The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.

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BCR-ABL1 International Scale（IS）測定はチロシンキナーゼ阻害剤で治療されている慢性骨髄性白血病（CML）患者の治療効果をモニターする上で重要な検査法である。稀ではあるが，BCR-ABL1 IS測定ができないCMLが存在することが知られている。本研究において，我々は，そのようなBCR-ABL1 IS測定のできないCML患者を経験し，分子生物学的な方法で，その原因を解明した。本例ではABL1遺伝子における切断点がa2エクソン内にあることが分かり，そのことがABL1のa2エクソンを欠いた

14a（a）キメラ遺伝子のmRNAのみの発現を誘導していた。a2エクソンは本邦における検査部でのIS測定において重要な要素であり，これが欠損することが測定不能の原因であった。このようなIS測定ができない稀なCML症例をさらに集積して，その分子構造を解明することが待たれる。

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The effect of composition and controlled thermomechanical process parameters on the mechanical properties of HSLA steels is modelled using the Widrow-Hoff's concept of training a neural net with feed-forward topology by applying Rumelhart's back propagation type algorithm for supervised learning, using a Petri like net structure. The data used are from laboratory experiments as well as from the published literature. The results from the neural network are found to be consistent and in good agreement with the experimented results.

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Horizontal plate anchors are widely used in civil engineering constructions to resist vertical pulling loads. The available theoretical model suggested by Vesic to estimate the breakout resistance of plate anchors is in significant error, particularly for dense sandy soils. A theoretical model assuming a curved surface of failure through the surrounding soil, to evaluate the ultimate breakout resistance of horizontal plate anchors, has been proposed. It successfully brings out the concept of characteristics relative depth beyond which the breakout factor reaches a constant final value. It is capable of predicting breakout factors for wide range of values of angle of shearing resistance of sand.

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An unsupervised learning technique and an associative memory have been used for encoding weights by a special type of Petri network named Petri neural net for modelling the influence of alloying elements on the final property of the high strength low alloy steel. The combined effects of alloying elements for different strengthening mechanisms is predicted when weights and threshold values are chosen on the basis of metallurgical understanding. The technique is found to be effective to create an associative memory of input-output relations in unknown data sets so that the same can be subsequently be used as a predictive tool.

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Primarily from the point of view of improvement of yield strength due to additions of niobium, titanium and boron in HSLA steels, the experimental steels are divided into five classes. The data are then supplied for learning a Self Organising Map (Kohonen network). It is found that the network with six neurons possesses better capacity of prediction with unknown data. Another effort of clustering the steels according to its major strength contributing mechanisms is also made. But the capacity of the network to cluster unknown data is found to be rather poor and has failed to follow from the metallurgical principles. To avoid this limitation, Learning Vector Quantisation method is adopted to impart a certain amount of supervision in the learning process and it is found that the training pattern of the network attains a good convergence thereby leading to a good predictive ability.

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A boron treated copper bearing HSLA steel containing austenite formers like manganese and nickel, somewhat lower in amount than that in HSLA 100 variety of steel is chosen for the study. The role of thermomechanical processing on the microstructure and mechanical properties of the above steel has been investigated. Differential scanning calorimetric study is carried out for understanding the precipitation behaviour of copper in HSLA steel under the influence of boron. The microstructure of the experimental steel is found to consist of laths of martensites and bainite. MA constituents of ribbon like morphology are observed at the lath boundaries. Higher strength properties of the steel are attributed to the presence of finely distributed precipitates of copper and microalloy carbides.

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Simultaneous measurements of the total geomagnetic field intensity by the same type of the proton precession magnetometers at two stations in NW Turkey have been taken cooperatively by a research group since December 1970. Up to the end of July 1971 mainly three probable local magnetic changes were observed. It was seen that after a decrease in the local field at a magnetic station (Erdek) a few earthquakes occured at either nearly N or S of that station, and after an increase in the local field an earthquake took place nearly W of the same station. In this paper the data and some results of the first part of observations are given.

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Nine isoquinoline alkaloids belonging to the protoberberine, proaporphine and bisbenzyl-isoquinoline series were isolated from Caryomene olivascens (Menispermaceae). Four compounds are new : (-)-2-norlimacine (), (-)-caryolivine (6), (+)-1, 2-dehydro-2-norlimacusine () and N-formylstepharine (). The last one is the first N-formyl derivative to be reported in the proaporphine group. Its biogenetic origin is discussed. Structures were established on the basis of 360 MHz (FT) nuclear magnetic resonance measurements and also by chemical correlation in the case of .

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The aim of the present study was to evaluate the predation efficacy of Bdellovibrio bacteriovorus on multidrug-resistant (MDR) or extensive drug resistant (XDR) gram-negative pathogens and their corresponding biofilms. In this study, we examined the ability of

. bacteriovorus to prey on MDR and XDR gram-negative clinical bacteria, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Results showed that

B

. bacteriovorus was able to prey on all planktonic cultures, among which the most efficient predation was observed for drug-resistant

E

. coli, with a .11 log10 reduction in viability. Furthermore,

B

. bacteriovorus demonstrated promising efficacy in preventing biofilm formation and dispersing the established biofilm. Reductions in biofilm formation of

E

. coli, K. pneumoniae, P. aeruginosa, and A. baumannii co-cultured with

B

. bacteriovorus were 65.2%, .1%, 44.7%, and 36.%, respectively. Meanwhile, the established biofilms of

E

. coli, K. pneumoniae, P. aeruginosa, and A. baumannii were significantly reduced by .%, 81.%, .1%, and 79.%, respectively. A visual analysis supported by scanning electron microscopy demonstrated the role of

B

. bacteriovorus in removing the established biofilms. This study highlights the potential use of

B

. bacteriovorus as a biological control agent with the capability to prey on MDR/XDR gram-negative pathogens and eradicate biofilms.

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　Human space exploration missions require life support systems to sustain the crew. Plants help regulate the earth’s atmospheric and terrestrial environment; similarly, plants could be used in a closed system in space: cleaning carbon dioxide from the air, breaking down liquid and solid wastes, and producing fresh food. Advanced Life Support systems would use plants as part of a bioregenerative system. For space flight applications, the systems must be low in mass and energy consumption, and must be designed for reduced gravity operations. Four areas of research are reviewed in this article related to ALS system design, crop physiology and biology. The Water Offset Nutrient Delivery ExpeRiment (WONDER) will be conducted on the Space Shuttle to evaluate gravity-independent hydroponic systems and optimum water content targets for microgravity crop production. The Photosynthesis Experiment and System Testing and Operation (PESTO) project studied the photosynthesis rates and physiological responses of crops germinated and grown in microgravity. A project to study crop production systems in closed, controlled environments for multiple crops in the same root and aerial environment (International Space Station baseline conditions) is described. Finally, efficient light emitting diode (LED) lighting is being studied to determine plant photobiological responses to different light qualities.

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　新潟港海岸日和山浜地区にて，飛砂が発生する冬季(12月中旬から

月上旬)に，TLS測量とUAV測量による海浜地形測量を年に亘って実施した．精度の高いTLS測量は信頼し得る土量計算を可能にした．砂浜地形の土砂収支解析から，遡上帯からの飛砂発生の事実の確認，及びその発生量の推定ができた．1冬季期間の遡上帯からの飛砂発生量は概略1.6～/mであった．海浜のある一定の範囲(第2区画)にて，海浜陸端に設置してある堆砂垣周辺の堆積量から推定された飛砂量は，2016年度.6m/m，2017年/m得ている．2016年度/m / /m=0.49，2017年度/m / /m=0.49となり概略50％程度が遡上帯から発生していることになる．遡上帯の幅は20m～40m程度であった．地形データから判読された最大遡上高は改良仮想勾配法により算定される値と概略一致した．

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　阿字ヶ浦海岸におけるサンドリサイクルによる砂礫の掘削と投入後，養浜盛り土の変形状況を調べた．養浜直後の2021年7月16日と養浜から

か月経過後の2021年10月15日にはUAV映像を取得し，海浜の次元測量を行った．併せて養浜前後の海浜状況の変化について現地調査を行った．サンドリサイクルによる投入土砂はごく短時間汀線に留まるのみで，か月後には効果が全く失われた．この意味より，養浜砂が安定的に投入箇所に安定的に留まることが可能な方法を採用した後，養浜を行う方法に改良することが必要である．

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　波浪や潮流によってモノパイル式洋上風力発電設備の基部周辺に洗掘が発生すると，施設の安全性に深刻な影響を与える恐れがある．袋型根固め材とは繊維の網で石材をユニット化した資材である．防波堤や海岸堤防の侵食対策として実用化されている．本研究では袋型根固め材を用いた洗掘防止工の現地適用性と最適な敷設構造について検討した．水理模型実験は1/60縮尺で行った．無対策の実験では既往研究と同等の最大洗掘量が確認された．洗掘防止工はフィルター層の有無や複数の敷設構造について検討した．その結果，円形1層

列2層2列配置を最適な構造として提案した．モノパイル近傍の洗掘を最も抑制でき，袋型根固め材自体の耐波安定性も高められるためである．なお，この際の最大洗掘量は現地換算で0.2m以下であった．

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　浸透固化処理工法で背後地盤を液状化対策した岸壁を対象に，FLIPを用いて固化処理部の地盤定数の空間的ばらつきを考慮して地震応答解析を行った．本論文の結論は，次の通りである．(1) 適合率0.56～0.

の範囲で強度の空間的不均質性を有する浸透固化処理地盤において，L2地震の加振終了時の岸壁の残留変位は，モンテカルロシミュレーション100回で十分な統計値が得られる．(2) 加振終了時の岸壁の残留水平変位と残留沈下量は，有意水準5%で対数正規分布に従う．岸壁の残留水平変位の平均値と分布幅は，適合率の減少とともに大きくなる．() 許容水平変位を1.5mとし，その信頼度を0.，0.95および0.99に設定したとき，浸透固化処理地盤はそれぞれ0.62，0.63および0.67以上の適合率まで改良する必要がある．

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