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15(R)-15-Methylprostaglandin
E₂
(Arbaprostil)のラットにおける生体内動態の研究(第4報)：15(S)-15-Methylprostaglandin
E₂
投与後の血液中濃度および尿，糞中排泄

大澤康次, 幡野恵, 西宮一尋, 岡崎彬, 太田真一, 宇田文昭, 柳田由紀, 檜垣洋子, 吉田知江里

薬物動態
1988年 3 巻 4 号 441-446
発行日: 1988年
公開日: 2007/03/29

DOI https://doi.org/10.2133/dmpk.3.441

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ラットに^{3H
-CU-83
(S)を25μg/kgで静脈内あるいは経口投与し，血液中濃度および尿糞中排泄を検討した．
静脈内投与後の血液中濃度推移は投与後5
分より上昇し，投与後45分に25.74ng eq./mlのC_maxを示し，それ以後t₁
/2 3
.05時間とt₁
/2 33.09時間の二相で減少した．投与後72時間までのAUCは135.42ng eq.·hr/mlであった．
経口投与では，投与後3
時間でC_max 4.10ng eq./mlに達し，以後t₁
/2α 4.46時間とt₁
/2β 26.83
時間の二相で減少した．投与後72時間までのAUCは48.62ng eq.·hr/mlであった．
静脈内投与と経口投与のいずれの場合も，尿および糞中への放射能の排泄は，投与後48時間でほぼ終了した．静脈内投与では，投与後72時間までに投与量の30.52%が尿中に，60.42%が糞中に排泄された．経口投与では，同じく72時間までに40.34%が尿中に，69.24%が糞中に排泄された．
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ユーカリの材質育種における選抜指標抽出に関する研究 (第
5
報)

E. camaldulensis, E. globulus における容積重, および材形質含量の樹幹内変異と標準値を示す位置について

小名俊博, 園田哲也, 伊藤一弥, 柴田勝

紙パ技協誌
1995年 49 巻 8 号 1227-1234
発行日: 1995/08/01
公開日: 2009/11/16

DOI https://doi.org/10.2524/jtappij.49.1227

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Within-tree variations, whole-tree values and the representative heights for the whole tree value of basic density, and contents of wood components per volume were analysed for two trees of Eucalyptus camaldulensis and E
. globulus respectively, grown at the seed orchard in Western Australia to do quality breeding.
Within-tree variation of E
. camaldulensis was rather uniform as 500±40, 532 ±34 kg/
m³
, but that of E
. globulus was large as 595 ± 69, 616 ± 79 kg/
m³
and the basic density was higher in bark side and upper part in the trunk, to be expected to have higher pulp productivity.
The whole-tree values of E
. camaldulensis were 501, 520 kg/
m³
and those of E
. globulus were 594, 640 kg/
m³
and the difference of the species was observed.
Representative heights for the whole-tree contents ±
5
% were 0.32.
8
m on E
. camaldulensis, and 0.
8
and 2.
8
m on E
. globulus regardless the differences in the whole-tree height and the within-tree variation when they were chosen below
3
.
3
m height for sampling an increment core.
Representative heights were also determined for contents of wood components per volume as follows ; for E
. camaldulensis, holocellulose :
1
.
3
, 2.
8
m, cellulose : 2.
83
.
3
m, hemicellulose : 0.
82
.
8
m, lignin : 0.81.
3
, 2.
8
m, extractives : 2.
3
m, alkali-extractives :
1
.
3
m, and total-extractives : 2.32.
8
m, for E
. globulus, 2.
8
m, 2.32.
8
m, 2.
8
m, 0.30.
8
m, 2.
83
.
3
m, 2.
83
.
3
m and 2.
8
m in the same manner.
It is expected that whole-tree pulp properties including pulp productivity are predicted by the increment core taken from these representative heights.
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腹腔内注入による下痢性貝毒のマウステストにおける遊離不飽和脂肪酸の毒性

高木徹, 林賢治, 板橋豊

日本水産学会誌
1984年 50 巻 8 号 1413-1418
発行日: 1984/08/25
公開日: 2008/02/29

DOI https://doi.org/10.2331/suisan.50.1413

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The acetone extracts from three samples of the hepatopancreas of the poisonous scallops obtained on the Okhotsk Coast of Hokkaido Island were fractionated into two parts, hexane soluble fraction (fraction H) and 85% aqueous ethanol soluble fraction (fraction
E
) by partition to two layers. The majortoxic components in the mouse assay of “diarrheic shellfish toxin” by intra-peritoneal injection were found to be free unsaturated fatty acids showed the following toxicity in MU per g, 18:
1
n-
9
35, 18:2 n-6
83
, 18:
3
n-
3
167, 18:4 n-
3

83
, 20:
5
n-
3
167, and
22
:6 n-
3

83
, respectively. Toxicity of the fraction Hin MUper g was much lower than that of the fraction
E
. However, the toxicity of the fraction H per
1
g of the hepatopancreas was about twice that of the fraction
E
, since the fraction Hwas much more abundant than the fraction
E
in the hepatopancreas. The method for the assay of the diarrhetic shellfish toxin must be reexamined by considering the toxic effect of the free unsaturated fatty acids.
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機械弁の抗血栓性は向上したか

―St. Jude Medical valveの抗血栓性について―

藤田康雄, 林純一, 山崎芳彦, 江口昭治, 大谷信一

人工臓器
1988年 17 巻 3 号 1133-1136
発行日: 1988/06/15
公開日: 2011/10/07

DOI https://doi.org/10.11392/jsao1972.17.1133

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SJM弁の抗血栓性についてS-
E
ボール弁との比較検討を行った。S-
E
ボール弁で単弁置換をうけた132例と、SJM弁で単弁置換をうけた135例を対象とした。僧帽弁置換群の血栓塞栓症の発生頻度は、S-
E
非被覆弁2.14%/患者・年、S-
E
被覆弁
1
.
82
%/患者・年、SJM弁
1
.69%/患者・年であった。術後
7
年のThrombo-embolism Free RateはS-
E
非被覆弁で60.
5
±
7
.
5
%、S-
E
被覆弁で
83
.
9
±
5
.2%、SJM弁で92.4±
3
.
1
%であった。大動脈弁置換群の血栓塞栓症の発生頻度は、S-
E
非被覆弁
1
.36%/患者・年、S-
E
被覆弁、SJM弁では0であった。術後
7
年のThromboembolism Free RateはS-
E
非被覆弁75.6±10.6%、S-
E
被覆弁80.0±10.
3
%、SJM弁96.
7
±
3
.
3
%であった。SJM弁の抗血栓性はS-
E
非被覆弁に比し良好であったが、S-
E
被覆弁に比べ著しく向上したとはいえず、近年における血栓塞栓症の減少には厳重な抗凝固療法の施行も寄与していると考えられる。
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Potential causes of different gastric stability of original and generic proton pump inhibitors

Daria Kurguzova, Svetlana Serebrova, Alexey Prokofiev, Ludmila Krasnykh, Galina Vasilenko, Marina Zhuravleva, Elena Smolyarchuk, Anton Barkov

日本薬理学会年会要旨集
2018年 WCP2018 巻 WCP2018_PO3-5-27
発行日: 2018年
公開日: 2020/09/10

DOI https://doi.org/10.1254/jpssuppl.WCP2018.0_PO3-5-27

会議録・要旨集オープンアクセス

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Background
The differences in conditions of enteric-coated acid-labile drug release and absorption between healthy subjects in bioequivalence studies and gastrointestinal patients in clinical practice can lead to significant differences in gastric stability of original PPIs and generics. Thus, pathologic duodenogastric reflux (PDGR) and the pH increasing within PPIs administration still remain unaccounted for.
Methods
Two-stage modified comparative dissolution testing of original omeprazole (OO) and four generics (G
1
;2;
3
;4) was performed. At first, we moved drugs from solution with pH
1
.2 (
1
.2±0.05) to pH
7
.0 (
7
.0±0.05) and measure concentration of omeprazole in solution by high-performance liquid chromatography. According to our self-developed formula, pH
7
exposure time of resistance to PDGR for omeprazole is 4 minutes, i.
e
. the active substance should not be released within 4 minutes at pH
7
. The exposure at the second stage was conducted with pH 4 (4.0±0.05), that imitated gastric pH after PPI administration. And then we also moved drugs to pH
7
with the subsequent measurement of omeprazole concentration.
Results
Omeprazole concentrations after 4, 10, 15, 20, 30, 45, 60 minutes in pH
7
solution at the first stage were different for OO and generics. For OO, these values were 4,
7
±0,
7
%; 41,4±
3
,0%; 62,
8
±4,0%; 79,
5
±2,
9
%;
83
,
5
±2,
9
%; 81,6±2,
9
%; 80,6±4,4%; for Generic
1
- 0; 49,
3
±
9
,
9
%; 88,
8
±2,
8
%;
90
,4±
3
,
7
%; 88, 2±2,2%; 87,
3
±2,0%; 85,
9
±
1
,
1
%; for Generic2 - 0; 30,6±6,
3
%; 66,
7
±
8
,2%; 76,4±
7
,4%;
82
,
8
±
5
,
3
%;
86
,0±
3
,
7
%; 84,6±
3
,
3
%: for Generic
3
- 80,
8
±
3
,6%;
83
,
5
±
1
,
9
%;
83
,
8
±
3
,2%;
83
,
3
±2,
7
%; 81,
9
±2,
1
%;
82
,
1
±2,0%;
82
,0±2,4%; for Generic4 -
82
,
5
±
1
,
7
%; 84,4±0,
8
%; 84,2±
1
,2%;
82
,
9
±0,
9
%;
82
,
9
±0,
9
%;
82
,
9
±0,
9
%;
82
,
8
±
1
,
1
%, respectively.
An analysis of the omeprazole concentration in pH
7
solution at the second stage revealed the following parameters after the same time: for OO - 4,4±0,6%; 40,
5
±
3
,0%; 62,
8
±2,0%; 80,0±
3
,
1
%; 85,4±2,
9
%;
82
,
8
±
3
,4%; 80,
9
±
3
,
5
%; for Generic
1
- 0; 67,0±
7
,
8
%; 89,
7
±2,
3
%; 91,
9
±4,
3
%; 89,
1
±
1
,6%; 88,
3
±
1
,4%; 87,
8
±
1
,2%; for Generic2 - 0; 42,2±
5
,6%; 75,
1
±
7
,
3
%; 81,0±6,0%; 88,4±
3
,2%; 88, 6±
1
,
3
%; 87,
9
±
1
,0%; for Generic4 - 85,
5
±0,
5
%; 85,6±0,
5
%; 84,
7
±0,
9
%;
82
,
7
±
3
,0%; 84,4±0,
3
%; 84,4±0,
3
%; 84,
3
±0,4%, respectively. Generic
3
release and degradation were completely realized at pH 4.
Conclusion
Decreased gastric stability of Generic
3
and Generic4 makes PDGR and inhibited gastric acid secretion due to PPIs administration the potential causes of decreased enteric-coated acid-labile drugs stability.

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Optical Energy-Levels of Cu⁺

Yosizo YAMAMOTO

Nippon Sugaku-Buturigakkwai Kizi Dai
3
Ki
1940年 22 巻 12 号 1048-1052
発行日: 1940年
公開日: 2009/06/09

DOI https://doi.org/10.11429/ppmsj1919.22.12_1048

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The numerical values of the intervals betrween optieal levels are competed for the configurations
1s²2s²2p⁸3s²3p⁸3
*⁹4s,
5
s, 6s and
7
s of Cu⁺, according to the general expression of energy-levels derived in the previous paper The self-consistent field radial functions computed by Hartree adn Hartree are used for
1
s, 2s, 2p,
3
s,
3
p and
3
d. Those of 4s,
5
s,
e
.s and are ealenlated from Hartree Hartree's core-functions by the numerical integrations. The calculated results are shown in Table I.The agreement with experiment is satisfactory
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SEEPAGE FAILURE EXPERIMENTS AND THEIR ANALYSES OF LOOSE AND MEDIUM DENSE SANDS

浅岡顕, 小高猛司

土質工学会論文報告集
1992年 32 巻 3 号 117-129
発行日: 1992/09/15
公開日: 2008/02/29

DOI https://doi.org/10.3208/sandf1972.32.3_117

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Failure problems of saturated soils are classified in the present study into the following four types : Type I : The failure of loose and/or normally consolidated soils under fully drained loading conditions. Type II : The same soils but under perfectly undrained conditions. Type III : The failure of dense and/or overconsolidated soils under fully drained conditions. Type IV : The same soils but under perfectly undrained conditions. The soil-water coupling limiting equilibrium analysis on the basis of the critical state concept is shown possible to draw a distinction between type I, II and IV problems, and the limitations of the analysis procedure happen in solving the type problem in the above. This is demonstrated experimentally, in which seepage failure experiments in laboratory with the use of a saturated silty sand are employed to make distinctions clearly between the four types of failure problems. The definite distinctions both in failure load and failure mode appeared in the four types of experiments are summarized as follows : (
1
) the smallest failure load in loose sand in the undrained condition, (2) the largest failure load with the largest failure region in dense sand under undrained loading, (
3
) the observation of no global deformation before failure within the soil under the fully drained condition that suggests the development of very localized shear deformation in the sand. Three out of four experiments are described well by the limit analysis computation mentioned above as far as the failure load and the shape and the size of the failure region after boiling failure are concerned, and thus the type III problem is identified to be the problem that should be solved by any other means in near future.
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E
-
1
.
3
.
3
(信号の色),
E
-
3
.
3
.
1
(道路照明),
E
-
3
.
3
.2.
1
(飛行場照明),
E
-
3
.
3
.
3
(航空機照明と標識),
E
-
3
.
3
.
7
(交通信号灯) について

馬場輝郎

照明学会雑誌
1968年 52 巻 3 号 107-111
発行日: 1968/03/25
公開日: 2011/07/19

DOI https://doi.org/10.2150/jieij1917.52.3_107

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15 (R)-15-Methylprostaglandin
E₂
(Arbaprostil) のヒトにおける生体内動態の研究(第2報)

未変化体とその異性体の血液中濃度ならびに尿中排泄

関野久之, 中道昇, 西宮一尋, 大澤康次, 岡崎彬

臨床薬理
1989年 20 巻 2 号 407-413
発行日: 1989/06/30
公開日: 2010/06/28

DOI https://doi.org/10.3999/jscpt.20.407

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The plasma concentration and urinary excretion of 15 (R)-15-methylprostaglandin
E₂
(Arbaprostil, CU-
83
) and its 15 (S)-15-methyl epimer (CU-
83
(S)) were studied in healthymale volunteers after a single oral administration of CU-
83
.
Maximum plasma concentrations of CU-
83
following the administration at doses of 20, 40 and 60μg were 127.4, 152.
8
and 164.2pg/ml, respectively, from 0.6 to 0.
9
hr. On theother hand, maximum plasma concentration of CU-
83
(S) following the administration was
7
.4 pg/ml at
1
.
1
hr in the case of 20μg dose, 17.
7
pg/ml at
1
.0 hr in 40μg and 44.
1
pg/mlat
1
.0hr in 60μg.
Urinary excretion half-lives of CU-
83
and CU-
83
(S) were
1
.2-
1
. 6hr and
3
. 2-
5
.2hr, respectively. Of the administered dose,
1
. 45-
1
. 65% as CU-
83
and 0.98-
1
.62% as CU-
83
(S) were excreted in urine until 24 hr after administration.
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非対称型
3
,4:
9
,10-ペリレンビス(ジカルボキシミド)誘導体の合成と性質

琴尾幸徳, 石川成実, 田辺順子, 御園生尭久

日本化学会誌（化学と工業化学）
1980年 1980 巻 9 号 1391-1396
発行日: 1980/09/10
公開日: 2011/05/30

DOI https://doi.org/10.1246/nikkashi.1980.1391

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Nアルキル
3
,4:
9
,10-ペリレンテトラカルボン酸モノアンヒドリド=モノイミド[4a～
e
]と芳香族アミン(アニリン,p-トルイジン,p-アニシジン,
3
,
5
-キシリジン,4-アミノナゾベンゼン,およびo-フェニレンジアミン)を縮合して非対称型
3
,4:
9
,10-ペリレンビス(ジカルボキシミド)誘導体-N-アルキル-N'-アリール-
3
,4:
9
,10-ペリレンビス(ジカルボキシミド)(〔
5
a～
e
〕,〔6a～
e
〕,〔
7
a～
e
〕,〔
8
a～
e
〕,〔
9
a～
e
〕,および〔10a～
b
〕)を合成した. これらの各誘導体はすべて赤色系の色相を示し, 顔料試験の結果N-ブチル-N'-アリール-
3
,4:
9
,10-ペリレンビス(ジカルボキシミド)(たとえば〔
5
e
〕や〔6
e
〕)がとくにすぐれた耐光性を示した.
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Predation Efficacy of Bdellovibrio bacteriovorus on Multidrug-Resistant Clinical Pathogens and Their Corresponding Biofilms

Yao Sun, Jianzhong Ye, Yuanbo Hou, Huale Chen, Jianming Cao, Tieli Zhou

Japanese Journal of Infectious Diseases
2017年 70 巻 5 号 485-489
発行日: 2017年
公開日: 2017/09/25
[早期公開] 公開日: 2017/03/28

DOI https://doi.org/10.7883/yoken.JJID.2016.405

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The aim of the present study was to evaluate the predation efficacy of Bdellovibrio bacteriovorus on multidrug-resistant (MDR) or extensive drug resistant (XDR) gram-negative pathogens and their corresponding biofilms. In this study, we examined the ability of
B
. bacteriovorus to prey on MDR and XDR gram-negative clinical bacteria, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Results showed that B
. bacteriovorus was able to prey on all planktonic cultures, among which the most efficient predation was observed for drug-resistant E
. coli, with a
3
.11 log10 reduction in viability. Furthermore, B
. bacteriovorus demonstrated promising efficacy in preventing biofilm formation and dispersing the established biofilm. Reductions in biofilm formation of E
. coli, K. pneumoniae, P. aeruginosa, and A. baumannii co-cultured with B
. bacteriovorus were 65.2%, 37.
1
%, 44.
7
%, and 36.
8
%, respectively. Meanwhile, the established biofilms of E
. coli, K. pneumoniae, P. aeruginosa, and A. baumannii were significantly reduced by
83
.4%, 81.
8
%,
83
.
1
%, and 79.
9
%, respectively. A visual analysis supported by scanning electron microscopy demonstrated the role of B
. bacteriovorus in removing the established biofilms. This study highlights the potential use of B
. bacteriovorus as a biological control agent with the capability to prey on MDR/XDR gram-negative pathogens and eradicate biofilms.

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Identification of possible ion-drag induced neutral instability in the lower thermosphere over Svalbard

C. M. Hall, T. Aso

Earth, Planets and Space
2000年 52 巻 9 号 639-643
発行日: 2000年
公開日: 2010/03/09

DOI https://doi.org/10.1186/BF03351672

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The EISCAT Svalbard Radar (ESR) has been used to obtain ion velocities in the lower thermosphere. By using beam swinging and assuming homogeneity and stationarity of the plasma, first approximations to the electric field have been deduced, and thus the thermospheric neutral wind has been estimated. From these derived parameters, we have estimated the gradient Richardson Number. Although many assumptions must be made, there is an indication that electrodynamics is able to contribute to enhancement or even production of neutral-air turbulence in the lower thermosphere. Finally, we outline a proposal for an analogy to the Reynolds Number, but reflecting the relative importance's of the contribution of ion-drag to the neutral dynamics and the kinematic viscosity.
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CONTINUOUS SHIFTWORKING IN PROCESS INDUSTRIES: DOES FIRM EFFICIENCY IMPLY HIGH HUMAN COSTS?

Cbesseredes HORTS

Journal of Human Ergology
1982年 11 巻 Supplement 号 429-440
発行日: 1982/12/15
公開日: 2011/02/23

DOI https://doi.org/10.11183/jhe1972.11.Supplement_429

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注意障害

高次脳機能研究（旧失語症研究）
2019年 39 巻 1 号 55-56
発行日: 2019/03/31
公開日: 2020/04/03

DOI https://doi.org/10.2496/hbfr.39.55

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性周期における牛末梢血中遊離estrogenの螢光測定

百目鬼郁男, 中原達夫, 山内亮

家畜繁殖研究會誌
1974年 20 巻 2 号 76-80
発行日: 1974/08/30
公開日: 2008/05/15

DOI https://doi.org/10.1262/jrd1955.20.76

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性周期における牛の末梢血中遊離estrogen測定にITTRICH螢光法を応用して次の成績を得た。
Ittrich colorの最大波長をspectrofluorometer Hitachi MPF-2AおよびType203で測定した結果,励起光538nm,螢光552.
5
nmであった。この螢光特性は
E₁
,
E₂
および
E₃
にそれぞれ共通であった。実際の測定では最大波長が接近しているので感度は若干低下するが510~520nmで励起し•螢光側552•
5
±
22
•
5nm
を読み,ALLENの補正を行なった。この条件において
E₁
,
E₂
および
E₃
-methyletherの最少検出量は
1ng
であった。回収率補正の目的で加えた6,
7
-^{3H
-E₂
-17βの全過程における回収率は平均60.3
±11.7
%であった。正常性周期を示す黒毛和種2頭の頸静脈血についてestrogenを分画測定した。その結果,両牛共E₁
,E₂
の各消長型は性周期の全期間を通じてほぼ同じ傾向を示したが,E₂
はE₁
にくらべ全般に高値であった。またE₃
は検出されなかった。これらの牛のtotalestrogenは発情前期に増加し,排卵前に鋭いピーク(35.3
および99.8ng
/l;E₁5.9
および16.0ng/l,E₂29.4
および83.8ng
/l)を形成し,排卵後は急激に減少して最低値(3
.8
~5.3ng
/l;E₁1.6
および1.9ng
/l,E₂2.2
および3.4ng
/l)を示した。黄体期の最高値(10.1
および27.0ng/l;E₁2.4
および3.4ng
/l,E₂7.7
および23.6ng/l)は排卵後6~8日に認めた。すなわちestrogenの血中濃度は性周期の間に2つのピークを形成することを認めた。
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散発下痢症患者由来のフルオロキノロン耐性大腸菌におけるgyrA遺伝子およびparC遺伝子の変異

石畝史, 東方美保, 山崎貢, 松雪星子, 森屋一雄, 田中大祐, 磯部順子, 京田芳人, 村岡道夫

感染症学雑誌
2006年 80 巻 5 号 507-512
発行日: 2006/09/20
公開日: 2011/02/07

DOI https://doi.org/10.11150/kansenshogakuzasshi1970.80.507

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1991年～2005年の福井県など4県における散発下痢症患者由来の大腸菌0153107株について, 市販の薬剤感受性ディスクを用いたKB (Kirby-Bauer) 法で12剤の薬剤感受性を調べた. 薬剤別耐性菌出現率はampicillinが72.
9
%, streptomycinが48.6%, tetracyclinおよびsulfisoxazoleが46.
7
%, nalidixic acid (NA) が29.
9
%およびciprofloxacin (CPFX) が24.
3
%などであった.
7
～10剤に耐性を示す18株中16株など計26株が, NAおよびCPFXに耐性を示した. NAおよびCPFXに耐性を示した24株とNAに耐性を示した
1
株について, gyrAおよびparC遺伝子の解析を行った結果, 次の4typesに分けられた. type
1
(
1
株) GyrA (S
83
L) ・ParC (S80I), type2 (12株) GyrA (S
83
L & D87N) ・ParC (S80I), type
3
(
8
株) GyrA (S
83
L & D87N) ・ParC (S80I &
E
84G) または (S80R &
E
84V), type4 (4株) GyrA (S
83
L & D87N) ・ParC (S80I & A108T). アミノ酸変異とfluoroquinolone (FQ) 系薬剤の最小発育阻止濃度 (MIC) との関連をみると, CPFX, ofioxacinおよびnorfloxacinのMICはtype
1
では, それぞれ
1
μg/mL, 2μg/mLおよび
8
μg/mL, type2では
8
～32μg/mL,
8
～32μg/mLおよび16～256μg/mL, type
3
, 4では32～256μg/mL, 32～128μg/mLおよび128～>512μg/mLであった. 患者由来のFQ系剤耐性大腸菌O153が多剤耐性傾向を示すとともに, gyrAおよびparCで各々
1
～2カ所の変異がみられた.
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Detection of 6 periodontal bacteria in dental plaque samples from Japanese children

Tamami Saito, Ohmi Ueda, Ken Ouryouji, Hiroyuki Kawabata, Hisao Oguchi, Sachiyo Teramoto, Hiroo Miyazawa

Pediatric Dental Journal
2007年 17 巻 2 号 141-147
発行日: 2007年
公開日: 2007/12/27

DOI https://doi.org/10.11411/pdj.17.141

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We analyzed the distribution of 6 periodontal bacteria (Porphyromonas gingivalis, Prevotella nigrescens, Prevotella intermedia, Eikenella corrodens, Actinobacillus actinomycetemcomitans and Capnocytophaga sputigena) in dental plaque materials from 227 children (
3
-6 years old). The plaque materials were collected from all erupted teeth sites using a sterile toothbrush. Chromosomal DNA was extracted from each plaque sample, followed by a polymerase chain reaction with species-specific sets of primers. Standard strains of 6 bacteria were used as controls. Total detection rate of P.gingivalis, P.nigrescens, P.intermedia,
E.corrodens
, A.actinomycetemcomitans and C.sputigena were
5
.
3
%, 47.
1
%,
8
.4%,
83
.
7
%,
83
.
3
% and 81.
1
%, respectively.
E.corrodens
, C.sputigena and A.actinomycetemcomitans were very frequently detected at all ages. On the other hand, P.gingivalis and P.intermedia were detected less frequently. Detection rate of P.nigrescens,
E.corrodens
and C.sputigena increased with age. The average detection number for each age group increased with age (2.63, 2.98,
3
.43 and
3
.45 for age
3
, 4,
5
and 6, respectively). The number of bacterial species in the plaque materials increased with age as well. Our results indicate that P.nigrescens,
E.corrodens
, A.actinomycetemcomitans and C.sputigena are established quite early in childhood, these bacteria increase with age in the oral cavity.
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E
.A. Moelwyn-Hughes: Physical Chemistry, Second revised ed. Pergamon Press, 1961, 1333ページ.
83
S

小野周

日本物理学会誌
1961年 16 巻 12 号 798-
発行日: 1961/12/05
公開日: 2021/04/14

DOI https://doi.org/10.11316/butsuri1946.16.12.798_1

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合成ゼオライトを触媒とするピナン, 2-および2 (10)- ピネンの熱異性化反応

野村正人, 藤原義人

日本農芸化学会誌
1983年 57 巻 12 号 1227-1229
発行日: 1983年
公開日: 2008/11/21

DOI https://doi.org/10.1271/nogeikagaku1924.57.1227

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The thermo-isomerization of l-cis-pinane (
1
), 2-pinene (2) and 2 (10)-pinene (
3
) in the presence of synthetic zeolites (A-
3
, A-4, A-
5
,
F
-
9
and TSZ-642) was investigated. Whith TSZ-642 zeolite, dihydromyrcene (
5
) was obtained with high selec-tivity (high 85%) in all converted products from (
1
). 4
E
/6 Z-Alloocimene (10) and 4
E
/6
E
-alloo-cimene (11) were obtained from (2) as the main products, amounting to
86
% (77:
9
) of the isom-erization product. Myrcene (12) was obtained from (
3
) as the main product, amounting to
83
% of the isomerization product under the best conditions.
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The production of nematode-immobilizing secretory cells by Climacodon septentrionalis

Joey
B
. Tanney, Leonard J. Hutchison

Mycoscience
2012年 53 巻 1 号 31-35
発行日: 2012年
公開日: 2023/03/31

DOI https://doi.org/10.1007/s10267-011-0128-1

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The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–
1
,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

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