. The combined effects of alloying elements for different strengthening mechanisms is predicted when weights and threshold values are chosen on the basis of metallurgical understanding. The technique is found to be effective to create an associative memory of input-output relations in unknown data sets so that the same can be subsequently be used as a predictive tool.
  • S. Datta, M. K. Banerjee
    ISIJ International
    2004年 44 巻 5 号 846-851
    発行日: 2004/05/15
    公開日: 2007/05/31
    ジャーナル フリー
    Primarily from the point of view of improvement of yield strength due to additions of niobium, titanium and boron in HSLA steels, the experimental steels are divided into five classes. The data are then supplied for learning a Self Organising Map (Kohonen network). It is found that the network with six neurons possesses better capacity of prediction with unknown data. Another effort of clustering the steels according to its major strength contributing mechanisms is also made. But the capacity of the network to cluster unknown data is found to be rather poor and has failed to follow from the metallurgical principles. To avoid this limitation, Learning Vector Quantisation method is adopted to impart a certain amount of supervision in the learning process and it is found that the training pattern of the network attains a good convergence thereby leading to a good predictive ability.
  • M. K. Banerjee, P. S. Banerjee, S. Datta
    ISIJ International
    2001年 41 巻 3 号 257-261
    発行日: 2001/03/15
    公開日: 2007/05/31
    ジャーナル フリー
    A boron treated copper bearing HSLA steel containing austenite formers like manganese and nickel, somewhat lower in amount than that in HSLA 100 variety of steel is chosen for the study. The role of thermomechanical processing on the microstructure and mechanical properties of the above steel has been investigated. Differential scanning calorimetric study is carried out for understanding the precipitation behaviour of copper in HSLA steel under the influence of boron. The microstructure of the experimental steel is found to consist of laths of martensites and bainite. MA constituents of ribbon like morphology are observed at the lath boundaries. Higher strength properties of the steel are attributed to the presence of finely distributed precipitates of copper and microalloy carbides.
  • Zhenhua Dan, Yasunobu Yamada, Yan Zhang, Masahiko Nishijima, Nobuyoshi Hara, Hiroyuki Matsumoto, Akihiro Makino
    MATERIALS TRANSACTIONS
    2013年 54 巻 4 号 561-565
    発行日: 2013/04/01
    公開日: 2013/03/25
    [早期公開] 公開日: 2013/02/22
    ジャーナル フリー
    The nanocrystalline soft-magnetic
    Fe83.3Si3B10P3Cu0.7
    ribbon alloy with a width of 10 mm prepared through annealing amorphous
    Fe83.3Si3B10P3Cu0.7
    ribbon alloy at 698 K had a saturation magnetization flux density of 1.
    82
    T and a coercivity of 11.
    8
    A m−1. The nanohetero-amorphous microstructure consisted of α-Fe nanocrystals with an average size of
    22
    nm and amorphous neighbor phases. The results of polarization curves and electrochemical impedance spectra obtained in 0.5 M Na2SO4 and 0.5 M NaCl solutions demonstrated the positive shift of the corrosion potentials, the decrease in the passive current density, the increase in the breakdown potentials and the increase in the polarization resistance for the nanocrystalline
    Fe83.3Si3B10P3Cu0.7
    ribbon alloy, compared with its amorphous counterpart alloy. The corrosion performance was improved via annealing, which is thought to result from the enrichment of
    B2O3
    constituent in the surface oxide layer.
  • Toshiyuki KOJIMA, Manabu SHIMIZU, Tsuneo TOMIZUKA
    Journal of Reproduction and Development
    1995年 41 巻 4 号 277-286
    発行日: 1995年
    公開日: 2001/11/30
    ジャーナル フリー
    The aim of the present study was to examine the survival rate of embryos after bilateral nonsurgical transfer in recipient cows given a superovulatory treatment of low-dose FSH. In total, 54 parous Holstein or Japanese Black breed cows were used as recipients. These recipients were assigned to the three groups based on hormonal treatments during the preceding estrous cycle. The treatments included A) FSH (10 or 15 mg) and PGF (n=18),
    B
    ) PGF (n=14), and C) no treatment (n=
    22
    ). Morula to blastocyst-staged embryos that were transferred were derived either from in vitro maturation & in vitro fertilization or they were collected from superovulated Japanese Black heifers. Some embryos collected from donors were routinely frozen and thawed. Most of the cows (
    83
    %, 15/18) that were given the combination of FSH and PGF2α formed corpora lutea (CLs) on the ovaries (mean number CLs ± s.
    e
    . per cow=
    3
    .1 ± 0.48). Pregnancy rates on day 30 in groups A,
    B
    and C were 67% (12/18), 64% (
    9
    /14) and 55% (12/
    22
    ), respectively (P>0.05). The rates of twin pregnancies to all pregnancies were 50% (6/12),
    22
    % (2/
    9
    ) and 42% (5/12), respectively (P>0.05). Consequently, 19 cows carried their pregnancies to term, producing 25 calves, including six pairs of twins. Calving rates in the three groups were 67% (
    8
    /12), 33% (
    3
    /
    9
    ), and 67% (
    8
    /12), respectively (P>0.05). Calf crop rates were 125% (10/
    8
    ), 133% (4/
    3
    ), and 138% (11/
    8
    ), respectively (P>0.05). The embryonic survival rate at Day 30 in group A was likely to be higher than those of cows in the other two groups (50% [18/36] vs 39% [28/72]). No difference between the origins of embryos was observed in the embryonic survival rates. These results suggested that superovulatory treatment with low-dose FSH to recipients bilaterally receiving embryos would be beneficial for increasing embryonic survival, although the results were not statistically significant.
  • Tamie NAKAJIMA
    Journal of Occupational Health
    1997年 39 巻 2 号 83-91
    発行日: 1997年
    公開日: 2006/04/07
    ジャーナル フリー
    Cytochrome P450 Isoforms and the Metabolism of Volatile Hydrocarbons of Low Relative Molecular Mass: Tamie NAKAJIMA. Department of Hygiene, Shinshu University School of Medicine—Cytochrome P450 isoforms responsible for the metabolism of volatile hydrocarbons of low relative molecular mass are reviewed. Rat CYP2
    E
    1 catalyse the metabolism of all hydrocarbons with a low Km, whereas CYP1A1/2, CYP2
    B
    1/2 and CYP2C11/6 catalyse the metabolism of many hydrocarbons with a high Km although the contribution of the first two is minimal. The metabolism of hydrocarbons is affected by physiological and environmental factors, changes in the expression of P450 isoforms and the affinity of the chemicals for the isoforms. Human CYP2
    E
    1 also catalysed all of the hydrocarbons investigated, with the same kinetics as that of rat CYP2
    E
    1. Human CYP2
    B
    6 and CYP2C
    8
    catalyse the metabolism of some hydrocarbons, but with slighty different catalytic properties for the formation of o- and p- cresol from toluene. Although CYP2
    B
    1/2 is poorly expressed in liver microsomes from control rats, CYP2
    B
    6 is found immunochemically to be constitutive in human liver microsomes. Human CYP1A2 also catalyses the metabolism of some organic solvents, with varying kinetic and catalytic features. The contribution of human CYP
    3
    A
    3
    , CYP
    3
    A4 and CYP
    3
    A5 to metabolism is very low. In conclusion, CYP2
    E
    1 is an essential isoform for the metabolism of hydrocarbons in both rodents and humans, especially at low concentrations. (J Occup Health 1997; 39:
    83
    -
    91
    )
  • Yao Sun, Jianzhong Ye, Yuanbo Hou, Huale Chen, Jianming Cao, Tieli Zhou
    Japanese Journal of Infectious Diseases
    2017年 70 巻 5 号 485-489
    発行日: 2017年
    公開日: 2017/09/25
    [早期公開] 公開日: 2017/03/28
    ジャーナル フリー

    The aim of the present study was to evaluate the predation efficacy of Bdellovibrio bacteriovorus on multidrug-resistant (MDR) or extensive drug resistant (XDR) gram-negative pathogens and their corresponding biofilms. In this study, we examined the ability of

    B
    . bacteriovorus to prey on MDR and XDR gram-negative clinical bacteria, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Results showed that
    B
    . bacteriovorus
    was able to prey on all planktonic cultures, among which the most efficient predation was observed for drug-resistant
    E
    . coli
    , with a
    3
    .11 log10 reduction in viability. Furthermore,
    B
    . bacteriovorus
    demonstrated promising efficacy in preventing biofilm formation and dispersing the established biofilm. Reductions in biofilm formation of
    E
    . coli, K. pneumoniae, P. aeruginosa
    , and A. baumannii co-cultured with
    B
    . bacteriovorus
    were 65.2%, 37.1%, 44.7%, and 36.
    8
    %, respectively. Meanwhile, the established biofilms of
    E
    . coli, K. pneumoniae, P. aeruginosa
    , and A. baumannii were significantly reduced by
    83
    .4%, 81.
    8
    %,
    83
    .1%, and 79.
    9
    %, respectively. A visual analysis supported by scanning electron microscopy demonstrated the role of
    B
    . bacteriovorus
    in removing the established biofilms. This study highlights the potential use of
    B
    . bacteriovorus
    as a biological control agent with the capability to prey on MDR/XDR gram-negative pathogens and eradicate biofilms.

  • Suguru TAKATSUTO, Kiyomi KOBAYASHI, Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE
    Agricultural and Biological Chemistry
    1988年 52 巻 12 号 3217-3218
    発行日: 1988年
    公開日: 2006/04/05
    ジャーナル フリー
  • Yilmaz ISPIR, Orhan UYAR
    Journal of geomagnetism and geoelectricity
    1971年 23 巻 3-4 号 295-305
    発行日: 1972/02/25
    公開日: 2010/09/14
    ジャーナル フリー
    Simultaneous measurements of the total geomagnetic field intensity by the same type of the proton precession magnetometers at two stations in NW Turkey have been taken cooperatively by a research group since December 1970. Up to the end of July 1971 mainly three probable local magnetic changes were observed. It was seen that after a decrease in the local field at a magnetic station (Erdek) a few earthquakes occured at either nearly N or S of that station, and after an increase in the local field an earthquake took place nearly W of the same station. In this paper the data and some results of the first part of observations are given.
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